KEGG PATHWAY: mdo04210

PATHWAY: mdo04210

Entry

mdo04210 Pathway

Name

Apoptosis - Monodelphis domestica (opossum)

Description

Apoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily members and ligands) and the intrinsic (mitochondria-associated) pathways, both of which are found in the cytoplasm. The extrinsic pathway is triggered by death receptor engagement, which initiates a signaling cascade mediated by caspase-8 activation. Caspase-8 both feeds directly into caspase-3 activation and stimulates the release of cytochrome c by the mitochondria. Caspase-3 activation leads to the degradation of cellular proteins necessary to maintain cell survival and integrity. The intrinsic pathway occurs when various apoptotic stimuli trigger the release of cytochrome c from the mitochondria (independently of caspase-8 activation). Cytochrome c interacts with Apaf-1 and caspase-9 to promote the activation of caspase-3. Recent studies point to the ER as a third subcellular compartment implicated in apoptotic execution. Alterations in Ca2+ homeostasis and accumulation of misfolded proteins in the ER cause ER stress. Prolonged ER stress can result in the activation of BAD and/or caspase-12, and execute apoptosis.

Class

Cellular Processes; Cell growth and death

Pathway map

mdo04210

Apoptosis

Other DBs

BSID:

87161

GO:

0006915

Organism

Monodelphis domestica (opossum) [GN:mdo]

Gene

100010299	tumor necrosis factor ligand superfamily member 10-like; K04721 tumor necrosis factor ligand superfamily member 10 [KO:K04721]
100023069	tumor necrosis factor-like; K03156 tumor necrosis factor superfamily, member 2 [KO:K03156]
100026024	interleukin-1 beta-like; K04519 interleukin 1 beta [KO:K04519]
100017751	interleukin-1 receptor type 1-like; K04386 interleukin 1 receptor type I [KO:K04386]
100016835	IL1RAP; interleukin 1 receptor accessory protein [KO:K04723]
100031941	protein FADD-like; K02373 FAS-associated death domain protein [KO:K02373]
100019832	tumor necrosis factor receptor type 1-associated DEATH domain protein-like; K03171 tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
100617513	CASP8 and FADD-like apoptosis regulator-like; K04724 CASP8 and FADD-like apoptosis regulator [KO:K04724]
100016987	caspase-10-like; K04400 caspase 10 [EC:3.4.22.63] [KO:K04400] [EC:3.4.22.63]
100017025	CASP18; caspase-18 [KO:K04398] [EC:3.4.22.61]
100617599	caspase-8-like; K04398 caspase 8 [EC:3.4.22.61] [KO:K04398] [EC:3.4.22.61]
654273	caspase-3-like protein 1; K02187 caspase 3 [EC:3.4.22.56] [KO:K02187] [EC:3.4.22.56]
654275	caspase-3-like protein 2; K02187 caspase 3 [EC:3.4.22.56] [KO:K02187] [EC:3.4.22.56]
100009858	caspase-6-like; K04396 caspase 6 [EC:3.4.22.59] [KO:K04396] [EC:3.4.22.59]
100010782	BIRC2; baculoviral IAP repeat containing 2 [KO:K16060]
100016651	baculoviral IAP repeat-containing protein 4-like; K04725 E3 ubiquitin-protein ligase XIAP [KO:K04725]
100025295	baculoviral IAP repeat-containing protein 7-like; K16061 baculoviral IAP repeat-containing protein 7/8 [KO:K16061]
100021895	envelope glycoprotein-like; K04726 BH3 interacting domain death agonist [KO:K04726]
100016570	apoptosis regulator Bcl-2-like; K02161 apoptosis regulator BCL-2 [KO:K02161]
100010654	bcl-2-like protein 1-like; K04570 BCL2-like 1 (apoptosis regulator Bcl-X) [KO:K04570]
100010620	cytochrome c-like; K08738 cytochrome c [KO:K08738]
100026811	cytochrome c; K08738 cytochrome c [KO:K08738]
100013051	APAF1; apoptotic peptidase activating factor 1 [KO:K02084]
100027338	caspase-9-like; K04399 caspase 9 [EC:3.4.22.62] [KO:K04399] [EC:3.4.22.62]
100024248	DNA fragmentation factor subunit alpha-like; K02310 DNA fragmentation factor, 45 kD, alpha subunit [KO:K02310]
100026012	DNA fragmentation factor subunit beta-like; K02311 DNA fragmentation factor, 40 kD, beta subunit [EC:3.-.-.-] [KO:K02311] [EC:3.-.-.-]
100021984	AIFM1; apoptosis-inducing factor, mitochondrion-associated, 1 [KO:K04727] [EC:1.-.-.-]
100013530	endonuclease G; K01173 endonuclease G, mitochondrial [KO:K01173]
100026797	ATM; ataxia telangiectasia mutated [KO:K04728] [EC:2.7.11.1]
497248	TP53; tumor protein p53 [KO:K04451]
100028597	RIPK1; receptor (TNFRSF)-interacting serine-threonine kinase 1 [KO:K02861] [EC:2.7.11.1]
100017243	TANK; TRAF family member-associated NFKB activator [KO:K03173]
100024326	IRAK2; interleukin-1 receptor-associated kinase 2 [KO:K04731] [EC:2.7.11.1]
100024979	IRAK3; interleukin-1 receptor-associated kinase 3 [KO:K04732] [EC:2.7.11.1]
100019202	IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
100020668	MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
100027952	CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
100033031	IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [KO:K07209] [EC:2.7.11.10]
100022918	NF-kappa-B essential modulator-like; K07210 inhibitor of nuclear factor kappa-B kinase subunit gamma [KO:K07210]
100011769	NF-kappa-B inhibitor alpha-like; K04734 NF-kappa-B inhibitor alpha [KO:K04734]
100014446	NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 [KO:K02580]
100030053	transcription factor p65-like; K04735 transcription factor p65 [KO:K04735]
100010246	beta-nerve growth factor-like; K02582 nerve growth factor, beta [KO:K02582]
100618744	NTRK1; neurotrophic tyrosine kinase, receptor, type 1 [KO:K03176] [EC:2.7.10.1]
100009879	phosphatidylinositol-4; K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153] [KO:K00922] [EC:2.7.1.153]
100010412	phosphatidylinositol-4; K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153] [KO:K00922] [EC:2.7.1.153]
100017332	phosphatidylinositol-4; K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153] [KO:K00922] [EC:2.7.1.153]
100019317	PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [KO:K02649]
100012464	PIK3R5; phosphoinositide-3-kinase, regulatory subunit 5 [KO:K02649]
100032726	phosphatidylinositol 3-kinase regulatory subunit beta-like; K02649 phosphoinositide-3-kinase, regulatory subunit [KO:K02649]
100014564	AKT2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
100019947	RAC-alpha serine/threonine-protein kinase-like; K04456 RAC serine/threonine-protein kinase [EC:2.7.11.1] [KO:K04456] [EC:2.7.11.1]
100027373	AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) [KO:K04456] [EC:2.7.11.1]
100029185	cAMP-dependent protein kinase type I-alpha regulatory subunit-like; K04739 cAMP-dependent protein kinase regulator [KO:K04739]
100010130	PRKAR2B; protein kinase, cAMP-dependent, regulatory, type II, beta [KO:K04739]
100020977	PRKAR1B; protein kinase, cAMP-dependent, regulatory, type I, beta [KO:K04739]
100027250	cAMP-dependent protein kinase type II-alpha regulatory subunit-like; K04739 cAMP-dependent protein kinase regulator [KO:K04739]
100011211	cAMP-dependent protein kinase catalytic subunit beta-like; K04345 protein kinase A [EC:2.7.11.11] [KO:K04345] [EC:2.7.11.11]
100032298	cAMP-dependent protein kinase catalytic subunit alpha-like; K04345 protein kinase A [EC:2.7.11.11] [KO:K04345] [EC:2.7.11.11]
100026861	cAMP-dependent protein kinase catalytic subunit alpha-like; K04345 protein kinase A [EC:2.7.11.11] [KO:K04345] [EC:2.7.11.11]
100009830	serine/threonine-protein kinase PRKX-like; K04345 protein kinase A [EC:2.7.11.11] [KO:K04345] [EC:2.7.11.11]
100031246	bcl2 antagonist of cell death-like; K02158 BCL2-antagonist of cell death [KO:K02158]
100030412	apoptosis regulator BAX-like; K02159 apoptosis regulator BAX [KO:K02159]
100014900	PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme [KO:K04348] [EC:3.1.3.16]
100011077	PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme [KO:K04348] [EC:3.1.3.16]
100033104	PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme [KO:K04348] [EC:3.1.3.16]
100027667	calcium-binding protein p22-like; K06268 protein phosphatase 3, regulatory subunit [KO:K06268]
100033302	calcineurin subunit B type 1-like; K06268 protein phosphatase 3, regulatory subunit [KO:K06268]
100030405	calpain-1 catalytic subunit-like; K01367 calpain-1 [EC:3.4.22.52] [KO:K01367] [EC:3.4.22.52]
100018672	calpain-2 catalytic subunit-like; K03853 calpain-2 [EC:3.4.22.53] [KO:K03853] [EC:3.4.22.53]
100032606	caspase-12-like; K04741 caspase 12 [EC:3.4.22.-] [KO:K04741] [EC:3.4.22.-]
100032604	caspase-12-like; K04741 caspase 12 [EC:3.4.22.-] [KO:K04741] [EC:3.4.22.-]

Reference

(Japanese)

Authors

Murakawa M, Yonehara S.

Title

[Apoptosis induced by death receptors.] (In Japanese)

Journal

Experimental Medicine 19(13):1690-1694 (2001)

Reference

PMID:14663476

Authors

Kucharczak J, Simmons MJ, Fan Y, Gelinas C.

Title

To be, or not to be: NF-kappaB is the answer--role of Rel/NF-kappaB in the regulation of apoptosis.

Journal

Oncogene 22:8961-82 (2003)

Reference

PMID:14996498

Authors

Donovan M, Cotter TG.

Title

Control of mitochondrial integrity by Bcl-2 family members and caspase-independent cell death.

Journal

Biochim Biophys Acta 1644:133-47 (2004)

Reference

PMID:14996497

Authors

Sprick MR, Walczak H.

Title

The interplay between the Bcl-2 family and death receptor-mediated apoptosis.

Journal

Biochim Biophys Acta 1644:125-32 (2004)

Reference

PMID:10690403

Authors

Nagata S.

Title

Fas ligand-induced apoptosis.

Journal

Annu Rev Genet 33:29-55 (1999)

Reference

(Japanese)

Authors

Suda T.

Title

[The apoptosis is Kin to the inflammation.] (In Japanese)

Journal

Experimental Medicine 19(13):1790-1797 (2001)

Reference

PMID:11048732

Authors

Yuan J, Yankner BA.

Title

Apoptosis in the nervous system.

Journal

Nature 407:802-9 (2000)

Reference

PMID:14556717

Authors

Yuan J, Lipinski M, Degterev A.

Title

Diversity in the mechanisms of neuronal cell death.

Journal

Neuron 40:401-13 (2003)

Reference

PMID:14737178

Authors

Steelman LS, Pohnert SC, Shelton JG, Franklin RA, Bertrand FE, McCubrey JA.

Title

JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.

Journal

Leukemia 18:189-218 (2004)

Reference

PMID:10692573

Authors

Martinon F, Holler N, Richard C, Tschopp J.

Title

Activation of a pro-apoptotic amplification loop through inhibition of NF-kappaB-dependent survival signals by caspase-mediated inactivation of RIP.

Journal

FEBS Lett 468:134-6 (2000)

Reference

PMID:11290317

Authors

Goyal L.

Title

Cell death inhibition: keeping caspases in check.

Journal

Cell 104:805-8 (2001)

Reference

PMID:10195903

Authors

Wang HG, Pathan N, Ethell IM, Krajewski S, Yamaguchi Y, Shibasaki F, McKeon F, Bobo T, Franke TF, Reed JC.

Title

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.

Journal

Science 284:339-43 (1999)

Reference

PMID:14656699

Authors

Remillard CV, Yuan JX.

Title

Activation of K+ channels: an essential pathway in programmed cell death.

Journal

Am J Physiol Lung Cell Mol Physiol 286:L49-67 (2004)

Reference

PMID:9670005

Authors

Gross A, Jockel J, Wei MC, Korsmeyer SJ.

Title

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis.

Journal

EMBO J 17:3878-85 (1998)

KO pathway

ko04210

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Pathway (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (72)   
   KEGG GENES (72)   
All databases (74)   

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