KEGG   Monodelphis domestica (opossum): 100017332Help
Entry
100017332         CDS       T01031                                 

Gene name
PIK3CB
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
mdo  Monodelphis domestica (opossum)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:mdo00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100017332 (PIK3CB)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100017332 (PIK3CB)
   04015 Rap1 signaling pathway
    100017332 (PIK3CB)
   04012 ErbB signaling pathway
    100017332 (PIK3CB)
   04370 VEGF signaling pathway
    100017332 (PIK3CB)
   04630 Jak-STAT signaling pathway
    100017332 (PIK3CB)
   04668 TNF signaling pathway
    100017332 (PIK3CB)
   04066 HIF-1 signaling pathway
    100017332 (PIK3CB)
   04068 FoxO signaling pathway
    100017332 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    100017332 (PIK3CB)
   04024 cAMP signaling pathway
    100017332 (PIK3CB)
   04022 cGMP - PKG signaling pathway
    100017332 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    100017332 (PIK3CB)
   04152 AMPK signaling pathway
    100017332 (PIK3CB)
   04150 mTOR signaling pathway
    100017332 (PIK3CB)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    100017332 (PIK3CB)
  Cell growth and death
   04210 Apoptosis
    100017332 (PIK3CB)
  Cellular commiunity
   04510 Focal adhesion
    100017332 (PIK3CB)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100017332 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    100017332 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    100017332 (PIK3CB)
   04660 T cell receptor signaling pathway
    100017332 (PIK3CB)
   04662 B cell receptor signaling pathway
    100017332 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    100017332 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    100017332 (PIK3CB)
   04670 Leukocyte transendothelial migration
    100017332 (PIK3CB)
   04062 Chemokine signaling pathway
    100017332 (PIK3CB)
  Endocrine system
   04910 Insulin signaling pathway
    100017332 (PIK3CB)
   04915 Estrogen signaling pathway
    100017332 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    100017332 (PIK3CB)
   04917 Prolactin signaling pathway
    100017332 (PIK3CB)
   04921 Oxytocin signaling pathway
    100017332 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    100017332 (PIK3CB)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100017332 (PIK3CB)
  Digestive system
   04973 Carbohydrate digestion and absorption
    100017332 (PIK3CB)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100017332 (PIK3CB)
  Nervous system
   04725 Cholinergic synapse
    100017332 (PIK3CB)
   04722 Neurotrophin signaling pathway
    100017332 (PIK3CB)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100017332 (PIK3CB)
  Development
   04380 Osteoclast differentiation
    100017332 (PIK3CB)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100017332 (PIK3CB)
   05205 Proteoglycans in cancer
    100017332 (PIK3CB)
   05203 Viral carcinogenesis
    100017332 (PIK3CB)
   05210 Colorectal cancer
    100017332 (PIK3CB)
   05212 Pancreatic cancer
    100017332 (PIK3CB)
   05214 Glioma
    100017332 (PIK3CB)
   05221 Acute myeloid leukemia
    100017332 (PIK3CB)
   05220 Chronic myeloid leukemia
    100017332 (PIK3CB)
   05218 Melanoma
    100017332 (PIK3CB)
   05211 Renal cell carcinoma
    100017332 (PIK3CB)
   05215 Prostate cancer
    100017332 (PIK3CB)
   05213 Endometrial cancer
    100017332 (PIK3CB)
   05222 Small cell lung cancer
    100017332 (PIK3CB)
   05223 Non-small cell lung cancer
    100017332 (PIK3CB)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    100017332 (PIK3CB)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    100017332 (PIK3CB)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    100017332 (PIK3CB)
   05166 HTLV-I infection
    100017332 (PIK3CB)
   05162 Measles
    100017332 (PIK3CB)
   05164 Influenza A
    100017332 (PIK3CB)
   05161 Hepatitis B
    100017332 (PIK3CB)
   05160 Hepatitis C
    100017332 (PIK3CB)
   05169 Epstein-Barr virus infection
    100017332 (PIK3CB)
   05146 Amoebiasis
    100017332 (PIK3CB)
   05145 Toxoplasmosis
    100017332 (PIK3CB)
   05142 Chagas disease (American trypanosomiasis)
    100017332 (PIK3CB)
Enzymes [BR:mdo01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100017332 (PIK3CB)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
Position
4
AA seq 1069 aa AA seqDB search
MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISHIKQMLW
KQAHSYPMFNLLMEIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKVVTRNCDPGE
KLDSKIGVLIGKGLHEFDALEDPEVMEFRSKMRQFSEEKIQSLIGLSWMDWLKHTYPPEQ
EPSIPENLEDKLYGGNLVVAVHFENCQDVFSFQVSPNMNPIKLNELAIRKRLTIHGKEDE
VDPYDYVLQVSGRLEYVFGDHPLIQFQYIRNCVMNRTLPKLTLVECCNIKKMCEQEMIAI
EAAINRNSSNLPLPLPPKKTRIISNVWENTQPFQIVLVKGTKLNTEETVKVHVRAGLFHG
TELLCKPVVSSEISGRNDHVWSEPLEFDINICDLPRMARLCFAVYAVDKVKTKKSTKAIN
PSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLKSGDIILHSWSSFPDELEEMLNPMGTVQT
NPYTENATALHIKFPENKKQPYYYPPFDKIIEKAAEIASSDSGNVSSRGGKKFHVVLKEI
MERDPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSVKWNKLEDVAQLQALLQXWPKL
PPREALELLDFNYPDQYVREYAVGCLKQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLL
DRALANRRIGQFLFWHLRSEVHIPAFSVQFGVILEAYCRGSVGYMKVLSKQVEALNKLKT
LNSLIKLNAMKLNKAKGREAMHTCLKQNAYREALSDLQSPLNPCVILSELYVEKCKYMDS
KMKPLRIVYNNKVFGGDPVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGC
LATGDRSGLIEVVSTSETIADIQLNSSNVAATAAFNKDALLNWLKEYNSGDDLDRAIEEF
TLSCAGYCVASYVLGIGDRHSDNIMVRKTGQLFHIDFGHILGNFKSKFGIKRERVPFILT
YDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDI
QYLKDSLALGKSDEEALKQFKQKFDEALRESWTTKVNWMAHTMRKDYRS
NT seq 3210 nt NT seq  +upstreamnt  +downstreamnt
atgtgcttcagttttataatgcctcctgctatggcagacatccttgacatttgggctgtg
gattctcagatagcatcagatggctccattccagtggatttcctattgcccacggggatc
tatatccaattggaagtacctcgggaggccactatttctcatattaaacagatgctatgg
aagcaagctcacagctacccaatgtttaatcttcttatggaaattgactcttacatgttt
gcatgtgtgaaccaaactgcagtttatgaggagctcgaagatgaaacaagaagactctgt
gatgtcagaccttttcttccagttctcaaagtggtgacaagaaattgtgacccaggggaa
aaattagactccaaaattggagttcttataggaaaaggtcttcatgagtttgatgccctg
gaagatcctgaggtgatggagttccgaagtaaaatgcgccaattcagtgaagaaaagatc
caatcccttataggattgtcttggatggattggttaaagcatacttatccaccagaacaa
gaaccttccattcctgaaaatttggaagataaactttatggtggaaatcttgtggtagct
gtgcattttgaaaattgccaggatgtatttagtttccaagtatctcctaatatgaatccc
atcaagctaaatgagttggcaatccgaaaacggttgactatccatgggaaggaagatgaa
gttgatccctatgactatgtgctacaagtcagtgggagactagaatatgtgtttggtgat
cacccactaattcagttccaatatattcggaactgtgtcatgaataggactcttcccaaa
ctcactcttgttgaatgttgcaatataaagaagatgtgtgaacaggaaatgattgccata
gaagctgccataaatcgaaattcatccaaccttcctcttccactgccaccaaaaaaaaca
cgaataatttctaatgtttgggaaaatacacaaccatttcaaattgtattggttaagggg
actaaattgaacacagaagaaactgtcaaagttcatgtcagggctggactttttcatgga
accgaacttctttgtaaaccagttgtaagctcagagatatctgggagaaatgaccacgtt
tggagtgaaccattggaattcgatattaacatctgtgacttaccacgaatggctcggtta
tgttttgcagtttatgctgtggataaagtgaaaacaaaaaagtcaactaaggcaattaat
ccctccaaatatcagactatcagaaaagctggaaaagtgcactatcctgtagcatgggta
aataccatggtatttgactttaaaggacagctgaaaagtggagacattatactgcacagc
tggtcatcatttcctgatgaacttgaagaaatgttaaatccaatgggaactgttcaaaca
aatccatatactgaaaatgcaacagctttacatattaaattccctgagaataaaaaacaa
ccttattattaccctccctttgataagattattgaaaaggcagctgagattgcaagtagt
gacagtggtaatgtatcaagtcgaggtggaaaaaaatttcatgttgtgcttaaagaaatc
atggagagagatcccttatctcaactgtgtgaaaatgaaatggatcttatttggactttg
cgacaagactgtagagaaaattttccacagtctttgccaaaattgctgctgtctgtcaaa
tggaataaacttgaagatgttgctcagctacaggctcttcttcaantatggcctaaattg
cctcctagagaagcattggaattattagactttaattatccagaccagtatgtaagagag
tatgctgtgggatgcttgaaacaaatgagtgatgaagaactgtctcagtatcttttacaa
ctggtacaagttttgaaatatgaaccttttcttgattgtgcactgtctagattcctgtta
gacagagcacttgctaataggaggatagggcaatttctattttggcatcttaggtcagag
gtgcacattcctgccttttcagtgcaatttggtgtaatacttgaagcttactgtcgggga
agtgtgggctatatgaaagtgctttctaaacaggtagaagctcttaataagctgaagacc
ttaaatagtttaataaaactgaatgcaatgaagttaaacaaagcaaaaggaagagaggca
atgcacacgtgcttaaaacaaaatgcttaccgagaagccctttctgatcttcagtcacct
ttgaatccttgtgtcatactttcagaactttatgttgagaaatgcaaatacatggattct
aagatgaagcctctgagaatcgtgtacaacaataaggtatttggaggagatccagtgggg
gtcattttcaaaaatggggatgatctacgacaagatatgttaacactccagatgttgcgt
ttgatggatttactttggaaagaagcaggtttggatctccgaatgctgccatatggttgt
ttagcaacaggagaccgctctggcctgattgaagttgttagcacctctgaaacaattgcc
gatattcagctaaatagtagtaatgttgctgctacagccgccttcaataaagatgctctt
ctaaactggcttaaagaatacaattccggcgatgacttagatcgcgccattgaagagttc
actctctcctgtgctggctactgtgtagcttcttatgtcttaggaattggtgatagacat
agtgacaatatcatggtcaggaagactggacagctcttccacatcgattttgggcatatt
cttggaaacttcaagtctaaatttggcattaaacgggaacgagtgcctttcattcttacc
tatgatttcattcatgtcattcagcaaggaaaaacaggaaacacagagaagtttggccgg
ttccgtcagtgttgtgaagatgcttatctgattttacgaagacacgggaatctctttatc
actctgtttgccctgatgttgactgcagggcttcctgagctcacctccgtgaaagatata
cagtatcttaaggactctttggccttagggaagagtgatgaagaagcactaaaacaattt
aagcagaaatttgatgaggcactcagggaaagttggactactaaagtaaactggatggcg
cacaccatgagaaaagattaccggtcttaa

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