KEGG   Mus musculus (house mouse): 19225
Entry
19225             CDS       T01002                                 
Symbol
Ptgs2, COX2, Cox-2, PES-2, PGHS-2, PHS_II, PHS-2, Pghs2, TIS10, gripghs
Name
(RefSeq) prostaglandin-endoperoxide synthase 2
  KO
K11987  prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00590  Arachidonic acid metabolism
mmu01100  Metabolic pathways
mmu04064  NF-kappa B signaling pathway
mmu04148  Efferocytosis
mmu04370  VEGF signaling pathway
mmu04625  C-type lectin receptor signaling pathway
mmu04657  IL-17 signaling pathway
mmu04668  TNF signaling pathway
mmu04723  Retrograde endocannabinoid signaling
mmu04726  Serotonergic synapse
mmu04913  Ovarian steroidogenesis
mmu04921  Oxytocin signaling pathway
mmu04923  Regulation of lipolysis in adipocytes
mmu05010  Alzheimer disease
mmu05022  Pathways of neurodegeneration - multiple diseases
mmu05140  Leishmaniasis
mmu05163  Human cytomegalovirus infection
mmu05165  Human papillomavirus infection
mmu05167  Kaposi sarcoma-associated herpesvirus infection
mmu05200  Pathways in cancer
mmu05204  Chemical carcinogenesis - DNA adducts
mmu05206  MicroRNAs in cancer
mmu05222  Small cell lung cancer
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    19225 (Ptgs2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04370 VEGF signaling pathway
    19225 (Ptgs2)
   04064 NF-kappa B signaling pathway
    19225 (Ptgs2)
   04668 TNF signaling pathway
    19225 (Ptgs2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    19225 (Ptgs2)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    19225 (Ptgs2)
   04657 IL-17 signaling pathway
    19225 (Ptgs2)
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    19225 (Ptgs2)
   04913 Ovarian steroidogenesis
    19225 (Ptgs2)
   04921 Oxytocin signaling pathway
    19225 (Ptgs2)
  09156 Nervous system
   04726 Serotonergic synapse
    19225 (Ptgs2)
   04723 Retrograde endocannabinoid signaling
    19225 (Ptgs2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    19225 (Ptgs2)
   05206 MicroRNAs in cancer
    19225 (Ptgs2)
   05204 Chemical carcinogenesis - DNA adducts
    19225 (Ptgs2)
  09162 Cancer: specific types
   05222 Small cell lung cancer
    19225 (Ptgs2)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    19225 (Ptgs2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    19225 (Ptgs2)
   05165 Human papillomavirus infection
    19225 (Ptgs2)
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    19225 (Ptgs2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    19225 (Ptgs2)
   05022 Pathways of neurodegeneration - multiple diseases
    19225 (Ptgs2)
Enzymes [BR:mmu01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.99  Miscellaneous
    1.14.99.1  prostaglandin-endoperoxide synthase
     19225 (Ptgs2)
SSDB
Motif
Pfam: An_peroxidase EGF
Other DBs
NCBI-GeneID: 19225
NCBI-ProteinID: NP_035328
MGI: 97798
Ensembl: ENSMUSG00000032487
UniProt: Q05769
Structure
Position
1:149975851..149983978
AA seq 604 aa
MLFRAVLLCAALGLSQAANPCCSNPCQNRGECMSTGFDQYKCDCTRTGFYGENCTTPEFL
TRIKLLLKPTPNTVHYILTHFKGVWNIVNNIPFLRSLIMKYVLTSRSYLIDSPPTYNVHY
GYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDSKEVLEKVLLRREFIPDPQGS
NMMFAFFAQHFTHQFFKTDHKRGPGFTRGLGHGVDLNHIYGETLDRQHKLRLFKDGKLKY
QVIGGEVYPPTVKDTQVEMIYPPHIPENLQFAVGQEVFGLVPGLMMYATIWLREHNRVCD
ILKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQ
NRIASEFNTLYHWHPLLPDTFNIEDQEYSFKQFLYNNSILLEHGLTQFVESFTRQIAGRV
AGGRNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAAELKAL
YSDIDVMELYPALLVEKPRPDAIFGETMVELGAPFSLKGLMGNPICSPQYWKPSTFGGEV
GFKIINTASIQSLICNNVKGCPFTSFNVQDPQPTKTATINASASHSRLDDINPTVLIKRR
STEL
NT seq 1815 nt   +upstreamnt  +downstreamnt
atgctcttccgagctgtgctgctctgcgctgccctggggctcagccaggcagcaaatcct
tgctgttccaatccatgtcaaaaccgtggggaatgtatgagcacaggatttgaccagtat
aagtgtgactgtacccggactggattctatggtgaaaactgtactacacctgaatttctg
acaagaatcaaattactgctgaagcccaccccaaacacagtgcactacatcctgacccac
ttcaagggagtctggaacattgtgaacaacatccccttcctgcgaagtttaatcatgaaa
tatgtgctgacatccagatcatatttgattgacagtccacctacttacaatgtgcactat
ggttacaaaagctgggaagccttctccaacctctcctactacaccagggcccttcctccc
gtagcagatgactgcccaactcccatgggtgtgaagggaaataaggagcttcctgattca
aaagaagtgctggaaaaggttcttctacggagagagttcatccctgacccccaaggctca
aatatgatgtttgcattctttgcccagcacttcacccatcagtttttcaagacagatcat
aagcgaggacctgggttcacccgaggactgggccatggagtggacttaaatcacatttat
ggtgaaactctggacagacaacataaactgcgccttttcaaggatggaaaattgaaatat
caggtcattggtggagaggtgtatccccccacagtcaaagacactcaggtagagatgatc
taccctcctcacatccctgagaacctgcagtttgctgtggggcaggaagtctttggtctg
gtgcctggtctgatgatgtatgccaccatctggcttcgggagcacaacagagtgtgcgac
atactcaagcaggagcatcctgagtggggtgatgagcaactattccaaaccagcagactc
atactcataggagagactatcaagatagtgatcgaagactacgtgcaacacctgagcggt
taccacttcaaactcaagtttgacccagagctccttttcaaccagcagttccagtatcag
aaccgcattgcctctgaattcaacacactctatcactggcaccccctgctgcccgacacc
ttcaacattgaagaccaggagtacagcttcaaacagtttctctacaacaactccatcctc
ctggaacatggactcactcagtttgttgagtcattcaccagacagattgctggccgggtt
gctgggggaagaaatgtgccaattgctgtacaagcagtggcaaaggcctccattgaccag
agcagagagatgaaataccagtctctcaatgagtaccgcaaacgcttctccctgaagccg
tacacatcatttgaagaacttacaggagagaaggaaatggctgcagaattgaaagccctc
tacagtgacatcgatgtcatggaactgtaccctgccctgctggtggaaaaacctcgtcca
gatgctatctttggggagaccatggtagagcttggagcaccattctccttgaaaggactt
atgggaaatcccatctgttctcctcaatactggaagccgagcacctttggaggcgaagtg
ggttttaagatcatcaatactgcctcaattcagtctctcatctgcaataatgtgaagggg
tgtcccttcacttctttcaatgtgcaagatccacagcctaccaaaacagccaccatcaat
gcaagtgcctcccactccagactagatgacattaaccctacagtactaatcaaaaggcgt
tcaactgagctgtaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (23)   
   KEGG PATHWAY (23)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (14)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (29)   
   RefSeq(nuc) (1)   
   GenBank (14)   
   EMBL (14)   
3D Structure (50)   
   PDB (50)   
Protein domain (2)   
   Pfam (2)   
All databases (142)   

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