KEGG   Mus musculus (mouse): 18707Help
Entry
18707             CDS       T01002                                 

Gene name
Pik3cd, 2410099E07Rik, 2610208K16Rik, AW545373, p110delta
Definition
phosphatidylinositol 3-kinase catalytic delta polypeptide (EC:2.7.1.153)
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
mmu  Mus musculus (mouse)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:mmu00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    18707 (Pik3cd)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    18707 (Pik3cd)
   04015 Rap1 signaling pathway
    18707 (Pik3cd)
   04012 ErbB signaling pathway
    18707 (Pik3cd)
   04370 VEGF signaling pathway
    18707 (Pik3cd)
   04630 Jak-STAT signaling pathway
    18707 (Pik3cd)
   04668 TNF signaling pathway
    18707 (Pik3cd)
   04066 HIF-1 signaling pathway
    18707 (Pik3cd)
   04068 FoxO signaling pathway
    18707 (Pik3cd)
   04070 Phosphatidylinositol signaling system
    18707 (Pik3cd)
   04024 cAMP signaling pathway
    18707 (Pik3cd)
   04022 cGMP - PKG signaling pathway
    18707 (Pik3cd)
   04151 PI3K-Akt signaling pathway
    18707 (Pik3cd)
   04152 AMPK signaling pathway
    18707 (Pik3cd)
   04150 mTOR signaling pathway
    18707 (Pik3cd)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    18707 (Pik3cd)
  Cell growth and death
   04210 Apoptosis
    18707 (Pik3cd)
  Cellular commiunity
   04510 Focal adhesion
    18707 (Pik3cd)
   04550 Signaling pathways regulating pluripotency of stem cells
    18707 (Pik3cd)
 Organismal Systems
  Immune system
   04611 Platelet activation
    18707 (Pik3cd)
   04620 Toll-like receptor signaling pathway
    18707 (Pik3cd)
   04650 Natural killer cell mediated cytotoxicity
    18707 (Pik3cd)
   04660 T cell receptor signaling pathway
    18707 (Pik3cd)
   04662 B cell receptor signaling pathway
    18707 (Pik3cd)
   04664 Fc epsilon RI signaling pathway
    18707 (Pik3cd)
   04666 Fc gamma R-mediated phagocytosis
    18707 (Pik3cd)
   04670 Leukocyte transendothelial migration
    18707 (Pik3cd)
   04062 Chemokine signaling pathway
    18707 (Pik3cd)
  Endocrine system
   04910 Insulin signaling pathway
    18707 (Pik3cd)
   04915 Estrogen signaling pathway
    18707 (Pik3cd)
   04914 Progesterone-mediated oocyte maturation
    18707 (Pik3cd)
   04917 Prolactin signaling pathway
    18707 (Pik3cd)
   04921 Oxytocin signaling pathway
    18707 (Pik3cd)
   04919 Thyroid hormone signaling pathway
    18707 (Pik3cd)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    18707 (Pik3cd)
  Digestive system
   04973 Carbohydrate digestion and absorption
    18707 (Pik3cd)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    18707 (Pik3cd)
  Nervous system
   04725 Cholinergic synapse
    18707 (Pik3cd)
   04722 Neurotrophin signaling pathway
    18707 (Pik3cd)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    18707 (Pik3cd)
  Development
   04380 Osteoclast differentiation
    18707 (Pik3cd)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    18707 (Pik3cd)
   05205 Proteoglycans in cancer
    18707 (Pik3cd)
   05203 Viral carcinogenesis
    18707 (Pik3cd)
   05210 Colorectal cancer
    18707 (Pik3cd)
   05212 Pancreatic cancer
    18707 (Pik3cd)
   05214 Glioma
    18707 (Pik3cd)
   05221 Acute myeloid leukemia
    18707 (Pik3cd)
   05220 Chronic myeloid leukemia
    18707 (Pik3cd)
   05218 Melanoma
    18707 (Pik3cd)
   05211 Renal cell carcinoma
    18707 (Pik3cd)
   05215 Prostate cancer
    18707 (Pik3cd)
   05213 Endometrial cancer
    18707 (Pik3cd)
   05222 Small cell lung cancer
    18707 (Pik3cd)
   05223 Non-small cell lung cancer
    18707 (Pik3cd)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    18707 (Pik3cd)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    18707 (Pik3cd)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    18707 (Pik3cd)
   05166 HTLV-I infection
    18707 (Pik3cd)
   05162 Measles
    18707 (Pik3cd)
   05164 Influenza A
    18707 (Pik3cd)
   05161 Hepatitis B
    18707 (Pik3cd)
   05160 Hepatitis C
    18707 (Pik3cd)
   05169 Epstein-Barr virus infection
    18707 (Pik3cd)
   05146 Amoebiasis
    18707 (Pik3cd)
   05145 Toxoplasmosis
    18707 (Pik3cd)
   05142 Chagas disease (American trypanosomiasis)
    18707 (Pik3cd)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     18707 (Pik3cd)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
MGI: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
4 E2; 4
AA seq 1047 aa AA seqDB search
MPPGVDCPMEFWTKEESQSVVVDFLLPTGVYLNFPVSRNANLSTIKQVLWHRAQYEPLFH
MLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLRLVAREGDRVKKLINSQISLL
IGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAAHRQQLGWVEWLQYSFPLQLEPSARGWRA
GLLRVSNRALLVNVKFEGSEESFTFQVSTKDMPLALMACALRKKATVFRQPLVEQPEEYA
LQVNGRHEYLYGNYPLCHFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPR
AKPPPIPAKKPSSVSLWSLEQPFSIELIEGRKVNADERMKLVVQAGLFHGNEMLCKTVSS
SEVNVCSEPVWKQRLEFDISVCDLPRMARLCFALYAVVEKAKKARSTKKKSKKADCPIAW
ANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPAGTVRGNPNTESAAALVIYLPEVAP
HPVYFPALEKILELGRHGERGRITEEEQLQLREILERRGSGELYEHEKDLVWKMRHEVQE
HFPEALARLLLVTKWNKHEDVAQLSQMLYLLCSWPELPVLSALELLDFSFPDCYVGSFAI
KSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLGRALANRKIGHFLFWHLRSEMHV
PSVALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKVSSQKTTKPQTKEMMHM
CMRQETYMEALSHLQSPLDPSTLLEEVCVEQCTFMDSKMKPLWIMYSSEEAGSAGNVGII
FKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIANI
QLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSD
NIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFR
GYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRV
KFNEALRESWKTKVNWLAHNVSKDNRQ
NT seq 3144 nt NT seq  +upstreamnt  +downstreamnt
atgccccctggggtggactgccccatggagttctggaccaaagaggagagccagagcgtg
gttgttgacttcttgctgcccacaggggtctacttgaacttccccgtgtcccgcaatgcc
aacctcagcaccatcaagcaggtgctgtggcaccgtgcacagtatgagccactcttccac
atgctcagtgaccccgaggcctatgtgttcacctgtgtgaaccagacggcggagcagcag
gagttggaggatgagcagcggaggctgtgcgacatccagcccttcctgcccgtgctgcgc
ctcgtggcccgagagggggaccgcgtgaagaagctcattaactcccagatcagcctcctc
attggcaaaggtctccatgagtttgattccctgcgggacccggaagtaaacgacttccgc
actaagatgcgccagttttgtgaagaggctgctgctcaccgccagcagctgggctgggtg
gaatggctgcagtacagcttccccctgcagctggagccctcagcaaggggttggcgggcc
ggcttattgcgtgtcagcaaccgagccctgctggtcaacgtgaagttcgagggcagtgag
gagagcttcaccttccaggtatccaccaaggacatgcccctggcactgatggcctgtgcc
ctccgaaaaaaggccacagtgttccggcagcctctggtggagcagcctgaggaatatgcc
ctgcaggtgaacgggaggcacgaatacctctacggcaactacccgctctgccactttcag
tacatctgcagctgcctacacagcgggctgacccctcatctgaccatggtccactcctcc
tccatccttgctatgcgggatgagcagagcaatcctgccccccaagtacagaaaccacgt
gccaaacctcccccgatccctgccaagaagccctcctctgtgtccctgtggtccctggaa
cagccattctccattgagctgatcgagggccgaaaagtgaatgctgacgagcggatgaag
ctggttgttcaggccgggctcttccatggcaatgagatgctgtgcaagactgtgtcaagc
tcggaggtgaatgtatgctcagagcccgtgtggaagcagcgactggagttcgatatcagc
gtctgtgacctcccgcgcatggctcgactctgttttgctctctatgccgtcgtggagaag
gctaagaaggcacgctccacaaagaagaagtctaagaaggcggactgccccatcgcttgg
gccaacctcatgctattcgactacaaagatcagctcaagacgggggagcgctgcctctac
atgtggccctctgtcccagatgagaagggagagctgctgaatcctgcgggtacagtgcgc
gggaaccccaacacggagagtgccgctgccctggtcatctacctgcctgaggtggccccc
caccctgtgtacttccccgctctggagaagatcctggagctggggcgtcacggggagcgt
gggcgcatcacggaggaggagcagctgcagctgcgggagatcctggaacggcggggatcc
ggggaactgtacgaacatgagaaggacctggtgtggaagatgcgccacgaagtccaggag
catttcccagaggcgctggcccgcctgctgctggtcaccaagtggaataaacacgaggat
gtggcccagctgtcccagatgctctatttgctgtgctcctggcccgagctgcctgtgctg
agcgccctggaacttctggactttagctttcccgactgctacgtgggctccttcgccatc
aagtcccttcggaagctgacggacgatgagctcttccagtaccttctgcagctggtgcaa
gtgctcaaatatgagtcctacctggactgcgagctgaccaaattcttgctgggccgagcc
ctggctaaccgcaagatcggacacttcctgttctggcacctccgctctgagatgcacgta
ccatcagtggctctgcggtttggtctcatcatggaagcctactgcagaggcagcacccac
cacatgaaggtgctgatgaagcagggggaagcactgagcaagcttaaggcactgaatgac
tttgtgaaggtgagttcccagaagaccaccaagccccaaaccaaggagatgatgcatatg
tgcatgcgccaggagacctacatggaggccctgtcccacctgcagtctccactcgacccc
agcaccctgctggaggaagtctgtgtggagcagtgcaccttcatggactccaaaatgaag
cccctgtggatcatgtacagcagcgaggaggcgggcagtgctggcaacgtgggcatcatc
tttaagaacggggatgacctccgccaggacatgctgactctgcagatgatccagctcatg
gacgtcctgtggaagcaggagggcctggacctgaggatgacgccctacggctgcctcccc
accggggaccgcacaggtctcatcgaggtggtcctccactcggacaccatcgccaacatc
cagctgaacaaaagcaacatggcggccacagctgccttcaacaaggacgccctgctcaac
tggctcaagtccaagaaccctggggaggccctggatcgggccattgaggaattcaccctc
tcctgtgctggctactgtgtggccacatatgttctgggcatcggtgaccggcacagcgac
aacatcatgatcagagagagtgggcagctcttccacattgattttggccactttctgggg
aacttcaagaccaagtttggaatcaaccgagagcgcgtccccttcattctcacctacgac
tttgtccacgtgatccagcaggggaagactaacaacagtgagaagtttgaaaggttccgc
ggctactgtgaacgagcctataccatcctgcggcgccacgggctgcttttcctccatctc
ttcgccctgatgcgggccgcaggtctgcctgagcttagctgctccaaagatatccagtat
ctcaaggactctctggcactggggaagacggaggaagaggcgctaaagcacttccgggtg
aagttcaacgaagctctccgagaaagctggaaaaccaaagtcaactggctggcgcacaat
gtgtccaaggataaccgacagtag

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