Maser P, Thomine S, Schroeder JI, Ward JM, Hirschi K, Sze H,
Talke IN, Amtmann A, Maathuis FJ, Sanders D, Harper JF, Tchieu J,
Gribskov M, Persans MW, Salt DE, Kim SA, Guerinot ML.
Phylogenetic relationships within cation transporter families of Arabidopsis.
Plant Physiol. 2001 Aug;126(4):1646-67.
Uptake and translocation of cationic nutrients play essential roles in
physiological processes including plant growth, nutrition, signal transduction,
and development. Approximately 5% of the Arabidopsis genome appears to encode
membrane transport proteins. These proteins are classified in 46 unique families
containing approximately 880 members. In addition, several hundred putative
transporters have not yet been assigned to families. In this paper, we have
analyzed the phylogenetic relationships of over 150 cation transport proteins.
This analysis has focused on cation transporter gene families for which initial
characterizations have been achieved for individual members, including potassium
transporters and channels, sodium transporters, calcium antiporters, cyclic
nucleotide-gated channels, cation diffusion facilitator proteins, natural
resistance-associated macrophage proteins (NRAMP), and Zn-regulated transporter
Fe-regulated transporter-like proteins. Phylogenetic trees of each family define
the evolutionary relationships of the members to each other. These families
contain numerous members, indicating diverse functions in vivo. Closely related
isoforms and separate subfamilies exist within many of these gene families,
indicating possible redundancies and specialized functions. To facilitate their
further study, the PlantsT database (http://plantst.sdsc.edu) has been created
that includes alignments of the analyzed cation transporters and their
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