KEGG   Monodelphis domestica (gray short-tailed opossum): 100024769
Entry
100024769         CDS       T01031                                 
Symbol
PIK3CD
Name
(RefSeq) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
mdo  Monodelphis domestica (gray short-tailed opossum)
Pathway
mdo00562  Inositol phosphate metabolism
mdo01100  Metabolic pathways
mdo01521  EGFR tyrosine kinase inhibitor resistance
mdo01522  Endocrine resistance
mdo01524  Platinum drug resistance
mdo04012  ErbB signaling pathway
mdo04014  Ras signaling pathway
mdo04015  Rap1 signaling pathway
mdo04024  cAMP signaling pathway
mdo04062  Chemokine signaling pathway
mdo04066  HIF-1 signaling pathway
mdo04068  FoxO signaling pathway
mdo04070  Phosphatidylinositol signaling system
mdo04071  Sphingolipid signaling pathway
mdo04072  Phospholipase D signaling pathway
mdo04140  Autophagy - animal
mdo04150  mTOR signaling pathway
mdo04151  PI3K-Akt signaling pathway
mdo04152  AMPK signaling pathway
mdo04210  Apoptosis
mdo04211  Longevity regulating pathway
mdo04213  Longevity regulating pathway - multiple species
mdo04218  Cellular senescence
mdo04360  Axon guidance
mdo04370  VEGF signaling pathway
mdo04380  Osteoclast differentiation
mdo04510  Focal adhesion
mdo04550  Signaling pathways regulating pluripotency of stem cells
mdo04611  Platelet activation
mdo04613  Neutrophil extracellular trap formation
mdo04620  Toll-like receptor signaling pathway
mdo04625  C-type lectin receptor signaling pathway
mdo04630  JAK-STAT signaling pathway
mdo04650  Natural killer cell mediated cytotoxicity
mdo04660  T cell receptor signaling pathway
mdo04662  B cell receptor signaling pathway
mdo04664  Fc epsilon RI signaling pathway
mdo04666  Fc gamma R-mediated phagocytosis
mdo04668  TNF signaling pathway
mdo04670  Leukocyte transendothelial migration
mdo04722  Neurotrophin signaling pathway
mdo04725  Cholinergic synapse
mdo04750  Inflammatory mediator regulation of TRP channels
mdo04810  Regulation of actin cytoskeleton
mdo04910  Insulin signaling pathway
mdo04914  Progesterone-mediated oocyte maturation
mdo04915  Estrogen signaling pathway
mdo04917  Prolactin signaling pathway
mdo04919  Thyroid hormone signaling pathway
mdo04923  Regulation of lipolysis in adipocytes
mdo04926  Relaxin signaling pathway
mdo04929  GnRH secretion
mdo04930  Type II diabetes mellitus
mdo04931  Insulin resistance
mdo04932  Non-alcoholic fatty liver disease
mdo04933  AGE-RAGE signaling pathway in diabetic complications
mdo04935  Growth hormone synthesis, secretion and action
mdo04960  Aldosterone-regulated sodium reabsorption
mdo04973  Carbohydrate digestion and absorption
mdo05010  Alzheimer disease
mdo05017  Spinocerebellar ataxia
mdo05020  Prion disease
mdo05100  Bacterial invasion of epithelial cells
mdo05132  Salmonella infection
mdo05135  Yersinia infection
mdo05142  Chagas disease
mdo05146  Amoebiasis
mdo05160  Hepatitis C
mdo05161  Hepatitis B
mdo05162  Measles
mdo05163  Human cytomegalovirus infection
mdo05164  Influenza A
mdo05165  Human papillomavirus infection
mdo05166  Human T-cell leukemia virus 1 infection
mdo05167  Kaposi sarcoma-associated herpesvirus infection
mdo05168  Herpes simplex virus 1 infection
mdo05169  Epstein-Barr virus infection
mdo05170  Human immunodeficiency virus 1 infection
mdo05171  Coronavirus disease - COVID-19
mdo05200  Pathways in cancer
mdo05203  Viral carcinogenesis
mdo05205  Proteoglycans in cancer
mdo05206  MicroRNAs in cancer
mdo05207  Chemical carcinogenesis - receptor activation
mdo05208  Chemical carcinogenesis - reactive oxygen species
mdo05210  Colorectal cancer
mdo05211  Renal cell carcinoma
mdo05212  Pancreatic cancer
mdo05213  Endometrial cancer
mdo05214  Glioma
mdo05215  Prostate cancer
mdo05218  Melanoma
mdo05220  Chronic myeloid leukemia
mdo05221  Acute myeloid leukemia
mdo05222  Small cell lung cancer
mdo05223  Non-small cell lung cancer
mdo05224  Breast cancer
mdo05225  Hepatocellular carcinoma
mdo05226  Gastric cancer
mdo05230  Central carbon metabolism in cancer
mdo05231  Choline metabolism in cancer
mdo05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mdo05415  Diabetic cardiomyopathy
mdo05417  Lipid and atherosclerosis
mdo05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mdo00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100024769 (PIK3CD)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100024769 (PIK3CD)
   04014 Ras signaling pathway
    100024769 (PIK3CD)
   04015 Rap1 signaling pathway
    100024769 (PIK3CD)
   04370 VEGF signaling pathway
    100024769 (PIK3CD)
   04630 JAK-STAT signaling pathway
    100024769 (PIK3CD)
   04668 TNF signaling pathway
    100024769 (PIK3CD)
   04066 HIF-1 signaling pathway
    100024769 (PIK3CD)
   04068 FoxO signaling pathway
    100024769 (PIK3CD)
   04070 Phosphatidylinositol signaling system
    100024769 (PIK3CD)
   04072 Phospholipase D signaling pathway
    100024769 (PIK3CD)
   04071 Sphingolipid signaling pathway
    100024769 (PIK3CD)
   04024 cAMP signaling pathway
    100024769 (PIK3CD)
   04151 PI3K-Akt signaling pathway
    100024769 (PIK3CD)
   04152 AMPK signaling pathway
    100024769 (PIK3CD)
   04150 mTOR signaling pathway
    100024769 (PIK3CD)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100024769 (PIK3CD)
  09143 Cell growth and death
   04210 Apoptosis
    100024769 (PIK3CD)
   04218 Cellular senescence
    100024769 (PIK3CD)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100024769 (PIK3CD)
   04550 Signaling pathways regulating pluripotency of stem cells
    100024769 (PIK3CD)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100024769 (PIK3CD)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100024769 (PIK3CD)
   04613 Neutrophil extracellular trap formation
    100024769 (PIK3CD)
   04620 Toll-like receptor signaling pathway
    100024769 (PIK3CD)
   04625 C-type lectin receptor signaling pathway
    100024769 (PIK3CD)
   04650 Natural killer cell mediated cytotoxicity
    100024769 (PIK3CD)
   04660 T cell receptor signaling pathway
    100024769 (PIK3CD)
   04662 B cell receptor signaling pathway
    100024769 (PIK3CD)
   04664 Fc epsilon RI signaling pathway
    100024769 (PIK3CD)
   04666 Fc gamma R-mediated phagocytosis
    100024769 (PIK3CD)
   04670 Leukocyte transendothelial migration
    100024769 (PIK3CD)
   04062 Chemokine signaling pathway
    100024769 (PIK3CD)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100024769 (PIK3CD)
   04923 Regulation of lipolysis in adipocytes
    100024769 (PIK3CD)
   04929 GnRH secretion
    100024769 (PIK3CD)
   04915 Estrogen signaling pathway
    100024769 (PIK3CD)
   04914 Progesterone-mediated oocyte maturation
    100024769 (PIK3CD)
   04917 Prolactin signaling pathway
    100024769 (PIK3CD)
   04926 Relaxin signaling pathway
    100024769 (PIK3CD)
   04935 Growth hormone synthesis, secretion and action
    100024769 (PIK3CD)
   04919 Thyroid hormone signaling pathway
    100024769 (PIK3CD)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100024769 (PIK3CD)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100024769 (PIK3CD)
  09156 Nervous system
   04725 Cholinergic synapse
    100024769 (PIK3CD)
   04722 Neurotrophin signaling pathway
    100024769 (PIK3CD)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100024769 (PIK3CD)
  09158 Development and regeneration
   04360 Axon guidance
    100024769 (PIK3CD)
   04380 Osteoclast differentiation
    100024769 (PIK3CD)
  09149 Aging
   04211 Longevity regulating pathway
    100024769 (PIK3CD)
   04213 Longevity regulating pathway - multiple species
    100024769 (PIK3CD)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100024769 (PIK3CD)
   05206 MicroRNAs in cancer
    100024769 (PIK3CD)
   05205 Proteoglycans in cancer
    100024769 (PIK3CD)
   05207 Chemical carcinogenesis - receptor activation
    100024769 (PIK3CD)
   05208 Chemical carcinogenesis - reactive oxygen species
    100024769 (PIK3CD)
   05203 Viral carcinogenesis
    100024769 (PIK3CD)
   05230 Central carbon metabolism in cancer
    100024769 (PIK3CD)
   05231 Choline metabolism in cancer
    100024769 (PIK3CD)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100024769 (PIK3CD)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100024769 (PIK3CD)
   05212 Pancreatic cancer
    100024769 (PIK3CD)
   05225 Hepatocellular carcinoma
    100024769 (PIK3CD)
   05226 Gastric cancer
    100024769 (PIK3CD)
   05214 Glioma
    100024769 (PIK3CD)
   05221 Acute myeloid leukemia
    100024769 (PIK3CD)
   05220 Chronic myeloid leukemia
    100024769 (PIK3CD)
   05218 Melanoma
    100024769 (PIK3CD)
   05211 Renal cell carcinoma
    100024769 (PIK3CD)
   05215 Prostate cancer
    100024769 (PIK3CD)
   05213 Endometrial cancer
    100024769 (PIK3CD)
   05224 Breast cancer
    100024769 (PIK3CD)
   05222 Small cell lung cancer
    100024769 (PIK3CD)
   05223 Non-small cell lung cancer
    100024769 (PIK3CD)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100024769 (PIK3CD)
   05170 Human immunodeficiency virus 1 infection
    100024769 (PIK3CD)
   05161 Hepatitis B
    100024769 (PIK3CD)
   05160 Hepatitis C
    100024769 (PIK3CD)
   05171 Coronavirus disease - COVID-19
    100024769 (PIK3CD)
   05164 Influenza A
    100024769 (PIK3CD)
   05162 Measles
    100024769 (PIK3CD)
   05168 Herpes simplex virus 1 infection
    100024769 (PIK3CD)
   05163 Human cytomegalovirus infection
    100024769 (PIK3CD)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100024769 (PIK3CD)
   05169 Epstein-Barr virus infection
    100024769 (PIK3CD)
   05165 Human papillomavirus infection
    100024769 (PIK3CD)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100024769 (PIK3CD)
   05135 Yersinia infection
    100024769 (PIK3CD)
   05100 Bacterial invasion of epithelial cells
    100024769 (PIK3CD)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100024769 (PIK3CD)
   05142 Chagas disease
    100024769 (PIK3CD)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100024769 (PIK3CD)
   05017 Spinocerebellar ataxia
    100024769 (PIK3CD)
   05020 Prion disease
    100024769 (PIK3CD)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100024769 (PIK3CD)
   05418 Fluid shear stress and atherosclerosis
    100024769 (PIK3CD)
   05415 Diabetic cardiomyopathy
    100024769 (PIK3CD)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100024769 (PIK3CD)
   04932 Non-alcoholic fatty liver disease
    100024769 (PIK3CD)
   04931 Insulin resistance
    100024769 (PIK3CD)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100024769 (PIK3CD)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100024769 (PIK3CD)
   01524 Platinum drug resistance
    100024769 (PIK3CD)
   01522 Endocrine resistance
    100024769 (PIK3CD)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mdo04131]
    100024769 (PIK3CD)
Enzymes [BR:mdo01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100024769 (PIK3CD)
Membrane trafficking [BR:mdo04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100024769 (PIK3CD)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_p85B PI3K_rbd PI3K_C2 DUF4135
Other DBs
NCBI-GeneID: 100024769
NCBI-ProteinID: XP_016288758
Ensembl: ENSMODG00000003005
Position
4:complement(371983763..372002923)
AA seq 1004 aa
MPPGVDCPMEFWSKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQVLWHHAQYEPLFH
MLSDPEAYVFTCINQTAEQQELEDEQRRLCDIQPFLPVLRLVARQGDRVKKLINSQISLL
IGKGLHEFDSLRDPEVNDFRAKMRQFCEEAAAHRQQLGWEAWMHYNFPLQLEPSSHGWGA
GTLRAPNRNLFVNVKFEGNEESFTFQVSPNDLPLALMACALKKRATVFRQSGLERPEDYT
LQVNGKYEYLYGNHPLFQFQYICHCLHKGLTPHLTMVHSSSILAMRDEQSNPPAQAPKLR
AKPPPIPVKKPSSVSLWSLEQPFCIELVQGSKVNADERMKLVVLAGLFHGNEMLCKTVSS
SEVTVCSEPVWRQRLEFDINVCDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAW
ANLMLFDYKDQLKTGECCLYMWSSVPDEKGELLNPMGTVRSNPNTESAAALVICIPEVAP
HPVYYPTLEKILELGKNGEHARFTEDEQQQLREILERKVAGELYEHEKDLVWKMRREIQE
QFPEALARLLLVTKWNRHEDVAQMLFLLRSWPELPVLSALELLDFSFPDRHVGSFAIQSL
RKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSV
ALRFGLIMEAYCRGSNHHMKVLMKQGEALNKMKALNDFVKVSSQKTTKPQTKELMHVCMR
QETYLEALSNVQSPLNPSTLLSEVCVEQCTFMDSKMKPLWIVYSNEEAAGGADSHVGIIF
KNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLSTGDRTGLIEVVSHSDTIANIQ
LNKSNMAATAAFNRTPCSLAQEAQERAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRES
GQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRSYCERAY
TILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKETPGFGKND
NT seq 3015 nt   +upstreamnt  +downstreamnt
atgcccccgggagtcgactgtcctatggaattctggtccaaggaggaaaaccagagcgtg
gtggtcgatttcttgctgcccacgggggtctacctgaacttccccgtctctcgaaatgcc
aacctcagcaccatcaagcaggtcctctggcaccatgcccagtacgagcccctgttccac
atgctcagcgaccccgaggcctacgtcttcacctgcatcaaccagacggccgagcagcag
gagctggaggacgagcagcggcgcctgtgcgacatccagcccttcctgcccgtgctgcgg
ctcgtggcccgccagggggaccgtgtgaagaagctcatcaactcgcagatcagcctcctc
atcggcaaagggctgcatgaattcgactctctgcgggatcccgaagtcaatgacttccgc
gccaagatgcgccagttctgcgaggaggccgcggcccaccggcagcagctgggctgggag
gcctggatgcattacaacttccccctccagctggagccctcgtcccatggctggggggcc
ggcacgctgcgggcacccaacaggaacctctttgtcaatgtcaagtttgagggcaatgag
gagagcttcaccttccaggtgtcccccaatgacctccccctggcgctgatggcctgcgcc
ctcaagaagagggccaccgtgttccggcagtcggggctcgagcggcccgaggactacacg
ctgcaggtgaacggcaagtacgagtacctgtatgggaaccaccccctcttccagttccag
tatatctgccactgcctgcacaaggggctcaccccccacctcaccatggtccactcgtcc
tccatcctggccatgcgcgacgagcagagcaaccccccggcccaggccccgaagctccgg
gccaagccgccccccatccccgtgaagaagccctcctccgtgtctctgtggtccctggag
cagcccttctgcatcgagctggttcagggcagcaaggtgaacgccgatgagcggatgaag
ctcgtggtgctggctggcctcttccacgggaatgaaatgctgtgcaagacggtgtccagc
tctgaggtgaccgtgtgctcggagcccgtgtggaggcagcggctcgagttcgacatcaac
gtctgtgacctgccccgcatggcccggctctgctttgccctctacgccgtcatcgagaag
gccaagaaggcccgctccaccaagaagaagtccaagaaggccgactgccccattgcctgg
gccaacctcatgctgtttgactacaaggaccagctgaagaccggcgagtgctgcctgtac
atgtggtcctccgtcccggatgagaagggggaactgctgaaccccatgggcactgtgcgg
agtaaccccaacaccgagagtgccgcagccctcgtcatctgcatccccgaagtggctccc
caccctgtgtactaccctactctggagaagattttggagctggggaaaaacggagagcac
gcacgattcaccgaggacgagcagcagcagcttcgggagatcctagagcgcaaggtggca
ggagagctgtacgagcacgagaaagacctggtgtggaaaatgcgccgtgagatccaggag
cagttccccgaggccctggccaggctcctgctggtcaccaagtggaacaggcacgaagat
gtggcccagatgctctttctgctccgctcctggcccgagctccctgtgctcagtgcgctg
gagctgctggacttcagcttccccgatcgccacgtgggctcctttgccatccagtccttg
aggaagctgacggatgacgagcttttccagtacctcctgcagctggtgcaggtgctcaag
tacgaatcctacctagactgtgagctgaccaagttcctactggatcgggcccttgccaac
cgcaagatcggccacttcctcttctggcacctgcgctcggagatgcacgtcccctcagtg
gctttgcgctttggcctcatcatggaggcctattgccggggcagcaaccaccacatgaag
gtgttgatgaagcagggggaggcactgaacaagatgaaggccctgaatgactttgtcaaa
gtgagctcccagaagaccaccaagccgcagaccaaggagctgatgcatgtgtgtatgagg
caggagacctacttagaggccctctcgaacgtgcaatctcccctgaaccccagtacctta
ctgtctgaagtctgcgtggagcagtgcaccttcatggactccaagatgaagccgctgtgg
atcgtgtacagcaacgaggaggccgccgggggcgccgacagccacgtgggcatcatcttc
aagaacggcgacgacctgcgccaggacatgctcaccctgcagatgatccagctcatggac
gtgctgtggaagcaggaggggctggacctgcggatgaccccctacgggtgcctctcgacg
ggcgaccggacgggcctcatcgaggtcgtgtcgcactcggacaccatcgccaacatccag
ctcaacaagagcaacatggccgccacggccgccttcaacaggacgccctgctcactggct
caagaggcccaggagcgagccatcgaggagttcacgctctcctgtgcgggctactgcgtg
gccacctacgtgctgggcatcggcgaccggcacagcgacaacatcatgatccgcgagagc
gggcagctcttccacatcgattttggccatttcttgggaaacttcaagaccaagttcggg
atcaaccgtgagcgcgtgccgttcatcctcacctacgacttcgtgcacgtgatccagcag
gggaagaccaacaacagcgagaagttcgagaggttccggagctactgcgagagggcctac
accatcctgcgccgccacgggctcctgttcctccatctcttcgcactgatgcgggcagcc
ggcctgcccgagctcagctgctccaaagacatccagtatctcaaggaaaccccgggcttt
gggaaaaacgactaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (105)   
   KEGG PATHWAY (105)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG ORTHOLOGY (1)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (3)   
   RefSeq(pep) (3)   
DNA sequence (4)   
   RefSeq(nuc) (4)   
Protein domain (6)   
   Pfam (6)   
All databases (148)   

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