Entry |
|
Name |
Deleted PTEN to PI3K signaling pathway
|
Definition |
PTEN* // PIP3 -> AKT |
Expanded |
5728v1 // C05981 -> (207,208,10000) |
Class |
|
Type |
Variant
|
Pathway |
|
Disease |
|
Gene |
5728 | PTEN; phosphatase and tensin homolog |
207 | AKT1; AKT serine/threonine kinase 1 |
208 | AKT2; AKT serine/threonine kinase 2 |
10000 | AKT3; AKT serine/threonine kinase 3 |
|
Variant |
|
Metabolite |
C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
|
Reference |
|
Authors |
Chalhoub N, Baker SJ |
Title |
PTEN and the PI3-kinase pathway in cancer. |
Journal |
|
Reference |
|
Authors |
Soni D, King JA, Kaye AH, Hovens CM. |
Title |
Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge. |
Journal |
|
Reference |
|
Authors |
Curtin JA, Fridlyand J, Kageshita T, Patel HN, Busam KJ, Kutzner H, Cho KH, Aiba S, Brocker EB, LeBoit PE, Pinkel D, Bastian BC |
Title |
Distinct sets of genetic alterations in melanoma. |
Journal |
|
Reference |
|
Authors |
Miller AJ, Mihm MC Jr. |
Title |
Melanoma. |
Journal |
|