KEGG   Mus musculus (mouse): 110157Help
Entry
110157            CDS       T01002                                 

Gene name
Raf1, 6430402F14Rik, AA990557, BB129353, Craf1, D830050J10Rik, Raf-1, c-Raf, v-Raf
Definition
(RefSeq) v-raf-leukemia viral oncogene 1 (EC:2.7.11.1)
  KO
K04366  
RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
mmu  Mus musculus (mouse)
Pathway
EGFR tyrosine kinase inhibitor resistance
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Phospholipase D signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Vascular smooth muscle contraction
Axon guidance
VEGF signaling pathway
Focal adhesion
Gap junction
Signaling pathways regulating pluripotency of stem cells
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Long-term potentiation
Neurotrophin signaling pathway
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Alcoholism
Tuberculosis
Hepatitis C
Hepatitis B
Influenza A
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
Module
MAPK (ERK1/2) signaling
Brite
KEGG Orthology (KO) [BR:mmu00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    110157 (Raf1)
   04015 Rap1 signaling pathway
    110157 (Raf1)
   04010 MAPK signaling pathway
    110157 (Raf1)
   04012 ErbB signaling pathway
    110157 (Raf1)
   04370 VEGF signaling pathway
    110157 (Raf1)
   04630 Jak-STAT signaling pathway
    110157 (Raf1)
   04068 FoxO signaling pathway
    110157 (Raf1)
   04072 Phospholipase D signaling pathway
    110157 (Raf1)
   04071 Sphingolipid signaling pathway
    110157 (Raf1)
   04024 cAMP signaling pathway
    110157 (Raf1)
   04022 cGMP - PKG signaling pathway
    110157 (Raf1)
   04151 PI3K-Akt signaling pathway
    110157 (Raf1)
   04150 mTOR signaling pathway
    110157 (Raf1)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    110157 (Raf1)
  Cell growth and death
   04210 Apoptosis
    110157 (Raf1)
  Cellular commiunity
   04510 Focal adhesion
    110157 (Raf1)
   04540 Gap junction
    110157 (Raf1)
   04550 Signaling pathways regulating pluripotency of stem cells
    110157 (Raf1)
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    110157 (Raf1)
   04660 T cell receptor signaling pathway
    110157 (Raf1)
   04662 B cell receptor signaling pathway
    110157 (Raf1)
   04664 Fc epsilon RI signaling pathway
    110157 (Raf1)
   04666 Fc gamma R-mediated phagocytosis
    110157 (Raf1)
   04062 Chemokine signaling pathway
    110157 (Raf1)
  Endocrine system
   04910 Insulin signaling pathway
    110157 (Raf1)
   04912 GnRH signaling pathway
    110157 (Raf1)
   04915 Estrogen signaling pathway
    110157 (Raf1)
   04914 Progesterone-mediated oocyte maturation
    110157 (Raf1)
   04917 Prolactin signaling pathway
    110157 (Raf1)
   04921 Oxytocin signaling pathway
    110157 (Raf1)
   04919 Thyroid hormone signaling pathway
    110157 (Raf1)
   04916 Melanogenesis
    110157 (Raf1)
  Circulatory system
   04270 Vascular smooth muscle contraction
    110157 (Raf1)
  Nervous system
   04726 Serotonergic synapse
    110157 (Raf1)
   04720 Long-term potentiation
    110157 (Raf1)
   04730 Long-term depression
    110157 (Raf1)
   04722 Neurotrophin signaling pathway
    110157 (Raf1)
  Development
   04360 Axon guidance
    110157 (Raf1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    110157 (Raf1)
   05230 Central carbon metabolism in cancer
    110157 (Raf1)
   05231 Choline metabolism in cancer
    110157 (Raf1)
   05206 MicroRNAs in cancer
    110157 (Raf1)
   05205 Proteoglycans in cancer
    110157 (Raf1)
   05210 Colorectal cancer
    110157 (Raf1)
   05212 Pancreatic cancer
    110157 (Raf1)
   05214 Glioma
    110157 (Raf1)
   05221 Acute myeloid leukemia
    110157 (Raf1)
   05220 Chronic myeloid leukemia
    110157 (Raf1)
   05218 Melanoma
    110157 (Raf1)
   05211 Renal cell carcinoma
    110157 (Raf1)
   05219 Bladder cancer
    110157 (Raf1)
   05215 Prostate cancer
    110157 (Raf1)
   05213 Endometrial cancer
    110157 (Raf1)
   05223 Non-small cell lung cancer
    110157 (Raf1)
  Substance dependence
   05034 Alcoholism
    110157 (Raf1)
  Infectious diseases
   05152 Tuberculosis
    110157 (Raf1)
   05164 Influenza A
    110157 (Raf1)
   05161 Hepatitis B
    110157 (Raf1)
   05160 Hepatitis C
    110157 (Raf1)
  Antineoplastic resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    110157 (Raf1)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     110157 (Raf1)
Protein kinases [BR:mmu01001]
 Serine/threonine protein kinases: TKL group
  RAF family [OT]
   110157 (Raf1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
MGI: 
Ensembl: 
Vega: 
UniProt: 
Position
6 C3; 6 53.62 cM
AA seq 648 aa AA seqDB search
MEHIQGAWKTISNGFGLKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLQEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTVGDSGVPAPPSFPMRRMRESVSRMPASSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLHVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDDNPFSFQSDVYSYGIVLYE
LMAGELPYAHINNRDQIIFMVGRGYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
NT seq 1947 nt NT seq  +upstreamnt  +downstreamnt
atggagcacatacagggagcttggaagacgatcagcaatggctttggactcaaagatgcg
gtgtttgatggctccagctgcatctcccctaccattgttcagcagtttggctatcagcgc
cgggcctcagatgatggcaagctcacggattcttctaagacaagcaatactatccgggtt
ttcttgccgaataagcaaaggactgtggtcaatgtgcggaatggaatgagcttacatgac
tgccttatgaaagctctgaaggtgagaggcctgcagccagagtgctgtgcagtgttcaga
cttctccaggaacacaaaggtaagaaagcacgcttagattggaacaccgatgccgcctct
ctgattggagaagaactgcaagtggattttttggatcatgttccactcacaactcacaac
tttgctcggaaaacgttcctgaagcttgcattctgtgacatctgtcagaagttcctgcta
aatggatttcgatgtcagacttgtggctacaagtttcatgagcactgtagcaccaaagta
cctactatgtgtgtggactggagtaatatcagacagctcttgctgtttccaaattccact
gttggtgacagtggagtcccagcaccaccttctttcccaatgcgtcggatgcgagaatct
gtttcccggatgcctgctagttcccagcacagatactctacaccccatgccttcactttc
aacacctccagcccttcctcagaaggttccctgtcccagaggcagaggtcaacgtccact
cccaatgtccacatggtcagcaccaccctgcatgtggacagcaggatgattgaggatgca
attcgaagtcacagtgaatcagcctcaccttcagccctgtccagcagcccaaacaacctg
agtccaacaggctggtcacagcccaaaacccctgtgccagcacaaagagagcgggcacca
ggatctgggacccaggaaaaaaacaaaattaggcctcgtgggcagagagactcgagttat
tactgggaaatagaagccagtgaggtgatgctgtctactcggatcgggtcaggttccttt
ggcactgtgtacaagggcaagtggcatggagatgttgcagtaaagatcctaaaggtggtt
gacccaactccagagcaacttcaggccttcaggaacgaggtggctgttttgcgcaaaaca
cggcatgttaacatcctgctgttcatggggtacatgacaaaggacaacctggcgattgtg
actcagtggtgtgaaggcagcagtctctacaaacacctgcatgtccaggagaccaaattc
cagatgttccagctaattgacattgcccgacagacagctcagggaatggactatttgcat
gcaaagaacatcatccacagagacatgaaatccaacaatatatttctccatgaaggcctc
acggtgaaaattggagattttggtttggcaacagtgaagtcacgctggagtggttctcag
caggttgaacagcccactggctctgtgctgtggatggccccagaagtaatccggatgcag
gatgacaacccgttcagcttccagtccgacgtgtactcgtacggcatcgtgctgtacgag
ctgatggctggggagcttccctacgcccacatcaacaaccgagaccagatcatcttcatg
gtaggccgtgggtatgcatcccctgatctcagcaggctctacaagaactgccccaaggca
atgaagaggttggtggctgactgtgtgaagaaagtcaaagaagagagacctttgtttccc
cagatcctgtcttccatcgagctgcttcagcactctctgccgaaaatcaacaggagcgcc
tctgagccttccctgcatcgggcagctcacactgaggacatcaatgcttgcacgctgact
acatccccaaggctaccagtcttctag

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