KEGG   Mus musculus (mouse): 20963Help
Entry
20963             CDS       T01002                                 

Gene name
Syk, Sykb
Definition
spleen tyrosine kinase (EC:2.7.10.2)
Orthology
K05855  
spleen tyrosine kinase [EC:2.7.10.2]
Organism
mmu  Mus musculus (mouse)
Pathway
NF-kappa B signaling pathway
PI3K-Akt signaling pathway
Osteoclast differentiation
Platelet activation
Natural killer cell mediated cytotoxicity
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Tuberculosis
Epstein-Barr virus infection
Viral carcinogenesis
Brite
KEGG Orthology (KO) [BR:mmu00001]
 Environmental Information Processing
  Signal transduction
   04064 NF-kappa B signaling pathway
    20963 (Syk)
   04151 PI3K-Akt signaling pathway
    20963 (Syk)
 Organismal Systems
  Immune system
   04611 Platelet activation
    20963 (Syk)
   04650 Natural killer cell mediated cytotoxicity
    20963 (Syk)
   04662 B cell receptor signaling pathway
    20963 (Syk)
   04664 Fc epsilon RI signaling pathway
    20963 (Syk)
   04666 Fc gamma R-mediated phagocytosis
    20963 (Syk)
  Development
   04380 Osteoclast differentiation
    20963 (Syk)
 Human Diseases
  Cancers
   05203 Viral carcinogenesis
    20963 (Syk)
  Infectious diseases
   05152 Tuberculosis
    20963 (Syk)
   05169 Epstein-Barr virus infection
    20963 (Syk)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     20963 (Syk)
Protein kinases [BR:mmu01001]
 Tyrosine protein kinases
  Syk family
   20963 (Syk)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
MGI: 
Ensembl: 
Vega: 
UniProt: 
Position
13 B-C2; 13 27.41 cM
AA seq 629 aa AA seqDB search
MAGSAVDSANHLTYFFGNITREEAEDYLVQGGMTDGLYLLRQSRNYLGGFALSVAHNRKA
HHYTIERELNGTYAISGGRAHASPADLCHYHSQEPDGLICLLKKPFNRPPGVQPKTGPFE
DLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGNISRDESEQT
VLIGSKTNGKFLIRARDNSGSYALCLLHEGKVLHYRIDRDKTGKLSIPEGKKFDTLWQLV
EHYSYKPDGLLRVLTVPCQKIGAQMGHPGSPNAHPVTWSPGGIISRIKSYSFPKPGHKKP
APPQGSRPESTVSFNPYEPTGGPWGPDRGLQREALPMDTEVYESPYADPEEIRPKEVYLD
RSLLTLEDNELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQ
LDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHIKDKNIIELVHQVSMGMKYLE
ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINY
YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMN
LCWTYDVENRPGFTAVELRLRNYYYDVVN
NT seq 1890 nt NT seq  +upstreamnt  +downstreamnt
atggcgggaagtgctgtggacagcgccaaccacctgacctacttttttggcaacatcacc
cgggaagaggctgaagactacctggtccagggaggcatgaccgatgggctctacctgcta
cgccagagccgcaattacctgggtggttttgctttgtcggtggctcacaacaggaaggca
caccactacaccatcgagagggaacttaatggcacctacgccatctccgggggcagggcc
catgccagcccagcagacctctgccattaccactcccaggaacctgatggccttatctgc
ctccttaagaagcccttcaaccggcccccgggagtacagcccaagaccggaccctttgag
gacctgaaggagaacctcatcagggaatatgtgaaacagacctggaaccttcagggccag
gctctggagcaagccatcatcagccagaagccccagctggagaagctgatcgccaccacg
gcccatgagaagatgccctggttccatggcaacatctccagagatgaatcagagcagacg
gtcctcatagggtcaaagaccaatggaaaattcctgatcagggccagagacaacagcggc
tcctatgctctgtgcctgctgcacgaagggaaagtattgcactaccgcattgacagggac
aagaccgggaagctctccattcctgaggggaagaagtttgacaccctctggcagctagtg
gaacattactcttacaagccagatgggctactaagagtcctcacggtaccatgccaaaag
attggtgcacagatgggccacccaggaagcccaaatgcccatcccgtgacttggtcaccg
ggtggaataatctcaaggatcaaatcctactccttcccaaagcctggccacaaaaagcct
gccccaccccaagggagccgtccagagagcactgtgtccttcaacccctatgagccaacg
ggagggccctggggcccagacagaggccttcagagagaagccctgcccatggacacagag
gtgtacgagagcccttatgctgaccctgaagagatccggcccaaagaggtctacctggac
aggagcctgctgaccctggaggacaatgaactgggctccggtaacttcgggactgtgaaa
aagggatactaccaaatgaaaaaagttgtgaaaaccgtggctgtgaaaatcctgaagaac
gaggccaacgacccggctttgaaggacgagctgctggcagaggcgaacgtcatgcagcag
ctggacaacccctacattgtgcgcatgatcggaatctgcgaggcggagtcctggatgctg
gtgatggagatggcggagctggggccgctcaacaagtacctgcagcagaacaggcacatt
aaggataagaacatcatagagctggttcaccaggtttccatggggatgaagtatttggaa
gagagcaactttgtgcacagagatctggctgcgcggaacgtgcttctggtcacacagcac
tatgccaagatcagcgatttcggtctttccaaagccctgcgtgctgatgaaaactactac
aaggcccagacccacgggaagtggcccgtgaagtggtacgcccccgaatgcatcaactac
tacaagttctccagtaagagtgacgtctggagcttcggagtcctgatgtgggaagcgttc
tcctatgggcagaagccctacagagggatgaaagggagcgaagtgaccgccatgctggag
aaaggagagcggatggggtgccctgcaggatgcccgagagagatgtacgacctgatgaac
ctgtgctggacttacgatgtggagaacaggccaggattcacagctgtggaactgaggctt
cgcaattactactacgacgtggttaactaa

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