KEGG NETWORK: N00133

NETWORK: N00133

Entry

N00133                      Network

Name

EWSR1-FLI1 fusion to transcriptional activation

Definition

EWSR1-FLI1 => (IGF1,MYC,ID2)

Expanded

2313v1 => (3479,4609,3398)

Class

nt06240 Transcription (cancer)

Type

Variant

Disease

H00035

Ewing sarcoma

Gene

2313	FLI1; Fli-1 proto-oncogene, ETS transcription factor

3479	IGF1; insulin like growth factor 1

4609	MYC; MYC proto-oncogene, bHLH transcription factor

3398	ID2; inhibitor of DNA binding 2, HLH protein

Variant

2313v1 (EWSR1-FLI1) EWSR1-FLI1 fusion

Reference

PMID:19738075

Authors

Ordonez JL, Osuna D, Herrero D, de Alava E, Madoz-Gurpide J

Title

Advances in Ewing's sarcoma research: where are we now and what lies ahead?

Journal

Cancer Res 69:7140-50 (2009)
DOI:10.1158/0008-5472.CAN-08-4041

Reference

PMID:17250957

Authors

Riggi N, Stamenkovic I.

Title

The Biology of Ewing sarcoma.

Journal

Cancer Lett 254:1-10 (2007)
DOI:10.1016/j.canlet.2006.12.009

Reference

PMID:20490326

Authors

Jedlicka P

Title

Ewing Sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions.

Journal

Int J Clin Exp Pathol 3:338-47 (2010)

Reference

PMID:18648544

Authors

Cironi L, Riggi N, Provero P, Wolf N, Suva ML, Suva D, Kindler V, Stamenkovic I

Title

IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells.

Journal

PLoS One 3:e2634 (2008)
DOI:10.1371/journal.pone.0002634

Reference

PMID:12527902

Authors

Fukuma M, Okita H, Hata J, Umezawa A

Title

Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma.

Journal

Oncogene 22:1-9 (2003)
DOI:10.1038/sj.onc.1206055

Reference

PMID:15826838

Authors

Aman P

Title

Fusion oncogenes in tumor development.

Journal

Semin Cancer Biol 15:236-43 (2005)
DOI:10.1016/j.semcancer.2005.01.009

All links

Network (1)   
   KEGG VARIANT (1)   
Gene (4)   
   KEGG GENES (4)   
Literature (6)   
   PubMed (6)   
All databases (11)   

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