KEGG   Monodelphis domestica (opossum): 100031660Help
Entry
100031660         CDS       T01031                                 

Gene name
PLCB1
Definition
phospholipase C, beta 1 (phosphoinositide-specific)
Orthology
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
mdo  Monodelphis domestica (opossum)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mdo00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100031660 (PLCB1)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    100031660 (PLCB1)
   04310 Wnt signaling pathway
    100031660 (PLCB1)
   04020 Calcium signaling pathway
    100031660 (PLCB1)
   04070 Phosphatidylinositol signaling system
    100031660 (PLCB1)
   04022 cGMP - PKG signaling pathway
    100031660 (PLCB1)
 Cellular Processes
  Cell communication
   04540 Gap junction
    100031660 (PLCB1)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100031660 (PLCB1)
   04062 Chemokine signaling pathway
    100031660 (PLCB1)
  Endocrine system
   04911 Insulin secretion
    100031660 (PLCB1)
   04912 GnRH signaling pathway
    100031660 (PLCB1)
   04915 Estrogen signaling pathway
    100031660 (PLCB1)
   04921 Oxytocin signaling pathway
    100031660 (PLCB1)
   04918 Thyroid hormone synthesis
    100031660 (PLCB1)
   04919 Thyroid hormone signaling pathway
    100031660 (PLCB1)
   04916 Melanogenesis
    100031660 (PLCB1)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100031660 (PLCB1)
   04270 Vascular smooth muscle contraction
    100031660 (PLCB1)
  Digestive system
   04970 Salivary secretion
    100031660 (PLCB1)
   04971 Gastric acid secretion
    100031660 (PLCB1)
   04972 Pancreatic secretion
    100031660 (PLCB1)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    100031660 (PLCB1)
  Nervous system
   04724 Glutamatergic synapse
    100031660 (PLCB1)
   04725 Cholinergic synapse
    100031660 (PLCB1)
   04728 Dopaminergic synapse
    100031660 (PLCB1)
   04726 Serotonergic synapse
    100031660 (PLCB1)
   04720 Long-term potentiation
    100031660 (PLCB1)
   04730 Long-term depression
    100031660 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    100031660 (PLCB1)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100031660 (PLCB1)
  Environmental adaptation
   04713 Circadian entrainment
    100031660 (PLCB1)
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    100031660 (PLCB1)
   05016 Huntington's disease
    100031660 (PLCB1)
  Infectious diseases
   05146 Amoebiasis
    100031660 (PLCB1)
   05142 Chagas disease (American trypanosomiasis)
    100031660 (PLCB1)
   05143 African trypanosomiasis
    100031660 (PLCB1)
Enzymes [BR:mdo01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100031660 (PLCB1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
1
AA seq 1218 aa AA seqDB search
MAGAQPGVHALQLKPVSVSDNLKKGIKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGKHARAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISYLNLV
AFQEEVAKEWTDEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRMFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSRPYL
TVDQMMEFINLKQRDPRLNEILYPPLKQEQVQLLIEKYEPNNSLAKKGQISVDGFMRYLS
GEENGVVPPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPYPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSAKK
KLSEQASNTYSDSSSVFEPSSPGAGEADMESDDDDDDDDDCKKSSMDEGTAGSEAMATEE
MSNLVNYIQPVKFESFETSKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYP
KGTRVDSSNYMPQVFWNAGCQMVALNFQTVDLAMQLNLGMYEYNGKSGYRLKPEFMRRPD
KHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEIDMFGLPVDTRRKALKTKTSQ
GNAVNPVWEEEPIVFKKVVLPSLACLRIAAYEEGGKFIGHRILPVQAIRPGYHYICLRNE
RNQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVK
KEADLGETPTESKSEPRPAPAENGVNHTASLAPKPPSQVVHSQPAPGSVKAPAKTEDLIQ
SVLTDVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDY
LRRRAVLEKNAKRDSKKKSEPSSPDHVSSTMEQDLAALDAEMTQKLVELKDKQQQQLLNL
RQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEK
ITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEDAQSKRQEKLLEKHKEIRQQILDEK
PKMQVELDQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHSSVSSSITSYSSKANHKSPP
NEEELEEDNAERVFDTPL
NT seq 3657 nt NT seq  +upstreamnt  +downstreamnt
atggccggggcacagccaggagttcacgctttgcaactcaaacctgtcagcgtctccgac
aacctgaagaaaggcatcaaatttgtcaaatgggatgatgactctactattgttactccc
attattctgaggacagatccacaaggatttttcttttattggacagatcagaataaggag
actgaactcttagatctcagccttgtcaaggatgccagatgtgggaaacatgccagagcc
ccaaaggacccaaaattacgtgagcttttggatgtgggaaacataggacgcctggaacaa
cgaatgataactgtggtatatggtccagatttggtcaacatttcctatttgaacttagta
gcatttcaagaagaagtagccaaggaatggacagatgaggttttcagtttggcaacaaac
ctgctggcacaaaacatgtctagggacgcatttctggaaaaagcctataccaaactcaag
cttcaagttactcctgaaggaagaattcctctcaaaaacatctatcgcatgttttcagca
gatcgaaaacgtgttgaaactgctttagaagcttgtagtcttccatcttcaaggaatgat
tcaataccacaagaggacttcactccagaagtatacagagttttcttaaacaatctttgt
cctcgacctgaaatcgataacatcttttctgaattcggtgccaagagtagaccatatctt
actgttgatcaaatgatggagtttatcaatttaaagcaacgcgatccccgactcaatgaa
atcctttatccacccttaaaacaggaacaagtccaactactgattgagaagtatgaacct
aacaattccttagcaaaaaaaggacagatctcagtggatggattcatgcgctatctgagt
ggagaagaaaatggagtcgttccgcccgagaaactggatttgaatgaagatatgtctcag
ccactctctcactatttcatcaattcttcacacaacacctacctcacagctggccagtta
gctggcaactcctcagtagagatgtatcgccaagtactcttgtctggctgtcgctgtgtg
gagctggactgctggaagggaaggacagcagaagaagagcctgtcattactcatggtttc
accatgacaacagagatctcttttaaggaggtgatagaagctattgctgaatgtgcattt
aagacatcaccatacccgatcctcctttcttttgaaaaccatgtggattctccaaaacag
caagccaagatggcagaatattgcagactaatatttggagatgcacttcttatggagcca
ttagaaaaatacccacttgaatctggagttcctcttccaagccctatggacttaatgtat
aaaattttggtaaaaaataaaaagaaatcacacaagtcttcagaaggaagtgccaaaaag
aagctttcagaacaggcatccaatacttacagtgactcatccagtgtgtttgaaccttca
tctcctggagcaggagaagcagatatggagagtgatgatgatgatgatgatgacgatgac
tgtaaaaagtcttccatggatgagggaactgctggtagtgaagccatggccacagaagaa
atgtctaacctggtaaactatatacagccagtgaaatttgagtcttttgagacatcaaaa
aaaagaaacaaaagttttgaaatgtcctcttttgtggaaaccaaaggacttgaacaacta
acaaagtctccagtagaatttgtagaatataacaaaatgcagcttagcaggatttatcca
aagggaacacgtgtggattcttcaaattatatgccccaagtcttctggaatgctggctgt
caaatggtagctcttaactttcaaacagtagacttggctatgcaattgaacttgggaatg
tatgaatacaatgggaaaagtggttacagattaaagccagaatttatgagacgaccagac
aaacattttgatccatttactgaaggtatcgtggatggtatagtagccaatactttatct
gttaagatcatttcaggtcaatttctttctgataaaaaagttggcacttatgtggaaata
gatatgtttggcttaccagtggataccaggagaaaagccttgaaaaccaagacttctcag
gggaatgccgtgaatccagtctgggaagaagaacctatagtgtttaagaaggttgtcctg
ccttctctggcatgtctaaggatagcagcatatgaagaaggaggtaaatttattggtcat
cggatattgcctgtacaagcaatacgaccaggttatcactacatttgtctgaggaatgaa
aggaatcagcctctgatgctcccagcagtctttgtatacatagaggttaaagactatgta
ccagatacatatgcggatgtaattgaagcattatcaaatcccatcagatatgtgaatctg
atggaacaaagggctaaacagctggcagcactgaccctagaagatgaagaagaagtaaag
aaagaggccgatcttggggaaacaccaacagagtcgaagagtgaacccagaccggcacca
gcagagaacggggtcaatcacactgcatcactggcaccaaaaccaccatctcaggttgtc
cacagtcaaccagccccaggttcagtaaaagcacctgcaaaaactgaagatcttattcag
agtgtcttaacagatgtggaagcacagacaattgaggaattaaaacaacagaagtctttt
gtgaaacttcagaagaagcattacaaagaaatgaaggaccttgtgaagagacaccacaag
aaaaccactgatctgatcaaagagcacaccacaaagtacaatgaaatccaaaatgattac
ttgcgaaggagggctgtgctagaaaaaaatgcaaaaagagacagtaagaaaaaatctgaa
cccagcagtcctgatcatgtttcttcaacaatggagcaggatcttgctgccctggatgca
gaaatgacacaaaaactggtagaattaaaggacaagcaacagcagcagctactgaatctg
cgacaagaacagtattatagtgaaaaatatcagaagcgagagcatatcaaattgcttatt
cagaagttgacagatgttgcagaagaatgtcagaacaatcaattaaagaaactgaaagaa
atttgtgagaaagaaaagaaagagttgaagaagaaaatggataaaaaaagacaggagaag
ataacagaagcaaagtcaaaagacaagagtcaaatggaagaagagaagactgaaatgatc
cggtcatacatccaagaagtggtgcagtacataaagagactagaagatgcacaaagcaaa
agacaggagaaacttttagagaaacacaaggaaattcgtcaacagatactggatgaaaaa
ccaaagatgcaggtagaacttgatcaggaatatcaagacaaattcaaaaggctccccctg
gaaattctggaatttgtacaagaagccatgaaaggaaaaatcagtgaagatagcaatcac
agttcagtctcttcctccatcacctcatatagcagcaaagcaaaccacaaatctcccccg
aatgaggaagaactagaagaagacaatgcagaaagagtatttgatacacccctttga

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