KEGG   Monodelphis domestica (opossum): 100027579Help
Entry
100027579         CDS       T01031                                 

Gene name
PLCG2
Definition
phospholipase C, gamma 2 (phosphatidylinositol-specific)
Orthology
K05859  
phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
mdo  Monodelphis domestica (opossum)
Pathway
Inositol phosphate metabolism
Metabolic pathways
ErbB signaling pathway
Ras signaling pathway
Calcium signaling pathway
NF-kappa B signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
VEGF signaling pathway
Osteoclast differentiation
Platelet activation
Natural killer cell mediated cytotoxicity
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Inflammatory mediator regulation of TRP channels
Thyroid hormone signaling pathway
Epstein-Barr virus infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Non-small cell lung cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mdo00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100027579 (PLCG2)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100027579 (PLCG2)
   04012 ErbB signaling pathway
    100027579 (PLCG2)
   04370 VEGF signaling pathway
    100027579 (PLCG2)
   04064 NF-kappa B signaling pathway
    100027579 (PLCG2)
   04066 HIF-1 signaling pathway
    100027579 (PLCG2)
   04020 Calcium signaling pathway
    100027579 (PLCG2)
   04070 Phosphatidylinositol signaling system
    100027579 (PLCG2)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100027579 (PLCG2)
   04650 Natural killer cell mediated cytotoxicity
    100027579 (PLCG2)
   04662 B cell receptor signaling pathway
    100027579 (PLCG2)
   04664 Fc epsilon RI signaling pathway
    100027579 (PLCG2)
   04666 Fc gamma R-mediated phagocytosis
    100027579 (PLCG2)
   04670 Leukocyte transendothelial migration
    100027579 (PLCG2)
  Endocrine system
   04919 Thyroid hormone signaling pathway
    100027579 (PLCG2)
  Nervous system
   04722 Neurotrophin signaling pathway
    100027579 (PLCG2)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100027579 (PLCG2)
  Development
   04380 Osteoclast differentiation
    100027579 (PLCG2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100027579 (PLCG2)
   05206 MicroRNAs in cancer
    100027579 (PLCG2)
   05205 Proteoglycans in cancer
    100027579 (PLCG2)
   05214 Glioma
    100027579 (PLCG2)
   05223 Non-small cell lung cancer
    100027579 (PLCG2)
  Infectious diseases
   05169 Epstein-Barr virus infection
    100027579 (PLCG2)
Enzymes [BR:mdo01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100027579 (PLCG2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
UniProt: 
Position
1
AA seq 1264 aa AA seqDB search
MTTKINIDTLPEYEKSQIKRTLELGTVMTLFSLKKSNPERRTVQVITETRQVAWSKTADK
IEGFLDLMEIKEIRPGKNSKDFERGKASRQKEDCCFTIFYGTQFVLNTLSLAADSKDDAS
KWLCGLTILHQEAQNASTPTITESWLRKQIYSVDQTRKNSITFRELKTILPLVNFKVSSA
KFLKDKFLEIGAYKDELSFEQFHLFYKKMMFDQQKSILDEFKKDSSVFILGNTDRPDASA
IHLHDFQRFLMHEQQETWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSKENS
IWDDKYDSVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTESYIRCLRMGCRCIELDC
WDGPDGKPIIYHGWTRTTKIKFDDVVQAIRDHAFVSSQFPVILSIEEHCCVEQQRHMARV
FKEVFGDLLLTRPTEASADQLPSPAQLKEKIIIKHKKLGPRGDVDINIEDKKEEKKQQGE
LYMWDTIDQKWYRHYCAIADEKLSFSDDIEQNMEEDSVKDVAQTDLHFGEKWFHKRMEKR
TSAEKLLQEYCAETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTPEGGAMKYY
LTDNLMFNSIYDLIQHYREAHLRCAEFELRLTDPVPNPNPHESKAWYYDSLSRGEAEDML
MRIPRDGAFLIRKREGGDAYAITFRAKGKVKHCRINKDGHHFVLGTSAYFESLVELVSYY
EKHALYRKMRLRYPVTPELLERYNTERDINSLYDVRMYVDPSEINPSTPQRTVKALYDYK
AKRRDELSFCRGALIHNVSKEPGGWWKGDYGGRIQQYFPSNYVEDISTVDFEELEKQIIE
DNPLGSLCRGILDLNTYNVVKVPHGKNQKSFVFILEPKNPNDPPVEFATDKVEELFEWYQ
SIREITWKNATVETNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVET
KADSIVRQKPIDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGAQMVALNFQTADKYM
QLNHALFALNGRTGYVLQPESMRNENYDPTPLESQRKILMTLTVKVLGARHLPKLGRSIA
CPFVEVEICGTEYDNNKFKTTVVNDNGLSPVWASTQEKVTFEIYDPNLAFLRFVVYEEDM
FSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSCR
QLRRRQEELNNQLFLYDTHQNIRNANRDALVNEFNVNENQLQLYQEKCNRRLREKRVSNS
KFYS
NT seq 3795 nt NT seq  +upstreamnt  +downstreamnt
atgaccaccaagatcaacatagacacccttcccgaatatgagaaaagtcagatcaagcgg
actctggaattgggaactgtcatgaccttgtttagcctcaagaagtctaaccctgagagg
agaacggtccaggtcatcacggagaccaggcaggtggcctggagcaagacggctgacaag
attgaaggattcttggacttaatggagataaaggaaatccgtccagggaaaaattcaaaa
gactttgaacgtgggaaagcaagtcgccagaaagaagattgctgcttcaccatattttat
ggcactcagtttgtcctcaacaccctgagtttagcagctgactccaaggatgacgctagt
aaatggctttgtggcttgacaattttgcaccaagaagcccagaatgcctcaacaccaact
attactgagagctggctaagaaagcaaatttattctgtagatcaaactcggaaaaatagt
atcaccttccgagaactgaagaccattcttcccttagtaaacttcaaagttagtagtgcc
aagttcctgaaggacaaattcctggaaataggtgcctacaaggatgaactcagctttgaa
cagttccacttattctacaaaaagatgatgtttgatcaacagaaatcaattcttgatgag
ttcaaaaaagattcatctgtgtttattctgggaaatacagaccggccagatgcatctgcc
attcacttgcatgatttccagaggtttctgatgcatgaacagcaggaaacctgggcacag
gatctaaataaagtaagagagaggatgaccaaatttatagatgacactatgagagaaaca
gctgagccattcctgtttgtcgatgagttccttacttacctgttttcaaaagaaaacagc
atttgggatgataaatatgactctgttgacatgcaagacatgaataaccccttgtctcat
tactggatttcttcatctcataacacatacctcaccggggaccaacttcgaagtgaatct
tctactgaatcgtacattcgatgtcttcgaatgggttgccggtgtatagagttggattgc
tgggatgggcctgatgggaagccgatcatctatcatggctggacacggacgacgaaaatc
aagtttgacgatgtggtgcaggccatcagagaccatgcttttgtctcctcacagttccca
gtgatcctctccattgaagaacactgctgtgtggaacagcaacgtcatatggccagggta
tttaaggaagtttttggagacctcctccttacaaggcccactgaagccagtgccgaccag
cttccatcccctgcccagctgaaagaaaagatcatcattaagcacaagaagctgggtccc
agaggagatgtggacatcaacattgaagacaagaaagaggaaaaaaaacagcaaggagaa
ctgtacatgtgggacaccattgatcagaaatggtatcgccattattgtgctatagctgat
gagaagctgtctttcagtgatgatatagaacagaatatggaggaggattctgtaaaggat
gtagcacagactgacctgcattttggtgagaagtggtttcataaaagaatggagaagaga
acaagtgctgagaaactattgcaagaatactgtgctgaaaccgggggcaaggatggaacc
ttcttagtccgtgaaagcgagactttccccaatgattatacattgtccttctggagatca
ggcagagtccagcactgtcgaatacggtcgactcctgagggaggggccatgaaatactat
ttgactgacaacctcatgttcaacagcatctatgacttgattcaacactaccgagaagcc
cacctgagatgtgctgaatttgaacttcgtttgacagacccagtgcccaaccccaatcct
catgaatcaaaagcttggtactatgatagcctgagcagaggagaagccgaagacatgttg
atgagaattccccgagatggagccttcctgattaggaaaagagaagggggagatgcgtac
gccattactttcagagccaagggaaaagtgaagcattgccggattaacaaagatgggcat
cattttgtgctggggacatctgcttactttgaaagtttggtagaattggtcagctactat
gaaaagcatgcgctctacaggaagatgaggctgcgctaccccgtgactcctgaattgctg
gagcgttacaacactgaaagggacataaattcgctctatgatgtcaggatgtatgtggat
cccagtgaaattaacccctcaacgcctcagagaaccgtgaaggctctatatgactacaaa
gccaagcgtagggatgagctcagcttctgtcggggagccctcatccacaacgtctccaag
gagcctggtggctggtggaagggtgattatggaggaaggattcagcaatattttccatct
aattatgtggaggacatatcaacagttgatttcgaagagctggaaaaacagattattgaa
gataaccctttaggatccctatgcagaggaatcttggacctcaacacttacaatgttgtg
aaagtaccacatgggaaaaatcagaaatcgtttgtgttcatcctggaacccaagaatccc
aatgatcctcctgtggagtttgcaacagacaaagtggaagaactctttgagtggtaccag
agcatcagagaaatcacttggaagaatgcgacagtggagaccaacatgaaatattgggag
aagaaccaatcaattgccatagagctatctgacttagtcgtctactgtaaaccaaccagc
aaaaccaaggataatctagaaaatcctgatttcagagaaattcgctcttttgtggagacc
aaggctgacagcatcgttaggcagaagccgattgatctcttgaaatacaatcaaaaggga
ctgactcgggtctacccgaaaggccaaagggtggactcatcaaattatgatccttttcga
ctctggctttgtggcgctcagatggttgctctgaatttccagacagcagacaaatatatg
cagctaaaccatgctttatttgcacttaatggccggactggttatgtcctacagcctgaa
agcatgaggaatgaaaactatgatccgacacccctggaatcacaaaggaagatcctgatg
actctcactgtgaaggtcttgggggcccgccatcttcccaagcttggccgaagcattgcc
tgtccatttgtagaggtggaaatttgtggcactgagtatgataataacaaattcaagaca
acggtagtaaatgataatggtctgagtccagtctgggcgtctactcaggaaaaagtgaca
tttgaaatttatgacccaaatctcgcatttctacgttttgttgtttatgaggaggatatg
ttcagcgatcccaactttctggcacatgccacttatcccattaaaggaatcaaatcaggg
tttagatctgttcctcttaaaaatggttacagtgaagatattgaactggcctcccttttg
gttttctgtgagatgcgccctgtcttggaaagcgaagaagagctctattcttcctgtcgc
caacttcgaaggcggcaagaggagctgaacaaccaactctttctctatgacactcatcag
aacatacgcaatgctaacagagatgccctggtgaatgaattcaatgtcaatgaaaatcag
ttgcagctgtatcaggaaaaatgcaacaggaggttaagggagaagagagttagtaacagc
aaattctactcctag

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