KEGG   Macaca mulatta (rhesus monkey): 707870Help
Entry
707870            CDS       T01028                                 

Gene name
IRS1
Definition
(RefSeq) insulin receptor substrate 1
  KO
K16172  
insulin receptor substrate 1
Organism
mcc  Macaca mulatta (rhesus monkey)
Pathway
cGMP-PKG signaling pathway
FoxO signaling pathway
Autophagy - animal
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Longevity regulating pathway
Longevity regulating pathway - multiple species
Neurotrophin signaling pathway
Insulin signaling pathway
Adipocytokine signaling pathway
Regulation of lipolysis in adipocytes
Type II diabetes mellitus
Insulin resistance
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
MicroRNAs in cancer
Module
PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:mcc00001]
 Environmental Information Processing
  Signal transduction
   04068 FoxO signaling pathway
    707870 (IRS1)
   04022 cGMP - PKG signaling pathway
    707870 (IRS1)
   04151 PI3K-Akt signaling pathway
    707870 (IRS1)
   04152 AMPK signaling pathway
    707870 (IRS1)
   04150 mTOR signaling pathway
    707870 (IRS1)
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    707870 (IRS1)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    707870 (IRS1)
   04923 Regulation of lipolysis in adipocyte
    707870 (IRS1)
   04920 Adipocytokine signaling pathway
    707870 (IRS1)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    707870 (IRS1)
  Nervous system
   04722 Neurotrophin signaling pathway
    707870 (IRS1)
  Aging
   04211 Longevity regulating pathway - mammal
    707870 (IRS1)
   04213 Longevity regulating pathway - multiple species
    707870 (IRS1)
 Human Diseases
  Cancers
   05206 MicroRNAs in cancer
    707870 (IRS1)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    707870 (IRS1)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    707870 (IRS1)
   04931 Insulin resistance
    707870 (IRS1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
Ensembl: 
UniProt: 
Position
12
AA seq 1253 aa AA seqDB search
MASPPESDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP
KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH
HDGAAALGAGGGGGSCSGSSGVGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI
GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV
DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT
RRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR
GSARLHPPLNHSRSIPMPASRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP
SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGPSTLTAPN
GHYILSRGGNGHRYTPGTGLGTSPALAGDEASSAADLDNRFRKRTHSAGTSPTITHQKTP
SQSSVASIEEYTEMMPAYPPGGGSGGRLPGHRHSAFVPTHSYPEEGLEMHPLERRGGHHR
PDSSTLHTDDGYMPMSPGVAPVPSSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN
GYMMMSPSGGCSPDIGGGPSSSSSSAVPSGSSYGKLWTNGVGGHHSHVLPHPKPPVESSG
GKLLPCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEPEE
GARHQHLRLSASSGRLLYAATVDDSSSSTSSDSLGGGYCGARLEPSLPHPHHQVLQPHLP
RKVDTAAQTNSRLARPTRLSLGDPKASTLPRAREQQQQQQQQQQQQQQQQQQPLLHPPEP
KSPGEYVNIEFGSDQPGYLSGPVASRSSPSVRCPSQLQPAPREEETGTEEYMKMDLGPGR
RAAWQESTGVEMGRLGPAPPGAASICRPTRAVPSSRGDYMTMQMSCPRQSYVDTSPIAPV
SYADMRTGIAAEEVSLPRATMAAASSSSAASASPTGPQGAAELAAHSSLLGGPQGPGGMS
AFTRVNLSPNRNQSAKVIRADPQGCRRRHSSETFSSTPSATRVGNTVPFGAGAAIGGGGG
SSSSSEDVKRHSSASFENVWLRPGELGGAPKEPAQLCGAAGGLENGLNYIDLDLVKDFKQ
RPQECSPQPQPPPPPPPHQPLGSSESSSTRRCSSEDLSAYASISFQKQPEDLQ
NT seq 3762 nt NT seq  +upstreamnt  +downstreamnt
atggcgagccctccggagagcgatggcttctcggacgtgcgcaaggtgggctacctgcgc
aaacccaagagcatgcacaaacgcttcttcgtactgcgcgcggccagcgaggctgggggc
ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc
aaacgctcgatcccccttgagagctgcttcaacatcaacaagcgggctgactccaagaac
aagcacctggtggctctctacacccgggacgagcactttgccatcgcggcggacagcgag
gcggagcaagacagctggtaccaggctctcctacagctgcacaaccgtgccaagggccac
cacgacggagctgcggccctcggggcgggaggtggcgggggcagctgcagtggcagctcc
ggcgttggtgaggctggggaggacttgagctacggtgacgtgcccccaggacccgcgttc
aaagaggtctggcaggtgatcctgaagcccaagggcctgggtcagacaaagaacctgatt
ggtatctaccgcctctgcctgaccagcaagaccatcagcttcgtgaagctgaactcggag
gcagccgccgtggtgctgcagctgatgaacatcaggcgctgcggccactcggagaacttc
ttcttcatcgaggtgggccgttctgccgtgacggggcccggggagttctggatgcaggtg
gatgactccgtggtggcccagaacatgcacgagaccatcctggaggccatgcgggctatg
agcgatgagttccgccctcgcagcaagagtcagtcctcgtccaactgctccaaccccatc
agcgtccccctgcgccggcaccatctcaacaaccccccgcccagccaggtggggctgacc
cgacgatctcgcactgagagcatcactgccacctccccggccagcatggtgggcgggaaa
ccaggctccttccgcgtccgcgcctccagtgacggcgaaggcaccatgtcccgcccagcc
tcggtggatggcagccctgtgagtccgagcaccaacagaacccacgcccaccggcatcgg
ggcagcgcccggctgcaccccccgctcaaccacagccgctccatccccatgccagcttcc
cgctgctcgccttcggccaccagccccgtcagtctgtcgtccagcagcaccagcggccat
ggctccacctcggattgtctcttcccacggcgatctagtgcttcggtgtctggttctccc
agcgatggcggtttcatctcctcagatgagtatggctccagtccctgcgatttccggagt
tccttccgcagtgtgactccggattccctgggccacaccccaccagcccgcggtgaggag
gagctaagcaactatatctgcatgggcggcaaggggccctccaccctgaccgcccccaac
ggtcactacattttgtctcggggtggcaatggccaccgctacaccccaggaacaggcttg
ggcacgagtccagccttggctggggatgaagcatccagtgctgcggatctggataatcgc
ttccgaaagagaactcactctgcaggcacatcccctaccattacccaccagaagaccccg
tcccagtcctcagtggcttccattgaggagtatacagagatgatgcctgcctacccacca
ggaggtggcagtggaggccgactgccgggacacaggcactctgccttcgtgcccacccac
tcctacccagaggagggtctggaaatgcaccccttggagcgtcgggggggccaccaccgc
ccagacagctctaccctccacactgatgatggctacatgcccatgtccccaggggtggcc
ccagtgcccagcagccgaaagggcagtggagactatatgcccatgagccccaagagcgtg
tctgccccacagcagatcatcaatcccatcagacgccatccccagagagtggaccccaat
ggctacatgatgatgtcccccagcggtggctgctctcctgacattggaggtggccccagc
agcagcagcagcagtgctgtcccttctgggagcagctatggaaagctgtggacaaacggg
gtagggggccaccactctcatgtcttgcctcaccccaaacccccagtggagagcagcggt
ggcaagctcttaccttgcacaggtgactacatgaacatgtcaccagtgggggactccaac
accagcagcccctctgactgctactatggccctgaggacccccagcacaagccagtcctc
tcgtactactcattgccaagatcctttaagcacacccagcgccctggggagccggaggag
ggtgcccggcatcagcacctccgcctttctgctagctctggtcgccttctctatgctgca
acagtggatgattcttcctcctccaccagcagcgacagcctgggtgggggatactgtggg
gctaggctggagcccagccttccacatccccaccatcaggttctgcagccccatctgcct
cgaaaggtggacacagctgctcagaccaatagccgcctggcccggcctacgaggctgtcc
ctgggggatcccaaggccagcaccttacctcgggcccgagagcagcagcagcagcagcag
cagcagcagcaacagcagcaacagcagcaacagcagcccctgctgcaccctccggagccc
aagagcccaggggaatatgtgaatattgaatttgggagtgatcagcctggctacttgtct
ggcccggtggcttcccgtagctcaccttctgtcaggtgtccatcccagctccagccagct
cccagagaggaagagactggcactgaggagtacatgaagatggacctggggccgggccgg
agggcagcctggcaggagagcactggggtcgagatgggcagactggggcccgcacctccc
ggggctgctagcatttgcaggcctacccgggcagtgcccagcagccggggtgactatatg
accatgcagatgagttgtccccgccagagctatgtggacacctcgccaattgcccctgta
agctatgctgacatgcggacaggcattgctgcagaggaggtgagcctgcccagggccacc
atggctgctgcctcctcatcctcagcagcctctgcttcccccactgggcctcaaggggca
gcagagctggctgcccactcatccctgctggggggcccacaaggacctgggggcatgagc
gccttcacccgggtgaacctcagtcctaaccgcaaccagagtgccaaagtgatccgtgca
gacccacaagggtgccggaggaggcatagctccgagaccttctcctcaacacccagtgcc
acccgggtgggcaacacagtgccctttggagccggggcagcaatagggggtggtggcggt
agcagcagcagcagcgaggatgtgaaacgtcacagctctgcttcctttgagaatgtgtgg
ctgaggcctggggaacttgggggagcccccaaggagccagcccaactgtgtggggctgct
gggggtttggagaatggtcttaactacatagatctggatttggtcaaggacttcaaacag
cgccctcaggagtgcagccctcaaccgcagcctcccccacccccaccccctcatcaaccc
ctgggtagcagtgagagcagctccacccgccgctgctcaagtgaggatttaagcgcctat
gccagcatcagtttccagaagcagccagaggaccttcagtag

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