KEGG   Macaca mulatta (rhesus monkey): 718418Help
Entry
718418            CDS       T01028                                 

Gene name
PLCB4
Definition
phospholipase C, beta 4
Orthology
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
mcc  Macaca mulatta (rhesus monkey)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mcc00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    718418 (PLCB4)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    718418 (PLCB4)
   04310 Wnt signaling pathway
    718418 (PLCB4)
   04020 Calcium signaling pathway
    718418 (PLCB4)
   04070 Phosphatidylinositol signaling system
    718418 (PLCB4)
   04022 cGMP - PKG signaling pathway
    718418 (PLCB4)
 Cellular Processes
  Cellular commiunity
   04540 Gap junction
    718418 (PLCB4)
 Organismal Systems
  Immune system
   04611 Platelet activation
    718418 (PLCB4)
   04062 Chemokine signaling pathway
    718418 (PLCB4)
  Endocrine system
   04911 Insulin secretion
    718418 (PLCB4)
   04912 GnRH signaling pathway
    718418 (PLCB4)
   04915 Estrogen signaling pathway
    718418 (PLCB4)
   04921 Oxytocin signaling pathway
    718418 (PLCB4)
   04918 Thyroid hormone synthesis
    718418 (PLCB4)
   04919 Thyroid hormone signaling pathway
    718418 (PLCB4)
   04916 Melanogenesis
    718418 (PLCB4)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    718418 (PLCB4)
   04270 Vascular smooth muscle contraction
    718418 (PLCB4)
  Digestive system
   04970 Salivary secretion
    718418 (PLCB4)
   04971 Gastric acid secretion
    718418 (PLCB4)
   04972 Pancreatic secretion
    718418 (PLCB4)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    718418 (PLCB4)
  Nervous system
   04724 Glutamatergic synapse
    718418 (PLCB4)
   04725 Cholinergic synapse
    718418 (PLCB4)
   04728 Dopaminergic synapse
    718418 (PLCB4)
   04726 Serotonergic synapse
    718418 (PLCB4)
   04720 Long-term potentiation
    718418 (PLCB4)
   04730 Long-term depression
    718418 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    718418 (PLCB4)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    718418 (PLCB4)
  Environmental adaptation
   04713 Circadian entrainment
    718418 (PLCB4)
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    718418 (PLCB4)
   05016 Huntington's disease
    718418 (PLCB4)
  Infectious diseases
   05146 Amoebiasis
    718418 (PLCB4)
   05142 Chagas disease (American trypanosomiasis)
    718418 (PLCB4)
   05143 African trypanosomiasis
    718418 (PLCB4)
Enzymes [BR:mcc01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     718418 (PLCB4)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
10
AA seq 1169 aa AA seqDB search
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVL
ECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPTAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPHLSPSLCMFLLTEQLEALRSMMEAGESASPANILEDDNE
EEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKASDDLEHENNKKGLVTVEDEQ
AWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKT
HAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFE
YNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDM
YGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNKLIGQRI
LPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITE
KRADQMRAMGIETSDIADVPSDTSKNDKKGKANTTKANVTPQSSSELRPTTTAALASGVE
AKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVA
QYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQHTKEWSE
MINTHSAEEQEIRDLHLSQQCELLKKLLISAHEQQTQQLKLSHDRESKEMRAHQAKISME
NSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQLEHLEF
LEKQNEQAKEMQQMVKLEAEMDRRPATVV
NT seq 3510 nt NT seq  +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaactggcagaaggaagttccttcctttttgcaagaagga
gcagtttttgacagatacgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtggatgagtttggcttctttctgacatggaaaagtgaaggcaaggaaggacaggtgcta
gaatgctccctcatcaacagtattcggtcgggagccataccaaaggatcccaaaatcttg
gctgctcttgaagctgttggaaaatcagaaaatgatctggaaggtcggatagtttgtgtc
tgcagtggcacagatctagtgaacattagttttacctacatggtggctgaaaatccagaa
gtaactaagcaatgggtagaaggcctgagatcaatcatacacaacttcagggccaacaat
gtcagtccaatgacgtgcctcaagaaacactggatgaaattggcatttatgaccaacaca
aatggtaaaattccagttaggagtattactagaacctttgcatcggggaaaacagaaaag
gtgatctttcaagcactcaaggagttaggtcttcccagtggaaagaatgatgaaattgag
cccacggcatttacttatgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaagatcttttcaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagatcctcgattgaatgaaattttattt
ccattttatgatgccaaaagggcaatgcagatcattgagatgtatgaacctgatgaagat
ttgaagaaaaaaggccttatatcaagtgatgggttttgcagatatctgatgtcagatgaa
aacgccccagtcttcctagatcgtttagaactttaccaagaaatggaccatcctctggct
cactacttcatcagttcttcccataacacttacctgactggcagacagttcggcgggaag
tcttcggtagagatgtacagacaggttctcctggctggttgcagatgtgttgaacttgac
tgctgggatggaaaaggtgaagaccaagaaccaataataactcatggaaaagcaatgtgt
acagatatcctttttaaggatgtaattcaagccatcaaggaaactgcatttgtcacatca
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgcgaagatctatttggagatctcctgttgaaacaagcgcttgaatcacat
ccacatctgtcaccatctctttgcatgtttttgctaacagaacagctggaagctttgaga
agcatgatggaagctggagaatctgcctccccagcaaacatcttagaggatgataatgaa
gaggagatcgaaagtgctgaccaagaggaggaagctcaccccgaattcaaatttggaaat
gaactttctgctgatgacttgggtcacaaggaagctgttgcaaatagcgtcaagaaggcc
tcagatgaccttgaacatgaaaacaacaaaaagggcctggtaactgtagaagatgagcag
gcgtggatggcatcttataaatatgtaggtgctaccactaatatccatccatatttgtcc
acaatgatcaactacgcccagcctgtaaagtttcaaggtttccatgtggcagaagaacgc
aatattcattataacatgtcttcttttaatgaatcagtcggtcttggctacttgaagaca
catgcaattgaatttgtcaattataacaaacggcaaatgagtcgcatttaccccaaggga
ggccgagtcgattccagtaattacatgcctcagattttctggaacgctggctgccagatg
gtttccctgaactatcaaaccccagatttagcgatgcaattgaatcagggaaaatttgag
tataatggatcgtgcgggtaccttctcaaaccagatttcatgaggcggcctgatcgaaca
tttgaccccttctctgaaactcctgttgatggcgttattgcagccacttgctcagtgcag
gttatatcaggtcaattcttatcagataagaaaattggcacctatgtagaagtggatatg
tatgggttgcccactgacactatacgtaaggaattccgaactcgtatggttatgaataat
ggactaaatccagtttacaatgaagagtctttcgtatttcggaaggtgatcctgccagac
ctggctgtcttgagaatagcagtgtatgatgataacaacaagctgattggccagaggatc
ctcccgcttgatggcctccaagcaggataccgacacatttcccttcgaaatgagggaaat
aaaccattatcactgccaacaattttctgcaatattgttcttaaaacatacgtgcctgat
ggatttggagatattgtggatgctttatcagatccaaagaaatttctctcaattacagaa
aagagagcagaccaaatgagagctatgggcattgaaactagtgacatagctgatgtgccc
agtgacacttccaaaaatgacaagaaaggaaaggccaataccaccaaagcaaacgtgacc
cctcagagtagctctgagctcagaccaaccaccacagctgccctggcctctggtgtggaa
gccaaaaaaggtattgaacttatccctcaagtaaggatagaagatttaaagcagatgaag
gcttacttgaagcatttaaagaaacagcagaaagagctaaattctttaaagaagaaacat
gcaaaggagcacagtaccatgcagaagttacactgcacgcaagttgacaaaattgtggca
cagtatgacaaagagaagtcgactcatgagaaaatcctagagaaggcaatgaagaagaag
gggggaagtaattgtctcgaaatgaaaaaagaaacagaaattaaaattcagacgctgaca
tcagatcacaaatctaaggtcaaagagattgtagcacagcacacaaaggaatggtcagaa
atgatcaatacccacagtgctgaggagcaagaaatccgagacctgcacctcagccagcag
tgtgagctgctgaaaaagctactcatcagtgcccacgagcagcaaacccagcagctgaaa
ctgtcccatgacagggaaagcaaggaaatgcgagcacaccaggctaagatttctatggaa
aatagcaaagccatcagccaagataaatctatcaagaataaggcagaacgggaaaggcga
gtcagggagttaaacagcagcaacactaaaaagtttctggaagaaagaaagagactcgca
atgaagcagtccaaagaaatggatcagttgaaaaaagtccagcttgaacatctagaattc
ctagagaaacagaatgagcaggcgaaggagatgcagcagatggtgaaattggaagccgag
atggaccgcagaccagcaacagtagtatga

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