KEGG   Monodelphis domestica (opossum): 100031869Help
Entry
100031869         CDS       T01031                                 

Gene name
PLCB2
Definition
(RefSeq) phospholipase C beta 2
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
mdo  Monodelphis domestica (opossum)
Pathway
mdo00562  Inositol phosphate metabolism
mdo01100  Metabolic pathways
mdo04015  Rap1 signaling pathway
mdo04020  Calcium signaling pathway
mdo04022  cGMP-PKG signaling pathway
mdo04062  Chemokine signaling pathway
mdo04070  Phosphatidylinositol signaling system
mdo04071  Sphingolipid signaling pathway
mdo04072  Phospholipase D signaling pathway
mdo04261  Adrenergic signaling in cardiomyocytes
mdo04270  Vascular smooth muscle contraction
mdo04310  Wnt signaling pathway
mdo04371  Apelin signaling pathway
mdo04540  Gap junction
mdo04611  Platelet activation
mdo04621  NOD-like receptor signaling pathway
mdo04713  Circadian entrainment
mdo04720  Long-term potentiation
mdo04723  Retrograde endocannabinoid signaling
mdo04724  Glutamatergic synapse
mdo04725  Cholinergic synapse
mdo04726  Serotonergic synapse
mdo04728  Dopaminergic synapse
mdo04730  Long-term depression
mdo04750  Inflammatory mediator regulation of TRP channels
mdo04911  Insulin secretion
mdo04912  GnRH signaling pathway
mdo04915  Estrogen signaling pathway
mdo04916  Melanogenesis
mdo04918  Thyroid hormone synthesis
mdo04919  Thyroid hormone signaling pathway
mdo04921  Oxytocin signaling pathway
mdo04922  Glucagon signaling pathway
mdo04924  Renin secretion
mdo04925  Aldosterone synthesis and secretion
mdo04926  Relaxin signaling pathway
mdo04927  Cortisol synthesis and secretion
mdo04928  Parathyroid hormone synthesis, secretion and action
mdo04933  AGE-RAGE signaling pathway in diabetic complications
mdo04934  Cushing's syndrome
mdo04961  Endocrine and other factor-regulated calcium reabsorption
mdo04970  Salivary secretion
mdo04971  Gastric acid secretion
mdo04972  Pancreatic secretion
mdo05010  Alzheimer's disease
mdo05016  Huntington's disease
mdo05142  Chagas disease (American trypanosomiasis)
mdo05143  African trypanosomiasis
mdo05146  Amoebiasis
mdo05200  Pathways in cancer
Module
mdo_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mdo00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100031869 (PLCB2)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    100031869 (PLCB2)
   04310 Wnt signaling pathway
    100031869 (PLCB2)
   04371 Apelin signaling pathway
    100031869 (PLCB2)
   04020 Calcium signaling pathway
    100031869 (PLCB2)
   04070 Phosphatidylinositol signaling system
    100031869 (PLCB2)
   04072 Phospholipase D signaling pathway
    100031869 (PLCB2)
   04071 Sphingolipid signaling pathway
    100031869 (PLCB2)
   04022 cGMP - PKG signaling pathway
    100031869 (PLCB2)
 Cellular Processes
  Cellular community - eukaryotes
   04540 Gap junction
    100031869 (PLCB2)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100031869 (PLCB2)
   04621 NOD-like receptor signaling pathway
    100031869 (PLCB2)
   04062 Chemokine signaling pathway
    100031869 (PLCB2)
  Endocrine system
   04911 Insulin secretion
    100031869 (PLCB2)
   04922 Glucagon signaling pathway
    100031869 (PLCB2)
   04912 GnRH signaling pathway
    100031869 (PLCB2)
   04915 Estrogen signaling pathway
    100031869 (PLCB2)
   04921 Oxytocin signaling pathway
    100031869 (PLCB2)
   04926 Relaxin signaling pathway
    100031869 (PLCB2)
   04918 Thyroid hormone synthesis
    100031869 (PLCB2)
   04919 Thyroid hormone signaling pathway
    100031869 (PLCB2)
   04928 Parathyroid hormone synthesis, secretion and action
    100031869 (PLCB2)
   04916 Melanogenesis
    100031869 (PLCB2)
   04924 Renin secretion
    100031869 (PLCB2)
   04925 Aldosterone synthesis and secretion
    100031869 (PLCB2)
   04927 Cortisol synthesis and secretion
    100031869 (PLCB2)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100031869 (PLCB2)
   04270 Vascular smooth muscle contraction
    100031869 (PLCB2)
  Digestive system
   04970 Salivary secretion
    100031869 (PLCB2)
   04971 Gastric acid secretion
    100031869 (PLCB2)
   04972 Pancreatic secretion
    100031869 (PLCB2)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    100031869 (PLCB2)
  Nervous system
   04724 Glutamatergic synapse
    100031869 (PLCB2)
   04725 Cholinergic synapse
    100031869 (PLCB2)
   04728 Dopaminergic synapse
    100031869 (PLCB2)
   04726 Serotonergic synapse
    100031869 (PLCB2)
   04720 Long-term potentiation
    100031869 (PLCB2)
   04730 Long-term depression
    100031869 (PLCB2)
   04723 Retrograde endocannabinoid signaling
    100031869 (PLCB2)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100031869 (PLCB2)
  Environmental adaptation
   04713 Circadian entrainment
    100031869 (PLCB2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100031869 (PLCB2)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    100031869 (PLCB2)
   05016 Huntington's disease
    100031869 (PLCB2)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    100031869 (PLCB2)
   04934 Cushing's syndrome
    100031869 (PLCB2)
  Infectious diseases
   05146 Amoebiasis
    100031869 (PLCB2)
   05142 Chagas disease (American trypanosomiasis)
    100031869 (PLCB2)
   05143 African trypanosomiasis
    100031869 (PLCB2)
Enzymes [BR:mdo01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100031869 (PLCB2)
Membrane trafficking [BR:mdo04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    100031869 (PLCB2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    100031869 (PLCB2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: PLC-beta_C PI-PLC-X PI-PLC-Y EF-hand_like C2 DUF1154 MMACHC
Motif
Other DBs
NCBI-GeneID: 100031869
NCBI-ProteinID: XP_001381023
Ensembl: ENSMODG00000000528
UniProt: F6Y4X0
Position
1
AA seq 1188 aa AA seqDB search
MSLLNPVLLPPELKSYLTRGERFIKWDDETSVASPVILRVDPKGYYLYWTYQSKEMEFLD
ITSIRDTRFGKFAKMPKTQKLREVFNLDFPDNTFLLKTLTVVSGPDMVDLTFHNFVSYKE
NVGKDWAEDVLALAKNPWAANAPRSTFLEKILVKLKMQLSPEGKIPVKNFFQMFPADRKR
VEAALSACHLPKGKNDSINPEDFPEPVYRSFLMSLCPRPEIDEIFTSHHAKAKPYMTKEH
LTKFINQKQRDARLNSLLFPPARPDQVQCLIEKYEPSGINIQRGQLSPEGMVWFLCGPEN
SIVAQDKLMLHQDMSQPLNHYFINSSHNTYLTAGQFSGPSSSEMYRQVLLSGCRCVELDC
WKGKPPEEEPIITHGFTMTTDILFKDAVEAIAESAFKTSLYPVILSFENHVDSPRQQAKM
AEYCRTIFGDMLLTEPLDKFPLKSGVPLPSPQDLLGKILIKNKKNQSSAPVPPKKELCTE
TEGSQANAAMGEDTVWVGEEEAELEEEEEEEEEEEESGSLDEEEIKKMQSDEGTAGLEVT
AYEEMSSLVNYIQPTKFISFEFSSQKNRSYVISSFTELKAYDLLTKSPVQFVDYNKRQMS
RIYPKGTRMDSSNYSPQMFWNAGCQMVALNFQTMDMPMQQNMALFEFNGQSGYLLKHEFM
RRPDKHFDPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVEVFGLPGDPKRRYRTK
LTPSANSINPVWKEDPFVFEKIMMPELASLRVAVLEEGGKFIGHRIIPVHALHSGYHHLC
LRSESNMPLTMPALFVFLEMKDYVPDTWADLTVALANPIKFFNAQDKKSVKLKETENSAP
EKPLTPRNSAVGQLNGALASAGSSTAPPSNGPAVAVTWLKEEALKEAAEPQTASLEELQQ
LKGFLKLQKRQEKELRELERQGARRWEEVLQKYANLQTELTPQGGCRKLSITKGSRKKRS
LPCEETGGAGMGPIEGPESSDGRIRELKEKLEMELYQQGEEQYESIMKRKEAHGSELMDK
VLKLAQEKQAAELKALKESADGNTKEMKKKLEVKRLERIQAMSKITSDKMAQERLKREIN
NSHIQEVVHIIKQMTETLERHQERLEEKQAACLEQIREKGKQFQQEALSEYEERMKGLEA
KVKEAVKCCLSFPQDVHNKKPETPGAVEEPLEETLSPAEASSQLDSRL
NT seq 3567 nt NT seq  +upstreamnt  +downstreamnt
atgtctctgctgaaccccgtcctgctgccccctgagctgaagagctacctgacccgagga
gagcgcttcatcaagtgggatgatgagacttcagtggcctccccggtcatccttcgagtg
gatcctaagggatattatttgtactggacctatcaaagcaaggagatggagttcctggac
atcaccagcatccgggacactcggtttggcaagtttgctaagatgcccaagacccagaaa
cttcgagaagttttcaacttggacttccctgacaacaccttcttgctgaagaccctgact
gtggtgtctggcccagacatggtggacctgaccttccataactttgtctcctacaaagag
aatgtcggcaaggactgggctgaagacgttctggctttggctaagaacccatgggcagcc
aatgctccccggagcacattcctggagaagatcctggtaaagcttaagatgcagctcagt
cctgaagggaagatccccgtgaagaatttttttcagatgtttcctgctgaccggaaacga
gtagaggctgcactcagtgcctgtcaccttcccaagggcaaaaatgactccatcaacccg
gaggatttccctgagcctgtctacaggagcttcctcatgagtctgtgtccccgacctgag
atcgatgagattttcacctctcatcatgccaaagcaaagccttacatgaccaaggagcat
ctgaccaagttcattaaccaaaagcagcgggatgcccgactcaactccctactcttccca
ccggcccgacctgaccaagtacagtgcctcattgaaaagtatgaacccagtggcatcaac
atccagaggggtcagctgtccccagaggggatggtttggttcctatgtggtccagagaac
agtatagtggcccaagacaaactgatgctgcatcaggacatgagccagcctctgaatcac
tacttcatcaactcctcccacaacacctacctgacagctggccagttctcggggccctcg
tcctcagagatgtacagacaggtcttgctctctggatgtcgctgtgtggagcttgactgc
tggaaggggaagcctcctgaagaagagcccatcatcactcatggtttcaccatgaccaca
gacattttattcaaggatgcggtagaggccattgctgagagtgccttcaagacctccctc
tacccggtcatcttgtcctttgagaaccatgtagactcgcctcgacagcaagctaagatg
gcagagtactgtagaaccatatttggggacatgctgctcactgagcccctggacaagttc
cctttgaagtcaggggtccccctccccagtccccaggaccttctgggcaagatccttatc
aagaataagaagaatcagtcctccgctcctgttccacccaagaaagaactgtgtacggaa
acagagggtagccaggccaatgcagccatgggtgaggacacagtgtgggttggtgaagaa
gaggctgagctggaggaagaggaggaagaagaagaagaagaggaagaatcaggtagtttg
gatgaagaggaaatcaagaagatgcagtcggatgagggcacagctggcctggaggtgaca
gcatacgaggagatgtctagcctggtcaactacatccagcccaccaagttcatctccttc
gagttctcctcccagaagaatcggagttatgtcatctcttcctttacggagctgaaggcc
tatgatctgctcaccaagtcccctgtgcagtttgtggactataacaagaggcaaatgagt
cggatctaccccaagggcacacgaatggactcatctaactactctccccagatgttctgg
aatgcaggctgccaaatggtggccctcaatttccagacaatggatatgcccatgcagcag
aacatggcactgtttgagttcaacgggcagagtggctaccttctcaagcacgagttcatg
cgccggccggacaagcattttgacccgttctccgtggaccgcatcgatgtggtggtggcc
accactctctccatcacggtgatttctggccagtttctgtcggaacgaagtgtccgaact
tacgtggaggtggaggtgtttggcttgcctggagaccccaagaggcgctaccgcaccaaa
ctgacacccagcgccaactccataaatcccgtctggaaagaggacccctttgtctttgag
aagatcatgatgccagaactagcctctctgagagtggcagtcctggaagaaggaggcaag
tttatcgggcaccgaattatcccagtccatgccctgcactcagggtaccatcacttgtgc
ctcaggagtgagagcaacatgcccctcaccatgcctgccctcttcgttttcctggagatg
aaagattatgtgcctgacacatgggcagatctcactgtggctcttgccaaccccatcaaa
ttcttcaatgctcaagacaagaagtcagtcaagctgaaggaaacagagaacagcgcccct
gagaagcctttgacgcccaggaactcggctgtgggccagctcaacggggccctggcgtcc
gccggctcctccacggcgccgccgtccaacggtcctgcagtggctgtgacctggctgaag
gaggaagcattgaaagaggcagcagaacctcagacagccagtctggaggagctgcagcag
ttgaaagggttcctgaagcttcagaagagacaggaaaaggaacttcgggaactggagagg
caaggtgcccgtcgctgggaagaagttctgcaaaagtatgccaacttacagactgaattg
acaccccagggtgggtgcaggaagctgtccatcactaagggatccaggaagaagagaagc
ttgccttgtgaggagactggcggggccgggatgggaccaatcgaaggaccagaaagctca
gatgggcgcattcgagagctgaaggagaagctggagatggaactgtaccaacaaggggag
gagcagtatgaaagcatcatgaaacgcaaggaagctcatggtagtgagctaatggacaag
gtgctaaagctggcccaggaaaaacaagcagccgaactaaaggctctcaaggagtctgca
gacggcaataccaaagagatgaaaaagaagcttgaagtcaagaggctagagcggatccag
gccatgagcaagatcactagtgacaagatggcccaggagaggctgaagagagaaattaac
aactcacatatacaggaagtggtccatatcatcaaacagatgacagagactctggagagg
caccaggagaggctggaagaaaagcaggcggcttgtctggagcagatccgggagaaaggg
aagcagttccagcaagaggcattgtctgaatatgaggaacgcatgaagggcctggaagcc
aaagtgaaggaggcggtgaagtgctgtctcagtttcccccaagatgtccacaacaagaag
ccagagacacctggtgctgtggaagaacctttggaggagacattgagcccagctgaggct
tcttcccagctagacagccgtctctaa

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