KEGG   Mus musculus (mouse): 18127Help
Entry
18127             CDS       T01002                                 

Gene name
Nos3, 2310065A03Rik, Nos-3, eNOS, ecNOS
Definition
(RefSeq) nitric oxide synthase 3, endothelial cell (EC:1.14.13.39)
  KO
K13242  
nitric-oxide synthase, endothelial [EC:1.14.13.39]
Organism
mmu  Mus musculus (mouse)
Pathway
Arginine biosynthesis
Arginine and proline metabolism
Metabolic pathways
Calcium signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
Sphingolipid signaling pathway
PI3K-Akt signaling pathway
VEGF signaling pathway
Platelet activation
Estrogen signaling pathway
Oxytocin signaling pathway
Insulin resistance
AGE-RAGE signaling pathway in diabetic complications
Brite
KEGG Orthology (KO) [BR:mmu00001]
 Metabolism
  Amino acid metabolism
   00220 Arginine biosynthesis
    18127 (Nos3)
   00330 Arginine and proline metabolism
    18127 (Nos3)
 Environmental Information Processing
  Signal transduction
   04370 VEGF signaling pathway
    18127 (Nos3)
   04066 HIF-1 signaling pathway
    18127 (Nos3)
   04020 Calcium signaling pathway
    18127 (Nos3)
   04071 Sphingolipid signaling pathway
    18127 (Nos3)
   04022 cGMP - PKG signaling pathway
    18127 (Nos3)
   04151 PI3K-Akt signaling pathway
    18127 (Nos3)
 Organismal Systems
  Immune system
   04611 Platelet activation
    18127 (Nos3)
  Endocrine system
   04915 Estrogen signaling pathway
    18127 (Nos3)
   04921 Oxytocin signaling pathway
    18127 (Nos3)
 Human Diseases
  Endocrine and metabolic diseases
   04931 Insulin resistance
    18127 (Nos3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    18127 (Nos3)
Enzymes [BR:mmu01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.39  nitric-oxide synthase (NADPH)
     18127 (Nos3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
MGI: 
Ensembl: 
Vega: 
UniProt: 
Position
5 A3; 5 11.32 cM
AA seq 1202 aa AA seqDB search
MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPAPEPSQAPAPPSPTRPAPDHSPPLTR
PPDGPRFPRVKNWEVGSITYDTLSAQAQQDGPCTSRRCLGSLVFPRKLQSRPTQGPSPTE
QLLGQARDFINQYYNSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNA
PRCVGRIQWGKLQVFDARDCRTAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGDF
RIWNSQLIRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPPE
LFTLPPEMVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSSE
IGMRDLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDHH
AATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPWK
GSAAKGAGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGRL
FRKAFDPRVLCMDEYDVVSLEHEALVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSP
RPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFC
AFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAAR
DIFSPKRSWKRQRYRLSTQAESLQLLPGLTHVHRRKMFQATILSVENLQSSKSTRATILV
RLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPPSTEPVAVEQLEKGSPGGPP
PGWVRDPRLPPCTLRQALTYFLDITSPPSPRLLRLLSTLAEESSEQQELEALSQDPRRYE
EWKWFSCPTLLEVLEQFPSVALPAPLILTQLPLLQPRYYSVSSAPSAHPGEIHLTIAVLA
YRTQDGLGPLHYGVCSTWMSQLKAGDPVPCFIRGAPSFRLPPDPNLPCILVGPGTGIAPF
RGFWQDRLHDIEIKGLQPAPMTLVFGCRCSQLDHLYRDEVLDAQQRGVFGQVLTAFSRDP
GSPKTYVQDLLRTELAAEVHRVLCLEQGHMFVCGDVTMATSVLQTVQRILATEGGMELDE
AGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWSFDPPGPEIP
GS
NT seq 3609 nt NT seq  +upstreamnt  +downstreamnt
atgggcaacttgaagagtgtgggccaggagcctgggccaccctgtggcctagggctcggg
ctgggtttagggctgtgcggcaagcagggcccagcctctccagcaccggagcctagccag
gcgccagcacccccgtccccaacccgaccagcaccagaccacagccccccgctaacccgg
cccccagacggacccaggtttcctcgagtaaagaattgggaagtgggcagcatcacctac
gacaccctcagtgcccaggctcagcaggatgggccctgtacctcaagacgctgcttggga
tccctggtgtttccaaggaagttacagagccggcccacccagggcccttcacccactgag
cagctattgggtcaagcccgggacttcatcaatcagtactataactccatcaaaaggagt
ggctcccaggctcatgagcagcggcttcaggaagtggaggctgaggtggcagccacaggc
acctaccagctccgggagagcgagctggtgtttggggccaagcaggcctggcgcaatgct
ccccgctgtgtgggccggatccagtggggaaagctgcaggtatttgatgctcgggactgc
aggactgcacaggaaatgttcacctacatctgtaaccacattaaatacgcaacaaataga
ggcaatcttcgttcagccatcacagtgttcccccagcgctgccctggccggggagacttc
cggatctggaacagccagctgatacgctatgcgggctataggcagcaggatggctccgtg
cgaggggaccccgccaacgtggagatcactgagctctgtatccaacatggctggacccca
ggaaatggccgctttgatgtgctgcccctgttactccaggctcctgatgagcccccagaa
ctcttcactctgcccccagagatggtcctcgaggtgcctctggagcaccccacgctcgag
tggtttgctgcccttggcctgcgctggtatgccctcccagctgtgtccaacatgctgcta
gaaatcgggggcctggagtttcctgctgcccctttcagcggctggtacatgagttcagag
attggcatgagggacctgtgtgaccctcaccgctacaacatacttgaggatgtggctgtg
tgcatggatctggacaccaggacaacctcatccctgtggaaagacaaggcagcggtggaa
attaatgtggccgtgttgcacagttaccagctggccaaagtgaccatagtggaccaccac
gccgccacagcctccttcatgaagcacctggaaaatgagcagaaggccagagggggctgc
cctgccgattgggcctggattgtgccccccatctcaggcagcctaactcctgtcttccat
caagagatggtcaactatttcctgtcccctgccttccgctaccagccagacccctggaag
ggaagtgcagcaaagggggcaggcatcaccaggaagaagacctttaaggaagtagccaat
gcagtgaagatctctgcctcactcatgggcacggtgatggcgaagcgtgtgaaggcaacc
attctgtatggctctgagactggccgggcccagagctacgcacagcagctgggaagactc
ttccggaaggcgtttgatccccgggtcctgtgcatggatgagtatgatgtggtgtcccta
gagcacgaggcactggtgttggtggtgaccagcacatttggcaatggggatcctccggag
aatggagagagctttgcagcagcgctcatggaaatgtcaggcccgtacaacagctcccct
aggcctgagcagcacaagagctacaaaatccgattcaacagtgtctcctgctcagaccca
ctggtatcctcttggcggcgcaagaggaaggagtctagcaacacagacagtgcaggagcc
ctgggcaccctcaggttctgtgtgtttgggctgggctcccgagcatacccccacttctgt
gcctttgctcgagcggtggacacaaggctggaggagctgggcggggagcgactactgcag
ctgggccaaggtgatgagctctgtggccaggaggaggctttccgaggctgggcccaggcc
gccttccaggctgcctgtgaaaccttctgtgtgggagaagatgccaaagctgctgcccga
gatatcttcagccccaaacgcagctggaagcgccagaggtaccggctgagtacccaggct
gagagcctgcaattactaccagggctgactcacgtgcacaggcggaagatgttccaggct
acaatcctctctgtggaaaacctacagagcagcaaatccacccgagccacgatcctggtg
cgtctggacaccggaggccaggagggactgcagtaccagccaggggaccacataggtgtg
tgcccacccaaccgtcctggcctagtggaggcactgctgagccgagtggaggaccctccg
ccatccacagaacctgtggctgtggaacaactggagaaaggcagccctggtggccctccc
cccggctgggtacgggacccccggctacccccatgtacgctgcggcaggctctcacctac
ttcctggacatcacttccccgcctagtcctcgcctccttcgactgctcagcaccctggca
gaagagtccagcgaacagcaggagctagaggctctcagccaggacccccggcgctacgaa
gaatggaagtggttcagctgccccacactgctagaggtgctggagcaatttccttcagtg
gcactgcctgccccgctgatcctcacccagctgcccttgctccagccccggtactactct
gtcagttcagcacccagcgcccacccaggagagatccacctcaccatagctgtgctggct
tacagaacccaggatgggctgggccctctgcactacggtgtctgctccacgtggatgagc
cagctcaaggcgggagatccagtgccctgcttcatcaggggggctccctccttccggctg
ccacctgatcctaacttgccctgcatcctggtgggcccagggactggcattgcacccttc
cggggattctggcaagacagactacacgacattgagatcaaagggctacaacctgccccc
atgactttggtgtttggctgccgatgctcccaactggaccatctctaccgggacgaggta
ctggacgcccagcagcgtggggtgtttggacaagtcctcaccgccttttccagggatcct
ggcagccccaagacctacgtgcaagacctcctgaggacagagctagccgcggaggttcac
cgtgtgctgtgccttgagcaaggacatatgtttgtctgcggcgatgtcactatggcaacc
agcgtcctgcaaaccgtgcagagaattctggcaacagagggcggcatggagctggatgaa
gccggtgacgtcatcggcgtgctgcgggatcagcaacgctaccacgaggacattttcgga
ctcacattgcgcacccaggaggtgacaagccgcatacgcacccagagcttttctttgcag
gagcgacagctgaggggcgcagtgccctggtcctttgacccgcctggcccagaaatacct
ggttcctga

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