KEGG   MODULE: nfa_M00121Help
Entry
nfa_M00121        Pathway   Module                                 
Name
Heme biosynthesis, glutamate => protoheme/siroheme
Definition
(K01885,K14163) K02492 K01845 K01698 K01749 (K01719,K13542,K13543)
K01599 (K00228,K02495) (K00230,K00231) K01772
(K02302,(K00589,K02303,K02496,K13542,K13543)+K02304+K03794)
Module map
nfa_M00121

Orthology
glutamyl-tRNA synthetase [EC:6.1.1.17] [RN:R05578]
K02492  
glutamyl-tRNA reductase [EC:1.2.1.70] [RN:R04109]
K01845  
glutamate-1-semialdehyde 2,1-aminomutase [EC:5.4.3.8] [RN:R02272]
K01698  
porphobilinogen synthase [EC:4.2.1.24] [RN:R00036]
K01749  
hydroxymethylbilane synthase [EC:2.5.1.61] [RN:R00084]
uroporphyrinogen-III synthase [EC:4.2.1.75] [RN:R03165]
K01599  
uroporphyrinogen decarboxylase [EC:4.1.1.37] [RN:R03197]
K00228  
coproporphyrinogen III oxidase [EC:1.3.3.3] [RN:R03220]
K02495  
oxygen-independent coproporphyrinogen III oxidase [EC:1.3.99.22] [RN:R06895]
protoporphyrinogen oxidase [EC:1.3.3.4 1.3.5.3] [RN:R03222 R09489]
K01772  
ferrochelatase [EC:4.99.1.1] [RN:R00310]
uroporphyrin-III C-methyltransferase [EC:2.1.1.107] [RN:R03194]
precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase [EC:1.3.1.76 4.99.1.4] [RN:R03947 R02864]
K03794  
sirohydrochlorin ferrochelatase [EC:4.99.1.4] [RN:R02864]
Ortholog tableTaxonomy
Class
Pathway module; Nucleotide and amino acid metabolism; Cofactor and vitamin biosynthesis
BRITE hierarchy
Pathway
Porphyrin and chlorophyll metabolism
Organism
Nocardia farcinica [GN:nfa]
Gene
coproporphyrinogen III oxidase [KO:K02495]
glutamyl-Q tRNA(Asp) synthetase [KO:K01885]
hemH; ferrochelatase (EC:4.99.1.1) [KO:K01772]
protoporphyrinogen oxidase (EC:1.3.3.4) [KO:K00231]
hemE; uroporphyrinogen decarboxylase (EC:4.1.1.37) [KO:K01599]
cysG; uroporphyrinogen III methylase [KO:K02302]
gltX; glutamyl-tRNA synthetase (EC:6.1.1.17) [KO:K01885]
bifunctional uroporphyrinogen-III synthetase/response regulator domain protein (EC:4.2.1.75) [KO:K01719]
hypothetical protein [KO:K01885]
hypothetical protein [KO:K01885]
hemL; glutamate-1-semialdehyde aminotransferase (EC:5.4.3.8) [KO:K01845]
hemB; delta-aminolevulinic acid dehydratase (EC:4.2.1.24) [KO:K01698]
hemDX; uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase [KO:K13542]
hemC; porphobilinogen deaminase (EC:2.5.1.61) [KO:K01749]
hemA; glutamyl-tRNA reductase [KO:K02492]
Reaction
Compound
C00025  
L-Glutamate
C02987  
L-Glutamyl-tRNA(Glu)
C03741  
(S)-4-Amino-5-oxopentanoate
C00430  
5-Aminolevulinate
C00931  
Porphobilinogen
C01024  
Hydroxymethylbilane
C01051  
Uroporphyrinogen III
C03263  
Coproporphyrinogen III
C01079  
Protoporphyrinogen IX
C02191  
Protoporphyrin
C00032  
Heme
C02463  
Precorrin 2
C05778  
Sirohydrochlorin
C00748  
Siroheme
Other DBs
BSID: 
KO module

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