KEGG   Mus musculus (mouse): 16337Help
Entry
16337             CDS       T01002                                 

Gene name
Insr, 4932439J01Rik, CD220, D630014A15Rik, IR, IR-A, IR-B
Definition
(RefSeq) insulin receptor
  KO
K04527  
insulin receptor [EC:2.7.10.1]
Organism
mmu  Mus musculus (mouse)
Pathway
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phospholipase D signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Longevity regulating pathway
Longevity regulating pathway - multiple species
Adherens junction
Insulin signaling pathway
Ovarian steroidogenesis
Regulation of lipolysis in adipocytes
Type II diabetes mellitus
Insulin resistance
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Module
PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:mmu00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    16337 (Insr)
   04015 Rap1 signaling pathway
    16337 (Insr)
   04010 MAPK signaling pathway
    16337 (Insr)
   04066 HIF-1 signaling pathway
    16337 (Insr)
   04068 FoxO signaling pathway
    16337 (Insr)
   04072 Phospholipase D signaling pathway
    16337 (Insr)
   04022 cGMP - PKG signaling pathway
    16337 (Insr)
   04151 PI3K-Akt signaling pathway
    16337 (Insr)
   04152 AMPK signaling pathway
    16337 (Insr)
   04150 mTOR signaling pathway
    16337 (Insr)
 Cellular Processes
  Cellular community - eukaryotes
   04520 Adherens junction
    16337 (Insr)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    16337 (Insr)
   04923 Regulation of lipolysis in adipocyte
    16337 (Insr)
   04913 Ovarian Steroidogenesis
    16337 (Insr)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    16337 (Insr)
  Aging
   04211 Longevity regulating pathway - mammal
    16337 (Insr)
   04213 Longevity regulating pathway - multiple species
    16337 (Insr)
 Human Diseases
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    16337 (Insr)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    16337 (Insr)
   04931 Insulin resistance
    16337 (Insr)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     16337 (Insr)
Protein kinases [BR:mmu01001]
 Tyrosine protein kinases
  InsR family [OT]
   16337 (Insr)
Enzyme-linked receptors [BR:mmu01020]
 Receptor tyrosine kinases
  RTK class II (Insulin receptor family)
   16337 (Insr)
Cytokine receptors [BR:mmu04050]
 Receptor tyrosine kinase
  RTK class II (Insulin receptor family)
   16337 (Insr)
CD molecules [BR:mmu04090]
 Proteins
  16337 (Insr)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
MGI: 
Ensembl: 
Vega: 
UniProt: 
Position
8 A1.1; 8 1.82 cM
AA seq 1372 aa AA seqDB search
MGFGRGCETTAVPLLVAVAALLVGTAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHL
QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL
VIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE
ECGDVCPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHKECL
GNCSEPDDPTKCVACRNFYLDGQCVETCPPPYYHFQDWRCVNFSFCQDLHFKCRNSRKPG
CHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPKVCQILEGEKTIDSVTSAQELRGC
TVINGSLIINIRGGNNLAAELEANLGLIEEISGFLKIRRSYALVSLSFFRKLHLIRGETL
EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE
RNDIALKTNGDQASCENELLKFSFIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQ
NVTEFDGQDACGSNSWTVVDIDPPQRSNDPKSQTPSHPGWLMRGLKPWTQYAIFVKTLVT
FSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVY
WERQAEDSELFELDYCLKGLKLPSRTWSPPFESDDSQKHNQSEYDDSASECCSCPKTDSQ
ILKELEESSFRKTFEDYLHNVVFVPRPSRKRRSLEEVGNVTATTLTLPDFPNVSSTIVPT
SQEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPDERCSVAAYVSARTMPEAKA
DDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERG
CRLRGLSPGNYSVRVRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSV
VIGSIYLFLRKRQPDGPMGPLYASSNPEYLSASDVFPSSVYVPDEWEVPREKITLLRELG
QGSFGMVYEGNAKDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLL
GVVSKGQPTLVVMELMAHGDLKSHLRSLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYL
NAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKD
GVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDPPDNCPERLTDLMR
MCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFYSEENKAPESEELEMEFEDMENVPLD
RSSHCQREEAGGREGGSSLSIKRTYDEHIPYTHMNGGKKNGRVLTLPRSNPS
NT seq 4119 nt NT seq  +upstreamnt  +downstreamnt
atgggcttcgggagaggatgtgagacgacggctgtgccattgctggtggccgtggccgcg
ttgctggtgggcacagccggccacctgtaccctggagaggtgtgccctggtatggacatc
cggaacaacctgaccaggctacatgagctggagaactgctcagtcattgagggccatctg
cagatcctcctgatgttcaagaccagacccgaagatttccgagacctcagtttccccaaa
ctcatcatgatcacagattacctgcttctcttccgtgtctatggtctggaaagtctgaaa
gacctcttcccaaatctcacagtcatccgaggctcccgtctcttcttcaactatgccctg
gttatcttcgagatggtccacctgaaggagctggggctttataacctcatgaacatcacc
cggggctctgtccgcatcgagaagaataatgagctctgctacctggccactatcgactgg
tcccgtatcctggattctgtggaggacaactacattgtactgaacaaagatgacaacgag
gaatgtggggatgtctgtccaggcaccgccaagggcaagaccaactgtcctgccactgtc
atcaatgggcagtttgtggaacggtgctggacacacagtcattgtcagaaagtttgccca
accatctgtaagtcacatggctgcacagctgaaggcctgtgctgccacaaagagtgcctg
ggcaactgttcggaacctgatgaccccaccaagtgtgtggcctgtcgcaacttctatctg
gatggtcagtgtgtggagacctgcccgccaccctactatcacttccaggactggcgctgt
gtgaacttcagcttctgccaagaccttcacttcaaatgcaggaactctcggaagcctggc
tgccaccaatacgtcattcacaacaataagtgcatccccgagtgcccgtctggctatacc
atgaattccagcaacttgatgtgcaccccatgtctgggaccctgccctaaggtctgccaa
atcctcgaaggtgagaagaccattgattctgtgacatctgcccaggagctccgaggctgc
actgtgatcaacggtagcctgatcatcaacatccgagggggcaacaacctggcagctgag
ctggaggctaaccttggcctcattgaagaaatttcgggatttctaaagatccgccgctcc
tatgctctggtatcactttctttcttcaggaagctacatctgattcgaggagagaccttg
gaaattgggaactattctttttatgccttggacaaccagaacctgaggcaactctgggac
tggagcaaacacaacctcaccatcactcagggcaagctcttcttccattacaacccgaaa
ctctgcttgtctgaaattcacaagatggaagaagtctccggaactaagggccgtcaggag
aggaacgacattgccctgaagaccaatggggaccaggcatcgtgtgaaaatgaattgctt
aaattttctttcattcggacatcttttgacaagatcctgttgaggtgggaaccctactgg
ccccccgacttccgagatctcctgggattcatgttgttctacaaagaggccccttatcag
aatgtgacagagtttgatgggcaggatgcttgtggctccaacagctggactgtggtggat
attgacccgccccagaggtccaacgaccccaagtctcagaccccaagccaccctgggtgg
ctgatgcggggcctcaaaccctggacccaatacgccatctttgtgaagaccttggttacc
ttctctgatgaacggcggacctatggagccaaaagtgatatcatctatgtgcaaacagat
gccactaatccttctgtccccctggatcccatatcagtttctaattcctcatctcagatt
atcttaaagtggaagcccccctctgaccccaatggcaacatcacacactacctggtgtac
tgggagaggcaagcagaggacagcgagctgtttgagctggattattgtctcaaagggctg
aagctcccttcacggacctggtccccaccctttgagtctgatgattctcagaagcacaat
cagagtgagtatgacgactcggccagtgagtgctgctcatgccctaagactgactctcag
atcctgaaggagctggaggagtcttcattcaggaagaccttcgaggattacctgcacaac
gtggtttttgtccccaggccatcccgaaagcgaagatcccttgaagaggtggggaatgtg
acagccaccacactcacacttccagatttccccaacgtctcctctaccattgtgcccaca
agtcaggaggagcacaggccatttgagaaagtggtgaacaaggagtcacttgtcatctct
ggcctgagacacttcactgggtaccgcattgagctgcaggcatgcaatcaagattcccca
gatgagaggtgcagtgtggctgcctacgtcagtgcccggaccatgcctgaagctaaggca
gatgacatcgttggccctgtgactcatgaaatctttgagaacaatgttgtacacttaatg
tggcaagagccaaaggaacctaatggtctgattgtgctatatgaagtgagctatcgccga
tatggtgatgaggagctgcacctctgtgtctcccggaagcattttgccctggagcggggc
tgcaggctgcgagggctctccccaggaaactacagtgttcgagtccgggctacctctctg
gcaggaaatggctcctggacagaacccacctatttttatgtgactgattatttagatgtc
ccatcaaatattgccaaaattatcattggacccctcatctttgtcttcctcttcagtgtt
gtgattggaagtatttatctatttctgagaaagaggcagccggatgggccaatgggacca
ctgtatgcatcttcaaaccctgagtacctcagtgccagtgatgtgtttccatcttctgtg
tacgtgccggacgagtgggaggtgcctcgagagaagatcacccttcttcgagagctgggg
cagggatcctttggtatggtgtatgaaggcaatgccaaggatatcatcaagggtgaggca
gagacccgtgttgcggttaagactgtcaatgagtcagccagtcttcgagaacggatcgag
ttcctcaatgaggcatcagtcatgaagggattcacctgccatcatgtggtccgccttctt
ggggtggtatccaaaggacagccaacgctggtagtgatggaattgatggctcatggagac
ctgaaaagtcacctccgttctctgaggccagatgctgagaataacccaggccgccctccc
cctaccttgcaagaaatgattcagatgacagcagaaattgctgatggcatggcatacttg
aacgccaagaagtttgtgcaccgggacctggcagctcgaaactgcatggttgcccatgat
tttactgtcaaaattggagactttggaatgacaagggacatctacgagacagattactat
cggaaagggggcaagggactgcttcctgtgaggtggatgtcacctgagtccctgaaggat
ggagtctttactgcttcttctgatatgtggtcctttggggtggtcctttgggaaatcact
agcctggctgagcaaccttatcaaggcctgtctaatgaacaggtgttgaagtttgtcatg
gatggaggctatctggatccccctgataactgtccagagagactcactgacctgatgcgc
atgtgctggcagttcaaccccaagatgaggccaaccttcctggaaatcgtcaacctgctc
aaggatgacctccaccccagctttccagaagtttccttcttctacagcgaggagaacaag
gctcctgagagtgaggagctggagatggagtttgaagacatggagaatgtcccgttggat
cgttcctctcactgtcagagagaagaggctgggggccgggagggagggtcctcactgagc
atcaaacggacctatgatgaacacatcccctatacccacatgaatgggggcaagaagaac
ggacgtgtccttaccctgccaaggtcaaacccttcctaa

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