KEGG   Macaca mulatta (rhesus monkey): 718418Help
Entry
718418            CDS       T01028                                 

Gene name
PLCB4
Definition
(RefSeq) phospholipase C beta 4
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
mcc  Macaca mulatta (rhesus monkey)
Pathway
mcc00562  Inositol phosphate metabolism
mcc01100  Metabolic pathways
mcc04015  Rap1 signaling pathway
mcc04020  Calcium signaling pathway
mcc04022  cGMP-PKG signaling pathway
mcc04062  Chemokine signaling pathway
mcc04070  Phosphatidylinositol signaling system
mcc04071  Sphingolipid signaling pathway
mcc04072  Phospholipase D signaling pathway
mcc04261  Adrenergic signaling in cardiomyocytes
mcc04270  Vascular smooth muscle contraction
mcc04310  Wnt signaling pathway
mcc04371  Apelin signaling pathway
mcc04540  Gap junction
mcc04611  Platelet activation
mcc04621  NOD-like receptor signaling pathway
mcc04713  Circadian entrainment
mcc04720  Long-term potentiation
mcc04723  Retrograde endocannabinoid signaling
mcc04724  Glutamatergic synapse
mcc04725  Cholinergic synapse
mcc04726  Serotonergic synapse
mcc04728  Dopaminergic synapse
mcc04730  Long-term depression
mcc04750  Inflammatory mediator regulation of TRP channels
mcc04911  Insulin secretion
mcc04912  GnRH signaling pathway
mcc04915  Estrogen signaling pathway
mcc04916  Melanogenesis
mcc04918  Thyroid hormone synthesis
mcc04919  Thyroid hormone signaling pathway
mcc04921  Oxytocin signaling pathway
mcc04922  Glucagon signaling pathway
mcc04924  Renin secretion
mcc04925  Aldosterone synthesis and secretion
mcc04926  Relaxin signaling pathway
mcc04927  Cortisol synthesis and secretion
mcc04928  Parathyroid hormone synthesis, secretion and action
mcc04933  AGE-RAGE signaling pathway in diabetic complications
mcc04934  Cushing's syndrome
mcc04961  Endocrine and other factor-regulated calcium reabsorption
mcc04970  Salivary secretion
mcc04971  Gastric acid secretion
mcc04972  Pancreatic secretion
mcc05010  Alzheimer's disease
mcc05016  Huntington's disease
mcc05142  Chagas disease (American trypanosomiasis)
mcc05143  African trypanosomiasis
mcc05146  Amoebiasis
mcc05200  Pathways in cancer
Module
mcc_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mcc00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    718418 (PLCB4)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    718418 (PLCB4)
   04310 Wnt signaling pathway
    718418 (PLCB4)
   04371 Apelin signaling pathway
    718418 (PLCB4)
   04020 Calcium signaling pathway
    718418 (PLCB4)
   04070 Phosphatidylinositol signaling system
    718418 (PLCB4)
   04072 Phospholipase D signaling pathway
    718418 (PLCB4)
   04071 Sphingolipid signaling pathway
    718418 (PLCB4)
   04022 cGMP - PKG signaling pathway
    718418 (PLCB4)
 Cellular Processes
  Cellular community - eukaryotes
   04540 Gap junction
    718418 (PLCB4)
 Organismal Systems
  Immune system
   04611 Platelet activation
    718418 (PLCB4)
   04621 NOD-like receptor signaling pathway
    718418 (PLCB4)
   04062 Chemokine signaling pathway
    718418 (PLCB4)
  Endocrine system
   04911 Insulin secretion
    718418 (PLCB4)
   04922 Glucagon signaling pathway
    718418 (PLCB4)
   04912 GnRH signaling pathway
    718418 (PLCB4)
   04915 Estrogen signaling pathway
    718418 (PLCB4)
   04921 Oxytocin signaling pathway
    718418 (PLCB4)
   04926 Relaxin signaling pathway
    718418 (PLCB4)
   04918 Thyroid hormone synthesis
    718418 (PLCB4)
   04919 Thyroid hormone signaling pathway
    718418 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    718418 (PLCB4)
   04916 Melanogenesis
    718418 (PLCB4)
   04924 Renin secretion
    718418 (PLCB4)
   04925 Aldosterone synthesis and secretion
    718418 (PLCB4)
   04927 Cortisol synthesis and secretion
    718418 (PLCB4)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    718418 (PLCB4)
   04270 Vascular smooth muscle contraction
    718418 (PLCB4)
  Digestive system
   04970 Salivary secretion
    718418 (PLCB4)
   04971 Gastric acid secretion
    718418 (PLCB4)
   04972 Pancreatic secretion
    718418 (PLCB4)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    718418 (PLCB4)
  Nervous system
   04724 Glutamatergic synapse
    718418 (PLCB4)
   04725 Cholinergic synapse
    718418 (PLCB4)
   04728 Dopaminergic synapse
    718418 (PLCB4)
   04726 Serotonergic synapse
    718418 (PLCB4)
   04720 Long-term potentiation
    718418 (PLCB4)
   04730 Long-term depression
    718418 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    718418 (PLCB4)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    718418 (PLCB4)
  Environmental adaptation
   04713 Circadian entrainment
    718418 (PLCB4)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    718418 (PLCB4)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    718418 (PLCB4)
   05016 Huntington's disease
    718418 (PLCB4)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    718418 (PLCB4)
   04934 Cushing's syndrome
    718418 (PLCB4)
  Infectious diseases
   05146 Amoebiasis
    718418 (PLCB4)
   05142 Chagas disease (American trypanosomiasis)
    718418 (PLCB4)
   05143 African trypanosomiasis
    718418 (PLCB4)
Enzymes [BR:mcc01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     718418 (PLCB4)
Membrane trafficking [BR:mcc04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    718418 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    718418 (PLCB4)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: PI-PLC-X PI-PLC-Y DUF1154 EF-hand_like C2 EF-hand_6
Motif
Other DBs
NCBI-GeneID: 718418
NCBI-ProteinID: XP_015004953
Ensembl: ENSMMUG00000001012
UniProt: H9FVW1
Position
10
AA seq 1206 aa AA seqDB search
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVL
ECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPTAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALRSM
MEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKASD
DLEHENNKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTTKANVTPQ
SSSELRPTTTAALASGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLISAHEQQTQQLKLS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQSQGEGDAADGEIGSRDGPQTSNSSM
KLQNAN
NT seq 3621 nt NT seq  +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaactggcagaaggaagttccttcctttttgcaagaagga
gcagtttttgacagatacgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtggatgagtttggcttctttctgacatggaaaagtgaaggcaaggaaggacaggtgcta
gaatgctccctcatcaacagtattcggtcgggagccataccaaaggatcccaaaatcttg
gctgctcttgaagctgttggaaaatcagaaaatgatctggaaggtcggatagtttgtgtc
tgcagtggcacagatctagtgaacattagttttacctacatggtggctgaaaatccagaa
gtaactaagcaatgggtagaaggcctgagatcaatcatacacaacttcagggccaacaat
gtcagtccaatgacgtgcctcaagaaacactggatgaaattggcatttatgaccaacaca
aatggtaaaattccagttaggagtattactagaacctttgcatcggggaaaacagaaaag
gtgatctttcaagcactcaaggagttaggtcttcccagtggaaagaatgatgaaattgag
cccacggcatttacttatgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaagatcttttcaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagatcctcgattgaatgaaattttattt
ccattttatgatgccaaaagggcaatgcagatcattgagatgtatgaacctgatgaagat
ttgaagaaaaaaggccttatatcaagtgatgggttttgcagatatctgatgtcagatgaa
aacgccccagtcttcctagatcgtttagaactttaccaagaaatggaccatcctctggct
cactacttcatcagttcttcccataacacttacctgactggcagacagttcggcgggaag
tcttcggtagagatgtacagacaggttctcctggctggttgcagatgtgttgaacttgac
tgctgggatggaaaaggtgaagaccaagaaccaataataactcatggaaaagcaatgtgt
acagatatcctttttaaggatgtaattcaagccatcaaggaaactgcatttgtcacatca
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgcgaagatctatttggagatctcctgttgaaacaagcgcttgaatcacat
ccacttgaaccaggcagacctttgccatcccccaatgacctcaaaagaaaaatactcata
aaaaacaagaggctgaaacctgaagttgaaaaaaaacagctggaagctttgagaagcatg
atggaagctggagaatctgcctccccagcaaacatcttagaggatgataatgaagaggag
atcgaaagtgctgaccaagaggaggaagctcaccccgaattcaaatttggaaatgaactt
tctgctgatgacttgggtcacaaggaagctgttgcaaatagcgtcaagaaggcctcagat
gaccttgaacatgaaaacaacaaaaagggcctggtaactgtagaagatgagcaggcgtgg
atggcatcttataaatatgtaggtgctaccactaatatccatccatatttgtccacaatg
atcaactacgcccagcctgtaaagtttcaaggtttccatgtggcagaagaacgcaatatt
cattataacatgtcttcttttaatgaatcagtcggtcttggctacttgaagacacatgca
attgaatttgtcaattataacaaacggcaaatgagtcgcatttaccccaagggaggccga
gtcgattccagtaattacatgcctcagattttctggaacgctggctgccagatggtttcc
ctgaactatcaaaccccagatttagcgatgcaattgaatcagggaaaatttgagtataat
ggatcgtgcgggtaccttctcaaaccagatttcatgaggcggcctgatcgaacatttgac
cccttctctgaaactcctgttgatggcgttattgcagccacttgctcagtgcaggttata
tcaggtcaattcttatcagataagaaaattggcacctatgtagaagtggatatgtatggg
ttgcccactgacactatacgtaaggaattccgaactcgtatggttatgaataatggacta
aatccagtttacaatgaagagtctttcgtatttcggaaggtgatcctgccagacctggct
gtcttgagaatagcagtgtatgatgataacaacaagctgattggccagaggatcctcccg
cttgatggcctccaagcaggataccgacacatttcccttcgaaatgagggaaataaacca
ttatcactgccaacaattttctgcaatattgttcttaaaacatacgtgcctgatggattt
ggagatattgtggatgctttatcagatccaaagaaatttctctcaattacagaaaagaga
gcagaccaaatgagagctatgggcattgaaactagtgacatagctgatgtgcccagtgac
acttccaaaaatgacaagaaaggaaaggccaataccaccaaagcaaacgtgacccctcag
agtagctctgagctcagaccaaccaccacagctgccctggcctctggtgtggaagccaaa
aaaggtattgaacttatccctcaagtaaggatagaagatttaaagcagatgaaggcttac
ttgaagcatttaaagaaacagcagaaagagctaaattctttaaagaagaaacatgcaaag
gagcacagtaccatgcagaagttacactgcacgcaagttgacaaaattgtggcacagtat
gacaaagagaagtcgactcatgagaaaatcctagagaaggcaatgaagaagaagggggga
agtaattgtctcgaaatgaaaaaagaaacagaaattaaaattcagacgctgacatcagat
cacaaatctaaggtcaaagagattgtagcacagcacacaaaggaatggtcagaaatgatc
aatacccacagtgctgaggagcaagaaatccgagacctgcacctcagccagcagtgtgag
ctgctgaaaaagctactcatcagtgcccacgagcagcaaacccagcagctgaaactgtcc
catgacagggaaagcaaggaaatgcgagcacaccaggctaagatttctatggaaaatagc
aaagccatcagccaagataaatctatcaagaataaggcagaacgggaaaggcgagtcagg
gagttaaacagcagcaacactaaaaagtttctggaagaaagaaagagactcgcaatgaag
cagtccaaagaaatggatcagttgaaaaaagtccagcttgaacatctagaattcctagag
aaacagaatgagcagcttttgaaatcctgtcatgcagtgtcccaatcgcaaggcgaagga
gatgcagcagatggtgaaattggaagccgagatggaccgcagaccagcaacagtagtatg
aaactccaaaatgcaaactga

DBGET integrated database retrieval system