KEGG   Mus musculus (house mouse): 110893
Entry
110893            CDS       T01002                                 
Symbol
Slc8a3, Ncx3
Name
(RefSeq) solute carrier family 8 (sodium/calcium exchanger), member 3
  KO
K05849  solute carrier family 8 (sodium/calcium exchanger)
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu04020  Calcium signaling pathway
mmu04022  cGMP-PKG signaling pathway
mmu04260  Cardiac muscle contraction
mmu04261  Adrenergic signaling in cardiomyocytes
mmu04371  Apelin signaling pathway
mmu04740  Olfactory transduction
mmu04961  Endocrine and other factor-regulated calcium reabsorption
mmu04974  Protein digestion and absorption
mmu04978  Mineral absorption
mmu05410  Hypertrophic cardiomyopathy
mmu05412  Arrhythmogenic right ventricular cardiomyopathy
mmu05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    110893 (Slc8a3)
   04020 Calcium signaling pathway
    110893 (Slc8a3)
   04022 cGMP-PKG signaling pathway
    110893 (Slc8a3)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    110893 (Slc8a3)
   04261 Adrenergic signaling in cardiomyocytes
    110893 (Slc8a3)
  09154 Digestive system
   04974 Protein digestion and absorption
    110893 (Slc8a3)
   04978 Mineral absorption
    110893 (Slc8a3)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    110893 (Slc8a3)
  09157 Sensory system
   04740 Olfactory transduction
    110893 (Slc8a3)
 09160 Human Diseases
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    110893 (Slc8a3)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    110893 (Slc8a3)
   05414 Dilated cardiomyopathy
    110893 (Slc8a3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:mmu02000]
    110893 (Slc8a3)
   00536 Glycosaminoglycan binding proteins [BR:mmu00536]
    110893 (Slc8a3)
Transporters [BR:mmu02000]
 Solute carrier family (SLC)
  SLC8: Na+/Ca2+ exchanger
   110893 (Slc8a3)
Glycosaminoglycan binding proteins [BR:mmu00536]
 Heparan sulfate / Heparin
  Others
   110893 (Slc8a3)
SSDB
Motif
Pfam: Calx-beta Na_Ca_ex_C Na_Ca_ex
Other DBs
NCBI-GeneID: 110893
NCBI-ProteinID: NP_536688
MGI: 107976
Ensembl: ENSMUSG00000079055
UniProt: S4R2P9 Q3UTP5 Q8BXN1
Structure
Position
12:complement(81244686..81380506)
AA seq 928 aa
MAWLRLQPLTSAFLHFGLVTFVLFLNCLRAEAGDSGDVPSAGQNNESCSGSSDCKEGVIL
PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE
TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI
IIGICVYVIPDGETRKIKHLRVFFVTAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF
FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN
FTPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR
MMTGAGNILKKHAAEQAKKTSSMSEVHTDEPEDFASKVFFDPCSYQCLENCGAVLLTVVR
KGGDISKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF
FVRLSNVRVEEEQLAEGMLPAILNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH
VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDAYGELEFKNDETVKTIHI
KVIDDKAYEKNKNYVIEMMGPRMVDMSVQKALLLSPEVTDRKLTVEEEEAKRIAEMGKPV
LGEHPKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAGGDEDEDES
GEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFVVSILIIGMLTAIIGDLASHF
GCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLA
WSVAAIYWAMQGQEFHVSAGTLAFSVTLFTIFAFVCLSVLLYRRRPHLGGELGGPRGCKL
ATTWLFVSLWLLYILFATLEAYCYIKGF
NT seq 2787 nt   +upstreamnt  +downstreamnt
atggcgtggttacggctgcagcctctcacctctgccttcctccattttgggctggttact
tttgtgctcttcctgaattgtcttcgagcagaggctggtgactcgggggatgtgcccagt
gcagggcagaacaatgagtcctgttcggggtcatcagactgcaaggagggtgtcattttg
ccaatctggtatccagagaacccttcccttggggacaagattgccagggtcattgtctat
tttgtggccctgatatacatgtttcttggggtgtctatcattgctgaccgattcatggca
tctattgaagtcattacttcccaagagagggaagtgaccatcaagaagcccaatggagag
accagcacaactacaattcgggtatggaatgaaactgtctccaatctgaccctgatggcc
ctgggctcttctgctccagagattctcctgtctttaattgaggtgtgtggtcacgggttc
attgctggtgatctgggaccatctaccatcgttggcagtgcagccttcaacatgttcatc
atcattggcatctgtgtctatgtgatcccagatggggagactcgaaagatcaagcacctg
cgagtcttcttcgtcacggctgcttggagcatcttcgcctacatttggctctatatgatc
ctggcagtcttctctcctggtgtggtccaggtttgggaaggcctccttactctcttcttc
tttcccgtgtgtgtcctgctggcttgggtggcagataagcgactgctcttctacaaatac
atgcacaaaaaataccgcacagataaacaccgaggaattatcattgagacagagggtgac
caccctaagggcattgagatggatgggaaaatgatgaattctcactttctagatgggaac
tttacacctttggaaggaaaggaggtagatgaatctcgcagggaaatgatccggattcta
aaggatctgaaacaaaaacacccagaaaaggacctagatcagctggtggagatggccaat
tactatgctctttcccatcaacagaagagccgtgctttctaccgcatccaagccacccgg
atgatgactggtgcgggcaatatacttaagaagcatgcagccgagcaagccaagaagacc
tccagcatgagcgaggtgcataccgatgagccggaggactttgcctctaaggtcttcttt
gacccatgttcttatcagtgcctggagaactgtggagctgtcctcctgaccgtggtgagg
aaagggggagatatatccaagaccatgtacgtggactacaaaacagaggacggctccgcc
aatgcaggggcagactatgagttcacagagggcactgtggttctgaagccaggagagacc
cagaaggagttctctgtgggcatcattgatgatgacatttttgaggaggatgaacacttc
tttgtgaggctgagcaatgtccgtgtagaagaggagcagctggcggaggggatgctccca
gcaatactcaatagtcttcctttgcctcgggctgtcctggcctccccttgtgtggccaca
gtaaccatcttggatgatgaccatgcaggaattttcacttttgaatgtgataccattcat
gtcagtgaaagtattggtgttatggaagtcaaggttttgaggacatcaggtgccaggggc
acagtcatcgtcccttttaggacagtagaagggacagccaagggtggtggcgaggacttt
gaagatgcatatggggagctggagttcaagaatgatgaaacagtcaaaacaattcacatc
aaggtaattgatgataaggcgtatgagaaaaacaagaattacgtcattgagatgatgggc
ccccgcatggtggatatgagtgttcagaaagcgctcctgttatctccagaagtgacagac
aggaagctgactgtggaggaagaggaagccaagagaatagcagagatgggaaagccagta
ttgggtgaacaccccaaactagaggtcatcattgaagagtcctatgagttcaagagtaca
gtggataagctgatcaagaagacaaacctggcattggttgtggggacccattcctggagg
gaccagttcatggaagccatcactgttagtgcaggaggggatgaggatgaagacgaatct
ggagaggagaggctgccatcctgctttgactacgtcatgcacttcctgacggtcttctgg
aaggtgctctttgcctgtgtgccccccacagagtactgccacggctgggcctgcttcgtg
gtctccatcctcattattggcatgctcaccgccatcatcggggacctggcctctcacttc
ggctgcaccatcgggctcaaggattcggtcacagctgttgtttttgtggcattcggcacc
tctgtgccagatacatttgccagcaaagccgctgccctgcaggacgtgtatgcagatgct
tccattggcaacgtcacaggcagtaatgccgtcaatgtcttcctgggtattggtttggcc
tggtccgtggccgccatctactgggccatgcagggacaggagttccatgtgtccgctggc
actctggccttctcggtcactcttttcaccatctttgcatttgtctgcctcagtgtgctc
ttgtatcgtcggcggccccatctgggcggggagctcggaggtcctcgtggctgcaagctt
gccacgacatggctctttgtgagcctatggctcctctacatactatttgccacgctggag
gcctactgctacatcaaggggttctga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (12)   
   KEGG PATHWAY (12)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (12)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (27)   
   RefSeq(nuc) (9)   
   GenBank (9)   
   EMBL (9)   
3D Structure (1)   
   PDB (1)   
Protein domain (3)   
   Pfam (3)   
All databases (71)   

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