KEGG   Mus musculus (mouse): 26399Help
Entry
26399             CDS       T01002                                 

Gene name
Map2k6, MEK6, MKK6, Prkmk6, SAPKK3
Definition
mitogen-activated protein kinase kinase 6 (EC:2.7.12.2)
Orthology
K04433  
mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
Organism
mmu  Mus musculus (mouse)
Pathway
MAPK signaling pathway
Rap1 signaling pathway
Osteoclast differentiation
Toll-like receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
Inflammatory mediator regulation of TRP channels
GnRH signaling pathway
Amyotrophic lateral sclerosis (ALS)
Toxoplasmosis
Influenza A
Epstein-Barr virus infection
Brite
KEGG Orthology (KO) [BR:mmu00001]
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    26399 (Map2k6)
   04010 MAPK signaling pathway
    26399 (Map2k6)
   04668 TNF signaling pathway
    26399 (Map2k6)
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    26399 (Map2k6)
   04664 Fc epsilon RI signaling pathway
    26399 (Map2k6)
  Endocrine system
   04912 GnRH signaling pathway
    26399 (Map2k6)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    26399 (Map2k6)
  Development
   04380 Osteoclast differentiation
    26399 (Map2k6)
 Human Diseases
  Neurodegenerative diseases
   05014 Amyotrophic lateral sclerosis (ALS)
    26399 (Map2k6)
  Infectious diseases
   05164 Influenza A
    26399 (Map2k6)
   05169 Epstein-Barr virus infection
    26399 (Map2k6)
   05145 Toxoplasmosis
    26399 (Map2k6)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     26399 (Map2k6)
Protein kinases [BR:mmu01001]
 Serine/threonine protein kinases: STE group
  STE7 family
   26399 (Map2k6)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
MGI: 
Ensembl: 
Vega: 
UniProt: 
Position
11; 11 E1
AA seq 334 aa AA seqDB search
MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIVELG
RGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDVSMRTVDCPFTVTFYGALF
REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDV
KPSNVLINTLGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDI
WSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSADFVDFTSQCLKKNSK
ERPTYPELMQHPFFTVHESKAADVASFVKLILGD
NT seq 1005 nt NT seq  +upstreamnt  +downstreamnt
atgtctcagtcgaaaggcaagaagcgaaacccgggccttaagattccaaaagaagcgttt
gaacagcctcagaccagttccacgccgcctcgggatttagactccaaggcttgcatatct
attggaaaccagaactttgaggtgaaggcagatgacctggagccgatagtggagctggga
cgaggtgcgtacggggtggtggagaagatgcgtcacgtgcccagcgggcagatcatggca
gtgaagcggatacgggccacagttaatagccaggaacagaaacggctgctgatggatttg
gatgtctccatgaggacggtggactgtccattcaccgtgaccttctacggtgcactcttc
cgggagggcgacgtgtggatctgcatggagctcatggatacgtcactagataaattctac
aaacaagttattgataaaggccaaacaattccagaggatatcttaggaaagatagcagtt
tctattgtaaaagcgttagaacatttacacagtaagctgtctgttatccatcgagacgtc
aagccttctaatgtgctcattaacacactgggccaggtgaagatgtgtgactttggaatc
agtggctacctggtcgactctgttgctaaaacgatcgatgccggttgcaaaccatacatg
gctcctgaacgaataaatccagagctcaaccagaaggggtacagtgtgaagtctgacatt
tggagcctgggcatcaccatgatcgagctggccatccttcggtttccttatgattcttgg
ggaacgcccttccagcagctaaagcaggtggtcgaagagccctctcctcagctcccagca
gacaagttctccgcggactttgttgactttacctcacagtgcttgaagaaaaattccaaa
gaacggcccacatatccagagcttatgcaacatccatttttcaccgtacatgaatccaaa
gcagcagacgtggcatcttttgtaaaactgatacttggggactaa

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