Database: PubMedEntry: 8612769
Original site: 8612769
Meera P, Wallner M, Jiang Z, Toro L.
A calcium switch for the functional coupling between alpha (hslo) and beta
subunits (KV,Ca beta) of maxi K channels.
FEBS Lett. 1996 Mar 11;382(1-2):84-8.
KV,Ca beta subunit dramatically increases the apparent calcium sensitivity of the
alpha subunit of MaxiK channels when probed in the micromolar [Ca2+]i range.
Analysis in a wide range of [Ca2+]i revealed that this functional coupling is
exquisitely modulated by [Ca2+]i. Ca2+ ions switch MaxiK alpha+beta complex into
a functionally coupled state at concentrations beyond resting [Ca2+]i. At [Ca2+]
< or = 100 nM, MaxiK activity becomes independent of Ca2+, is purely
voltage-activated, and its functional coupling with its beta subunit is released.
The functional switch develops at [Ca2+]i that occur during cellular excitation,
providing the molecular basis of how MaxiK channels regulate smooth muscle
excitability and neurotransmitter release.
This page is constructed based on the NCBI service.
integrated database retrieval system