KEGG T01002: 18646

Mus musculus (mouse): 18646

Entry

18646 CDS T01002

Gene name

Prf1, Pfn, Pfp, Prf-1

Definition

perforin 1 (pore forming protein)

Orthology

K07818

perforin 1

Organism

mmu Mus musculus (mouse)

Pathway

mmu04650	Natural killer cell mediated cytotoxicity
mmu04940	Type I diabetes mellitus
mmu05320	Autoimmune thyroid disease
mmu05330	Allograft rejection
mmu05332	Graft-versus-host disease
mmu05416	Viral myocarditis

Class

Organismal Systems; Immune system; Natural killer cell mediated cytotoxicity [PATH:mmu04650]
Human Diseases; Immune diseases; Autoimmune thyroid disease [PATH:mmu05320]
Human Diseases; Immune diseases; Allograft rejection [PATH:mmu05330]
Human Diseases; Immune diseases; Graft-versus-host disease [PATH:mmu05332]
Human Diseases; Cardiovascular diseases; Viral myocarditis [PATH:mmu05416]
Human Diseases; Endocrine and metabolic diseases; Type I diabetes mellitus [PATH:mmu04940]

SSDB

Motif

Pfam:

MACPF C2

Other DBs

NCBI-GI:

NCBI-GeneID:

MGI:

Ensembl:

UniProt:

Structure

PDB:

3NSJ

Position

10 B4; 10 32.18 cM

AA seq 554 aa
MATCLFLLGLFLLLPRPVPAPCYTATRSECKQKHKFVPGVWMAGEGMDVTTLRRSGSFPV
NTQRFLRPDRTCTLCKNSLMRDATQRLPVAITHWRPHSSHCQRNVAAAKVHSTEGVAREA
AANINNDWRVGLDVNPRPEANMRASVAGSHSKVANFAAEKTYQDQYNFNSDTVECRMYSF
RLVQKPPLHLDFKKALRALPRNFNSSTEHAYHRLISSYGTHFITAVDLGGRISVLTALRT
CQLTLNGLTADEVGDCLNVEAQVSIGAQASVSSEYKACEEKKKQHKMATSFHQTYRERHV
EVLGGPLDSTHDLLFGNQATPEQFSTWTASLPSNPGLVDYSLEPLHTLLEEQNPKREALR
QAISHYIMSRARWQNCSRPCRSGQHKSSHDSCQCECQDSKVTNQDCCPRQRGLAHLVVSN
FRAEHLWGDYTTATDAYLKVFFGGQEFRTGVVWNNNNPRWTDKMDFENVLLSTGGPLRVQ
VWDADYGWDDDLLGSCDRSPHSGFHEVTCELNHGRVKFSYHAKCLPHLTGGTCLEYAPQG
LLGDPPGNRSGAVW

NT seq 1665 nt +upstreamnt +downstreamnt
atggccacgtgcctgttcctcctgggccttttcctgctgctgccacgacctgtccctgct
ccctgctacactgccactcggtcagaatgcaagcagaagcacaagttcgtgccaggtgta
tggatggctggggaaggcatggatgtgactaccctccgccgctccggctccttcccagtg
aacacacagaggttcctgaggcctgaccgcacctgcaccctctgtaaaaactccctaatg
agagacgccacacagcgcctacctgtggcaatcacccactggcggcctcacagctcacac
tgccagcgtaatgtggccgcagccaaggtccactccacggagggtgtggcccgggaggca
gctgctaatatcaataacgactggcgtgtggggctggatgtgaaccctaggccagaggca
aacatgcgcgcctccgtggctggctcccactccaaggtagccaattttgcagctgagaag
acctatcaggaccagtacaactttaatagcgacacagtagagtgtcgcatgtacagtttt
cgcctggtacaaaaacctccactccaccttgacttcaaaaaggcgctcagagccctcccc
cgcaactttaacagctccacagagcatgcttaccacaggctcatctcctcctatggcacg
cactttatcacggctgtggacctcggtggccgcatctcggtccttacagccctgcgtacc
tgtcagctgaccctgaatgggctcacagctgatgaggtaggagactgcctgaacgtggag
gcccaggtcagcatcggtgcccaagccagcgtctccagtgaatacaaagcttgtgaggag
aagaagaaacagcacaaaatggccacctctttccaccagacctaccgtgagcgtcacgtc
gaagtacttggtggccctctggactccacgcatgatctgctcttcgggaaccaagctaca
ccagagcagttctcaacctggacagcctcactgcccagcaaccctggtctggtggactac
agcctggagcccctgcacacattactggaagaacagaacccgaagcgggaggctctgaga
caggctatcagccattatataatgagcagagcccggtggcagaactgtagcaggccctgc
aggtcaggccagcataagagtagccatgattcatgccagtgtgagtgccaggattcaaag
gtcaccaaccaggactgctgcccacgacagaggggcttggcccatttggtggtaagcaat
ttccgggcagaacatctgtggggagactacaccacagctactgatgcctacctaaaggtc
ttctttggtggccaggagttcaggaccggtgtcgtgtggaacaataacaatccccggtgg
actgacaagatggactttgagaatgtgctcctgtccacagggggacccctcagggtgcag
gtctgggatgccgactacggctgggatgatgaccttcttggttcttgtgacaggtctccc
cactctggtttccatgaggtgacatgtgagctaaaccacggcagggtgaaattctcctac
catgccaagtgtctgccccatctcactggagggacctgcctggagtatgccccccagggg
cttctgggagatcctccaggaaaccgcagtggggctgtgtggtaa

All links

Pathway (6)   
   KEGG PATHWAY (6)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (6)   
   UniGene (1)   
   ENSEMBL-MMU (1)   
   MGI-MMU (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (2)   
   RefSeq(pep) (1)   
DNA sequence (11)   
   RefSeq(nuc) (1)   
   GenBank (5)   
   EMBL (5)   
3D Structure (1)   
   PDB (1)   
Protein domain (2)   
   Pfam (2)   
All databases (36)   

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