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Database: PubMed
Entry: 15377794
LinkDB: 15377794
Original site: 15377794 
PMID:
     15377794
Authors:
     Holden MT, Titball RW, Peacock SJ, Cerdeno-Tarraga AM, Atkins T, Crossman LC,
     Pitt T, Churcher C, Mungall K, Bentley SD, Sebaihia M, Thomson NR,
     Bason N, Beacham IR, Brooks K, Brown KA, Brown NF, Challis GL,
     Cherevach I, Chillingworth T, Cronin A, Crossett B, Davis P, DeShazer D,
     Feltwell T, Fraser A, Hance Z, Hauser H, Holroyd S, Jagels K,
     Keith KE, Maddison M, Moule S, Price C, Quail MA, Rabbinowitsch E,
     Rutherford K, Sanders M, Simmonds M, Songsivilai S, Stevens K, Tumapa S,
     Vesaratchavest M, Whitehead S, Yeats C, Barrell BG, Oyston PC, Parkhill J.
Title:
     Genomic plasticity of the causative agent of melioidosis, Burkholderia
     pseudomallei.
Journal:
     Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14240-5. Epub 2004 Sep 17.
Abstract:
     Burkholderia pseudomallei is a recognized biothreat agent and the causative agent
     of melioidosis. This Gram-negative bacterium exists as a soil saprophyte in
     melioidosis-endemic areas of the world and accounts for 20% of community-acquired
     septicaemias in northeastern Thailand where half of those affected die. Here we
     report the complete genome of B. pseudomallei, which is composed of two
     chromosomes of 4.07 megabase pairs and 3.17 megabase pairs, showing significant
     functional partitioning of genes between them. The large chromosome encodes many 
     of the core functions associated with central metabolism and cell growth, whereas
     the small chromosome carries more accessory functions associated with adaptation 
     and survival in different niches. Genomic comparisons with closely and more
     distantly related bacteria revealed a greater level of gene order conservation
     and a greater number of orthologous genes on the large chromosome, suggesting
     that the two replicons have distinct evolutionary origins. A striking feature of 
     the genome was the presence of 16 genomic islands (GIs) that together made up
     6.1% of the genome. Further analysis revealed these islands to be variably
     present in a collection of invasive and soil isolates but entirely absent from
     the clonally related organism B. mallei. We propose that variable horizontal gene
     acquisition by B. pseudomallei is an important feature of recent genetic
     evolution and that this has resulted in a genetically diverse pathogenic species.

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