KEGG   Macaca mulatta (rhesus monkey): 714173Help
Entry
714173            CDS       T01028                                 

Gene name
PLCG2
Definition
phospholipase C, gamma 2 (phosphatidylinositol-specific)
Orthology
K05859  
phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
mcc  Macaca mulatta (rhesus monkey)
Pathway
Inositol phosphate metabolism
Metabolic pathways
ErbB signaling pathway
Ras signaling pathway
Calcium signaling pathway
NF-kappa B signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
VEGF signaling pathway
Osteoclast differentiation
Platelet activation
Natural killer cell mediated cytotoxicity
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Inflammatory mediator regulation of TRP channels
Thyroid hormone signaling pathway
Epstein-Barr virus infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Non-small cell lung cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mcc00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    714173 (PLCG2)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    714173 (PLCG2)
   04012 ErbB signaling pathway
    714173 (PLCG2)
   04370 VEGF signaling pathway
    714173 (PLCG2)
   04064 NF-kappa B signaling pathway
    714173 (PLCG2)
   04066 HIF-1 signaling pathway
    714173 (PLCG2)
   04020 Calcium signaling pathway
    714173 (PLCG2)
   04070 Phosphatidylinositol signaling system
    714173 (PLCG2)
 Organismal Systems
  Immune system
   04611 Platelet activation
    714173 (PLCG2)
   04650 Natural killer cell mediated cytotoxicity
    714173 (PLCG2)
   04662 B cell receptor signaling pathway
    714173 (PLCG2)
   04664 Fc epsilon RI signaling pathway
    714173 (PLCG2)
   04666 Fc gamma R-mediated phagocytosis
    714173 (PLCG2)
   04670 Leukocyte transendothelial migration
    714173 (PLCG2)
  Endocrine system
   04919 Thyroid hormone signaling pathway
    714173 (PLCG2)
  Nervous system
   04722 Neurotrophin signaling pathway
    714173 (PLCG2)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    714173 (PLCG2)
  Development
   04380 Osteoclast differentiation
    714173 (PLCG2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    714173 (PLCG2)
   05206 MicroRNAs in cancer
    714173 (PLCG2)
   05205 Proteoglycans in cancer
    714173 (PLCG2)
   05214 Glioma
    714173 (PLCG2)
   05223 Non-small cell lung cancer
    714173 (PLCG2)
  Infectious diseases
   05169 Epstein-Barr virus infection
    714173 (PLCG2)
Enzymes [BR:mcc01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     714173 (PLCG2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
UniProt: 
Position
20
AA seq 1265 aa AA seqDB search
MSTMVNVDSLAEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAL
NWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSA
KFLKDKFVEIGAHRDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VYLHDFQRFLIHEQQEHWAQDLSKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDC
WDGPDGKPIIYHGWTRTTKIKFDDVVQAIKEHAFVTSSFPVILSIEEHCSVEQQRHMAKT
FKEVFGDLLLMKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNVEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTTEEEVPQDIPPTELHFGEKWFHKKVEKR
TSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYY
LTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYESLSRGEAEDML
MRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY
EKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTKIQQYFPSNYVEDISTADVEELEKQII
EDNPLGCLCRGILDLNTYNVVKAPQGKNQKPFVFILEPKKQGDPPVEFATDRVEELFEWF
QSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSITRQKPVDLLRYNQKGLTRIYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKF
MQMNHALFSLNGRTGYVLQPESMRAEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSI
ACPFVEVEICGADYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKAIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFNVNENQLQLYQEKCNKRLREKRVSN
SKFYS
NT seq 3798 nt NT seq  +upstreamnt  +downstreamnt
atgtccaccatggtcaatgtggattcccttgcggaatatgagaagagccagatcaagaga
gccctggagctggggacggtgatgactgtgttcagcttccgcaagtccacccctgagcgg
aggaccgtccaggtgatcatggagacgcggcaggtggcctggagcaagaccgctgacaag
atcgagggcttcttggatatcatggaaataaaagaaatccgcccagggaagaactccaaa
gatttcgaacgtgcaaaagcggttcgccagaaagaagattgctgcttcaccatcctgtat
ggcactcagttcgtcctcagcacactcagcttggcagctgactctaaagaagatgcactt
aattggctctctggcttgaaaatcttacaccaagaagcgatgaatgcgtccacacccacc
attatcgagagttggctgagaaagcagatatattctgtggatcaaaccagaagaaacagc
atcagtctccgagagttgaagaccatcttgcccctgatcaactttaaagtgagcagtgcc
aagttccttaaagataagtttgtggaaataggagcacacagagatgagctcagctttgaa
cagttccatctcttctataaaaaacttatgttcgagcagcaaaaatcgattctcgatgaa
ttcaaaaaggattcgtccgtgttcatcctggggaacacagacaggccggatgcctccgct
gtttacctgcatgacttccagaggtttctcatacatgaacagcaggagcattgggctcag
gatctgagcaaagtccgtgagcggatgacaaagttcatcgatgacaccatgcgcgaaact
gctgagcctttcttgtttgtggatgagttcctcacgtacctgttttcacgagaaaacagc
atctgggatgagaagtatgacgcggtggacatgcaggacatgaacaaccccctgtctcat
tactggatctcctcgtcccataacacgtacctcacaggtgaccagctgcggagcgagtca
tccccagaagcttacatccgctgcctgcgcatgggctgtcgctgcattgaactggactgc
tgggacgggcccgatgggaagccgatcatctaccacggctggacgcggaccaccaagatc
aagtttgacgacgtcgtacaggccatcaaagagcacgcctttgttacctcaagcttccca
gtgatcctgtccatcgaggagcactgcagcgtggagcagcagcgtcacatggccaagacc
ttcaaggaagtgtttggtgacctgctgctgatgaagcccacggaggccagcgctgaccag
ctgccctcgcccagccagctgcgggagaagatcatcatcaagcataagaagctgggtccc
cgaggcgacgtggatgtcaacgtggaggacaagaaggatgagcacaagcaacagggagag
ctgtacatgtgggattccatcgaccagaaatggactcggcactactgcgccattgctgac
gccaagctgtccttcagtgatgacattgaacagactacggaggaggaagtgccccaggat
ataccccctacagagctacattttggggagaaatggttccacaagaaggtggagaagagg
acgagtgccgagaagttgctgcaggaatactgcatggagacggggggcaaggacggcacc
ttcctggttcgggagagcgagaccttccccaatgactacaccctgtccttctggcggtca
ggccgggtgcagcactgccggatccgttccaccatggaaggtggaaccctaaagtactac
ctgactgacaacctcaccttcagcagcatctacgccctcatccagcactaccgcgagacg
cacctgcgctgcgccgagttcgagctgcggctcacggaccctgtgcccaaccccaacccc
cacgagtccaagccgtggtactatgagagcctgagccgcggagaggcagaggacatgctg
atgaggatcccccgggacggagccttcctgatccggaagcgagagggaagcgactcctac
gccatcaccttcagggctaggggcaaggtgaagcattgtcgaatcaaccgggatggccgg
cactttgtgctggggacctccgcctattttgagagcctggtggagctcgtcagttactac
gagaagcattcactctaccgaaagatgagactgcgctaccccgtgacccccgagctcctg
gagcgctacaacatggaaagagatataaactccctctacgacgtcagcagaatgtatgtg
gatcccagtgaaatcaatccgtccatgcctcagagaaccgtgaaagctctgtatgactac
aaagccaagcgaagcgatgagctgagcttctgccgtggtgccctcatccacaatgtctcc
aaggagcccgggggctggtggaaaggagactatggaaccaagatccagcagtacttccca
tccaactacgtcgaggacatctcaacggcagatgtcgaggagctggaaaagcagattatt
gaagacaatcccttagggtgtctttgcagaggaatattggacctcaatacctataacgtc
gtgaaagccccacagggaaaaaaccagaagccctttgtctttatcctggagcccaagaag
cagggcgatcctccggtggagtttgccacagacagggtggaggagctcttcgagtggttt
cagagcatccgagagatcacctggaagattgacaccaaggagaacaacatgaagtactgg
gagaagaaccagtccatcgccatcgagctctctgacctggttgtctactgcaaaccgacc
agcaaaaccaaggacaacttagaaaatcctgacttccgagaaatccgctcctttgtggag
acgaaggctgacagcatcaccagacagaagcccgtcgacctcctgaggtacaatcaaaag
ggcctgacccgcatctacccaaagggacaaagagttgactcttcaaactacgaccccttc
cgcctctggctgtgcggttctcagatggtggcactcaatttccagacagcagataagttc
atgcagatgaatcacgcgttgttttctctcaatgggcgcacgggctacgttctgcagcct
gagagcatgagggcagagaaatatgacccaatgccacccgagtcccagaggaagatcctg
atgacgctgacggtcaaggttctcggtgctcgccatctccccaaacttggacgaagtatt
gcctgtccttttgtagaggtggagatctgtggagccgactatgacaacaacaagttcaag
acgacggttgtgaatgataatggcctcagccctatctgggctccaacacaggagaaggtg
acatttgaaatttatgacccaaacctggcatttctgcgcttcgtggtttacgaagaagat
atgttcagtgatcccaactttcttgctcatgccacttaccccattaaagcaatcaaatca
ggattcaggtctgttcctctgaagaacgggtacagcgaggacatagagctggcttccctc
ctggtcttctgtgagatgcggccagtcctggagagcgaagaggaactttactcctcctgt
cgccagctaaggaggcggcaagaagaactgaacaaccaactctttctgtatgacacacac
cagaacttgcgcaatgccaaccgggatgccctggttaaagagttcaatgttaatgagaac
cagctccagctgtaccaggagaaatgcaacaagaggttaagagagaagagagtcagcaac
agcaagttttactcatag

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