KEGG   Monodelphis domestica (opossum): 100010412Help
Entry
100010412         CDS       T01031                                 

Gene name
PIK3CA
Definition
(RefSeq) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
  KO
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
mdo  Monodelphis domestica (opossum)
Pathway
Inositol phosphate metabolism
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
Platinum drug resistance
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Autophagy - animal
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Longevity regulating pathway
Longevity regulating pathway - multiple species
Cellular senescence
Axon guidance
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Regulation of lipolysis in adipocytes
Relaxin signaling pathway
Type II diabetes mellitus
Insulin resistance
Non-alcoholic fatty liver disease (NAFLD)
AGE-RAGE signaling pathway in diabetic complications
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
Human papillomavirus infection
HTLV-I infection
Kaposi's sarcoma-associated herpesvirus infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Breast cancer
Hepatocellular carcinoma
Central carbon metabolism in cancer
Choline metabolism in cancer
Fluid shear stress and atherosclerosis
Module
PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:mdo00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100010412 (PIK3CA)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100010412 (PIK3CA)
   04015 Rap1 signaling pathway
    100010412 (PIK3CA)
   04012 ErbB signaling pathway
    100010412 (PIK3CA)
   04370 VEGF signaling pathway
    100010412 (PIK3CA)
   04630 Jak-STAT signaling pathway
    100010412 (PIK3CA)
   04668 TNF signaling pathway
    100010412 (PIK3CA)
   04066 HIF-1 signaling pathway
    100010412 (PIK3CA)
   04068 FoxO signaling pathway
    100010412 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    100010412 (PIK3CA)
   04072 Phospholipase D signaling pathway
    100010412 (PIK3CA)
   04071 Sphingolipid signaling pathway
    100010412 (PIK3CA)
   04024 cAMP signaling pathway
    100010412 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    100010412 (PIK3CA)
   04152 AMPK signaling pathway
    100010412 (PIK3CA)
   04150 mTOR signaling pathway
    100010412 (PIK3CA)
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    100010412 (PIK3CA)
  Cell growth and death
   04210 Apoptosis
    100010412 (PIK3CA)
   04218 Cellular senescence
    100010412 (PIK3CA)
  Cellular community - eukaryotes
   04510 Focal adhesion
    100010412 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    100010412 (PIK3CA)
  Cell motility
   04810 Regulation of actin cytoskeleton
    100010412 (PIK3CA)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100010412 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    100010412 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    100010412 (PIK3CA)
   04660 T cell receptor signaling pathway
    100010412 (PIK3CA)
   04662 B cell receptor signaling pathway
    100010412 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    100010412 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    100010412 (PIK3CA)
   04670 Leukocyte transendothelial migration
    100010412 (PIK3CA)
   04062 Chemokine signaling pathway
    100010412 (PIK3CA)
  Endocrine system
   04910 Insulin signaling pathway
    100010412 (PIK3CA)
   04923 Regulation of lipolysis in adipocyte
    100010412 (PIK3CA)
   04915 Estrogen signaling pathway
    100010412 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    100010412 (PIK3CA)
   04917 Prolactin signaling pathway
    100010412 (PIK3CA)
   04926 Relaxin signaling pathway
    100010412 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    100010412 (PIK3CA)
  Digestive system
   04973 Carbohydrate digestion and absorption
    100010412 (PIK3CA)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100010412 (PIK3CA)
  Nervous system
   04725 Cholinergic synapse
    100010412 (PIK3CA)
   04722 Neurotrophin signaling pathway
    100010412 (PIK3CA)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100010412 (PIK3CA)
  Development
   04360 Axon guidance
    100010412 (PIK3CA)
   04380 Osteoclast differentiation
    100010412 (PIK3CA)
  Aging
   04211 Longevity regulating pathway - mammal
    100010412 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    100010412 (PIK3CA)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100010412 (PIK3CA)
   05230 Central carbon metabolism in cancer
    100010412 (PIK3CA)
   05231 Choline metabolism in cancer
    100010412 (PIK3CA)
   05205 Proteoglycans in cancer
    100010412 (PIK3CA)
   05203 Viral carcinogenesis
    100010412 (PIK3CA)
   05210 Colorectal cancer
    100010412 (PIK3CA)
   05212 Pancreatic cancer
    100010412 (PIK3CA)
   05225 Hepatocellular carcinoma
    100010412 (PIK3CA)
   05214 Glioma
    100010412 (PIK3CA)
   05221 Acute myeloid leukemia
    100010412 (PIK3CA)
   05220 Chronic myeloid leukemia
    100010412 (PIK3CA)
   05218 Melanoma
    100010412 (PIK3CA)
   05211 Renal cell carcinoma
    100010412 (PIK3CA)
   05215 Prostate cancer
    100010412 (PIK3CA)
   05213 Endometrial cancer
    100010412 (PIK3CA)
   05224 Breast cancer
    100010412 (PIK3CA)
   05222 Small cell lung cancer
    100010412 (PIK3CA)
   05223 Non-small cell lung cancer
    100010412 (PIK3CA)
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    100010412 (PIK3CA)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    100010412 (PIK3CA)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    100010412 (PIK3CA)
   04931 Insulin resistance
    100010412 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100010412 (PIK3CA)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    100010412 (PIK3CA)
   05166 HTLV-I infection
    100010412 (PIK3CA)
   05162 Measles
    100010412 (PIK3CA)
   05164 Influenza A
    100010412 (PIK3CA)
   05161 Hepatitis B
    100010412 (PIK3CA)
   05160 Hepatitis C
    100010412 (PIK3CA)
   05167 Kaposi's sarcoma-associated herpesvirus infection
    100010412 (PIK3CA)
   05169 Epstein-Barr virus infection
    100010412 (PIK3CA)
   05165 Human papillomavirus infection
    100010412 (PIK3CA)
   05146 Amoebiasis
    100010412 (PIK3CA)
   05142 Chagas disease (American trypanosomiasis)
    100010412 (PIK3CA)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    100010412 (PIK3CA)
   01524 Platinum drug resistance
    100010412 (PIK3CA)
   01522 Endocrine resistance
    100010412 (PIK3CA)
Enzymes [BR:mdo01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100010412 (PIK3CA)
Membrane trafficking [BR:mdo04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100010412 (PIK3CA)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
Ensembl: 
UniProt: 
Position
7
AA seq 1068 aa AA seqDB search
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLVTIKHELFKEARKYPLHQ
LLQDETSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDVHAPHSRALYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEHVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYLLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYTQLPLD
TFTMPSYSRRISTATPYMNGEASTKSLWVVNSALRIRILCATYVNVNIRDIDKIYVRTGI
CHGGEPLCDNVNTQRVPCSNPRWNEWLMYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SNPVKFPDMAVIEEHANWTVSRELGFNYSHAGLSNRIARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVSIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRAFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDYMDALQGFISPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt NT seq  +upstreamnt  +downstreamnt
atgcctccaagaccatcatccggtgaactgtggggcatccatttgatgcccccaagaatc
ttagtagaatgtctactacctaatggaatgatagtgactttagaatgcctccgtgaggct
acattagtaactattaaacacgagctatttaaagaagcaaggaaataccctcttcaccag
ctccttcaggatgaaacttcttacattttcgtaagcgttactcaagaagcagaaagggaa
gaattttttgatgaaactcgacgactttgtgacctacggctttttcagccttttctaaaa
gtcatcgaaccagtaggcaaccgagaagaaaagattctcaatcgagaaattggttttgct
attggtatgcctgtttgtgaatttgatatggttaaagatccagaagtacaagatttccga
agaaatattcttaatgtttgtaaagaggctgtggacctgagggatgtccatgcaccccat
agtagagcattatatgtctatcctccaaatgtagaatcttcaccagaattgccaaagcat
atatacaataaattagataaagggcaaataatagtggtgatttgggtgatagtttcccca
aacaatgacaagcagaagtacactttaaaaatcaatcatgactgtgtaccagaacatgtg
atcgctgaagcaatccggaaaaaaacgcggagtatgttgctgtcatcggagcagctgaag
ctctgcgttttagagtatcagggcaaatacattttaaaagtgtgtggatgtgatgagtat
ctgctagaaaaatatcctcttagccaatataagtacataagaagctgtataatgcttggt
cggatgcccaatctgatgctgatggctaaagaaagtctttacacccagctaccactggat
acttttacaatgccatcttattccagacgaatctccacagccacaccatacatgaatgga
gaagcttcaaccaaatccctttgggtcgtaaatagtgcactccggataagaattctttgt
gcaacttatgtaaatgtaaatattcgagacattgacaagatctatgttcgaacaggtatc
tgccatgggggagagccattatgtgacaatgtgaatactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgatgtatgatatatacattcctgatcttccacgagctgct
cgactttgcctttccatttgttctgttaaaggcaggaaaggtgcaaaagaggaacactgt
ccattggcttggggaaatataaacctctttgattatacggacactctggtatcggggaaa
atggctttgaatctgtggccagtacctcatggattagaagatttgctcaatcctattgga
gttactgggtcaaatcccaataaggaaactccatgtttagagctggaatttgactggttt
agcaatcctgtaaagttcccagatatggcagtgattgaagaacatgcgaattggactgta
tctcgagaactaggatttaactattcccatgctgggctgagtaataggatagctcgagat
aatgaattaagagaaaacgacaaagaacaacttcgagcaatttgtactcgagaccctctg
tctgagatcactgagcaagaaaaggactttctttggagtcacaggcattattgtgtcagt
atcccagaaattctacctaaacttcttttatccgttaaatggaattctagagatgaagta
gcccagatgtattgcttagtaaaagattggcccccaatcaaaccagaacaggccatggaa
cttttggactgtaattatccagaccctatggttcgagcttttgctgttcgctgcctggaa
aaatatttaactgatgacaaactttctcagtacttaattcaactagttcaggttctgaag
tatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcactaacaaat
caaaggataggacactttttcttttggcatttaaagtctgagatgcataataaaactgtc
agtcaaagatttggcttacttttggagtcctattgccgagcgtgtgggatgtatctaaag
catttgaatcggcaggtggaggccatggagaaactgattaacctcactgacattctcaaa
caggagaagaaggatgagactcaaaaggtacaaatgaagttcttggttgaacaaatgagg
cggcctgattacatggatgctttacaaggctttatctctccccttaatcctgctcatcaa
ctaggaaatctcaggcttgaggagtgtcggattatgtcttctgcaaaaagaccactctgg
ttgaattgggagaacccagacatcatgtcagagttactatttcagaacaatgagatcatc
tttaaaaatggggatgacttacgacaagatatgctaactcttcagatcattcgaattatg
gaaaatatctggcaaaatcagggtcttgatcttcggatgctgccttatggttgcctatca
attggggactgtgttggcctcattgaggtggtcagaaattctcatactatcatgcagatt
caatgtaaagggggcctaaagggggccttgcagttcaacagccatacattacatcagtgg
ctcaaagacaagaataaaggagaaatatacgatgcagccattgatttgtttacacgttca
tgtgctggatactgcgtggctaccttcattttgggaatcggtgaccggcacaatagtaat
atcatggtgaaggatgatggacaattatttcatatagactttggacactttttggatcac
aaaaagaagaaatttggttataaacgagagcgtgtgcccttcgtcttgacacaagatttc
ttgattgtaataagcaaaggagcccaagaatgcacaaagacgagagaatttgagagattt
caggaaatgtgctataaggcgtacttagctattcggcaacatgccaatctcttcatcaat
cttttctccatgatgcttggctctggaatgcccgaactacaatcatttgatgatattgca
tacattcgaaagaccctggccttggataaaactgagcaggaggctttggagtatttcatg
aagcagatgaatgatgctcatcatgggggctggacaaccaaaatggattggattttccat
acaataaagcagcacgctttgaactga

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