KEGG   Mus musculus (mouse): 30955Help
Entry
30955             CDS       T01002                                 

Gene name
Pik3cg, 5830428L06Rik, PI3Kgamma, p110gamma
Definition
phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
mmu  Mus musculus (mouse)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:mmu00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    30955 (Pik3cg)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    30955 (Pik3cg)
   04015 Rap1 signaling pathway
    30955 (Pik3cg)
   04012 ErbB signaling pathway
    30955 (Pik3cg)
   04370 VEGF signaling pathway
    30955 (Pik3cg)
   04630 Jak-STAT signaling pathway
    30955 (Pik3cg)
   04668 TNF signaling pathway
    30955 (Pik3cg)
   04066 HIF-1 signaling pathway
    30955 (Pik3cg)
   04068 FoxO signaling pathway
    30955 (Pik3cg)
   04070 Phosphatidylinositol signaling system
    30955 (Pik3cg)
   04024 cAMP signaling pathway
    30955 (Pik3cg)
   04022 cGMP - PKG signaling pathway
    30955 (Pik3cg)
   04151 PI3K-Akt signaling pathway
    30955 (Pik3cg)
   04152 AMPK signaling pathway
    30955 (Pik3cg)
   04150 mTOR signaling pathway
    30955 (Pik3cg)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    30955 (Pik3cg)
  Cell growth and death
   04210 Apoptosis
    30955 (Pik3cg)
  Cellular commiunity
   04510 Focal adhesion
    30955 (Pik3cg)
   04550 Signaling pathways regulating pluripotency of stem cells
    30955 (Pik3cg)
 Organismal Systems
  Immune system
   04611 Platelet activation
    30955 (Pik3cg)
   04620 Toll-like receptor signaling pathway
    30955 (Pik3cg)
   04650 Natural killer cell mediated cytotoxicity
    30955 (Pik3cg)
   04660 T cell receptor signaling pathway
    30955 (Pik3cg)
   04662 B cell receptor signaling pathway
    30955 (Pik3cg)
   04664 Fc epsilon RI signaling pathway
    30955 (Pik3cg)
   04666 Fc gamma R-mediated phagocytosis
    30955 (Pik3cg)
   04670 Leukocyte transendothelial migration
    30955 (Pik3cg)
   04062 Chemokine signaling pathway
    30955 (Pik3cg)
  Endocrine system
   04910 Insulin signaling pathway
    30955 (Pik3cg)
   04915 Estrogen signaling pathway
    30955 (Pik3cg)
   04914 Progesterone-mediated oocyte maturation
    30955 (Pik3cg)
   04917 Prolactin signaling pathway
    30955 (Pik3cg)
   04921 Oxytocin signaling pathway
    30955 (Pik3cg)
   04919 Thyroid hormone signaling pathway
    30955 (Pik3cg)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    30955 (Pik3cg)
  Digestive system
   04973 Carbohydrate digestion and absorption
    30955 (Pik3cg)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    30955 (Pik3cg)
  Nervous system
   04725 Cholinergic synapse
    30955 (Pik3cg)
   04722 Neurotrophin signaling pathway
    30955 (Pik3cg)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    30955 (Pik3cg)
  Development
   04380 Osteoclast differentiation
    30955 (Pik3cg)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    30955 (Pik3cg)
   05230 Central carbon metabolism in cancer
    30955 (Pik3cg)
   05205 Proteoglycans in cancer
    30955 (Pik3cg)
   05203 Viral carcinogenesis
    30955 (Pik3cg)
   05210 Colorectal cancer
    30955 (Pik3cg)
   05212 Pancreatic cancer
    30955 (Pik3cg)
   05214 Glioma
    30955 (Pik3cg)
   05221 Acute myeloid leukemia
    30955 (Pik3cg)
   05220 Chronic myeloid leukemia
    30955 (Pik3cg)
   05218 Melanoma
    30955 (Pik3cg)
   05211 Renal cell carcinoma
    30955 (Pik3cg)
   05215 Prostate cancer
    30955 (Pik3cg)
   05213 Endometrial cancer
    30955 (Pik3cg)
   05222 Small cell lung cancer
    30955 (Pik3cg)
   05223 Non-small cell lung cancer
    30955 (Pik3cg)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    30955 (Pik3cg)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    30955 (Pik3cg)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    30955 (Pik3cg)
   05166 HTLV-I infection
    30955 (Pik3cg)
   05162 Measles
    30955 (Pik3cg)
   05164 Influenza A
    30955 (Pik3cg)
   05161 Hepatitis B
    30955 (Pik3cg)
   05160 Hepatitis C
    30955 (Pik3cg)
   05169 Epstein-Barr virus infection
    30955 (Pik3cg)
   05146 Amoebiasis
    30955 (Pik3cg)
   05145 Toxoplasmosis
    30955 (Pik3cg)
   05142 Chagas disease (American trypanosomiasis)
    30955 (Pik3cg)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     30955 (Pik3cg)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
MGI: 
Ensembl: 
Vega: 
UniProt: 
Position
12; 12 B
AA seq 1102 aa AA seqDB search
MELENYEQPVVLREDNLRRRRRMKPRSAAGSLSSMELIPIEFVLPTSQRISKTPETALLH
VAGHGNVEQMKAQVWLRALETSVAAEFYHRLGPDQFLLLYQKKGQWYEIYDRYQVVQTLD
CLHYWKLMHKSPGQIHVVQRHVPSEETLAFQKQLTSLIGYDVTDISNVHDDELEFTRRRL
VTPRMAEVAGRDAKLYAMHPWVTSKPLPDYLSKKIANNCIFIVIHRGTTSQTIKVSADDT
PGTILQSFFTKMAKKKSLMNISESQSEQDFVLRVCGRDEYLVGETPLKNFQWVRQCLKNG
DEIHLVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRK
FRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFAEEVLWNVWLEFGIKI
KDLPKGALLNLQIYCCKTPSLSSKASAETPGSESKGKAQLLYYVNLLLIDHRFLLRHGDY
VLHMWQISGKAEEQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHRPTPDPEG
DRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQ
QEIVAKTYQLLARREIWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYL
LQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAY
LRGCGTAMLQDFTQQVHVIEMLQKVTIDIKSLSAEKYDVSSQVISQLKQKLESLQNSNLP
ESFRVPYDPGLKAGTLVIEKCKVMASKKKPLWLEFKCADPTVLSNETIGIIFKHGDDLRQ
DMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAQIQQSTVGNTG
AFKDEVLNHWLKEKCPIEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMISETGNL
FHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGSSGKKTSPHFQKFQDVCVRAYLAL
RHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKSEEDAKKYFLDQIEVCRDKGW
TVQFNWFLHLVLGIKQGEKHSA
NT seq 3309 nt NT seq  +upstreamnt  +downstreamnt
atggagctggagaactatgaacaaccggtggttctaagagaggacaacctccgccggcgc
cggaggatgaagccacgcagcgcagcaggcagcctgtcttccatggagctcatccccatt
gagttcgtactgcccaccagccagcgcatcagcaagactccagaaacagcgctgctgcat
gtggctggccatggcaatgtggaacagatgaaagctcaggtgtggctgcgcgcactggag
accagtgtggctgcggagttctaccaccgattgggcccggaccaattcctcctgctctac
cagaagaaaggacaatggtatgagatctatgacaggtaccaagtggtgcagaccctagac
tgcctgcattactggaagttgatgcacaagagccctggccagatccacgtggtacagcga
cacgtaccttctgaggagaccttggctttccagaagcagctcacctccctgattggctat
gacgtcactgacatcagcaatgtgcacgatgatgagctagagttcactcgccgccgtctg
gttacgccccgcatggctgaagtggctggccgggatgccaaactctatgctatgcaccct
tgggtaacgtccaaacctctcccagactacctgtcaaaaaagattgccaacaactgcatc
ttcatcgtcatccaccgcggtaccaccagccaaaccatcaaggtctccgcagatgatact
cctggtaccatcctccagagcttcttcaccaagatggccaagaagaagtccctaatgaat
atctcagaaagtcaaagtgagcaggattttgtattgcgggtttgtggccgcgatgagtac
ctggtgggtgaaacacccctcaaaaatttccagtgggtgaggcagtgcctcaagaacgga
gatgaaatacacctggtgctcgacacgcctccagacccagcccttgatgaggtgaggaag
gaagaatggccgctggtggatgactgcactggagtcaccggctaccacgagcagctgacc
atccatggcaaggaccacgagagtgtgttcacagtgtctttgtgggactgcgaccgaaag
ttcagggtcaagatcagaggcattgatatccctgtcctgcctcggaacaccgacctcact
gtgtttgtggaagcgaacatccagcacgggcaacaagtcctctgccaaaggagaaccagc
cctaagcccttcgcagaagaggtactctggaatgtgtggctggagtttggcatcaaaatc
aaagacttgcccaaaggggctctattgaacctacagatctactgctgcaaaaccccatca
ctgtccagcaaggcttctgcagagactccaggctccgagtccaagggcaaagcccagctt
ctctattacgtgaacttgctgttaatagaccaccgtttcctcctccgccacggggactat
gtgctccacatgtggcagatatctggcaaggcagaggagcagggcagcttcaatgctgac
aagctcacatccgcaaccaatcctgacaaggagaactcaatgtccatttccatcctgctg
gacaattactgtcaccccatagctttgcctaagcaccggcccacccctgacccagaggga
gacagggttcgggctgaaatgcccaatcagcttcgaaagcaattggaggcgatcatagcc
acagatccacttaaccccctcacagcagaggacaaagaattgctctggcattttcgatat
gaaagcctgaagcatccgaaggcttaccctaagctattcagctcagtgaaatgggggcag
caagaaattgttgccaaaacgtaccagctgttagccagaagggagatctgggatcaaagt
gctttggacgttggcttaaccatgcagctcctggactgcaacttttcagacgagaatgtc
cgggccattgcagttcagaaactggagagcttagaggacgatgacgttttacattacctt
ctccagctggtacaggctgtgaaatttgaaccgtaccacgacagtgcgctggccagattc
ctgctgaagcgtggcttgaggaacaaaagaatcggtcacttcttgttctggttcctgcga
agtgagatcgcacagtccagacactatcagcagaggttcgctgtgatcctggaggcgtac
ctgcgaggctgtggcacagccatgttgcaggacttcacacagcaggtccatgtgattgag
atgttacagaaagtcaccattgatattaaatcgctctcggcagagaagtatgacgtcagt
tcccaagttatttcacagcttaagcaaaagcttgaaagccttcagaactccaatctcccc
gagagctttagagttccctatgatcctggactaaaagccggtaccctggtgatcgagaaa
tgcaaagtgatggcctccaagaagaagcccctgtggcttgagtttaagtgtgctgatccc
acagtcctatccaacgaaaccattggaatcatctttaaacatggtgatgatctgcgccaa
gacatgttgatcttgcagattctacgcatcatggagtccatttgggagactgaatctctg
gacctgtgccttctgccttacggttgcatctcaactggtgacaaaataggaatgatcgag
attgtaaaggatgccacaacgatcgctcaaattcagcaaagcacagtgggtaacacgggg
gcattcaaagatgaagtcctgaatcactggctcaaggaaaaatgtcctattgaagaaaag
tttcaggccgcagtggaaaggtttgtttactcctgtgcaggctactgtgtggccacattt
gttcttgggatcggtgacaggcacaacgacaacattatgatctcagagacaggaaaccta
tttcatatagacttcggacacattcttgggaattacaagagtttcctgggcatcaataaa
gagagagtgcccttcgtcctaaccccagacttcttgtttgtgatgggatcttctggaaaa
aagacaagtccacacttccagaaattccaggatgtctgtgttagagcttacctagctctt
cgccatcacacaaacctgttgatcatcttgttctccatgatgctgatgacaggaatgccc
cagctgacaagcaaagaggacattgaatatatccgggatgccctcaccgtgggaaaaagc
gaggaggacgctaagaaatatttccttgatcagatcgaagtctgcagagacaaaggatgg
actgtgcagtttaactggttcctacatcttgttcttggcatcaaacaaggagaaaagcac
tccgcttga

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