KEGG   Mus musculus (mouse): 16367Help
Entry
16367             CDS       T01002                                 

Gene name
Irs1, G972R, IRS-1
Definition
insulin receptor substrate 1
Orthology
K16172  
insulin receptor substrate 1
Organism
mmu  Mus musculus (mouse)
Pathway
cGMP-PKG signaling pathway
FoxO signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Neurotrophin signaling pathway
Insulin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:mmu00001]
 Environmental Information Processing
  Signal transduction
   04068 FoxO signaling pathway
    16367 (Irs1)
   04022 cGMP - PKG signaling pathway
    16367 (Irs1)
   04151 PI3K-Akt signaling pathway
    16367 (Irs1)
   04152 AMPK signaling pathway
    16367 (Irs1)
   04150 mTOR signaling pathway
    16367 (Irs1)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    16367 (Irs1)
   04920 Adipocytokine signaling pathway
    16367 (Irs1)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    16367 (Irs1)
  Nervous system
   04722 Neurotrophin signaling pathway
    16367 (Irs1)
 Human Diseases
  Cancers
   05206 MicroRNAs in cancer
    16367 (Irs1)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    16367 (Irs1)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    16367 (Irs1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
MGI: 
Ensembl: 
Vega: 
UniProt: 
Position
1 C5; 1 42.0 cM
AA seq 1231 aa AA seqDB search
MASPPDTDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP
KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKAH
HDGAGGGCGGSCSGSSGVGEAGEDLSYDTGPGPAFKEVWQVILKPKGLGQTKNLIGIYRL
CLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVV
AQNMHETILEAMRAMSDEFRPRSKSQSSSSCSNPISVPLRRHHLNNPPPSQVGLTRRSRT
ESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHRGSSRL
HPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGGF
ISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLAAPNGHYIL
SRGGNGHRYIPGANLGTSPALPGDEAAGAADLDNRFRKRTHSAGTSPTISHQKTPSQSSV
ASIEEYTEMMPAAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHHLERRGGHHRPDTS
NLHTDDGYMPMSPGVAPVPSNRKGNGDYMPMSPKSVSAPQQIINPIRRHPQRVDPNGYMM
MSPSGSCSPDIGGGSSSSSSISAAPSGSSYGKPWTNGVGGHHTHALPHAKPPVESGGGKL
LPCTGDYMNMSPVGDSNTSSPSECYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEPEEGAR
HQHLRLSSSSGRLRYTATAEDSSSSTSSDSLGGGYCGARPESSLTHPHHHVLQPHLPRKV
DTAAQTNSRLARPTRLSLGDPKASTLPRVREQQQQQQSSLHPPEPKSPGEYVNIEFGSGQ
PGYLAGPATSRSSPSVRCPPQLHPAPREETGSEEYMNMDLGPGRRATWQESGGVELGRIG
PAPPGSATVCRPTRSVPNSRGDYMTMQIGCPRQSYVDTSPVAPVSYADMRTGIAAEKASL
PRPTGAAPPPSSTASSSVTPQGATAEQATHSSLLGGPQGPGGMSAFTRVNLSPNHNQSAK
VIRADTQGCRRRHSSETFSAPTRAGNTVPFGAGAAVGGSGGGGGGGSEDVKRHSSASFEN
VWLRPGDLGGVSKESAPVCGAAGGLEKSLNYIDLDLAKERSQDCPSQQQSLPPPPPHQPL
GSNEGNSPRRSSEDLSNYASISFQKQPEDRQ
NT seq 3696 nt NT seq  +upstreamnt  +downstreamnt
atggcgagccctccggataccgatggcttctcagacgtgcgcaaggtgggctacctgcgc
aagcccaagagtatgcataagcgctttttcgtgctgcgggcggccagcgaggccgggggc
ccagcgcgcctggagtattatgagaacgagaagaagtggcggcacaagtcgagcgccccc
aaacgctcgatccccctcgagagctgtttcaacatcaacaagcgggctgactccaagaac
aagcacctggtggctctctacacccgagacgaacactttgccattgccgcggatagcgag
gctgagcaagacagctggtaccaggctcttctgcagctgcataatcgggcaaaggcccac
catgacggggctggaggaggctgcggcggtagctgcagcggcagctctggcgttggagag
gcaggggaggacttgagctatgacacgggtccaggacccgcgttcaaggaggtctggcag
gttatcctgaaacccaagggcctgggtcagacaaagaacctgattggcatctaccgcctc
tgcctgaccagcaagaccatcagctttgtgaagctgaactccgaggcagccgctgtggtg
ctgcagctgatgaatatcagacgctgtggccactcagagaacttcttcttcatcgaggtg
gggcgttccgctgtgacagggcctggcgagttctggatgcaagtggatgactccgtggtg
gcccagaacatgcatgagaccattctagaggcaatgagggccatgagcgatgagtttcgc
cctcgcagcaaaagccagtcttcatccagttgctccaaccccatcagcgttcccctgcgc
aggcaccatctcaacaaccctccacccagccaggtgggactgactcggagatctcgaact
gagagcatcactgccacctcccctgccagtatggtgggtgggaaaccaggttccttccgg
gtgcgtgcctccagcgatggcgaaggcaccatgtcccgtccagcatcagtggatggcagt
cctgtgagccctagcaccaacaggacccacgcccatcggcatcgaggcagctccaggctg
caccccccactcaaccacagccgctccatccccatgccttcttctagatgctcaccttca
gccaccagcccagtgagtctgtcatctagtagtaccagtggccatggctccacttcagac
tgtctcttcccgaggcgctctagtgcttccgtgtccggttcgcctagcgatggcggtttc
atctcttctgatgagtatggttctagtccctgcgatttccgaagttccttccgcagtgtc
accccagattccctggggcacaccccaccagccaggggtgaggaggagctgagcaattat
atctgcatgggtggcaagggagcctccaccttggctgctcccaatggccactacattttg
tctaggggtggcaacggccatcgctacatcccaggtgctaacttggggacaagcccagcg
ctgcctggagatgaagccgcgggtgcagcagatctggataaccggtttcgaaagagaact
cactccgcaggcacatctcctaccatttcccatcagaagaccccctcacagtcttcagtg
gcttctattgaggaatatacagagatgatgcccgctgcctacccaccaggaggtggcagt
ggaggccgactgcccggctaccggcattccgccttcgtgcccacccactcctatcccgaa
gagggtctagagatgcaccacttggaacgtcgtggaggccaccaccgtccagacacctcc
aacctccacactgatgatggctatatgcccatgtctcctggggtggctccagtgcccagc
aaccgcaaaggaaatggggactatatgcccatgagccccaagagtgtatctgccccacag
cagatcattaaccccatcagacgccacccacagagagtggaccccaatggctacatgatg
atgtcacccagtggtagttgctcccctgacattggaggtgggtccagcagcagtagcagc
atcagcgcagccccttctgggagcagctatgggaagccatggacaaatggagtagggggg
caccatactcatgcccttcctcatgccaaacctcctgttgagagtggtggcggtaagctc
ttgccttgcacaggtgactacatgaacatgtccccagtgggagattccaacaccagcagc
ccctcagaatgctactatggcccagaagatccccagcacaagccggtcctctcttactac
tcattgccaaggtcctttaagcacacccagcgccctggagagccagaggagggtgccagg
caccagcatcttcgtctctcttctagctctggacgccttcgctataccgcaactgccgaa
gattcctcctcttctaccagcagcgacagtctgggtgggggttactgtggggctaggcca
gagtcaagcctcacacatccccaccaccatgtcttgcagccccacctgcctcgaaaggta
gacacagctgcacagaccaacagccgcctggctcgacccacaaggctgtccttgggggat
cccaaggcaagcaccttaccccgggttcgagagcagcaacagcagcagcagtcttccctg
caccctcccgagcccaaaagcccaggagaatatgtgaatattgaattcgggagcggccag
cctggctatttagctggccctgcaacttcccgtagctctccttcagttcgatgtccaccc
cagctccacccagctcctagagaagagactggctcggaagagtacatgaacatggacttg
gggccaggccggagggcaacctggcaggagagtggtggagttgagttgggcagaataggc
cctgcacctccggggtctgctacggtttgcaggccaacccgttcggtgccaaatagccgt
ggtgactacatgaccatgcagataggttgtcctcgtcaaagctatgtggatacctcacca
gtggccccagtcagctatgctgacatgcggacaggcattgctgcagagaaggcgagcctg
cctagacccacaggagctgctcctcctccatcctccacagcctcttcttctgttacacct
caaggagccaccgctgagcaagctactcactcttccttgctgggaggccctcagggacct
gggggcatgagtgcattcaccagggtgaacctcagtcccaaccataaccagagtgccaaa
gtgattcgcgcagacactcaagggtgccggaggaggcatagctctgagaccttctcagca
cctactcgggctggcaatacggtgccctttggagcaggggctgcagtagggggcagcggc
ggtggtggtggtggcggcagtgaggatgtaaaacgccacagctctgcatcctttgagaat
gtgtggctgagacctggggatctagggggagtctccaaggagtcggctccagtgtgtggg
gctgctgggggtttggagaagagtcttaactacatagacctggatttggccaaggagcgc
tctcaggactgcccctctcaacagcagtccctaccaccccctccccctcaccagccctta
ggcagcaatgagggcaactccccaagacgctccagtgaggatttaagcaactatgccagc
atcagcttccagaagcagccagaggatcgtcaatag

DBGET integrated database retrieval system