KEGG   Monodelphis domestica (opossum): 100025565Help
Entry
100025565         CDS       T01031                                 

Definition
(RefSeq) steroid 21-hydroxylase
  KO
K00513  steroid 21-monooxygenase [EC:1.14.14.16]
Organism
mdo  Monodelphis domestica (opossum)
Pathway
mdo00140  Steroid hormone biosynthesis
mdo01100  Metabolic pathways
mdo04925  Aldosterone synthesis and secretion
mdo04927  Cortisol synthesis and secretion
mdo04934  Cushing's syndrome
Module
mdo_M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
Brite
KEGG Orthology (KO) [BR:mdo00001]
 Metabolism
  Lipid metabolism
   00140 Steroid hormone biosynthesis
    100025565
 Organismal Systems
  Endocrine system
   04925 Aldosterone synthesis and secretion
    100025565
   04927 Cortisol synthesis and secretion
    100025565
 Human Diseases
  Endocrine and metabolic diseases
   04934 Cushing's syndrome
    100025565
Enzymes [BR:mdo01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.16  steroid 21-monooxygenase
     100025565
Cytochrome P450 [BR:mdo00199]
 Cytochrome P450, animal type
  CYP21 family
   100025565
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: p450
Motif
Other DBs
NCBI-GeneID: 100025565
NCBI-ProteinID: XP_001376456
Ensembl: ENSMODG00000014950
Position
2
AA seq 484 aa AA seqDB search
MLLSVVLLLVLLATLHWLWMRRTISPYHFPPLVPGFFHLFQADLPSHLQSLAQRYGPLYR
VHLGMQDVVVLNSKKAIEEALTKNWLDFSGRPQTFTNQEVSKNSHDLSLGDYTPLWKAQR
KLARSALLYVQNTMEPIIGQMVQDLCKRLLAQAGSPVSIHKELSMFTGSIISFLSFGEKR
ESVIQQFYSCIQELMVVWDSWQIQILDVLPILRVFPNSGLRKLRRLVKKRDRIVQEQLSR
HKETMVEGQIRDLTDYMLQKLREQAEGSNRLSEEHVHMALVDIFIGGMETMSSTLTWALA
FLLHHPEIQRRLQEELDEELDSGSPGSLPNYRDRDRFPLLNATITEVLRLRPAAPLALPH
YTRQPSTICGFDIPKNTIVIPNIYGAHHDDRIWEQPYDFRPDRFLESEPSQAGIPFSCGV
RVCLGETMARFELFLILAQLLWTFKLLPVEGNASLPSLKPEFGAFMLKAPNFLVRLLPRR
QELE
NT seq 1455 nt NT seq  +upstreamnt  +downstreamnt
atgttgctttctgtagtcctgttgctggtcctgctagctaccctccattggctatggatg
cggagaactatctcaccttatcatttcccacctctagtccctggcttcttccatctcttt
caagctgatctcccaagtcatttgcagagccttgcacagaggtatggccccctctatcgg
gttcaccttgggatgcaagatgtcgtggtgctaaactccaagaaagcaattgaggaggcc
ttgactaagaactggctggatttttcagggagaccccaaacattcacaaaccaagaggta
agcaagaacagccacgacctatctcttggggattacactccactgtggaaggcccaaagg
aagctggcccgttctgctcttctgtatgtccagaatactatggaacccatcatagggcag
atggtacaggacctgtgtaagaggcttcttgcccaggctgggtctcccgtgtccatacac
aaggagctctccatgttcactggtagcatcatcagcttcctcagttttggagaaaagaga
gaatctgtaatccagcagttttacagctgcattcaggaattaatggtagtttgggattct
tggcaaatccagatcttggacgtcctacccatcctcagggttttccccaactcaggtctc
aggaaactgagacggctggtaaagaaacgggacagaattgtgcaggagcagttgtcgagg
cacaaggagacaatggtggaaggacagattcgggatttgaccgactacatgctacaaaag
ctaagggaacaagcagaagggtcaaatcggctgtctgaggaacacgtacacatggccctg
gtggacatattcatcggcggcatggagaccatgtcgtccaccctcacctgggctctggcc
ttcctgttgcaccatccagagatacagaggcggctgcaggaagaactggatgaagagctg
gactcaggctccccgggaagccttcccaactaccgggacagggatcggttccccctgctc
aatgccaccatcaccgaggtgctccggctgcgcccggcagcccccttggctctgccacac
tacacccggcagcccagcaccatatgcggctttgacatcccgaagaacaccattgtcatc
cccaacatctatggggctcaccatgacgacagaatctgggaacaaccttatgatttcagg
cctgatcgtttcttggagtcagaaccgagccaggcagggatcccgttcagctgcggggtc
agagtgtgcctgggggagaccatggctcgctttgaactcttcctgatactggcccagcta
ctctggaccttcaaactgctgcctgtggagggcaatgcctcgttgccctctctgaagcct
gagtttggggccttcatgttaaaggccccaaactttctggtaaggctattgccccggcgg
caggagttggagtga

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