KEGG   Monodelphis domestica (opossum): 100033281Help
Entry
100033281         CDS       T01031                                 

Gene name
PLCB4
Definition
(RefSeq) phospholipase C beta 4
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
mdo  Monodelphis domestica (opossum)
Pathway
mdo00562  Inositol phosphate metabolism
mdo01100  Metabolic pathways
mdo04015  Rap1 signaling pathway
mdo04020  Calcium signaling pathway
mdo04022  cGMP-PKG signaling pathway
mdo04062  Chemokine signaling pathway
mdo04070  Phosphatidylinositol signaling system
mdo04071  Sphingolipid signaling pathway
mdo04072  Phospholipase D signaling pathway
mdo04261  Adrenergic signaling in cardiomyocytes
mdo04270  Vascular smooth muscle contraction
mdo04310  Wnt signaling pathway
mdo04371  Apelin signaling pathway
mdo04540  Gap junction
mdo04611  Platelet activation
mdo04621  NOD-like receptor signaling pathway
mdo04713  Circadian entrainment
mdo04720  Long-term potentiation
mdo04723  Retrograde endocannabinoid signaling
mdo04724  Glutamatergic synapse
mdo04725  Cholinergic synapse
mdo04726  Serotonergic synapse
mdo04728  Dopaminergic synapse
mdo04730  Long-term depression
mdo04750  Inflammatory mediator regulation of TRP channels
mdo04911  Insulin secretion
mdo04912  GnRH signaling pathway
mdo04915  Estrogen signaling pathway
mdo04916  Melanogenesis
mdo04918  Thyroid hormone synthesis
mdo04919  Thyroid hormone signaling pathway
mdo04921  Oxytocin signaling pathway
mdo04922  Glucagon signaling pathway
mdo04924  Renin secretion
mdo04925  Aldosterone synthesis and secretion
mdo04926  Relaxin signaling pathway
mdo04927  Cortisol synthesis and secretion
mdo04928  Parathyroid hormone synthesis, secretion and action
mdo04933  AGE-RAGE signaling pathway in diabetic complications
mdo04934  Cushing's syndrome
mdo04961  Endocrine and other factor-regulated calcium reabsorption
mdo04970  Salivary secretion
mdo04971  Gastric acid secretion
mdo04972  Pancreatic secretion
mdo05010  Alzheimer's disease
mdo05016  Huntington's disease
mdo05142  Chagas disease (American trypanosomiasis)
mdo05143  African trypanosomiasis
mdo05146  Amoebiasis
mdo05200  Pathways in cancer
Module
mdo_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mdo00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100033281 (PLCB4)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    100033281 (PLCB4)
   04310 Wnt signaling pathway
    100033281 (PLCB4)
   04371 Apelin signaling pathway
    100033281 (PLCB4)
   04020 Calcium signaling pathway
    100033281 (PLCB4)
   04070 Phosphatidylinositol signaling system
    100033281 (PLCB4)
   04072 Phospholipase D signaling pathway
    100033281 (PLCB4)
   04071 Sphingolipid signaling pathway
    100033281 (PLCB4)
   04022 cGMP - PKG signaling pathway
    100033281 (PLCB4)
 Cellular Processes
  Cellular community - eukaryotes
   04540 Gap junction
    100033281 (PLCB4)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100033281 (PLCB4)
   04621 NOD-like receptor signaling pathway
    100033281 (PLCB4)
   04062 Chemokine signaling pathway
    100033281 (PLCB4)
  Endocrine system
   04911 Insulin secretion
    100033281 (PLCB4)
   04922 Glucagon signaling pathway
    100033281 (PLCB4)
   04912 GnRH signaling pathway
    100033281 (PLCB4)
   04915 Estrogen signaling pathway
    100033281 (PLCB4)
   04921 Oxytocin signaling pathway
    100033281 (PLCB4)
   04926 Relaxin signaling pathway
    100033281 (PLCB4)
   04918 Thyroid hormone synthesis
    100033281 (PLCB4)
   04919 Thyroid hormone signaling pathway
    100033281 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    100033281 (PLCB4)
   04916 Melanogenesis
    100033281 (PLCB4)
   04924 Renin secretion
    100033281 (PLCB4)
   04925 Aldosterone synthesis and secretion
    100033281 (PLCB4)
   04927 Cortisol synthesis and secretion
    100033281 (PLCB4)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100033281 (PLCB4)
   04270 Vascular smooth muscle contraction
    100033281 (PLCB4)
  Digestive system
   04970 Salivary secretion
    100033281 (PLCB4)
   04971 Gastric acid secretion
    100033281 (PLCB4)
   04972 Pancreatic secretion
    100033281 (PLCB4)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    100033281 (PLCB4)
  Nervous system
   04724 Glutamatergic synapse
    100033281 (PLCB4)
   04725 Cholinergic synapse
    100033281 (PLCB4)
   04728 Dopaminergic synapse
    100033281 (PLCB4)
   04726 Serotonergic synapse
    100033281 (PLCB4)
   04720 Long-term potentiation
    100033281 (PLCB4)
   04730 Long-term depression
    100033281 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    100033281 (PLCB4)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100033281 (PLCB4)
  Environmental adaptation
   04713 Circadian entrainment
    100033281 (PLCB4)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100033281 (PLCB4)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    100033281 (PLCB4)
   05016 Huntington's disease
    100033281 (PLCB4)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    100033281 (PLCB4)
   04934 Cushing's syndrome
    100033281 (PLCB4)
  Infectious diseases
   05146 Amoebiasis
    100033281 (PLCB4)
   05142 Chagas disease (American trypanosomiasis)
    100033281 (PLCB4)
   05143 African trypanosomiasis
    100033281 (PLCB4)
Enzymes [BR:mdo01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100033281 (PLCB4)
Membrane trafficking [BR:mdo04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    100033281 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    100033281 (PLCB4)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: PI-PLC-X PI-PLC-Y DUF1154 EF-hand_like C2
Motif
Other DBs
NCBI-GeneID: 100033281
NCBI-ProteinID: XP_016283310
Ensembl: ENSMODG00000004697
Position
1
AA seq 1206 aa AA seqDB search
MAKPYEFNWQKPVSPFIQEGAIFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVL
ECSLINSIRFGSVPKDPKILAALEAFGKSESDLEGRIVCVCSGTDLVNISFTYMVAENPE
VAKQWVEGLRAIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFRKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDTKRAMQIIETYEPDDELKTKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQILLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRSLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESAAPVNILEDDNEEEIESADQEEEAHPEFKFGSELSADDFSQKEAVANSVKKAAE
DLEHENNKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFNVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTVFCNIVLKTYVPDGF
GDIVDALSDPKKFLSVMEKRADQMRAMGIETSDIADVPNDTSKNDKKGKANNAKASVTPQ
SSSELRPATTSALGAGIEGKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKLSHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCDLLKKLLISAHEQQTQQLKLS
HDRECKEMRANQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEVLEKQNEQLLKSCHAVSQTQGKGDAADGEIGSRDGPKTSNSGV
KLHNPN
NT seq 3621 nt NT seq  +upstreamnt  +downstreamnt
atggccaaaccatatgaatttaactggcagaaaccagtctctccatttatacaggaggga
gccatttttgacagatatgaagaggagtcctttgtatttgaacctaactgccttttcaaa
gtggatgaatttggcttctttttgacctggaaaagtgaaggaaaggaaggacaggtatta
gagtgttccctgattaacagcattcgttttggatctgtaccaaaggatcccaaaatacta
gcagctcttgaggcttttggaaaatcagagagtgatctggaggggaggatagtatgtgtc
tgcagtggcaccgacctggtgaatatcagcttcacttatatggtggcagaaaatccagaa
gttgctaagcaatgggtagaagggttaagagccatcatacataattttagagctaacaat
gttagtccaatgacatgcctcaagaaacactggatgaaattggcatttatgacaaacaca
aatggtaaaattccagttaggagtattactagaacttttgcatcaggtaaaacagaaaag
gtgatttttcaagcacttaaggagctaggtcttcccagcggaaagaatgatgaaatcgag
cctgcagcatttacttatgaaaaattttatgaactaacacaaaaaatttgtcctcggact
gacatagaggacctctttaggaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagaccctcgactgaatgaaattttattc
ccattctatgatacaaaaagggcaatgcagataattgagacttatgagcctgatgatgag
ttgaagacaaaagggctcatatccagtgatgggttttgcagatatctgatgtcagatgaa
aatgctccagtcttcctagaccgcctggaactttaccaagaaatggatcatcctttggca
cactatttcatcagttcttcccataacacatatctcacaggacgtcagtttggtgggaaa
tcttctgtggaaatgtacagacaaatactcttagctggatgcagatgtgttgagctagat
tgctgggatggtaaaggagaagatcaagaaccaattataactcacggaaaagcaatgtgt
acagatattctctttaaggatgtgattcaagccatcaaggaaacagcctttgttacatca
gagtatcctgtcattctgtcctttgaaaaccactgcagcaaatatcaacagtacaagatg
tccaagtattgtgaagatctatttggggatctcctgttgaaacaagcacttgaatcacat
ccacttgaaccaggaagatcattaccatcccctaatgacctcaaaagaaaaatactcatc
aaaaacaagagactgaaacctgaggtggaaaaaaaacagcttgaagcattaaaaagtatg
atggaagcaggagagtcagcagccccagtaaatatcttggaagatgacaacgaggaagaa
atagaaagtgctgaccaagaggaggaagctcacccagaattcaaatttggaagtgaactc
tctgctgatgacttcagtcaaaaggaagctgttgcaaatagtgtaaagaaggctgcagaa
gaccttgaacatgaaaacaataaaaagggattagttactgtggaagatgagcaggcatgg
atggcttcctataaatacgtgggcgctacaaccaatattcacccatatttatccacaatg
atcaactatgcccagcctgtaaagtttcagggcttcaatgtagcagaagaacgcaatatt
cattacaatatgtcttcttttaatgaatcagttggactaggttatttgaagacacatgca
attgaatttgtgaattataataaacgacaaatgagtcggatttaccccaagggaggccga
gtggattccagtaattacatgcctcagattttctggaacgctggctgccagatggtctca
ctgaactatcaaaccccagatttagcgatgcaattgaatcagggaaaatttgaatataac
ggatcatgcgggtaccttctcaaaccagatttcatgagacggccagatcgaacatttgat
cctttctctgaaacacctgtagatggtgttatagcagccacttgttcagtgcaggtcata
tcagggcaattcttatctgataagaaaattggtacgtatgtagaagtggatatgtatggt
ttgcccacagacactatccgtaaggagttccgaactcgtatggttatgaacaatggtctc
aatccggtttacaatgaggaatcgttcgtattccgaaaggttatcctccctgatctggct
gtcttgagaatagctgtgtatgatgacaacaacaagctgattggtcaaagaatcctccca
cttgatggcctccaggcaggctacagacacatttctcttcgaaatgaagggaataaacca
ttatcactgccaactgttttctgcaacattgtgcttaaaacatatgtgcccgatggtttt
ggagatattgtggatgctttgtcagacccaaagaaatttctttctgtaatggaaaagaga
gcagatcagatgagagccatgggtattgaaactagtgacatagctgatgtgccaaatgac
acttccaagaatgacaagaaaggaaaagccaataatgctaaggctagtgtgactcctcag
agcagttctgaactcagaccagccaccacctccgccttgggagcaggaattgaagggaag
aaaggtattgaacttatccctcaagtgaggatagaagatttaaaacaaatgaaggcttac
ttgaaacacttaaagaaacaacagaaagaattaaattctttaaagaagaagcatgcaaag
gaacacagcaccatgcagaagctacactgcacacaagttgacaaaatcgtggcacaatat
gacaaggagaagttatctcatgagaaaattttagagaaagcaatgaagaagaagggagga
agtaattgtcttgaaatgaagaaagaaactgaaattaaaattcagacattaacatcagat
cataaatctaaggtaaaagagattgtagctcagcatacaaaagagtggtcagaaatgatt
aatacccacagtgctgaggagcaagaaatccgggatcttcacctcagccagcaatgcgat
cttctgaaaaagctgctgatcagtgctcacgagcagcaaactcagcagctgaagctctcc
cacgacagagaatgcaaggaaatgcgtgccaatcaggccaagatttcgatggaaaacagc
aaagccatcagccaagacaaatctatcaaaaataaagcagaaagagagaggagagtcaga
gaactaaacagcagtaacactaaaaagtttctggaagaaagaaagagactcgcaatgaaa
cagtctaaagaaatggatcagttgaaaaaagttcaacttgaacatctagaagtcctggaa
aaacagaatgagcagcttttgaaatcctgtcatgcagtgtctcaaacacaaggcaaagga
gatgcagcagatggtgaaattggaagccgagatggaccgaagaccagcaacagtggtgta
aagctccacaaccccaattga

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