Database: PubMed
Entry: 15229592
LinkDB: 15229592
Original site: 15229592 
     Dujon B, Sherman D, Fischer G, Durrens P, Casaregola S, Lafontaine I,
     De Montigny J, Marck C, Neuveglise C, Talla E, Goffard N, Frangeul L,
     Aigle M, Anthouard V, Babour A, Barbe V, Barnay S, Blanchin S,
     Beckerich JM, Beyne E, Bleykasten C, Boisrame A, Boyer J, Cattolico L,
     Confanioleri F, De Daruvar A, Despons L, Fabre E, Fairhead C, Ferry-Dumazet H,
     Groppi A, Hantraye F, Hennequin C, Jauniaux N, Joyet P, Kachouri R,
     Kerrest A, Koszul R, Lemaire M, Lesur I, Ma L, Muller H,
     Nicaud JM, Nikolski M, Oztas S, Ozier-Kalogeropoulos O, Pellenz S, Potier S,
     Richard GF, Straub ML, Suleau A, Swennen D, Tekaia F, Wesolowski-Louvel M,
     Westhof E, Wirth B, Zeniou-Meyer M, Zivanovic I, Bolotin-Fukuhara M, Thierry A,
     Bouchier C, Caudron B, Scarpelli C, Gaillardin C, Weissenbach J, Wincker P,
     Souciet JL.
     Genome evolution in yeasts.
     Nature. 2004 Jul 1;430(6995):35-44. doi: 10.1038/nature02579.
     Identifying the mechanisms of eukaryotic genome evolution by comparative genomics
     is often complicated by the multiplicity of events that have taken place
     throughout the history of individual lineages, leaving only distorted and
     superimposed traces in the genome of each living organism. The hemiascomycete
     yeasts, with their compact genomes, similar lifestyle and distinct sexual and
     physiological properties, provide a unique opportunity to explore such
     mechanisms. We present here the complete, assembled genome sequences of four
     yeast species, selected to represent a broad evolutionary range within a single
     eukaryotic phylum, that after analysis proved to be molecularly as diverse as the
     entire phylum of chordates. A total of approximately 24,200 novel genes were
     identified, the translation products of which were classified together with
     Saccharomyces cerevisiae proteins into about 4,700 families, forming the basis
     for interspecific comparisons. Analysis of chromosome maps and genome
     redundancies reveal that the different yeast lineages have evolved through a
     marked interplay between several distinct molecular mechanisms, including tandem 
     gene repeat formation, segmental duplication, a massive genome duplication and
     extensive gene loss.

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