Database: PubMedEntry: 15477588
Original site: 15477588
Seabury CM, Honeycutt RL, Rooney AP, Halbert ND, Derr JN.
Prion protein gene (PRNP) variants and evidence for strong purifying selection in
functionally important regions of bovine exon 3.
Proc Natl Acad Sci U S A. 2004 Oct 19;101(42):15142-7. Epub 2004 Oct 11.
Amino acid replacements encoded by the prion protein gene (PRNP) have been
associated with transmissible and hereditary spongiform encephalopathies in
mammalian species. However, an association between bovine spongiform
encephalopathy (BSE) and bovine PRNP exon 3 has not been detected. Moreover,
little is currently known regarding the mechanisms of evolution influencing the
bovine PRNP gene. Therefore, in this study we evaluated the patterns of
nucleotide variation associated with PRNP exon 3 for 36 breeds of domestic cattle
and representative samples for 10 additional species of Bovinae. The results of
our study indicate that strong purifying selection has intensely constrained PRNP
over the long-term evolutionary history of the subfamily Bovinae, especially in
regions considered to be of functional, structural, and pathogenic importance in
humans as well as other mammals. The driving force behind this intense level of
purifying selection remains to be explained.
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