Entry |
|
Name |
EBV EBNA3C to p53-mediated transcription
|
Definition |
EBNA3C -> MDM2 -| TP53 => (CDKN1A,GADD45,BAX,BAK1,DDB2,POLK) |
Expanded |
K19458 -> 4193 -| 7157 => (1026,1647,4616,10912,581,578,1643,51426) |
Class |
|
Type |
Pathogen
|
Pathway |
|
Disease |
|
Gene |
4193 | MDM2; MDM2 proto-oncogene |
7157 | TP53; tumor protein p53 |
1026 | CDKN1A; cyclin dependent kinase inhibitor 1A |
1647 | GADD45A; growth arrest and DNA damage inducible alpha |
4616 | GADD45B; growth arrest and DNA damage inducible beta |
10912 | GADD45G; growth arrest and DNA damage inducible gamma |
581 | BAX; BCL2 associated X, apoptosis regulator |
578 | BAK1; BCL2 antagonist/killer 1 |
1643 | DDB2; damage specific DNA binding protein 2 |
51426 | POLK; DNA polymerase kappa |
|
Perturbant |
K19458 (EBNA3C) | EBNA6; EBV nuclear antigen 6 |
|
Reference |
|
Authors |
Saha A, Robertson ES |
Title |
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes. |
Journal |
|
Reference |
|
Authors |
Maruo S, Johannsen E, Illanes D, Cooper A, Zhao B, Kieff E |
Title |
Epstein-Barr virus nuclear protein 3A domains essential for growth of lymphoblasts: transcriptional regulation through RBP-Jkappa/CBF1 is critical. |
Journal |
|
Reference |
|
Authors |
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM |
Title |
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers. |
Journal |
|
Reference |
|
Authors |
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES |
Title |
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2. |
Journal |
|
Reference |
|
Authors |
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES |
Title |
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities. |
Journal |
|