KEGG T01031: 100619840

Monodelphis domestica (opossum): 100619840

Entry

100619840 CDS T01031

Gene name

DOT1L

Definition

DOT1-like, histone H3 methyltransferase (S. cerevisiae)

Orthology

K11427

histone-lysine N-methyltransferase, H3 lysine-79 specific [EC:2.1.1.43]

Organism

mdo Monodelphis domestica (opossum)

Pathway

mdo00310	Lysine degradation
mdo05202	Transcriptional misregulation in cancer

Class

Metabolism; Amino acid metabolism; Lysine degradation [PATH:mdo00310]
Human Diseases; Cancers; Transcriptional misregulation in cancers [PATH:mdo05202]

SSDB

Motif

Pfam:

DOT1

Other DBs

NCBI-GI:

334326748

NCBI-GeneID:

100619840

Ensembl:

ENSMODG00000004662

Position

AA seq 1794 aa
MAPKYKRGNVGSTDKPKKVIKCLAYWLSVDCPNEIQIASLAQRYNGLAMSQMLFLKEKPK
YRAKDVLNLVNDHCIGMLYHLLLSWGHPAKDKHHDAAHEIIETIRWVCEEIPDLKLAMEN
YVLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQVYNH
SVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAAT
NCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSV
IFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSAANGKEQGLENY
FSSLKNPKLREEQEAARRRQQRESKSNTTTPTKVQENKGAVALEPRMDSGAEEDKNGAAA
LKKPSPSKPRKKKLNKKGRKMAGRKRGRPKKMSAANPERKAKKTPTALELLHAQTVSQAA
ASSPQDAYKSPHSPYYQLPPKVQRHSSNQLLATPTPPALHKLLESFKVQYLQFLAYMKTP
QYKANLQQLVEQEKEKNTQLLGTAQQLFSHCQAQKEEIKRLFQQKLDELGVKALTYNDLI
QAQKEISAHNQQLKEQTKQLENDNSELRNQSLQLLKARCEELKLDWSTLSLENLLKEKQA
LKNQISEKQKHCLELQISIVELEKSQRQQELLQLKSYAPADDALSVHLRSKSTFSRELET
DPTRFQLELECSKLSLPHISSMSPELSMNGHATTYEIHSMLSRPSSKQNTPQYLTSHLDQ
EIVPCTPIHNNRQKADKLSSLSLPDYTRFSPAKLALRRHLNQDHVVHGKATTNEIHHRAE
HAKENGLTYQSPGISNGLKLSPQETRPSSPSALQIAGEKSSDKVLKERAYASNGETITSL
PISIPLSTVQPNKLPVSIPLASVVLPSRAEKVRNTPSPVHQNRESTSATLEKQFGANSHN
GMNSAVGNKSLALATSGFSYTGSLAVNGTLSSSPAHLNHGAEQAALDDSSNSGSLFNSVG
SRSSTPQHPSLLMMQSRNSGQNSPAHPLAASPRLNGASQSLMGILQFSDSTKLFSEGNKG
DLPLDSGFSDPENEVKRRILFTISTNTGNMKQSPSNKHSPLAASIRADCGQACVQEGKKR
GRRKRSSTGNPGANCAVSPKRKPLPSVAGLFTQSSGSPLNINSMVNNINQPLEITAISSP
ENSLKNSPIPYQDNDQPPVLKKEKPLIQTNGAHYSPLTSDEEPGSEDEHNSIRIERKIAT
ISLESKSPQKTENGGGLTGRKQTQLTESVNSSKWKSTFSPISDINLTKTSDSPLQAASSL
SQNSLFAFRPSSEDTMAIDAKISVHTRKNFPSSLSGTDGLSPNTNSSNGFSYAGGLSAAD
MSLHSFHDGASLSHKTTEVASLNSPLGFQSQRSKDSSDANPFLNKRQLDGLGSMKGEELQ
RSGGRSKEVLDLGLQLGGPSDKVSLQHNGKAGKGRDRDLEFKNGHNLFISAAAVPSGGLL
NGKGLSTAASTSGHPTSSVSTHHPFLNTFTTGSQFPLGPMSLQANLSSVAGSSVLQSLFN
SMPAAASLVHVSSAATRLTNSHAMGNFSSGVTGGTVGGVFNHAVPSASSHQFGASFSSSA
VCSSTMLSLNPMQAVVTPTSSSFQAPSSSIGTCSEARAPQPLNRVPVQPVLHPPPAPPLA
NVSLPPPPPLLAASNPEPGLLQTLASIPSNKAFVSPSSAASLQANASLSIKLASLPHKAS
RPSFTVHHQPLPRLALAQAAPVIPQSNAAGPPAMWVTLGMQSPYASHLSGVKPR

NT seq 5385 nt +upstreamnt +downstreamnt
atggccccaaagtacaagcgtggtaatgttggtagcactgataagcctaaaaaagtcata
aagtgcctagcctactggctgagtgttgactgtcctaatgagatacagatagcatcctta
gcacaaaggtataatggtttggccatgtcccagatgctgttcctgaaagaaaagcctaaa
tatagggccaaggatgtgctgaacctagttaatgaccactgcattggcatgctttatcac
cttctcttgtcatggggtcaccctgccaaagacaaacaccatgatgctgctcatgaaatc
attgagaccattcgatgggtctgtgaagaaataccggatctcaagcttgccatggaaaat
tatgttttaattgactatgataccaaaagctttgaaagcatgcagagactttgtgacaaa
tacaaccgagccattgatagcattcatcaactgtggaaaggaacaacccagcccatgaaa
ttgaacactcggccatccaatgggcttcttcgacatatcttgcaacaagtatataaccac
tcagtcacagatccagagaaactcaacaactatgagcccttttctccagaggtgtatgga
gaaacttcattcgacttagttgcccaaatgattgatgagattaaaatgaccgaggatgat
ttgtttgttgatttgggcagtggagtgggacaagtggttttgcaagtggccgcagctaca
aactgcaagcatcactatggtgtggagaaagcagacatcccagcgaagtatgctgagaca
atggacagagagttcagaaaatggatgaagtggtatgggaagaagcatgcagaatacaca
ctggaaagaggtgacttcctttcagaagaatggcgggaaagaattgcaaatacaagtgtt
atttttgtgaataattttgcctttggtcctgaggtggatcaccaactgaaggagcgattt
gctaatatgaaggaaggtggcagaatcgtatcctccaaaccttttgcacctctaaacttt
agaataaacagtagaaacttgagtgcagccaatgggaaggaacaagggcttgaaaactat
ttttctagtctcaaaaatccaaaactcagggaggagcaggaggcagcccgacgccggcaa
caaagagaaagcaaaagtaacacaacaacccccacaaaggtccaagaaaacaagggagct
gttgccttggaacctcgcatggattctggtgctgaagaagataaaaatggggcggctgct
cttaagaagccatctccttccaagcctcgaaaaaagaaattaaataagaaaggaaggaag
atggcaggaagaaagcgtgggcgtcccaagaaaatgagtgctgcaaaccctgaacgcaaa
gccaagaagactccaactgccttggaacttctgcatgctcagactgtgtcccaggcagct
gcatcctctcctcaggatgcatacaagtcacctcatagtccatattaccaactacctcct
aaagtacaacggcattcctccaatcagctattggcaacaccaactccgcctgcactccac
aagcttttagaatcttttaaggttcagtacctgcagttcctggcctacatgaaaacccct
cagtacaaggcaaacctgcagcagttggtagagcaggagaaggaaaagaacactcagttg
ttaggtacagcccaacagttgttcagccactgtcaggcccagaaagaagagatcaagaga
ttgtttcagcagaagcttgatgagttgggagtaaaggctctgacctacaatgatctgata
caagctcagaaagaaatctctgcccacaaccaacaactaaaagaacagacaaagcaacta
gaaaatgataacagtgaactcaggaaccaaagcttgcagctgcttaaggctcggtgtgaa
gagctaaagctggattggtctactctctcactggaaaatttgctgaaggagaagcaggca
ctgaagaatcaaatttctgagaagcaaaagcactgtctggagcttcagatcagcattgtg
gagcttgagaaaagccaaaggcagcaggagctactgcagctgaagtcctacgcaccggct
gatgatgccctgtccgtccaccttcgaagtaaaagcacttttagcagagagctggagact
gaccccacaaggttccagctggagcttgaatgctccaagttgtctttgccccacatcagt
agcatgagccctgaactatctatgaatggccatgcaaccacttatgagattcatagtatg
ctaagccgaccttcttccaaacaaaacactccacagtacctgacctcccacctggaccaa
gaaatagttccttgcacccccattcataacaacagacagaaggcagacaagttgtcaagt
ttgtccttacctgactacaccaggttttcccctgctaagttagctctaaggagacacttg
aatcaggatcatgtagtccatggaaaagctacaactaatgaaatacaccacagagctgaa
catgcaaaagagaatggccttacatatcagagtcctggtatttcaaatggcctaaagctg
agccctcaggaaactcggccttcctccccctcggccttacagattgcaggagagaagagc
agtgacaaggttttaaaagagagagcctatgccagcaatggagaaacaatcaccagccta
cctatcagtattcctctcagcacagtgcagcccaataaacttcctgtcagtatcccattg
gccagtgtagtgttgcctagccgtgcggagaaagtgaggaacacacctagtccagttcat
cagaatcgagagtctacttcagcaacacttgaaaaacagtttggtgctaattcccataat
ggtatgaacagtgctgtaggaaacaagtcccttgctttggctacctcaggtttttcttat
actggctccttggcagttaatggcaccctttccagtagcccagcccatcttaaccatggt
gctgagcaggcagccctagatgattcctctaattcagggagcctctttaattcagtgggt
tcccggagttctacaccacaacatccctctttactcatgatgcagtcccgcaactctggc
cagaactctccagcccatccacttgctgccagcccacgtctcaatggagcttctcaaagc
ctgatggggatcttgcagttctcggatagtacaaaattgttctctgaaggtaacaagggg
gatctcccactagattcaggcttttcagatcctgaaaatgaagtcaagagaagaatcctc
tttacaatctcgaccaatacaggaaacatgaagcagtctccttccaacaaacacagcccc
ctggcagccagcatccgcgcggattgtggacaggcttgtgtacaggagggcaagaagaga
ggcaggaggaagcgatcttctacagggaaccccggagcaaactgtgcagtatctcccaag
cgtaagcccttaccatctgtggcaggcctctttacccagtcttcaggctcacctctgaac
atcaactctatggtcaataacattaatcagcctttagaaataacagccatttcctcccct
gaaaactccctgaagaactctcctattccttaccaggacaacgaccagcctcccgtgctg
aaaaaggagaagcccttgatccagaccaatggggcacattactcacccttgacctctgat
gaagagccaggatctgaagatgagcacaatagcatcaggattgaaaggaaaattgcaaca
atctctttggagagcaaatctccccagaaaacagaaaatggtggtggccttacgggaagg
aagcaaacccagctgaccgagagcgtcaacagtagtaaatggaagtctaccttctcacca
atatcagacatcaaccttaccaaaacatctgacagccccctacaggcagcttcgtccctg
agccagaattccctctttgccttccgtccatcctcagaggatacgatggctatcgatgcc
aagatctctgtgcacacaaggaaaaacttccccagttcattgtctgggacggatggcctc
agccctaacacaaactcttccaatggattttcatatgccgggggcttgtctgctgctgac
atgagtttacacagctttcacgatggtgcttctctttctcataagactaccgaggtggcc
agcttaaactctcccctgggttttcagtcacagcggagcaaagatagctcagatgccaac
cctttcctgaacaagaggcagctggatggtctgggaagtatgaaaggggaagagttacag
agatctgggggcagaagcaaagaggtgctcgacctgggcttgcagctggggggtccttct
gacaaggtctccctgcaacacaatggcaaggctggcaaaggacgggaccgggatttggag
tttaaaaatggccacaatcttttcatttctgctgctgctgttccttctgggggcctcctc
aatggcaaaggcctttccactgcagcttccacctctggccatcccacttcttccgtttca
acacaccacccttttttgaacacttttaccactggatcccagttccccctgggccctatg
tccctgcaggccaacctcagctcggtggcaggctcctcagtattgcagtctttatttaat
tccatgcccgctgctgccagtttggtccacgtgtcatcagctgcgaccagattgacaaat
tctcacgctatgggaaacttctcttctggggttacaggtggaacagttggaggtgttttt
aaccatgcggtgccttctgcctcttctcatcaatttggagccagtttcagcagcagtgct
gtctgtagcagcaccatgctaagcttaaacccaatgcaggctgtggtcacccccacttcc
tcttccttccaggccccttcctctagcataggaacatgtagcgaggctcgagcccctcaa
cccctgaaccgagtgcccgtgcagcctgttctgcaccctcctcctgctcctcctcttgct
aacgtctcattacctcccccccctccattactcgctgcttctaacccggagccggggctt
ctgcagaccttagcatccattccctctaacaaagcttttgtctcgccctcttcagctgct
tctctccaggctaacgcttctctgtctatcaagctcgcttccctcccccacaaagcttcc
cgcccttccttcacagtccaccaccagcctctgccccgtttggccctggcccaggctgca
cccgtcatcccgcagtccaacgccgctggcccacccgctatgtgggttacccttggcatg
cagtctccttacgcttcgcacctttctggggttaagccgcgataa

All links

Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (5)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (1)   
   ENSEMBL-MDO (1)   
   OC (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (1)   
   Pfam (1)   
All databases (21)   

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