KEGG   Myotis brandtii (Brandt's bat): 102239669Help
Entry
102239669         CDS       T02920                                 

Gene name
PIK3CA
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
myb  Myotis brandtii (Brandt's bat)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:myb00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    102239669 (PIK3CA)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    102239669 (PIK3CA)
   04015 Rap1 signaling pathway
    102239669 (PIK3CA)
   04012 ErbB signaling pathway
    102239669 (PIK3CA)
   04370 VEGF signaling pathway
    102239669 (PIK3CA)
   04630 Jak-STAT signaling pathway
    102239669 (PIK3CA)
   04668 TNF signaling pathway
    102239669 (PIK3CA)
   04066 HIF-1 signaling pathway
    102239669 (PIK3CA)
   04068 FoxO signaling pathway
    102239669 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    102239669 (PIK3CA)
   04024 cAMP signaling pathway
    102239669 (PIK3CA)
   04022 cGMP - PKG signaling pathway
    102239669 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    102239669 (PIK3CA)
   04152 AMPK signaling pathway
    102239669 (PIK3CA)
   04150 mTOR signaling pathway
    102239669 (PIK3CA)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    102239669 (PIK3CA)
  Cell growth and death
   04210 Apoptosis
    102239669 (PIK3CA)
  Cellular commiunity
   04510 Focal adhesion
    102239669 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    102239669 (PIK3CA)
 Organismal Systems
  Immune system
   04611 Platelet activation
    102239669 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    102239669 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    102239669 (PIK3CA)
   04660 T cell receptor signaling pathway
    102239669 (PIK3CA)
   04662 B cell receptor signaling pathway
    102239669 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    102239669 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    102239669 (PIK3CA)
   04670 Leukocyte transendothelial migration
    102239669 (PIK3CA)
   04062 Chemokine signaling pathway
    102239669 (PIK3CA)
  Endocrine system
   04910 Insulin signaling pathway
    102239669 (PIK3CA)
   04915 Estrogen signaling pathway
    102239669 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    102239669 (PIK3CA)
   04917 Prolactin signaling pathway
    102239669 (PIK3CA)
   04921 Oxytocin signaling pathway
    102239669 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    102239669 (PIK3CA)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    102239669 (PIK3CA)
  Digestive system
   04973 Carbohydrate digestion and absorption
    102239669 (PIK3CA)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    102239669 (PIK3CA)
  Nervous system
   04725 Cholinergic synapse
    102239669 (PIK3CA)
   04722 Neurotrophin signaling pathway
    102239669 (PIK3CA)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102239669 (PIK3CA)
  Development
   04380 Osteoclast differentiation
    102239669 (PIK3CA)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    102239669 (PIK3CA)
   05205 Proteoglycans in cancer
    102239669 (PIK3CA)
   05203 Viral carcinogenesis
    102239669 (PIK3CA)
   05210 Colorectal cancer
    102239669 (PIK3CA)
   05212 Pancreatic cancer
    102239669 (PIK3CA)
   05214 Glioma
    102239669 (PIK3CA)
   05221 Acute myeloid leukemia
    102239669 (PIK3CA)
   05220 Chronic myeloid leukemia
    102239669 (PIK3CA)
   05218 Melanoma
    102239669 (PIK3CA)
   05211 Renal cell carcinoma
    102239669 (PIK3CA)
   05215 Prostate cancer
    102239669 (PIK3CA)
   05213 Endometrial cancer
    102239669 (PIK3CA)
   05222 Small cell lung cancer
    102239669 (PIK3CA)
   05223 Non-small cell lung cancer
    102239669 (PIK3CA)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    102239669 (PIK3CA)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    102239669 (PIK3CA)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    102239669 (PIK3CA)
   05166 HTLV-I infection
    102239669 (PIK3CA)
   05162 Measles
    102239669 (PIK3CA)
   05164 Influenza A
    102239669 (PIK3CA)
   05161 Hepatitis B
    102239669 (PIK3CA)
   05160 Hepatitis C
    102239669 (PIK3CA)
   05169 Epstein-Barr virus infection
    102239669 (PIK3CA)
   05146 Amoebiasis
    102239669 (PIK3CA)
   05145 Toxoplasmosis
    102239669 (PIK3CA)
   05142 Chagas disease (American trypanosomiasis)
    102239669 (PIK3CA)
Enzymes [BR:myb01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     102239669 (PIK3CA)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
UniProt: 
Position
Un
AA seq 1069 aa AA seqDB search
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLVTIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDYVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWGINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLEMEFDWF
SSSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDP
LSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAM
ELLDCNYPDPMVRSFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALT
NQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDIL
KQEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPL
WLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCL
SIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTR
SCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQD
FLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDI
AYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3210 nt NT seq  +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
acattagtaactataaagcatgaactatttaaagaagcaagaaagtaccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgatcttcggctctttcaaccctttttaaaa
gtaattgagccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggctttgct
atcggcatgccagtgtgtgaatttgacatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttagggatcttaattcacctcac
agtagagcaatgtatgtttatcctccaaatgtagaatcttcaccagaattgccaaaacac
atatataataaattagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgattatgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcatctgaacaactaaaa
ctttgtgttctagaatatcagggcaaatatattttaaaagtgtgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcaatataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaggaaagcctttactcgcagctgccaatggac
tgttttacaatgccatcttattccagacgcatctccacagctacaccatatatgaatgga
gaaacctctacaaaatccctttggggtataaatagtgcactcagaataaaaattctttgt
gcaacctatgtaaatgtaaatattcgagacattgacaagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgataatgtgaacactcaaagagtaccttgttccaat
cctaggtggaatgaatggctgaattatgacatatacattcctgatcttcctcgtgctgct
cggctttgcctttccatttgttctgttaaaggtcgaaaaggtgctaaagaggaacactgt
ccattggcgtggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaatcctattggt
gttactgggtcaaatccaaataaagaaaccccatgcttagagatggagtttgactggttc
agcagcagtgtggtaaagtttccagatatgtcagtgattgaagagcatgccaactggtct
gtgtcccgagaagcaggatttagttattcccatgcaggactgagtaacagactagctaga
gacaacgaattaagggaaaatgataaagaacagctccgagcaatttgtacccgagatcct
ctctctgaaatcactgagcaggagaaagattttctttggagccacagacactattgtgta
actatccctgaaattctacccaaattgcttctgtctgttaaatggaattctagagatgaa
gtagctcagatgtactgcttggtaaaagactggcctccaatcaaacccgaacaagctatg
gagcttctggactgcaactacccagaccctatggttcgaagttttgctgttcgatgctta
gaaaaatatttaacagatgacaaactttctcagtatctaattcagctagtacaggtccta
aaatatgaacagtatttggataacctgcttgtgagatttttactcaaaaaagcgttgact
aatcaaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaaca
gttagtcagaggtttggcctgcttttggaatcctactgccgtgcatgtgggatgtatttg
aagcacctgaacaggcaagtcgaggctatggaaaagctcatcaatttaactgacattctc
aaacaagagaagaaggatgagactcaaaaggtacagatgaaatttttagttgagcagatg
cggcgaccagatttcatggatgctctacagggctttctatctcctctaaatcctgctcat
caattaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactg
tggttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatc
atctttaaaaatggggatgatttgcggcaagatatgctaacacttcaaattattcgcatt
atggaaaatatctggcaaaatcaaggtcttgatcttcgaatgttgccttatggctgcctg
tccattggggactgtgtggggctcattgaggtggtgagaaactctcacaccatcatgcag
atccagtgcaaagggggcctgaaaggggccctgcagttcaacagccacacgctgcaccag
tggctcaaggacaagaacaaaggggaaatatacgatgcagccattgatctgtttacacgt
tcatgtgctggatattgtgtcgctaccttcattttgggaattggagatcgtcacaatagc
aacatcatggttaaagatgatggacaactgttccatatagattttggacactttttggat
cacaagaagaaaaaatttggttataaacgagaacgtgtgccatttgttttgacacaagat
ttcttaatagtgattagtaaaggagcccaggaatgcaccaagacaagagaatttgagagg
tttcaggagatgtgttacaaagcttatctagctatccggcagcatgccaatctcttcata
aatcttttctcaatgatgcttggctctgggatgccagaactacaatcttttgatgatatt
gcatacattcgaaagaccctagctttagataaaactgagcaagaggctttggaatatttc
atgaagcaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttc
cacacaattaagcagcatgctttgaactga

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