Dujon B, Sherman D, Fischer G, Durrens P, Casaregola S, Lafontaine I,
De Montigny J, Marck C, Neuveglise C, Talla E, Goffard N, Frangeul L,
Aigle M, Anthouard V, Babour A, Barbe V, Barnay S, Blanchin S,
Beckerich JM, Beyne E, Bleykasten C, Boisrame A, Boyer J, Cattolico L,
Confanioleri F, De Daruvar A, Despons L, Fabre E, Fairhead C, Ferry-Dumazet H,
Groppi A, Hantraye F, Hennequin C, Jauniaux N, Joyet P, Kachouri R,
Kerrest A, Koszul R, Lemaire M, Lesur I, Ma L, Muller H,
Nicaud JM, Nikolski M, Oztas S, Ozier-Kalogeropoulos O, Pellenz S, Potier S,
Richard GF, Straub ML, Suleau A, Swennen D, Tekaia F, Wesolowski-Louvel M,
Westhof E, Wirth B, Zeniou-Meyer M, Zivanovic I, Bolotin-Fukuhara M, Thierry A,
Bouchier C, Caudron B, Scarpelli C, Gaillardin C, Weissenbach J, Wincker P,
Genome evolution in yeasts.
Nature. 2004 Jul 1;430(6995):35-44. doi: 10.1038/nature02579.
Identifying the mechanisms of eukaryotic genome evolution by comparative genomics
is often complicated by the multiplicity of events that have taken place
throughout the history of individual lineages, leaving only distorted and
superimposed traces in the genome of each living organism. The hemiascomycete
yeasts, with their compact genomes, similar lifestyle and distinct sexual and
physiological properties, provide a unique opportunity to explore such
mechanisms. We present here the complete, assembled genome sequences of four
yeast species, selected to represent a broad evolutionary range within a single
eukaryotic phylum, that after analysis proved to be molecularly as diverse as the
entire phylum of chordates. A total of approximately 24,200 novel genes were
identified, the translation products of which were classified together with
Saccharomyces cerevisiae proteins into about 4,700 families, forming the basis
for interspecific comparisons. Analysis of chromosome maps and genome
redundancies reveal that the different yeast lineages have evolved through a
marked interplay between several distinct molecular mechanisms, including tandem
gene repeat formation, segmental duplication, a massive genome duplication and
extensive gene loss.
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