KEGG   Mycobacterium tuberculosis Erdman = ATCC 35801: ERDMAN_0561Help
Entry
ERDMAN_0561       CDS       T02526                                 

Gene name
hemD
Definition
uroporphyrin-III C-methyltransferase (EC:2.1.1.107)
Orthology
K13542  
uroporphyrinogen III methyltransferase / synthase [EC:2.1.1.107 4.2.1.75]
Organism
mtn  Mycobacterium tuberculosis Erdman = ATCC 35801
Pathway
Porphyrin and chlorophyll metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Module
Heme biosynthesis, glutamate => protoheme/siroheme
Brite
KEGG Orthology (KO) [BR:mtn00001]
 Metabolism
  Metabolism of cofactors and vitamins
   00860 Porphyrin and chlorophyll metabolism
    ERDMAN_0561 (hemD)
Enzymes [BR:mtn01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.107  uroporphyrinogen-III C-methyltransferase
     ERDMAN_0561 (hemD)
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.75  uroporphyrinogen-III synthase
     ERDMAN_0561 (hemD)
BRITE hierarchy
SSDB OrthologParalogGene clusterGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
UniProt: 
Position
604404..606110
Genome map
AA seq 568 aa AA seqDB search
MTIMTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDL
PPVSGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEAR
SGVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVA
DVRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQR
SVETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWT
VLVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTS
TNAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDD
FPPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTRERIK
TGGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGP
LVDALAEHAARLRAEGALPPPRKKSRRR
NT seq 1707 nt NT seq  +upstreamnt  +downstreamnt
gtgacaatcatgacgcgagggcgtaagccgagaccgggccgcatcgttttcgtgggctcc
ggtccgggcgaccccggcttgcttacgacacgggctgccgcggtgctggccaacgccgcg
ctggtgttcaccgatcccgacgtaccggagccggtggtggcgctgatcggcacggatctg
ccccccgtgtccggcccggcgcccgccgagccggttgccgggaacggcgatgcggccggc
ggaggaagtgcgcaggaacacggccgggccgcgtccgcggtagtctccggtggtcctgac
atccgcccggcgctgggcgatcccgccgatgtggccaagacgctgaccgccgaggcccgt
tcgggtgtcgacgtggtgcggctggtggcgggcgatccgctcacggtggatgcggtaatc
agcgaggtgaacgccgtcgcacgcacccacctgcacatcgaaatcgtgcccggcctggcc
gccagcagcgcggtcccgacctatgccgggttgccgctgggttcgtcgcacaccgtcgcc
gacgtgcgtatcgaccccgaaaacaccgactgggacgcgctggctgccgcacccgggccg
ctgatcctgcaggccaccgcatcgcatctagccgaatcggcccgcagcctgatcgatcac
cagctggccgagtccactccgtgcgtggtgaccgcacacggcaccacctgtcagcagcgt
tcggtcgagaccacacttcagggattgaccgacccggccgtcctgggcgctaccgacccc
gcgtgctccgcaaacgggagggactcccaggccggaccgctgatagtgaccatcggcaag
acggtgaccagtcgggcaaagctgaactggtgggagagccgcgccctctacggctggacg
gtgttggtgccgcgcaccaaggaccaggccggcgagatgagcgagcggctcacgtcgtac
ggcgcgctgccggtggaggtgccgaccatcgccgtcgagccgccgcgcagccccgcgcag
atggagcgcgccgtcaagggcctggtcgatggccgattccagtggatcgtgttcacctcc
accaacgcggtgcgtgcggtgtgggagaagttcggcgagttcggtctggatgcccgcgcg
ttctccggggtgaagatcgcctgtgtcggcgagtcgacggccgaccgggtgcgcgccttc
ggaatcagtcccgagctggtgccctccggggagcagtcctcgcttggcttgctagacgac
ttcccgccctacgacagcgttttcgacccggtgaaccgggttttgctgccgcgcgccgac
atcgccaccgaaacgctggccgagggactgcgagagcgtggctgggagatcgaggacgtc
accgcctaccggaccgtgcgggccgcgccgccgccggccactacccgggaaaggatcaag
acgggcgggtttgacgcggtatgtttcacctccagctcgacggtgcgaaacctggtcggc
atcgccggcaagccgcacgcgcggacgatcatcgcctgcatagggccaaagaccgccgag
accgcagccgagttcggcttgcgggtcgatgtccagccggacaccgccgccatcggcccg
ctggtcgatgcgctggccgagcatgccgcccggttgcgcgctgagggtgcgctgcccccg
ccgcgcaagaagagccgcaggcgctag

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