KEGG   Methylorubrum extorquens AM1: Mex_1p1494
Entry
Mex_1p1494        CDS       T00921                                 
Symbol
metH
Name
(GenBank) B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase
  KO
K00548  5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13]
Organism
mea  Methylorubrum extorquens AM1
Pathway
mea00270  Cysteine and methionine metabolism
mea00450  Selenocompound metabolism
mea00670  One carbon pool by folate
mea01100  Metabolic pathways
mea01110  Biosynthesis of secondary metabolites
mea01230  Biosynthesis of amino acids
mea04980  Cobalamin transport and metabolism
Module
mea_M00017  Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:mea00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    Mex_1p1494 (metH)
  09106 Metabolism of other amino acids
   00450 Selenocompound metabolism
    Mex_1p1494 (metH)
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    Mex_1p1494 (metH)
 09150 Organismal Systems
  09154 Digestive system
   04980 Cobalamin transport and metabolism
    Mex_1p1494 (metH)
Enzymes [BR:mea01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.13  methionine synthase
     Mex_1p1494 (metH)
SSDB
Motif
Pfam: Met_synt_B12 S-methyl_trans Pterin_bind B12-binding_2 B12-binding
Other DBs
NCBI-ProteinID: ACS39356
UniProt: C5AZM2
Position
1559814..1563566
AA seq 1250 aa
MTAFPPVDGTEIERALRQRASEKILVLDGAMGTVIQRLKYTEEDFRGERFKDHSHDQKGN
NDLLILTQPNAIRQIHLDYFLAGADVCETNTFSGTTIAQADYGMESIIHELNAEGARLAR
EAAKLAEEQDGRRRFVAGAIGPTNRTLSISPDVNNPGYRAVTFDGVKQAYVEQVRGLIDG
GAELILIETIFDTLNAKAAIAAAWQVFDETGIRLPIQISGTITDLSGRTLSGQTPAAFWN
SLRHSSPLTFGLNCALGAKEMRGHIAELSRICDTLVCAYPNAGLPNEFGLYDESPEAMGK
LVGEFAASGLVNMVGGCCGTTPDHIRAIAEAVADKKPREIPEIPRLMRLSGLEPFVLTKE
IPFVNVGERTNVTGSAKFRKLITNNDYAAALDVARDQVAAGAQVIDVNMDEGLLDSEKAM
VEFLNLVAAEPDIARVPVMVDSSKFEVIEAGLKCIQGKPIVNSISMKEGEAKFIEAAKIC
RSYGAAVVVMAFDEQGQADSYERKVEICTKAYKILTEQVGFPPEDIIFDPNIFAVATGIE
EHNPYGVAFIEATRTIRETLPHAHISGGVSNLSFAFRGNEPVREAMHAVFLFHCIKAGMD
MGIVNAGQLAVYDEIPAELRELCEDVVLNRREDSTERLLEAAERFKTGASAQAKTADLTW
REAPVAKRIEHALVNGITEYIVADTEEARKEAARPLHVIEGPLMAGMNVVGDLFGSGKMF
LPQVVKSARVMKQAVAYLEPFMEEEKRANGGDGKRQAAGKVLMATVKGDVHDIGKNIVGV
VLACNNYEIIDLGVMVPAAKILETAKRENVDIVGLSGLITPSLDEMVHVAAEMEREGMEM
PLLIGGATTSRVHTAVKIHPAYAKGQAVYVTDASRAVGVVSSLISKETRGATVEKVRAEY
AKVADAHRRSEADKQRLPLAKARANAFKVDWSAYKPAKPSFTGTRVYGSYEVADLVPYID
WTPFLQTYEFKGRYPAILDDPEQGPAARALFEDAQVMLKQIVEERWFNPKAVIGFWPANS
VGDDIRLFTGESRQETLATFHGLRQQLSKRDGRANTCISDFVAPAETGIADYVGAFVVTA
GLEEVRIAERFERANDDYRSILVKALADRIAEAFAERMHERVRKEFWGYAPDEAYAPEEL
VSEKYDGIRPAPGYPAQPDHTEKVQLFDLLKAESRIGVKLTESYAMWPGSSVSGLYLAHP
DAHYFGVAKVERDQVEDYALRKGMDVSEVERWLGPILNYDPVRYLKAAAE
NT seq 3753 nt   +upstreamnt  +downstreamnt
atgaccgctttcccccccgtcgacggcaccgagatcgagcgcgccctgcgccagcgcgcg
tcggaaaagatcctcgtcctcgacggggcaatgggcacggtgatccagcggctcaaatac
acggaagaggatttccggggtgagcgcttcaaggatcacagccacgatcagaagggcaac
aacgacctcctgatcctgacgcagcccaacgcgatccggcagatccacctcgactacttc
ctcgccggcgccgacgtctgcgagacgaacacgttttccggcaccacgatcgcccaggcc
gattacggcatggaatcgatcatccacgagctgaacgccgaaggcgcccgcctcgcccgc
gaggccgccaagctggccgaagaacaggacggccgccgccgcttcgtcgccggcgccatc
ggcccgaccaaccgcacgctgtcgatctcgcccgacgtgaacaatcccggctaccgcgcc
gtgaccttcgatggggtgaagcaggcctatgtcgagcaggtgcgcggcctcatcgacggc
ggcgccgaactcatcctgatcgagacgatcttcgacacgctcaacgccaaggcggcgatc
gccgccgcgtggcaggtgttcgacgagaccggcatccgcctgccgatccagatctccggc
accatcaccgatctctccggccgcaccctgtcgggccagacgccggcggcgttctggaat
tcgctgcgccattcgagcccgctcaccttcggcctcaactgcgcgctcggcgccaaggag
atgcgcggccacatcgccgaactgtcgcgcatctgcgacacgctggtctgtgcctatccg
aatgccggcctgcccaacgagttcggtctctacgacgagagcccggaagccatgggcaag
ctcgtgggcgagttcgccgcctcgggcctcgtcaacatggtcggcggctgctgcggcacg
acaccggaccacatccgcgccatcgccgaggccgtggccgacaagaagccgcgcgagatc
cccgagatcccgcgcctgatgcgcctgtccggcctcgagcccttcgtgctgacgaaggag
attcccttcgtgaacgtgggcgagcgcaccaacgtcaccggctcggccaaattccgcaag
ctcatcaccaacaacgattacgccgccgcgctcgatgtcgctcgcgatcaggtcgcggcc
ggcgcccaggtcatcgacgtcaacatggatgagggcctgctcgacagcgagaaggcgatg
gtcgagttcctcaacctcgtcgccgccgagcccgacatcgcccgcgtgccggtgatggtc
gattcctcgaagttcgaggtgatcgaggccggcctgaaatgcatccagggcaagccgatc
gtgaactcgatctccatgaaggagggcgaggcgaagttcatcgaggccgccaagatctgc
cgctcctacggcgcggcggtggtcgtcatggccttcgacgagcagggccaggccgattcc
tacgagcgcaaggtcgagatctgcaccaaggcctacaagatcctcaccgagcaggtcggc
ttcccgcccgaggacatcatcttcgacccgaacatctttgctgtcgccacgggtatcgaa
gagcataacccctacggcgtcgccttcatcgaggcgacccgcacgatccgcgagaccctg
ccccacgcccacatctccggcggcgtctcgaacctgtccttcgccttccgcggcaacgag
ccggtgcgcgaggcgatgcacgcggtgttcctgttccactgcatcaaggccggcatggat
atgggcatcgtcaatgccggccagttggccgtctacgacgagatcccggccgaactgcgc
gaactgtgcgaggacgtggtcctcaaccgccgcgaggactcgaccgagcgcctgctggag
gccgccgagcgcttcaagaccggcgcctcggcccaggccaagaccgccgacctgacgtgg
cgcgaggcgcccgtcgccaagcgcatcgagcacgcgctggtcaacggcatcaccgagtac
atcgtcgccgacaccgaggaggcacgcaaagaggccgcgcgtccgctccacgtcatcgaa
ggcccgctgatggccggcatgaacgtggtcggcgacctgttcggctcgggcaagatgttc
ctgccgcaggtggtgaagtccgcccgcgtgatgaagcaggcggtggcctatctcgaaccc
ttcatggaggaggagaagcgggccaatggcggcgacggcaagcgccaggccgccggcaag
gtgctgatggccaccgtgaagggcgacgtccacgacatcggcaagaacatcgtcggcgtg
gttctggcctgcaacaattacgagatcatcgatctcggcgtgatggtgccggcggccaag
atcctcgagacggccaagcgcgagaacgtcgacatcgtcggcctgtcgggcctcatcacc
ccctcgctcgacgagatggtgcatgtcgccgccgagatggagcgcgagggcatggaaatg
ccgctgctgatcggcggcgccaccaccagccgcgtccacaccgcggtgaagatccacccg
gcctacgccaagggtcaggcggtctacgtcaccgatgcgagccgcgcggtcggcgtggtg
tcgagcctgatctcgaaggagacccgcggggccaccgtggagaaggtgcgcgccgaatac
gccaaggtcgccgacgcccatcgccgctccgaggccgacaaacagcgcctgccgctcgcc
aaggcgcgggcgaacgctttcaaagtggattggtcggcctacaagccggccaagcccagc
ttcaccggcacccgcgtctacggttcctacgaggtggcggacctcgtcccctacatcgac
tggacgccgttcctgcagacctacgagttcaagggccgctaccccgcgatcctcgacgat
cccgagcagggcccggcggcgcgtgcgctgttcgaggacgcgcaggtgatgctcaagcag
atcgtggaggagcgctggttcaacccgaaggcggtgatcggcttctggccggccaacagc
gtcggcgacgacatccggctcttcaccggcgagagccggcaggagacgctcgcgaccttc
cacggcctgcgccagcagctctcgaagcgcgacgggcgcgccaacacctgcatctccgac
ttcgtggcgccggccgagaccggcatcgcggactatgtcggcgccttcgtggtgacggcg
ggcctggaggaggtgcgcatcgccgagcgcttcgagcgggccaacgacgattaccgctcg
atcctcgtgaaggcgctcgccgaccgcatcgccgaggccttcgccgagcggatgcacgag
cgcgtccgcaaggagttctggggctatgcgccggacgaggcttacgcccccgaggagctg
gtctcggaaaagtacgacggcatccggcccgcgccgggctacccggcccagcccgaccat
acggaaaaggtgcagttgttcgatctgctcaaggcggagagccgcatcggcgtgaagctc
accgagtcctacgccatgtggccgggctcctcggtctcgggcctctacctcgcccatccc
gacgcccattacttcggcgtcgccaaggtggagcgggatcaggtcgaggactacgccctg
cgcaagggcatggatgtgagcgaggtcgagcgctggctcgggccgatcctcaactacgac
ccggtccgctacctcaaggccgcggccgagtag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (8)   
   KEGG PATHWAY (7)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   OC (1)   
Protein sequence (1)   
   UniProt (1)   
Protein domain (5)   
   Pfam (5)   
All databases (31)   

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