Entry |
|
Name |
Mutation-activated EGFR to PLCG-ERK signaling pathway
|
Definition |
EGFR* -> PLCG -> IP3 -> (Ca2+,DAG) -> PKC -> RAF -> MEK -> ERK -> CCND1 |
Expanded |
(1956v2,1956v3) -> (5335,5336) -> C01245 -> (C00076,C00165) -> (5578,5579,5582) -> (369,673,5894) -> (5604,5605) -> (5594,5595) -> 595 |
Class |
|
Type |
Variant
|
Pathway |
|
Disease |
H00014 | Non-small cell lung cancer |
|
Gene |
1956 | EGFR; epidermal growth factor receptor |
5335 | PLCG1; phospholipase C gamma 1 |
5336 | PLCG2; phospholipase C gamma 2 |
5578 | PRKCA; protein kinase C alpha |
5579 | PRKCB; protein kinase C beta |
5582 | PRKCG; protein kinase C gamma |
369 | ARAF; A-Raf proto-oncogene, serine/threonine kinase |
673 | BRAF; B-Raf proto-oncogene, serine/threonine kinase |
5894 | RAF1; Raf-1 proto-oncogene, serine/threonine kinase |
5604 | MAP2K1; mitogen-activated protein kinase kinase 1 |
5605 | MAP2K2; mitogen-activated protein kinase kinase 2 |
5594 | MAPK1; mitogen-activated protein kinase 1 |
5595 | MAPK3; mitogen-activated protein kinase 3 |
|
Variant |
1956v2 (EGFR*) EGFR mutation in non-small cell lung cancer
1956v3 (EGFR*) First generation TKI-resistant EGFR mutation
|
Metabolite |
C01245 | D-myo-Inositol 1,4,5-trisphosphate |
|
Reference |
|
Authors |
Osada H, Takahashi T. |
Title |
Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer. |
Journal |
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