KEGG   Mus musculus (mouse): 74769Help
Entry
74769             CDS       T01002                                 

Gene name
Pik3cb, 1110001J02Rik, AI447572, p110beta
Definition
phosphatidylinositol 3-kinase, catalytic, beta polypeptide (EC:2.7.1.153)
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
mmu  Mus musculus (mouse)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
Module
PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:mmu00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    74769 (Pik3cb)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    74769 (Pik3cb)
   04015 Rap1 signaling pathway
    74769 (Pik3cb)
   04012 ErbB signaling pathway
    74769 (Pik3cb)
   04370 VEGF signaling pathway
    74769 (Pik3cb)
   04630 Jak-STAT signaling pathway
    74769 (Pik3cb)
   04668 TNF signaling pathway
    74769 (Pik3cb)
   04066 HIF-1 signaling pathway
    74769 (Pik3cb)
   04068 FoxO signaling pathway
    74769 (Pik3cb)
   04070 Phosphatidylinositol signaling system
    74769 (Pik3cb)
   04024 cAMP signaling pathway
    74769 (Pik3cb)
   04022 cGMP - PKG signaling pathway
    74769 (Pik3cb)
   04151 PI3K-Akt signaling pathway
    74769 (Pik3cb)
   04152 AMPK signaling pathway
    74769 (Pik3cb)
   04150 mTOR signaling pathway
    74769 (Pik3cb)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    74769 (Pik3cb)
  Cell growth and death
   04210 Apoptosis
    74769 (Pik3cb)
  Cellular commiunity
   04510 Focal adhesion
    74769 (Pik3cb)
   04550 Signaling pathways regulating pluripotency of stem cells
    74769 (Pik3cb)
 Organismal Systems
  Immune system
   04611 Platelet activation
    74769 (Pik3cb)
   04620 Toll-like receptor signaling pathway
    74769 (Pik3cb)
   04650 Natural killer cell mediated cytotoxicity
    74769 (Pik3cb)
   04660 T cell receptor signaling pathway
    74769 (Pik3cb)
   04662 B cell receptor signaling pathway
    74769 (Pik3cb)
   04664 Fc epsilon RI signaling pathway
    74769 (Pik3cb)
   04666 Fc gamma R-mediated phagocytosis
    74769 (Pik3cb)
   04670 Leukocyte transendothelial migration
    74769 (Pik3cb)
   04062 Chemokine signaling pathway
    74769 (Pik3cb)
  Endocrine system
   04910 Insulin signaling pathway
    74769 (Pik3cb)
   04915 Estrogen signaling pathway
    74769 (Pik3cb)
   04914 Progesterone-mediated oocyte maturation
    74769 (Pik3cb)
   04917 Prolactin signaling pathway
    74769 (Pik3cb)
   04921 Oxytocin signaling pathway
    74769 (Pik3cb)
   04919 Thyroid hormone signaling pathway
    74769 (Pik3cb)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    74769 (Pik3cb)
  Digestive system
   04973 Carbohydrate digestion and absorption
    74769 (Pik3cb)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    74769 (Pik3cb)
  Nervous system
   04725 Cholinergic synapse
    74769 (Pik3cb)
   04722 Neurotrophin signaling pathway
    74769 (Pik3cb)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    74769 (Pik3cb)
  Development
   04380 Osteoclast differentiation
    74769 (Pik3cb)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    74769 (Pik3cb)
   05230 Central carbon metabolism in cancer
    74769 (Pik3cb)
   05231 Choline metabolism in cancer
    74769 (Pik3cb)
   05205 Proteoglycans in cancer
    74769 (Pik3cb)
   05203 Viral carcinogenesis
    74769 (Pik3cb)
   05210 Colorectal cancer
    74769 (Pik3cb)
   05212 Pancreatic cancer
    74769 (Pik3cb)
   05214 Glioma
    74769 (Pik3cb)
   05221 Acute myeloid leukemia
    74769 (Pik3cb)
   05220 Chronic myeloid leukemia
    74769 (Pik3cb)
   05218 Melanoma
    74769 (Pik3cb)
   05211 Renal cell carcinoma
    74769 (Pik3cb)
   05215 Prostate cancer
    74769 (Pik3cb)
   05213 Endometrial cancer
    74769 (Pik3cb)
   05222 Small cell lung cancer
    74769 (Pik3cb)
   05223 Non-small cell lung cancer
    74769 (Pik3cb)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    74769 (Pik3cb)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    74769 (Pik3cb)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    74769 (Pik3cb)
   05166 HTLV-I infection
    74769 (Pik3cb)
   05162 Measles
    74769 (Pik3cb)
   05164 Influenza A
    74769 (Pik3cb)
   05161 Hepatitis B
    74769 (Pik3cb)
   05160 Hepatitis C
    74769 (Pik3cb)
   05169 Epstein-Barr virus infection
    74769 (Pik3cb)
   05146 Amoebiasis
    74769 (Pik3cb)
   05145 Toxoplasmosis
    74769 (Pik3cb)
   05142 Chagas disease (American trypanosomiasis)
    74769 (Pik3cb)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     74769 (Pik3cb)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
MGI: 
UniProt: 
Structure
PDB: 

Jmol
Position
9; 9 E4
AA seq 1064 aa AA seqDB search
MPPAMADNLDIWAVDSQIASDGAISVDFLLPTGIYIQLEVPREATISYIKQMLWKQVHNY
PMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPAEKLDSKI
GVLIGKGLHEFDALKDPEVNEFRRKMRKFSEAKIQSLVGLSWIDWLKHTYPPEHEPSVLE
NLEDKLYGGKLVVAVHFENSQDVFSFQVSPNLNPIKINELAIQKRLTIRGKEDEASPCDY
VLQVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFILVECCKIKKMYEQEMIAIEAAINR
NSSNLPLPLPPKKTRVISHIWDNNNPFQITLVKGNKLNTEETVKVHVRAGLFHGTELLCK
TVVSSEISGKNDHIWNEQLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQ
TIRKAGKVHYPVAWVNTMVFDFKGQLRSGDVILHSWSSFPDELEEMLNPMGTVQTNPYAE
NATALHITFPENKKQPCYYPPFDKIIEKAAELASGDSANVSSRGGKKFLAVLKEILDRDP
LSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREA
LELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALD
NRRIGQFLFWHLRSEVHTPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLKTLNSLI
KLNAVKLSRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMDSKMKPL
WLVYSSRAFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGD
RSGLIEVVSTSETIADIQLNSSNVAATAAFNKDALLNWLKEYNSGDDLDRAIEEFTLSCA
GYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIH
VIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQYLKD
SLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3195 nt NT seq  +upstreamnt  +downstreamnt
atgcctcctgctatggcagacaaccttgacatctgggcagtggactcacagattgcatcc
gatggcgccatatccgtcgatttccttctgcccaccgggatttatatccagttggaagta
cctcgggaagctaccatttcttatattaaacagatgttatggaagcaagttcacaactac
ccgatgtttaacctcctcatggacattgactcgtatatgtttgcatgtgtgaatcaaact
gctgtatatgaggaactggaagacgaaacacgaagactttgtgatgtcagaccttttctt
ccagttctcaaactagtgactagaagctgtgaccccgcagaaaaattggactcaaaaatt
ggggttcttataggaaaaggtcttcatgagtttgatgccttgaaggatcccgaagtgaat
gaatttagaagaaaaatgcgcaaattcagtgaggccaagattcagtctctggtagggttg
tcttggatcgactggctaaagcacacgtatccgcctgagcacgagccgtccgtcctggag
aacttggaagataaactttatggaggaaagctggttgtggctgtgcactttgaaaatagc
caggatgtatttagttttcaagtgtctcccaatttgaatcctataaaaataaatgaattg
gcaatccagaaacgcctcactattcgtggaaaggaagatgaagctagcccctgtgactat
gtgttacaggtcagtgggagagtggagtatgtgtttggcgatcatccactaattcagttc
cagtacatccggaattgtgtgatgaatagaaccctgccccacttcatccttgtggaatgt
tgtaagatcaagaaaatgtatgaacaagaaatgattgccatagaggctgccatcaaccga
aactcatccaaccttcctctccctttaccaccaaagaaaacgcgagttatttctcatatc
tgggacaacaacaaccctttccaaattaccttggttaaaggaaataagcttaatacagaa
gaaactgtgaaagttcatgtccgagctgggctttttcacggaaccgagctcctgtgtaaa
accgtcgtaagctcagagatatcaggaaagaacgaccatatttggaatgaacaactggaa
tttgatattaatatttgtgacttaccaagaatggctcgattatgttttgctgtttatgca
gttttggataaagtaaaaacgaagaaatcaacaaagactattaatccctctaagtatcag
accatcaggaaagccgggaaagtgcattatcctgtcgcatgggtaaataccatggttttt
gacttcaaaggacagctgaggtctggagacgtcatattgcatagctggtcttcgtttcct
gatgagctggaagaaatgctgaatcccatggggactgtgcagacgaacccatatgctgag
aacgccaccgccttgcacattacgttcccagagaataagaagcagccgtgttattatccc
cccttcgataagatcattgagaaggcagctgagcttgccagcggagacagtgctaatgtg
tcaagtcgtggtggaaaaaaatttcttgctgtgctgaaagaaatcttggacagggacccc
ctgtctcagctgtgtgagaacgaaatggaccttatttggactctacggcaagactgccga
gaaaatttccctcagtcactgccaaaactactcttgtcaatcaagtggaataaacttgaa
gatgttgctcagcttcaggcgctcctgcagatatggcccaaactgccccccagggaagcc
ctggaactcctggatttcaactatccagaccagtatgtccgggaatacgctgtaggctgc
cttcgacagatgagtgatgaagaactctctcagtatcttttacaattggtgcaagttttg
aaatatgagccttttctcgattgtgccctctccagattcctattagaaagagcacttgat
aatcggaggattgggcagtttctgttttggcatcttaggtcagaggtgcacactcctgct
gtgtccgtacagtttggtgtcatcctggaagcatactgtcgaggaagcgtggggcacatg
aaagtgctttccaaacaggtggaagcactcaataagttaaaaactttaaatagcttaatc
aaactgaatgcggtgaagctgagcagagctaagggaaaggaggccatgcacacgtgcctg
aaacagagtgcttaccgggaggcgctctctgacctgcagtcgccgctgaacccctgcgtc
atcctctcagagctctatgttgaaaagtgcaaatacatggactccaagatgaagcccctg
tggctggtctacagcagcagagcctttggagaggactcggttggagtgatctttaaaaat
ggtgacgatttgcggcaggacatgctgacgctgcagatgttgcgcctgatggatctgctt
tggaaagaagctggcttggacctgcggatgctcccctatggctgcttagcaacaggagat
cgctctggcctcattgaggttgtgagcacctctgagacaatcgctgacattcagctgaac
agtagtaacgtggctgccacggcagccttcaacaaagacgcactcctgaactggctcaag
gagtacaactctggggatgacctggaccgagcgattgaggagtttaccttgtcctgtgct
ggctactgtgtagcctcttatgtcctcggcattggtgacaggcacagtgacaacatcatg
gtgaagaaaaccggccagctcttccacatagattttgggcatattcttggaaatttcaaa
tctaaatttggcattaaaagggagcgagtaccttttattcttacttatgacttcattcat
gtcattcaacaaggaaaaacgggaaacactgaaaaatttggcagattccgccagtgctgt
gaagatgcgtatctgattttacggcggcatgggaatctcttcatcaccctgtttgccctg
atgttgactgcagggctgcctgagctcacatcggtcaaagatatacagtatcttaaggac
tcgcttgccttagggaagagcgaggaggaagcactgaagcagttcaagcagaagtttgac
gaggccctcagggaaagctggactactaaagtgaactggatggctcacacagtacggaaa
gactacaggtcctag

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