KEGG   Macaca fascicularis (crab-eating macaque): 102142026Help
Entry
102142026         CDS       T02918                                 

Gene name
PIK3CB
Definition
(RefSeq) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
  KO
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
mcf  Macaca fascicularis (crab-eating macaque)
Pathway
Inositol phosphate metabolism
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
Platinum drug resistance
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Autophagy - animal
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Longevity regulating pathway
Longevity regulating pathway - multiple species
Axon guidance
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Regulation of lipolysis in adipocytes
Type II diabetes mellitus
Insulin resistance
Non-alcoholic fatty liver disease (NAFLD)
AGE-RAGE signaling pathway in diabetic complications
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Kaposi's sarcoma-associated herpesvirus infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Breast cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
Fluid shear stress and atherosclerosis
Module
PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:mcf00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    102142026 (PIK3CB)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    102142026 (PIK3CB)
   04015 Rap1 signaling pathway
    102142026 (PIK3CB)
   04012 ErbB signaling pathway
    102142026 (PIK3CB)
   04370 VEGF signaling pathway
    102142026 (PIK3CB)
   04630 Jak-STAT signaling pathway
    102142026 (PIK3CB)
   04668 TNF signaling pathway
    102142026 (PIK3CB)
   04066 HIF-1 signaling pathway
    102142026 (PIK3CB)
   04068 FoxO signaling pathway
    102142026 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    102142026 (PIK3CB)
   04072 Phospholipase D signaling pathway
    102142026 (PIK3CB)
   04071 Sphingolipid signaling pathway
    102142026 (PIK3CB)
   04024 cAMP signaling pathway
    102142026 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    102142026 (PIK3CB)
   04152 AMPK signaling pathway
    102142026 (PIK3CB)
   04150 mTOR signaling pathway
    102142026 (PIK3CB)
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    102142026 (PIK3CB)
  Cell growth and death
   04210 Apoptosis
    102142026 (PIK3CB)
  Cellular community - eukaryotes
   04510 Focal adhesion
    102142026 (PIK3CB)
   04550 Signaling pathways regulating pluripotency of stem cells
    102142026 (PIK3CB)
  Cell motility
   04810 Regulation of actin cytoskeleton
    102142026 (PIK3CB)
 Organismal Systems
  Immune system
   04611 Platelet activation
    102142026 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    102142026 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    102142026 (PIK3CB)
   04660 T cell receptor signaling pathway
    102142026 (PIK3CB)
   04662 B cell receptor signaling pathway
    102142026 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    102142026 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    102142026 (PIK3CB)
   04670 Leukocyte transendothelial migration
    102142026 (PIK3CB)
   04062 Chemokine signaling pathway
    102142026 (PIK3CB)
  Endocrine system
   04910 Insulin signaling pathway
    102142026 (PIK3CB)
   04923 Regulation of lipolysis in adipocyte
    102142026 (PIK3CB)
   04915 Estrogen signaling pathway
    102142026 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    102142026 (PIK3CB)
   04917 Prolactin signaling pathway
    102142026 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    102142026 (PIK3CB)
  Digestive system
   04973 Carbohydrate digestion and absorption
    102142026 (PIK3CB)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    102142026 (PIK3CB)
  Nervous system
   04725 Cholinergic synapse
    102142026 (PIK3CB)
   04722 Neurotrophin signaling pathway
    102142026 (PIK3CB)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102142026 (PIK3CB)
  Development
   04360 Axon guidance
    102142026 (PIK3CB)
   04380 Osteoclast differentiation
    102142026 (PIK3CB)
  Aging
   04211 Longevity regulating pathway - mammal
    102142026 (PIK3CB)
   04213 Longevity regulating pathway - multiple species
    102142026 (PIK3CB)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    102142026 (PIK3CB)
   05230 Central carbon metabolism in cancer
    102142026 (PIK3CB)
   05231 Choline metabolism in cancer
    102142026 (PIK3CB)
   05205 Proteoglycans in cancer
    102142026 (PIK3CB)
   05203 Viral carcinogenesis
    102142026 (PIK3CB)
   05210 Colorectal cancer
    102142026 (PIK3CB)
   05212 Pancreatic cancer
    102142026 (PIK3CB)
   05214 Glioma
    102142026 (PIK3CB)
   05221 Acute myeloid leukemia
    102142026 (PIK3CB)
   05220 Chronic myeloid leukemia
    102142026 (PIK3CB)
   05218 Melanoma
    102142026 (PIK3CB)
   05211 Renal cell carcinoma
    102142026 (PIK3CB)
   05215 Prostate cancer
    102142026 (PIK3CB)
   05213 Endometrial cancer
    102142026 (PIK3CB)
   05224 Breast cancer
    102142026 (PIK3CB)
   05222 Small cell lung cancer
    102142026 (PIK3CB)
   05223 Non-small cell lung cancer
    102142026 (PIK3CB)
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    102142026 (PIK3CB)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    102142026 (PIK3CB)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    102142026 (PIK3CB)
   04931 Insulin resistance
    102142026 (PIK3CB)
   04933 AGE-RAGE signaling pathway in diabetic complications
    102142026 (PIK3CB)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    102142026 (PIK3CB)
   05166 HTLV-I infection
    102142026 (PIK3CB)
   05162 Measles
    102142026 (PIK3CB)
   05164 Influenza A
    102142026 (PIK3CB)
   05161 Hepatitis B
    102142026 (PIK3CB)
   05160 Hepatitis C
    102142026 (PIK3CB)
   05167 Kaposi's sarcoma-associated herpesvirus infection
    102142026 (PIK3CB)
   05169 Epstein-Barr virus infection
    102142026 (PIK3CB)
   05146 Amoebiasis
    102142026 (PIK3CB)
   05142 Chagas disease (American trypanosomiasis)
    102142026 (PIK3CB)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    102142026 (PIK3CB)
   01522 Endocrine resistance
    102142026 (PIK3CB)
   01524 Platinum drug resistance
    102142026 (PIK3CB)
Enzymes [BR:mcf01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     102142026 (PIK3CB)
Membrane trafficking [BR:mcf04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    102142026 (PIK3CB)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
UniProt: 
Position
2
AA seq 1070 aa AA seqDB search
MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLW
KQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEH
EPSIPENLEDKLYGGKLIVAIHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDE
VSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFILVECCKIKKMYEQEMIAI
EAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHG
TELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTI
NPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHIKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKE
ILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt NT seq  +upstreamnt  +downstreamnt
atgtgcttcagtttcataatgcctcctgctatggcagacatccttgacatctgggcggtg
gattcacagatagcatctgatggctccatacctgtggatttccttttgcccactgggatt
tatatccagttggaggtacctcgggaagctaccatttcttatattaagcagatgttatgg
aagcaagttcacaattacccaatgttcaacctccttatggatattgactcctatatgttt
gcatgtgtgaaccagactgctgtatatgaggagcttgaagatgaaacacgaagactctgt
gatgtcagaccttttcttccagttctcaaattagtgacaagaagttgtgacccaggggaa
aaattagactcaaaaattggagtccttataggaaaaggtctgcatgaatttgattccttg
aaggatcctgaagtaaatgaatttcgaagaaaaatgcgcaaattcagcgaggaaaagatc
ctgtcacttgtgggattgtcttggatggactggctaaaacaaacatatccaccggagcat
gaaccatccatccctgaaaacttagaagataaactttatgggggaaagctcattgtagct
attcattttgaaaactgccaggatgtgtttagctttcaagtatctcctaatatgaatcct
atcaaagtaaatgaattggcaatccaaaaacgtttgactattcatgggaaggaagatgaa
gttagcccctatgattatgtgttgcaagtcagtgggagagtagaatatgtttttggtgat
catccactaattcagttccagtatatccggaactgtgtaatgaacaggaccctgccccat
tttatacttgtggaatgctgcaagatcaagaaaatgtatgaacaggaaatgattgccata
gaggctgccataaatcggaattcatctaaccttcctcttccattaccaccaaagaaaacg
cgaattatttctcatgtttgggaaaataataaccctttccaaattgtcttggttaaggga
aataaacttaacacagaggaaactgtaaaagttcatgtcagggctggtctttttcatggt
actgaactcctgtgtaaaaccatcgtaagctcagaggtatcagggaaaaatgatcatatt
tggaatgaaccactggaatttgatattaatatttgtgacttaccaagaatggctcgatta
tgttttgctgtttatgctgttttggataaagtaaaaacgaagaaatcaacgaaaactatt
aatccctctaaatatcagaccatcagaaaagctggaaaagtgcattatcctgtagcgtgg
gtaaatacgatggtttttgactttaaaggacaattgagaactggagacataatattacac
agctggtcttcatttcctgatgaactcgaagaaatgttgaatccaatgggaactgttcaa
acaaatccatatactgaaaatgcaacagctttgcatattaaatttccagagaataaaaaa
caaccttattattaccctcccttcgataagattattgaaaaggctgctgagattgcaagc
agtgatagtgctaatgtgtcaagtcgaggtggaaaaaagtttcttcctgtattgaaagaa
atcttggacagggatcccttgtctcaactgtgtgaaaatgaaatggatcttatttggact
ttgcgacaagactgccgagagattttcccacaatcattgccaaaattactgctgtcaatc
aagtggaataaacttgaggatgttgctcagcttcaggcgctgcttcagatttggcctaaa
ctgcccccccgggaggccctagagcttctggatttcaactatccagaccagtacgttcga
gaatatgctgtaggctgcctgcgacagatgagtgatgaagaactttcgcagtatctttta
caactggtgcaagttttaaaatatgagccttttcttgattgtgccctctctagattccta
ttagaaagagcacttggtaatcggaggatagggcagtttctattttggcatcttaggtca
gaagtgcacattcctgctgtctcagtacaatttggtgtcatccttgaagcatactgccgg
ggaagtgtggggcacatgaaagtgctttctaagcaggttgaagcactcaataagttaaaa
actttaaatagtttaatcaaactgaatgcagtgaagttaaacagagccaaagggaaggag
gccatgcatacttgtttaaaacagagtgcttaccgggaagccctctctgacctgcagtca
cccctgaacccatgtgttatcctctcggaactctatgttgaaaagtgcaaatacatggat
tccaaaatgaagcctttgtggctggtatacaataacaaggtatttggtgaggattcagtt
ggagtgatttttaaaaatggtgatgatttacgacaggatatgttgacactccagatgttg
cgcttgatggatttactctggaaagaagctggtttggatcttcggatgttgccttatggc
tgtttagcaacaggagatcgctctggcctcattgaagttgtgagcacctctgaaacaatt
gctgacattcagctgaacagtagcaatgtggctgctgcagcagccttcaacaaagatgcc
cttctgaactggcttaaagaatacaattctggggatgacctggaccgagccattgaggaa
tttacactgtcctgtgctggctactgtgtagcttcttatgtccttgggattggtgacaga
catagtgacaacatcatggtcaaaaaaactggccagctcttccacattgactttggacat
attcttggaaatttcaaatctaagtttggcattaaaagggagcgagtgccttttattctt
acctatgatttcatccatgtcattcaacaaggaaaaacaggaaatacagaaaagtttggc
cggttccgccagtgttgtgaggatgcatatctgattttacgacggcatgggaatcttttc
atcactctctttgcgctgatgttgactgcagggcttcctgagctcacatcagtcaaggat
atacagtatcttaaggactctcttgcattagggaagagtgaagaagaagcactcaaacag
tttaagcaaaaatttgatgaggcgctcagggaaagctggactactaaagtgaactggatg
gcccacacagttcggaaagactacagatcttaa

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