KEGG   Mus musculus (mouse): 18646Help
Entry
18646             CDS       T01002                                 

Gene name
Prf1, Pfn, Pfp, Prf-1
Definition
perforin 1 (pore forming protein)
Orthology
K07818  
perforin 1
Organism
mmu  Mus musculus (mouse)
Pathway
Natural killer cell mediated cytotoxicity
Type I diabetes mellitus
Autoimmune thyroid disease
Allograft rejection
Graft-versus-host disease
Viral myocarditis
Brite
KEGG Orthology (KO) [BR:mmu00001]
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    18646 (Prf1)
 Human Diseases
  Immune diseases
   05320 Autoimmune thyroid disease
    18646 (Prf1)
   05330 Allograft rejection
    18646 (Prf1)
   05332 Graft-versus-host disease
    18646 (Prf1)
  Cardiovascular diseases
   05416 Viral myocarditis
    18646 (Prf1)
  Endocrine and metabolic diseases
   04940 Type I diabetes mellitus
    18646 (Prf1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 
Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
MGI: 
Ensembl: 
UniProt: 
Structure
PDB: 

Jmol
Position
10 B4; 10 32.18 cM
AA seq 554 aa AA seqDB search
MATCLFLLGLFLLLPRPVPAPCYTATRSECKQKHKFVPGVWMAGEGMDVTTLRRSGSFPV
NTQRFLRPDRTCTLCKNSLMRDATQRLPVAITHWRPHSSHCQRNVAAAKVHSTEGVAREA
AANINNDWRVGLDVNPRPEANMRASVAGSHSKVANFAAEKTYQDQYNFNSDTVECRMYSF
RLVQKPPLHLDFKKALRALPRNFNSSTEHAYHRLISSYGTHFITAVDLGGRISVLTALRT
CQLTLNGLTADEVGDCLNVEAQVSIGAQASVSSEYKACEEKKKQHKMATSFHQTYRERHV
EVLGGPLDSTHDLLFGNQATPEQFSTWTASLPSNPGLVDYSLEPLHTLLEEQNPKREALR
QAISHYIMSRARWQNCSRPCRSGQHKSSHDSCQCECQDSKVTNQDCCPRQRGLAHLVVSN
FRAEHLWGDYTTATDAYLKVFFGGQEFRTGVVWNNNNPRWTDKMDFENVLLSTGGPLRVQ
VWDADYGWDDDLLGSCDRSPHSGFHEVTCELNHGRVKFSYHAKCLPHLTGGTCLEYAPQG
LLGDPPGNRSGAVW
NT seq 1665 nt NT seq  +upstreamnt  +downstreamnt
atggccacgtgcctgttcctcctgggccttttcctgctgctgccacgacctgtccctgct
ccctgctacactgccactcggtcagaatgcaagcagaagcacaagttcgtgccaggtgta
tggatggctggggaaggcatggatgtgactaccctccgccgctccggctccttcccagtg
aacacacagaggttcctgaggcctgaccgcacctgcaccctctgtaaaaactccctaatg
agagacgccacacagcgcctacctgtggcaatcacccactggcggcctcacagctcacac
tgccagcgtaatgtggccgcagccaaggtccactccacggagggtgtggcccgggaggca
gctgctaatatcaataacgactggcgtgtggggctggatgtgaaccctaggccagaggca
aacatgcgcgcctccgtggctggctcccactccaaggtagccaattttgcagctgagaag
acctatcaggaccagtacaactttaatagcgacacagtagagtgtcgcatgtacagtttt
cgcctggtacaaaaacctccactccaccttgacttcaaaaaggcgctcagagccctcccc
cgcaactttaacagctccacagagcatgcttaccacaggctcatctcctcctatggcacg
cactttatcacggctgtggacctcggtggccgcatctcggtccttacagccctgcgtacc
tgtcagctgaccctgaatgggctcacagctgatgaggtaggagactgcctgaacgtggag
gcccaggtcagcatcggtgcccaagccagcgtctccagtgaatacaaagcttgtgaggag
aagaagaaacagcacaaaatggccacctctttccaccagacctaccgtgagcgtcacgtc
gaagtacttggtggccctctggactccacgcatgatctgctcttcgggaaccaagctaca
ccagagcagttctcaacctggacagcctcactgcccagcaaccctggtctggtggactac
agcctggagcccctgcacacattactggaagaacagaacccgaagcgggaggctctgaga
caggctatcagccattatataatgagcagagcccggtggcagaactgtagcaggccctgc
aggtcaggccagcataagagtagccatgattcatgccagtgtgagtgccaggattcaaag
gtcaccaaccaggactgctgcccacgacagaggggcttggcccatttggtggtaagcaat
ttccgggcagaacatctgtggggagactacaccacagctactgatgcctacctaaaggtc
ttctttggtggccaggagttcaggaccggtgtcgtgtggaacaataacaatccccggtgg
actgacaagatggactttgagaatgtgctcctgtccacagggggacccctcagggtgcag
gtctgggatgccgactacggctgggatgatgaccttcttggttcttgtgacaggtctccc
cactctggtttccatgaggtgacatgtgagctaaaccacggcagggtgaaattctcctac
catgccaagtgtctgccccatctcactggagggacctgcctggagtatgccccccagggg
cttctgggagatcctccaggaaaccgcagtggggctgtgtggtaa

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