KEGG   Macaca fascicularis (crab-eating macaque): 102139081Help
Entry
102139081         CDS       T02918                                 

Gene name
INSR
Definition
(RefSeq) insulin receptor
  KO
K04527  
insulin receptor [EC:2.7.10.1]
Organism
mcf  Macaca fascicularis (crab-eating macaque)
Pathway
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phospholipase D signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Longevity regulating pathway
Longevity regulating pathway - multiple species
Adherens junction
Insulin signaling pathway
Ovarian steroidogenesis
Regulation of lipolysis in adipocytes
Type II diabetes mellitus
Insulin resistance
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Module
PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:mcf00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    102139081 (INSR)
   04015 Rap1 signaling pathway
    102139081 (INSR)
   04010 MAPK signaling pathway
    102139081 (INSR)
   04066 HIF-1 signaling pathway
    102139081 (INSR)
   04068 FoxO signaling pathway
    102139081 (INSR)
   04072 Phospholipase D signaling pathway
    102139081 (INSR)
   04022 cGMP - PKG signaling pathway
    102139081 (INSR)
   04151 PI3K-Akt signaling pathway
    102139081 (INSR)
   04152 AMPK signaling pathway
    102139081 (INSR)
   04150 mTOR signaling pathway
    102139081 (INSR)
 Cellular Processes
  Cellular community - eukaryotes
   04520 Adherens junction
    102139081 (INSR)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    102139081 (INSR)
   04923 Regulation of lipolysis in adipocyte
    102139081 (INSR)
   04913 Ovarian Steroidogenesis
    102139081 (INSR)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    102139081 (INSR)
  Aging
   04211 Longevity regulating pathway - mammal
    102139081 (INSR)
   04213 Longevity regulating pathway - multiple species
    102139081 (INSR)
 Human Diseases
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    102139081 (INSR)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    102139081 (INSR)
   04931 Insulin resistance
    102139081 (INSR)
Enzymes [BR:mcf01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     102139081 (INSR)
Protein kinases [BR:mcf01001]
 Tyrosine protein kinases
  InsR family [OT]
   102139081 (INSR)
Enzyme-linked receptors [BR:mcf01020]
 Receptor tyrosine kinases
  RTK class II (Insulin receptor family)
   102139081 (INSR)
Cytokine receptors [BR:mcf04050]
 Receptor tyrosine kinase
  RTK class II (Insulin receptor family)
   102139081 (INSR)
CD molecules [BR:mcf04090]
 Proteins
  102139081 (INSR)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
Position
19
AA seq 1382 aa AA seqDB search
MGTGGRRGTAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHL
QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL
VIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE
ECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECL
GNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQG
CHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGC
TVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL
EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE
RNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQ
NVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS
DERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFGE
RQAEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQIL
KELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVGNVTVAVPTVAAF
PNTSSTSTPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYV
SARTMPEAKADDIVGPVTHEIFENNIVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCV
SRKHFALERGCRLRGLSPGNYSVRVRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIG
PLIFVFLFSIVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVPR
EKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKG
FTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMA
AEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPV
RWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDN
CPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPENEELEME
FEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPRSN
PS
NT seq 4149 nt NT seq  +upstreamnt  +downstreamnt
atgggcaccgggggccggcgggggacagctgccgcgccgctgctggtggcggtggccgcg
ctgctactgggcgccgcgggccacctgtaccccggagaggtgtgtcccggcatggacatc
cggaacaacctcaccaggttacacgagctggagaattgctctgtcatcgaaggacacttg
cagatactcttgatgttcaaaacgaggcccgaagatttccgggacctcagtttccccaaa
ctcataatgatcactgattacttgctgctcttccgggtctatgggctcgagagcctgaag
gacctgttccccaacctcacggtcatccggggatcacgactgttctttaactacgcgctg
gtcatcttcgagatggttcacctcaaggaacttggcctctacaatctaatgaacatcacc
cggggttctgtccgcatcgagaagaacaacgagctctgttacttggccactatcgactgg
tcccgcatcctggattccgtggaggataattacatcgtgttgaacaaagatgacaacgag
gagtgtggagacatctgtccgggtacagcgaagggcaagaccaactgccccgccactgtc
atcaatgggcagtttgtcgaacggtgttggactcatagtcactgccagaaagtttgccca
accatctgtaagtcacacggctgcactgccgaaggcctctgttgccacagcgagtgcctg
ggcaactgttctgagcccgacgaccccaccaagtgcgtggcctgccgcaacttctacctg
gacggcaggtgtgtggagacctgcccgcccccgtactaccacttccaggactggcgctgt
gtgaacttcagcttctgccaggacctgcaccacaaatgcaagaactcgcggaggcagggc
tgccaccagtacgtcattcataacaacaagtgcatccctgagtgtccctccgggtacacg
atgaattccagcaacttgctgtgcaccccgtgcctgggtccctgtcccaaggtatgccac
ctcctagaaggcgagaagaccatcgactcggtgacgtctgcccaggagctccgaggatgc
accgtcatcaacgggagtctgatcatcaacattcgaggaggcaataatctggcagctgag
ctagaagccaacctcggcctcattgaagaaatttcaggttatctaaaaatccgccgatcc
tacgctctggtgtcactttccttcttccggaagttacgtctgattcgaggagagaccttg
gaaatcgggaactattccttctatgccttggacaaccagaacctaaggcagctctgggac
tggagcaaacacaacctcacgatcactcaggggaaactcttcttccactataaccccaaa
ctctgcttgtcagaaatccacaagatggaagaagtttcaggaaccaaggggcgccaggag
agaaatgacattgccctgaagacaaatggggaccaggcatcctgtgaaaatgagttactt
aaattttcttacattcggacgtctttcgataagatcttgctgagatgggagccgtactgg
ccccccgacttccgagacctcctggggttcatgctgttctacaaagaagccccttaccag
aatgtgacggagtttgatgggcaggatgcgtgtggttccaacagctggacggtggtagac
attgacccgcccctgaggtccaacgaccccaaatcacagaaccacccaggatggctaatg
cggggtctcaagccctggacccagtatgccatctttgtgaagaccctggtcaccttttcg
gatgaacgccggacctatggagccaagagtgacatcatttatgtccagacagatgccacc
aacccctccgtgcccctggatccaatctcagtgtctaactcatcatcccagattattctg
aagtggaaaccgccctccgaccccaatggcaacatcacccactacctggttttcggggag
aggcaggcggaagacagtgagctgttcgagctggattattgcctcaaagggctgaagctg
ccctcgaggacctggtctccaccattcgagtctgaagattctcagaagcacaaccagagt
gaatatgaggattcagccggtgaatgttgctcctgtccaaagacagactctcagatcctg
aaggagctggaggagtcctcgtttaggaagacgtttgaggattacctgcacaacgtggtt
ttcgtccccagaaaaacctcttcaggcactggtgccgaggaccctaggccatctcggaaa
cgcaggtcccttggcgatgttgggaatgtgacggtggccgtgcccacggtggcagctttc
cccaacacttcctcgaccagcacgcccacaagtccggaggagcacaggccctttgagaag
gtggtgaacaaggagtcgctggtcatctccggcttgcgacacttcacgggctatcgcatc
gagctgcaggcttgcaaccaagacacccctgaggaacggtgcagtgtggcagcctacgtc
agcgccaggaccatgcctgaagccaaggctgatgacattgttggccctgtgacgcatgaa
atctttgagaacaacatcgtccacttgatgtggcaggagccgaaggagcccaatggtctg
attgtgctgtatgaagtgagttatcggcgatatggcgatgaggagctgcatctctgtgtc
tcccgcaagcacttcgctctggaacggggctgcaggctgcgcgggctgtcgccggggaac
tacagcgtgcgagtccgggccacctccctcgcgggcaacggctcctggacggaacccacc
tatttctacgtgacggactatttagatgtcccgtcaaatattgcaaaaattatcatcggc
cccctcatctttgtctttctcttcagtattgtgattggaagtatttatctattcctgaga
aagaggcagccagatgggccgctgggaccgctttacgcttcttcaaaccctgagtatctc
agtgccagtgatgtgtttccatgctctgtgtacgtgccggacgagtgggaggtgcctcga
gagaagatcaccctccttcgagagctggggcagggctccttcggcatggtgtatgagggc
aacgccagggacatcatcaagggtgaggcagagacccgcgtggcagtgaagacggtcaac
gagtcagccagtctccgagagcggattgagttcctcaatgaggcctcggtcatgaagggc
ttcacctgccatcatgtggtgcgcctcctgggagtggtgtccaagggccagcccacgctg
gtggtgatggaactgatggctcacggagacctgaagagctacctccgttctctgcggcca
gaggctgagaataatcctggccgccctccccctaccctgcaagagatgattcagatggcg
gcggagattgctgacgggatggcctacctgaatgccaagaagttcgtgcatcgggacctg
gcagcgagaaactgcatggtcgcccatgattttactgtcaaaatcggagactttggaatg
accagagacatatatgaaacggattactaccggaaaggaggcaagggtctgctccctgta
cggtggatggcaccggagtccctgaaggatggggtctttaccacttcttctgacatgtgg
tcctttggcgtggtcctttgggaaatcaccagcttggcagaacagccttaccaaggcctg
tctaatgaacaggtgttgaaatttgtcatggacggagggtatctggatcaacccgacaac
tgtccagagagagtcactgacctcatgcgcatgtgctggcaattcaaccccaagatgagg
ccaaccttcctggagatcgtcaacctgctcaaggacgacctgcaccccagctttccggag
gtgtcgttctttcacagcgaggagaacaaggctcccgagaatgaggagctggagatggag
tttgaggacatggagaacgtgcccctggaccgttcctcgcactgtcagagggaggaggcg
gggggccgggatggagggtcctcgctgggtttcaagcggagctacgaggaacacatccct
tatacccacatgaacggaggcaagaaaaacgggcggattctgaccttgcctcggtccaat
ccttcctaa

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