KEGG   Mus musculus (mouse): 18706Help
Entry
18706             CDS       T01002                                 

Gene name
Pik3ca, 6330412C24Rik, caPI3K, p110, p110alpha
Definition
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide (EC:2.7.11.1 2.7.1.153)
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
mmu  Mus musculus (mouse)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:mmu00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    18706 (Pik3ca)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    18706 (Pik3ca)
   04015 Rap1 signaling pathway
    18706 (Pik3ca)
   04012 ErbB signaling pathway
    18706 (Pik3ca)
   04370 VEGF signaling pathway
    18706 (Pik3ca)
   04630 Jak-STAT signaling pathway
    18706 (Pik3ca)
   04668 TNF signaling pathway
    18706 (Pik3ca)
   04066 HIF-1 signaling pathway
    18706 (Pik3ca)
   04068 FoxO signaling pathway
    18706 (Pik3ca)
   04070 Phosphatidylinositol signaling system
    18706 (Pik3ca)
   04024 cAMP signaling pathway
    18706 (Pik3ca)
   04022 cGMP - PKG signaling pathway
    18706 (Pik3ca)
   04151 PI3K-Akt signaling pathway
    18706 (Pik3ca)
   04152 AMPK signaling pathway
    18706 (Pik3ca)
   04150 mTOR signaling pathway
    18706 (Pik3ca)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    18706 (Pik3ca)
  Cell growth and death
   04210 Apoptosis
    18706 (Pik3ca)
  Cellular commiunity
   04510 Focal adhesion
    18706 (Pik3ca)
 Organismal Systems
  Immune system
   04611 Platelet activation
    18706 (Pik3ca)
   04620 Toll-like receptor signaling pathway
    18706 (Pik3ca)
   04650 Natural killer cell mediated cytotoxicity
    18706 (Pik3ca)
   04660 T cell receptor signaling pathway
    18706 (Pik3ca)
   04662 B cell receptor signaling pathway
    18706 (Pik3ca)
   04664 Fc epsilon RI signaling pathway
    18706 (Pik3ca)
   04666 Fc gamma R-mediated phagocytosis
    18706 (Pik3ca)
   04670 Leukocyte transendothelial migration
    18706 (Pik3ca)
   04062 Chemokine signaling pathway
    18706 (Pik3ca)
  Endocrine system
   04910 Insulin signaling pathway
    18706 (Pik3ca)
   04915 Estrogen signaling pathway
    18706 (Pik3ca)
   04914 Progesterone-mediated oocyte maturation
    18706 (Pik3ca)
   04917 Prolactin signaling pathway
    18706 (Pik3ca)
   04921 Oxytocin signaling pathway
    18706 (Pik3ca)
   04919 Thyroid hormone signaling pathway
    18706 (Pik3ca)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    18706 (Pik3ca)
  Digestive system
   04973 Carbohydrate digestion and absorption
    18706 (Pik3ca)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    18706 (Pik3ca)
  Nervous system
   04725 Cholinergic synapse
    18706 (Pik3ca)
   04722 Neurotrophin signaling pathway
    18706 (Pik3ca)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    18706 (Pik3ca)
  Development
   04380 Osteoclast differentiation
    18706 (Pik3ca)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    18706 (Pik3ca)
   05205 Proteoglycans in cancer
    18706 (Pik3ca)
   05203 Viral carcinogenesis
    18706 (Pik3ca)
   05210 Colorectal cancer
    18706 (Pik3ca)
   05212 Pancreatic cancer
    18706 (Pik3ca)
   05214 Glioma
    18706 (Pik3ca)
   05221 Acute myeloid leukemia
    18706 (Pik3ca)
   05220 Chronic myeloid leukemia
    18706 (Pik3ca)
   05218 Melanoma
    18706 (Pik3ca)
   05211 Renal cell carcinoma
    18706 (Pik3ca)
   05215 Prostate cancer
    18706 (Pik3ca)
   05213 Endometrial cancer
    18706 (Pik3ca)
   05222 Small cell lung cancer
    18706 (Pik3ca)
   05223 Non-small cell lung cancer
    18706 (Pik3ca)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    18706 (Pik3ca)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    18706 (Pik3ca)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    18706 (Pik3ca)
   05166 HTLV-I infection
    18706 (Pik3ca)
   05162 Measles
    18706 (Pik3ca)
   05164 Influenza A
    18706 (Pik3ca)
   05161 Hepatitis B
    18706 (Pik3ca)
   05160 Hepatitis C
    18706 (Pik3ca)
   05169 Epstein-Barr virus infection
    18706 (Pik3ca)
   05146 Amoebiasis
    18706 (Pik3ca)
   05145 Toxoplasmosis
    18706 (Pik3ca)
   05142 Chagas disease (American trypanosomiasis)
    18706 (Pik3ca)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     18706 (Pik3ca)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
MGI: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
3 B; 3 15.7 cM
AA seq 1068 aa AA seqDB search
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLVTIKHELFREARKYPLHQ
LLQDETSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFV
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPID
SFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHTGLSNRLARDNELRENDKEQLRALCTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRSFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRQPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQEYTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFTKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt NT seq  +upstreamnt  +downstreamnt
atgcctccacgaccatcttcgggtgaactgtggggcatccacttgatgcccccacgaatc
ctagtggaatgtttactccccaatggaatgatagtgactttagaatgcctccgtgaggcc
acactcgtcaccatcaaacatgaactgttcagagaggccaggaaataccctctccatcag
cttctgcaagacgaaacttcttacattttcgtaagtgtcacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gttattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgtt
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtccaagactttcga
aggaacattctgaatgtttgcaaagaagctgtggacctgcgggatctcaactcgcctcat
agcagagcaatgtatgtctaccctccaaatgtcgagtcttccccagaactgccaaagcac
atctacaacaagttagataaaggacaaatcatagtggtgatttgggtaatagtctctcca
aacaacgacaagcagaagtacactctgaagatcaatcatgactgtgtgccagagcaagtc
attgctgaagccatcaggaaaaagactcggagcatgttgttgtcctctgagcagctgaaa
ctctgtgtcttagaatatcagggcaagtatattctgaaagtgtgtggctgtgacgaatac
ttcctggaaaagtaccctctgagtcagtacaagtacataagaagctgtataatgctgggg
aggatgcccaacttgatgctgatggccaaagaaagcctatactctcagctgccgattgat
agcttcaccatgccgtcatactccaggcgcatctccacagccacaccctacatgaatgga
gagacatctacgaaatccctctgggtcataaatagtgcgctcagaataaaaattctttgt
gcaacctatgtaaatgtaaatattcgagacattgataagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgacaatgtgaacactcaaagagtaccttgttccaat
cctaggtggaatgaatggctgaattatgatatatacattcctgatcttcctcgtgctgcg
cgcctttgcctttcaatctgctctgttaaaggccgaaagggtgctaaggaggagcactgt
ccgttggcctggggaaacataaacttgtttgattatacagacaccctagtgtccgggaaa
atggctttgaatctctggcctgtaccgcatgggttagaagatctgctgaaccctattggt
gttactgggtcaaatccaaataaagaaactccatgcttagagttggagtttgattggttc
agcagtgtggtgaagtttccagacatgtctgtgatcgaagaacatgccaattggtccgtg
tcccgagaagctggattcagttactcccatacaggactgagtaacagactagccagagac
aatgagttaagagaaaatgacaaggaacagctccgagcactttgcacccgggacccacta
tctgaaatcactgaacaagagaaagacttcctatggagccacagacactactgcgtaact
attcctgaaatcctacccaaattgcttctgtctgtcaagtggaattccagagacgaagtg
gcccagatgtactgcttagtaaaagattggcctccaatcaaaccagagcaagccatggaa
ctcctggactgtaactatccagatcctatggttcggagttttgctgttcggtgcttagaa
aaatatttaacagatgacaaactttctcagtacctcattcaacttgtacaggtcttaaaa
tatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcattgacaaat
caaaggattggccattttttcttttggcatttaaaatctgagatgcacaataagactgtc
agtcagaggtttggcctgctattggagtcctactgccgtgcctgtgggatgtatctgaag
cacctgaacagacaagtagaggccatggagaagctcatcaacctaacggacatccttaag
caggagaagaaggatgagacacaaaaggtacagatgaagtttttggttgaacagatgaga
cagccagacttcatggatgctttgcagggttttctgtcccctctgaatcctgctcaccaa
ctaggaaacctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagctactgtttcagaacaatgagatcatc
tttaaaaatggcgacgacttacggcaagatatgttaacccttcagatcatccgaatcatg
gagaacatctggcaaaaccaaggccttgaccttcgcatgctaccttatggctgtctatcc
attggggactgtgtgggtctcatcgaggtggtgagaaactctcacaccatcatgcaaatc
cagtgcaaaggaggcctgaagggggcgctgcagttcaacagccacacactgcatcaatgg
ctcaaggacaagaacaagggcgagatatatgatgcagccattgacctgttcactcggtcc
tgcgctgggtactgcgtggcaacctttatcttgggaattggagaccggcacaacagcaac
atcatggtgaaagatgacggacagctgtttcatatagattttgggcactttttggatcac
aagaagaaaaaatttggctataagcgggaacgtgtgccatttgtgttgacacaggatttc
ttgattgtgattagtaagggagcacaagagtacaccaagaccagagagtttgagaggttt
caggagatgtgttacaaggcttacctagcaattcggcagcatgccaatctcttcatcaac
cttttttcaatgatgcttggctctggaatgccagaactacaatcttttgatgacattgca
tatatccgaaagactctagccttggacaaaactgagcaagaagctttggaatatttcaca
aagcaaatgaatgatgcacatcatggtggatggacgacaaaaatggattggatcttccac
accatcaagcagcatgctttgaactga

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