PMID:
     8612769
Authors:
     Meera P, Wallner M, Jiang Z, Toro L.
Title:
     A calcium switch for the functional coupling between alpha (hslo) and beta
     subunits (KV,Ca beta) of maxi K channels.
Journal:
     FEBS Lett. 1996 Mar 11;382(1-2):84-8.
Abstract:
     KV,Ca beta subunit dramatically increases the apparent calcium sensitivity of the
     alpha subunit of MaxiK channels when probed in the micromolar [Ca2+]i range.
     Analysis in a wide range of [Ca2+]i revealed that this functional coupling is
     exquisitely modulated by [Ca2+]i. Ca2+ ions switch MaxiK alpha+beta complex into 
     a functionally coupled state at concentrations beyond resting [Ca2+]i. At [Ca2+] 
     < or = 100 nM, MaxiK activity becomes independent of Ca2+, is purely
     voltage-activated, and its functional coupling with its beta subunit is released.
     The functional switch develops at [Ca2+]i that occur during cellular excitation, 
     providing the molecular basis of how MaxiK channels regulate smooth muscle
     excitability and neurotransmitter release.

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