KEGG   Mus musculus (mouse): 74769Help
Entry
74769             CDS       T01002                                 

Gene name
Pik3cb, 1110001J02Rik, AI447572, p110beta
Definition
phosphatidylinositol 3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
mmu  Mus musculus (mouse)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Class
Metabolism; Carbohydrate metabolism; Inositol phosphate metabolism [PATH:mmu00562]
Environmental Information Processing; Signal transduction; Ras signaling pathway [PATH:mmu04014]
Environmental Information Processing; Signal transduction; Rap1 signaling pathway [PATH:mmu04015]
Environmental Information Processing; Signal transduction; ErbB signaling pathway [PATH:mmu04012]
Environmental Information Processing; Signal transduction; VEGF signaling pathway [PATH:mmu04370]
Environmental Information Processing; Signal transduction; Jak-STAT signaling pathway [PATH:mmu04630]
Environmental Information Processing; Signal transduction; TNF signaling pathway [PATH:mmu04668]
Environmental Information Processing; Signal transduction; HIF-1 signaling pathway [PATH:mmu04066]
Environmental Information Processing; Signal transduction; FoxO signaling pathway [PATH:mmu04068]
Environmental Information Processing; Signal transduction; Phosphatidylinositol signaling system [PATH:mmu04070]
Environmental Information Processing; Signal transduction; PI3K-Akt signaling pathway [PATH:mmu04151]
Environmental Information Processing; Signal transduction; mTOR signaling pathway [PATH:mmu04150]
Cellular Processes; Cell motility; Regulation of actin cytoskeleton [PATH:mmu04810]
Cellular Processes; Cell growth and death; Apoptosis [PATH:mmu04210]
Cellular Processes; Cell communication; Focal adhesion [PATH:mmu04510]
Organismal Systems; Immune system; Toll-like receptor signaling pathway [PATH:mmu04620]
Organismal Systems; Immune system; Natural killer cell mediated cytotoxicity [PATH:mmu04650]
Organismal Systems; Immune system; T cell receptor signaling pathway [PATH:mmu04660]
Organismal Systems; Immune system; B cell receptor signaling pathway [PATH:mmu04662]
Organismal Systems; Immune system; Fc epsilon RI signaling pathway [PATH:mmu04664]
Organismal Systems; Immune system; Fc gamma R-mediated phagocytosis [PATH:mmu04666]
Organismal Systems; Immune system; Leukocyte transendothelial migration [PATH:mmu04670]
Organismal Systems; Immune system; Chemokine signaling pathway [PATH:mmu04062]
Organismal Systems; Endocrine system; Insulin signaling pathway [PATH:mmu04910]
Organismal Systems; Endocrine system; Estrogen signaling pathway [PATH:mmu04915]
Organismal Systems; Endocrine system; Progesterone-mediated oocyte maturation [PATH:mmu04914]
Organismal Systems; Endocrine system; Prolactin signaling pathway [PATH:mmu04917]
Organismal Systems; Endocrine system; Oxytocin signaling pathway [PATH:mmu04921]
Organismal Systems; Endocrine system; Thyroid hormone signaling pathway [PATH:mmu04919]
Organismal Systems; Circulatory system; Adrenergic signaling in cardiomyocytes [PATH:mmu04261]
Organismal Systems; Digestive system; Carbohydrate digestion and absorption [PATH:mmu04973]
Organismal Systems; Excretory system; Aldosterone-regulated sodium reabsorption [PATH:mmu04960]
Organismal Systems; Nervous system; Cholinergic synapse [PATH:mmu04725]
Organismal Systems; Nervous system; Neurotrophin signaling pathway [PATH:mmu04722]
Organismal Systems; Sensory system; Inflammatory mediator regulation of TRP channels [PATH:mmu04750]
Organismal Systems; Development; Osteoclast differentiation [PATH:mmu04380]
Human Diseases; Cancers; Pathways in cancer [PATH:mmu05200]
Human Diseases; Cancers; Proteoglycans in cancer [PATH:mmu05205]
Human Diseases; Cancers; Viral carcinogenesis [PATH:mmu05203]
Human Diseases; Cancers; Colorectal cancer [PATH:mmu05210]
Human Diseases; Cancers; Pancreatic cancer [PATH:mmu05212]
Human Diseases; Cancers; Glioma [PATH:mmu05214]
Human Diseases; Cancers; Acute myeloid leukemia [PATH:mmu05221]
Human Diseases; Cancers; Chronic myeloid leukemia [PATH:mmu05220]
Human Diseases; Cancers; Melanoma [PATH:mmu05218]
Human Diseases; Cancers; Renal cell carcinoma [PATH:mmu05211]
Human Diseases; Cancers; Prostate cancer [PATH:mmu05215]
Human Diseases; Cancers; Endometrial cancer [PATH:mmu05213]
Human Diseases; Cancers; Small cell lung cancer [PATH:mmu05222]
Human Diseases; Cancers; Non-small cell lung cancer [PATH:mmu05223]
Human Diseases; Endocrine and metabolic diseases; Type II diabetes mellitus [PATH:mmu04930]
Human Diseases; Endocrine and metabolic diseases; Non-alcoholic fatty liver disease (NAFLD) [PATH:mmu04932]
Human Diseases; Infectious diseases; Bacterial invasion of epithelial cells [PATH:mmu05100]
Human Diseases; Infectious diseases; HTLV-I infection [PATH:mmu05166]
Human Diseases; Infectious diseases; Measles [PATH:mmu05162]
Human Diseases; Infectious diseases; Influenza A [PATH:mmu05164]
Human Diseases; Infectious diseases; Hepatitis B [PATH:mmu05161]
Human Diseases; Infectious diseases; Hepatitis C [PATH:mmu05160]
Human Diseases; Infectious diseases; Epstein-Barr virus infection [PATH:mmu05169]
Human Diseases; Infectious diseases; Amoebiasis [PATH:mmu05146]
Human Diseases; Infectious diseases; Toxoplasmosis [PATH:mmu05145]
Human Diseases; Infectious diseases; Chagas disease (American trypanosomiasis) [PATH:mmu05142]
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
MGI: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
9; 9 E4
AA seq 1064 aa AA seqDB search
MPPAMADNLDIWAVDSQIASDGAISVDFLLPTGIYIQLEVPREATISYIKQMLWKQVHNY
PMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPAEKLDSKI
GVLIGKGLHEFDALKDPEVNEFRRKMRKFSEAKIQSLVGLSWIDWLKHTYPPEHEPSVLE
NLEDKLYGGKLVVAVHFENSQDVFSFQVSPNLNPIKINELAIQKRLTIRGKEDEASPCDY
VLQVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFILVECCKIKKMYEQEMIAIEAAINR
NSSNLPLPLPPKKTRVISHIWDNNNPFQITLVKGNKLNTEETVKVHVRAGLFHGTELLCK
TVVSSEISGKNDHIWNEQLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQ
TIRKAGKVHYPVAWVNTMVFDFKGQLRSGDVILHSWSSFPDELEEMLNPMGTVQTNPYAE
NATALHITFPENKKQPCYYPPFDKIIEKAAELASGDSANVSSRGGKKFLAVLKEILDRDP
LSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREA
LELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALD
NRRIGQFLFWHLRSEVHTPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLKTLNSLI
KLNAVKLSRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMDSKMKPL
WLVYSSRAFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGD
RSGLIEVVSTSETIADIQLNSSNVAATAAFNKDALLNWLKEYNSGDDLDRAIEEFTLSCA
GYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIH
VIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQYLKD
SLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3195 nt NT seq  +upstreamnt  +downstreamnt
atgcctcctgctatggcagacaaccttgacatctgggcagtggactcacagattgcatcc
gatggcgccatatccgtcgatttccttctgcccaccgggatttatatccagttggaagta
cctcgggaagctaccatttcttatattaaacagatgttatggaagcaagttcacaactac
ccgatgtttaacctcctcatggacattgactcgtatatgtttgcatgtgtgaatcaaact
gctgtatatgaggaactggaagacgaaacacgaagactttgtgatgtcagaccttttctt
ccagttctcaaactagtgactagaagctgtgaccccgcagaaaaattggactcaaaaatt
ggggttcttataggaaaaggtcttcatgagtttgatgccttgaaggatcccgaagtgaat
gaatttagaagaaaaatgcgcaaattcagtgaggccaagattcagtctctggtagggttg
tcttggatcgactggctaaagcacacgtatccgcctgagcacgagccgtccgtcctggag
aacttggaagataaactttatggaggaaagctggttgtggctgtgcactttgaaaatagc
caggatgtatttagttttcaagtgtctcccaatttgaatcctataaaaataaatgaattg
gcaatccagaaacgcctcactattcgtggaaaggaagatgaagctagcccctgtgactat
gtgttacaggtcagtgggagagtggagtatgtgtttggcgatcatccactaattcagttc
cagtacatccggaattgtgtgatgaatagaaccctgccccacttcatccttgtggaatgt
tgtaagatcaagaaaatgtatgaacaagaaatgattgccatagaggctgccatcaaccga
aactcatccaaccttcctctccctttaccaccaaagaaaacgcgagttatttctcatatc
tgggacaacaacaaccctttccaaattaccttggttaaaggaaataagcttaatacagaa
gaaactgtgaaagttcatgtccgagctgggctttttcacggaaccgagctcctgtgtaaa
accgtcgtaagctcagagatatcaggaaagaacgaccatatttggaatgaacaactggaa
tttgatattaatatttgtgacttaccaagaatggctcgattatgttttgctgtttatgca
gttttggataaagtaaaaacgaagaaatcaacaaagactattaatccctctaagtatcag
accatcaggaaagccgggaaagtgcattatcctgtcgcatgggtaaataccatggttttt
gacttcaaaggacagctgaggtctggagacgtcatattgcatagctggtcttcgtttcct
gatgagctggaagaaatgctgaatcccatggggactgtgcagacgaacccatatgctgag
aacgccaccgccttgcacattacgttcccagagaataagaagcagccgtgttattatccc
cccttcgataagatcattgagaaggcagctgagcttgccagcggagacagtgctaatgtg
tcaagtcgtggtggaaaaaaatttcttgctgtgctgaaagaaatcttggacagggacccc
ctgtctcagctgtgtgagaacgaaatggaccttatttggactctacggcaagactgccga
gaaaatttccctcagtcactgccaaaactactcttgtcaatcaagtggaataaacttgaa
gatgttgctcagcttcaggcgctcctgcagatatggcccaaactgccccccagggaagcc
ctggaactcctggatttcaactatccagaccagtatgtccgggaatacgctgtaggctgc
cttcgacagatgagtgatgaagaactctctcagtatcttttacaattggtgcaagttttg
aaatatgagccttttctcgattgtgccctctccagattcctattagaaagagcacttgat
aatcggaggattgggcagtttctgttttggcatcttaggtcagaggtgcacactcctgct
gtgtccgtacagtttggtgtcatcctggaagcatactgtcgaggaagcgtggggcacatg
aaagtgctttccaaacaggtggaagcactcaataagttaaaaactttaaatagcttaatc
aaactgaatgcggtgaagctgagcagagctaagggaaaggaggccatgcacacgtgcctg
aaacagagtgcttaccgggaggcgctctctgacctgcagtcgccgctgaacccctgcgtc
atcctctcagagctctatgttgaaaagtgcaaatacatggactccaagatgaagcccctg
tggctggtctacagcagcagagcctttggagaggactcggttggagtgatctttaaaaat
ggtgacgatttgcggcaggacatgctgacgctgcagatgttgcgcctgatggatctgctt
tggaaagaagctggcttggacctgcggatgctcccctatggctgcttagcaacaggagat
cgctctggcctcattgaggttgtgagcacctctgagacaatcgctgacattcagctgaac
agtagtaacgtggctgccacggcagccttcaacaaagacgcactcctgaactggctcaag
gagtacaactctggggatgacctggaccgagcgattgaggagtttaccttgtcctgtgct
ggctactgtgtagcctcttatgtcctcggcattggtgacaggcacagtgacaacatcatg
gtgaagaaaaccggccagctcttccacatagattttgggcatattcttggaaatttcaaa
tctaaatttggcattaaaagggagcgagtaccttttattcttacttatgacttcattcat
gtcattcaacaaggaaaaacgggaaacactgaaaaatttggcagattccgccagtgctgt
gaagatgcgtatctgattttacggcggcatgggaatctcttcatcaccctgtttgccctg
atgttgactgcagggctgcctgagctcacatcggtcaaagatatacagtatcttaaggac
tcgcttgccttagggaagagcgaggaggaagcactgaagcagttcaagcagaagtttgac
gaggccctcagggaaagctggactactaaagtgaactggatggctcacacagtacggaaa
gactacaggtcctag

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