KEGG   Macaca mulatta (rhesus monkey): 708938Help
Entry
708938            CDS       T01028                                 

Gene name
MAPK3
Definition
(RefSeq) mitogen-activated protein kinase 3
  KO
K04371  
mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
Organism
mcc  Macaca mulatta (rhesus monkey)
Pathway
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
Platinum drug resistance
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Oocyte meiosis
Autophagy - animal
mTOR signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Cellular senescence
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
TGF-beta signaling pathway
Axon guidance
VEGF signaling pathway
Apelin signaling pathway
Osteoclast differentiation
Focal adhesion
Adherens junction
Gap junction
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
Natural killer cell mediated cytotoxicity
IL-17 signaling pathway
Th1 and Th2 cell differentiation
Th17 cell differentiation
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Circadian entrainment
Long-term potentiation
Neurotrophin signaling pathway
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Relaxin signaling pathway
Type II diabetes mellitus
AGE-RAGE signaling pathway in diabetic complications
Aldosterone-regulated sodium reabsorption
Alzheimer's disease
Prion diseases
Alcoholism
Salmonella infection
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Hepatitis B
Influenza A
Human papillomavirus infection
Kaposi's sarcoma-associated herpesvirus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Breast cancer
Hepatocellular carcinoma
Central carbon metabolism in cancer
Choline metabolism in cancer
Module
MAPK (ERK1/2) signaling
Brite
KEGG Orthology (KO) [BR:mcc00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    708938 (MAPK3)
   04015 Rap1 signaling pathway
    708938 (MAPK3)
   04010 MAPK signaling pathway
    708938 (MAPK3)
   04012 ErbB signaling pathway
    708938 (MAPK3)
   04350 TGF-beta signaling pathway
    708938 (MAPK3)
   04370 VEGF signaling pathway
    708938 (MAPK3)
   04371 Apelin signaling pathway
    708938 (MAPK3)
   04668 TNF signaling pathway
    708938 (MAPK3)
   04066 HIF-1 signaling pathway
    708938 (MAPK3)
   04068 FoxO signaling pathway
    708938 (MAPK3)
   04072 Phospholipase D signaling pathway
    708938 (MAPK3)
   04071 Sphingolipid signaling pathway
    708938 (MAPK3)
   04024 cAMP signaling pathway
    708938 (MAPK3)
   04022 cGMP - PKG signaling pathway
    708938 (MAPK3)
   04151 PI3K-Akt signaling pathway
    708938 (MAPK3)
   04150 mTOR signaling pathway
    708938 (MAPK3)
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    708938 (MAPK3)
  Cell growth and death
   04114 Oocyte meiosis
    708938 (MAPK3)
   04210 Apoptosis
    708938 (MAPK3)
   04218 Cellular senescence
    708938 (MAPK3)
  Cellular community - eukaryotes
   04510 Focal adhesion
    708938 (MAPK3)
   04520 Adherens junction
    708938 (MAPK3)
   04540 Gap junction
    708938 (MAPK3)
   04550 Signaling pathways regulating pluripotency of stem cells
    708938 (MAPK3)
  Cell motility
   04810 Regulation of actin cytoskeleton
    708938 (MAPK3)
 Organismal Systems
  Immune system
   04611 Platelet activation
    708938 (MAPK3)
   04620 Toll-like receptor signaling pathway
    708938 (MAPK3)
   04621 NOD-like receptor signaling pathway
    708938 (MAPK3)
   04650 Natural killer cell mediated cytotoxicity
    708938 (MAPK3)
   04660 T cell receptor signaling pathway
    708938 (MAPK3)
   04658 Th1 and Th2 cell differentiation
    708938 (MAPK3)
   04659 Th17 cell differentiation
    708938 (MAPK3)
   04657 IL-17 signaling pathway
    708938 (MAPK3)
   04662 B cell receptor signaling pathway
    708938 (MAPK3)
   04664 Fc epsilon RI signaling pathway
    708938 (MAPK3)
   04666 Fc gamma R-mediated phagocytosis
    708938 (MAPK3)
   04062 Chemokine signaling pathway
    708938 (MAPK3)
  Endocrine system
   04910 Insulin signaling pathway
    708938 (MAPK3)
   04912 GnRH signaling pathway
    708938 (MAPK3)
   04915 Estrogen signaling pathway
    708938 (MAPK3)
   04914 Progesterone-mediated oocyte maturation
    708938 (MAPK3)
   04917 Prolactin signaling pathway
    708938 (MAPK3)
   04921 Oxytocin signaling pathway
    708938 (MAPK3)
   04926 Relaxin signaling pathway
    708938 (MAPK3)
   04919 Thyroid hormone signaling pathway
    708938 (MAPK3)
   04916 Melanogenesis
    708938 (MAPK3)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    708938 (MAPK3)
   04270 Vascular smooth muscle contraction
    708938 (MAPK3)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    708938 (MAPK3)
  Nervous system
   04724 Glutamatergic synapse
    708938 (MAPK3)
   04725 Cholinergic synapse
    708938 (MAPK3)
   04726 Serotonergic synapse
    708938 (MAPK3)
   04720 Long-term potentiation
    708938 (MAPK3)
   04730 Long-term depression
    708938 (MAPK3)
   04723 Retrograde endocannabinoid signaling
    708938 (MAPK3)
   04722 Neurotrophin signaling pathway
    708938 (MAPK3)
  Development
   04360 Axon guidance
    708938 (MAPK3)
   04380 Osteoclast differentiation
    708938 (MAPK3)
  Environmental adaptation
   04713 Circadian entrainment
    708938 (MAPK3)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    708938 (MAPK3)
   05230 Central carbon metabolism in cancer
    708938 (MAPK3)
   05231 Choline metabolism in cancer
    708938 (MAPK3)
   05205 Proteoglycans in cancer
    708938 (MAPK3)
   05203 Viral carcinogenesis
    708938 (MAPK3)
   05210 Colorectal cancer
    708938 (MAPK3)
   05212 Pancreatic cancer
    708938 (MAPK3)
   05225 Hepatocellular carcinoma
    708938 (MAPK3)
   05214 Glioma
    708938 (MAPK3)
   05216 Thyroid cancer
    708938 (MAPK3)
   05221 Acute myeloid leukemia
    708938 (MAPK3)
   05220 Chronic myeloid leukemia
    708938 (MAPK3)
   05218 Melanoma
    708938 (MAPK3)
   05211 Renal cell carcinoma
    708938 (MAPK3)
   05219 Bladder cancer
    708938 (MAPK3)
   05215 Prostate cancer
    708938 (MAPK3)
   05213 Endometrial cancer
    708938 (MAPK3)
   05224 Breast cancer
    708938 (MAPK3)
   05223 Non-small cell lung cancer
    708938 (MAPK3)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    708938 (MAPK3)
   05020 Prion diseases
    708938 (MAPK3)
  Substance dependence
   05034 Alcoholism
    708938 (MAPK3)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    708938 (MAPK3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    708938 (MAPK3)
  Infectious diseases
   05132 Salmonella infection
    708938 (MAPK3)
   05133 Pertussis
    708938 (MAPK3)
   05152 Tuberculosis
    708938 (MAPK3)
   05164 Influenza A
    708938 (MAPK3)
   05161 Hepatitis B
    708938 (MAPK3)
   05160 Hepatitis C
    708938 (MAPK3)
   05167 Kaposi's sarcoma-associated herpesvirus infection
    708938 (MAPK3)
   05165 Human papillomavirus infection
    708938 (MAPK3)
   05145 Toxoplasmosis
    708938 (MAPK3)
   05140 Leishmaniasis
    708938 (MAPK3)
   05142 Chagas disease (American trypanosomiasis)
    708938 (MAPK3)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    708938 (MAPK3)
   01524 Platinum drug resistance
    708938 (MAPK3)
   01522 Endocrine resistance
    708938 (MAPK3)
Enzymes [BR:mcc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     708938 (MAPK3)
Protein kinases [BR:mcc01001]
 Serine/threonine protein kinases: CMGC group
  MAPK family [OT]
   708938 (MAPK3)
Chromosome [BR:mcc03036]
 Eukaryotic Type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Protein kinases
     708938 (MAPK3)
Exosome [BR:mcc04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   708938 (MAPK3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
Position
20
AA seq 694 aa AA seqDB search
MALRSALGPRRPPLQAASPHGLLRPLPGPGAGWVAVTAARPRNPRLPHARRPTGGPRPGP
PAPPGPSLTCCRERTVTPQKPEVEEEEEEEEGAGGAGDSPAEDALVKTMNEKQPCARLQG
GRAPWGGALPGPPCAPGPLLRPPPSPAPARAPRTKALQARPPGLGVRPSPATPPPPPDPA
DASAGSAGGAGGTGEEKPRALPDPRDLALAWLRDLHMGGPGSRFSSLVSCLHREHPCPPA
EIIRHHGHLLRARGYRVERGRRARQAPAREEPSLGEGGGAHGRSKPGFGEGSRGGGVGPG
EPRGSARGPGGGGDGEGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPF
EHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQ
QLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHD
HTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNH
ILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPN
KRITVEEALAHPYLEQYYDPTDEVGQSPAAVGPGAGGXVGIPHARPEPCCLCPQPVAEEP
FTFAMELDDLPKERLKELIFQETARFQPGALEAP
NT seq 2085 nt NT seq  +upstreamnt  +downstreamnt
atggctctgaggagcgctctggggccccggcggcccccactccaggcagcgtccccccac
gggctgctgcgcccgctccctggccccggcgctggctgggtcgcggtgacagccgcgcgc
ccccgcaacccgcggctcccacacgcgcgccgccccacaggtggccctcgccccggtcca
cccgcgcctcctgggcccagcctcacctgctgcagagagaggacagtgaccccccaaaag
ccggaggtggaggaggaggaggaagaggaggaaggagctggaggagccggggactcgccc
gctgaggatgctcttgtcaagacaatgaatgagaagcagccgtgtgcccgcctccagggt
ggccgcgccccttggggcggagctcttccaggcccgccctgcgctcccgggcccctgctg
cggccgcctccctcccctgccccagcccgcgccccacgcacgaaagcgctccaggcccgc
ccgccaggcctcggtgtccgccccagcccggcgacgccgccccctcctcccgaccccgca
gacgcgagcgcggggagcgcggggggcgcggggggcacgggcgaggagaagcccagagcg
ctcccggacccaagggacctggctcttgcttggctccgagatctacacatgggtggcccc
gggagtcgcttctcctccctggtctcctgtcttcatcgggaacacccctgccctcctgct
gaaataattcggcatcacgggcacctacttcgtgccaggggctacagggtcgagcgaggc
aggcgagccaggcaggctcccgcccgtgaagagcccagcctgggggaaggaggaggagcc
cacggccgctccaagcccggctttggcgaaggctcgaggggcgggggtgtggggcccgga
gagccgagggggtcggcccggggtcccgggggaggtggagatggtgaagggcagccgttc
gacgtgggcccgcgctacacgcagctgcaatacatcggcgagggcgcgtacggcatggtc
agctcggcctatgaccacgtgcgcaagactcgcgtggccatcaagaagatcagccccttc
gagcatcagacctactgccagcgcacgctccgggagatccagatcctgctgcgcttccgc
catgagaatgtcatcggcatccgagacattctgcgtgcgtccaccctggaagccatgagg
gatgtctacattgtgcaggacctgatggagactgacctgtacaagttgctgaaaagccag
caactgagcaatgaccacatctgctacttcctctaccagatcctgcggggcctcaagtac
atccactccgctaatgtgctccaccgggatctaaagccctccaacctgctcatcaacacc
acctgcgaccttaagatttgcgatttcggcctggcccggattgccgatcctgagcatgac
cacactggcttcctgacggagtatgtggctacacgctggtaccgggccccagagatcatg
ctgaactccaagggctataccaagtccatcgacatctggtctgtgggctgcattctggct
gagatgctctctaaccggcccatcttccctggcaagcactacctggatcagctcaaccac
attctgggcatcctgggctccccatcccaggaggacctgaattgtatcatcaacatgaag
gcccgaaactacctacagtctctgccctccaagaccaaggtggcttgggccaagcttttc
cccaagtcagactccaaagcccttgacctgctggaccggatgttaacctttaaccccaat
aaacggatcacagtggaggaagcgctggctcacccctacctggagcagtactatgacccg
acggatgaggtgggccagtccccagcagcagtagggccaggggcaggggggtaagtaggc
atcccccatgccaggcctgagccttgctgtctctgcccccagccagtggccgaggagccc
ttcaccttcgccatggagctggatgacctacctaaggagcggctgaaggagctcatcttc
caggagacagcacgcttccagcctggggcgctagaggccccctaa

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