KEGG   Mus musculus (mouse): 30955Help
Entry
30955             CDS       T01002                                 

Gene name
Pik3cg, 5830428L06Rik, PI3Kgamma, p110gamma
Definition
phosphoinositide-3-kinase, catalytic, gamma polypeptide (EC:2.7.11.1 2.7.1.153)
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
mmu  Mus musculus (mouse)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Class
Metabolism; Carbohydrate metabolism; Inositol phosphate metabolism [PATH:mmu00562]
Environmental Information Processing; Signal transduction; Ras signaling pathway [PATH:mmu04014]
Environmental Information Processing; Signal transduction; Rap1 signaling pathway [PATH:mmu04015]
Environmental Information Processing; Signal transduction; ErbB signaling pathway [PATH:mmu04012]
Environmental Information Processing; Signal transduction; VEGF signaling pathway [PATH:mmu04370]
Environmental Information Processing; Signal transduction; Jak-STAT signaling pathway [PATH:mmu04630]
Environmental Information Processing; Signal transduction; TNF signaling pathway [PATH:mmu04668]
Environmental Information Processing; Signal transduction; HIF-1 signaling pathway [PATH:mmu04066]
Environmental Information Processing; Signal transduction; FoxO signaling pathway [PATH:mmu04068]
Environmental Information Processing; Signal transduction; Phosphatidylinositol signaling system [PATH:mmu04070]
Environmental Information Processing; Signal transduction; PI3K-Akt signaling pathway [PATH:mmu04151]
Environmental Information Processing; Signal transduction; mTOR signaling pathway [PATH:mmu04150]
Cellular Processes; Cell motility; Regulation of actin cytoskeleton [PATH:mmu04810]
Cellular Processes; Cell growth and death; Apoptosis [PATH:mmu04210]
Cellular Processes; Cell communication; Focal adhesion [PATH:mmu04510]
Organismal Systems; Immune system; Toll-like receptor signaling pathway [PATH:mmu04620]
Organismal Systems; Immune system; Natural killer cell mediated cytotoxicity [PATH:mmu04650]
Organismal Systems; Immune system; T cell receptor signaling pathway [PATH:mmu04660]
Organismal Systems; Immune system; B cell receptor signaling pathway [PATH:mmu04662]
Organismal Systems; Immune system; Fc epsilon RI signaling pathway [PATH:mmu04664]
Organismal Systems; Immune system; Fc gamma R-mediated phagocytosis [PATH:mmu04666]
Organismal Systems; Immune system; Leukocyte transendothelial migration [PATH:mmu04670]
Organismal Systems; Immune system; Chemokine signaling pathway [PATH:mmu04062]
Organismal Systems; Endocrine system; Insulin signaling pathway [PATH:mmu04910]
Organismal Systems; Endocrine system; Estrogen signaling pathway [PATH:mmu04915]
Organismal Systems; Endocrine system; Progesterone-mediated oocyte maturation [PATH:mmu04914]
Organismal Systems; Endocrine system; Prolactin signaling pathway [PATH:mmu04917]
Organismal Systems; Endocrine system; Oxytocin signaling pathway [PATH:mmu04921]
Organismal Systems; Endocrine system; Thyroid hormone signaling pathway [PATH:mmu04919]
Organismal Systems; Circulatory system; Adrenergic signaling in cardiomyocytes [PATH:mmu04261]
Organismal Systems; Digestive system; Carbohydrate digestion and absorption [PATH:mmu04973]
Organismal Systems; Excretory system; Aldosterone-regulated sodium reabsorption [PATH:mmu04960]
Organismal Systems; Nervous system; Cholinergic synapse [PATH:mmu04725]
Organismal Systems; Nervous system; Neurotrophin signaling pathway [PATH:mmu04722]
Organismal Systems; Sensory system; Inflammatory mediator regulation of TRP channels [PATH:mmu04750]
Organismal Systems; Development; Osteoclast differentiation [PATH:mmu04380]
Human Diseases; Cancers; Pathways in cancer [PATH:mmu05200]
Human Diseases; Cancers; Proteoglycans in cancer [PATH:mmu05205]
Human Diseases; Cancers; Viral carcinogenesis [PATH:mmu05203]
Human Diseases; Cancers; Colorectal cancer [PATH:mmu05210]
Human Diseases; Cancers; Pancreatic cancer [PATH:mmu05212]
Human Diseases; Cancers; Glioma [PATH:mmu05214]
Human Diseases; Cancers; Acute myeloid leukemia [PATH:mmu05221]
Human Diseases; Cancers; Chronic myeloid leukemia [PATH:mmu05220]
Human Diseases; Cancers; Melanoma [PATH:mmu05218]
Human Diseases; Cancers; Renal cell carcinoma [PATH:mmu05211]
Human Diseases; Cancers; Prostate cancer [PATH:mmu05215]
Human Diseases; Cancers; Endometrial cancer [PATH:mmu05213]
Human Diseases; Cancers; Small cell lung cancer [PATH:mmu05222]
Human Diseases; Cancers; Non-small cell lung cancer [PATH:mmu05223]
Human Diseases; Endocrine and metabolic diseases; Type II diabetes mellitus [PATH:mmu04930]
Human Diseases; Endocrine and metabolic diseases; Non-alcoholic fatty liver disease (NAFLD) [PATH:mmu04932]
Human Diseases; Infectious diseases; Bacterial invasion of epithelial cells [PATH:mmu05100]
Human Diseases; Infectious diseases; HTLV-I infection [PATH:mmu05166]
Human Diseases; Infectious diseases; Measles [PATH:mmu05162]
Human Diseases; Infectious diseases; Influenza A [PATH:mmu05164]
Human Diseases; Infectious diseases; Hepatitis B [PATH:mmu05161]
Human Diseases; Infectious diseases; Hepatitis C [PATH:mmu05160]
Human Diseases; Infectious diseases; Epstein-Barr virus infection [PATH:mmu05169]
Human Diseases; Infectious diseases; Amoebiasis [PATH:mmu05146]
Human Diseases; Infectious diseases; Toxoplasmosis [PATH:mmu05145]
Human Diseases; Infectious diseases; Chagas disease (American trypanosomiasis) [PATH:mmu05142]
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
MGI: 
Ensembl: 
Vega: 
UniProt: 
Position
12; 12 B
AA seq 1102 aa AA seqDB search
MELENYEQPVVLREDNLRRRRRMKPRSAAGSLSSMELIPIEFVLPTSQRISKTPETALLH
VAGHGNVEQMKAQVWLRALETSVAAEFYHRLGPDQFLLLYQKKGQWYEIYDRYQVVQTLD
CLHYWKLMHKSPGQIHVVQRHVPSEETLAFQKQLTSLIGYDVTDISNVHDDELEFTRRRL
VTPRMAEVAGRDAKLYAMHPWVTSKPLPDYLSKKIANNCIFIVIHRGTTSQTIKVSADDT
PGTILQSFFTKMAKKKSLMNISESQSEQDFVLRVCGRDEYLVGETPLKNFQWVRQCLKNG
DEIHLVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRK
FRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFAEEVLWNVWLEFGIKI
KDLPKGALLNLQIYCCKTPSLSSKASAETPGSESKGKAQLLYYVNLLLIDHRFLLRHGDY
VLHMWQISGKAEEQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHRPTPDPEG
DRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQ
QEIVAKTYQLLARREIWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYL
LQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAY
LRGCGTAMLQDFTQQVHVIEMLQKVTIDIKSLSAEKYDVSSQVISQLKQKLESLQNSNLP
ESFRVPYDPGLKAGTLVIEKCKVMASKKKPLWLEFKCADPTVLSNETIGIIFKHGDDLRQ
DMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAQIQQSTVGNTG
AFKDEVLNHWLKEKCPIEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMISETGNL
FHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGSSGKKTSPHFQKFQDVCVRAYLAL
RHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKSEEDAKKYFLDQIEVCRDKGW
TVQFNWFLHLVLGIKQGEKHSA
NT seq 3309 nt NT seq  +upstreamnt  +downstreamnt
atggagctggagaactatgaacaaccggtggttctaagagaggacaacctccgccggcgc
cggaggatgaagccacgcagcgcagcaggcagcctgtcttccatggagctcatccccatt
gagttcgtactgcccaccagccagcgcatcagcaagactccagaaacagcgctgctgcat
gtggctggccatggcaatgtggaacagatgaaagctcaggtgtggctgcgcgcactggag
accagtgtggctgcggagttctaccaccgattgggcccggaccaattcctcctgctctac
cagaagaaaggacaatggtatgagatctatgacaggtaccaagtggtgcagaccctagac
tgcctgcattactggaagttgatgcacaagagccctggccagatccacgtggtacagcga
cacgtaccttctgaggagaccttggctttccagaagcagctcacctccctgattggctat
gacgtcactgacatcagcaatgtgcacgatgatgagctagagttcactcgccgccgtctg
gttacgccccgcatggctgaagtggctggccgggatgccaaactctatgctatgcaccct
tgggtaacgtccaaacctctcccagactacctgtcaaaaaagattgccaacaactgcatc
ttcatcgtcatccaccgcggtaccaccagccaaaccatcaaggtctccgcagatgatact
cctggtaccatcctccagagcttcttcaccaagatggccaagaagaagtccctaatgaat
atctcagaaagtcaaagtgagcaggattttgtattgcgggtttgtggccgcgatgagtac
ctggtgggtgaaacacccctcaaaaatttccagtgggtgaggcagtgcctcaagaacgga
gatgaaatacacctggtgctcgacacgcctccagacccagcccttgatgaggtgaggaag
gaagaatggccgctggtggatgactgcactggagtcaccggctaccacgagcagctgacc
atccatggcaaggaccacgagagtgtgttcacagtgtctttgtgggactgcgaccgaaag
ttcagggtcaagatcagaggcattgatatccctgtcctgcctcggaacaccgacctcact
gtgtttgtggaagcgaacatccagcacgggcaacaagtcctctgccaaaggagaaccagc
cctaagcccttcgcagaagaggtactctggaatgtgtggctggagtttggcatcaaaatc
aaagacttgcccaaaggggctctattgaacctacagatctactgctgcaaaaccccatca
ctgtccagcaaggcttctgcagagactccaggctccgagtccaagggcaaagcccagctt
ctctattacgtgaacttgctgttaatagaccaccgtttcctcctccgccacggggactat
gtgctccacatgtggcagatatctggcaaggcagaggagcagggcagcttcaatgctgac
aagctcacatccgcaaccaatcctgacaaggagaactcaatgtccatttccatcctgctg
gacaattactgtcaccccatagctttgcctaagcaccggcccacccctgacccagaggga
gacagggttcgggctgaaatgcccaatcagcttcgaaagcaattggaggcgatcatagcc
acagatccacttaaccccctcacagcagaggacaaagaattgctctggcattttcgatat
gaaagcctgaagcatccgaaggcttaccctaagctattcagctcagtgaaatgggggcag
caagaaattgttgccaaaacgtaccagctgttagccagaagggagatctgggatcaaagt
gctttggacgttggcttaaccatgcagctcctggactgcaacttttcagacgagaatgtc
cgggccattgcagttcagaaactggagagcttagaggacgatgacgttttacattacctt
ctccagctggtacaggctgtgaaatttgaaccgtaccacgacagtgcgctggccagattc
ctgctgaagcgtggcttgaggaacaaaagaatcggtcacttcttgttctggttcctgcga
agtgagatcgcacagtccagacactatcagcagaggttcgctgtgatcctggaggcgtac
ctgcgaggctgtggcacagccatgttgcaggacttcacacagcaggtccatgtgattgag
atgttacagaaagtcaccattgatattaaatcgctctcggcagagaagtatgacgtcagt
tcccaagttatttcacagcttaagcaaaagcttgaaagccttcagaactccaatctcccc
gagagctttagagttccctatgatcctggactaaaagccggtaccctggtgatcgagaaa
tgcaaagtgatggcctccaagaagaagcccctgtggcttgagtttaagtgtgctgatccc
acagtcctatccaacgaaaccattggaatcatctttaaacatggtgatgatctgcgccaa
gacatgttgatcttgcagattctacgcatcatggagtccatttgggagactgaatctctg
gacctgtgccttctgccttacggttgcatctcaactggtgacaaaataggaatgatcgag
attgtaaaggatgccacaacgatcgctcaaattcagcaaagcacagtgggtaacacgggg
gcattcaaagatgaagtcctgaatcactggctcaaggaaaaatgtcctattgaagaaaag
tttcaggccgcagtggaaaggtttgtttactcctgtgcaggctactgtgtggccacattt
gttcttgggatcggtgacaggcacaacgacaacattatgatctcagagacaggaaaccta
tttcatatagacttcggacacattcttgggaattacaagagtttcctgggcatcaataaa
gagagagtgcccttcgtcctaaccccagacttcttgtttgtgatgggatcttctggaaaa
aagacaagtccacacttccagaaattccaggatgtctgtgttagagcttacctagctctt
cgccatcacacaaacctgttgatcatcttgttctccatgatgctgatgacaggaatgccc
cagctgacaagcaaagaggacattgaatatatccgggatgccctcaccgtgggaaaaagc
gaggaggacgctaagaaatatttccttgatcagatcgaagtctgcagagacaaaggatgg
actgtgcagtttaactggttcctacatcttgttcttggcatcaaacaaggagaaaagcac
tccgcttga

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