KEGG   Nannospalax galili (Upper Galilee mountains blind mole rat): 103740537
Entry
103740537         CDS       T03372                                 
Symbol
Pdhb
Name
(RefSeq) pyruvate dehydrogenase (lipoamide) beta
  KO
K00162  pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1]
Organism
ngi  Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
ngi00010  Glycolysis / Gluconeogenesis
ngi00020  Citrate cycle (TCA cycle)
ngi00620  Pyruvate metabolism
ngi00785  Lipoic acid metabolism
ngi01100  Metabolic pathways
ngi01200  Carbon metabolism
ngi01210  2-Oxocarboxylic acid metabolism
ngi04066  HIF-1 signaling pathway
ngi04922  Glucagon signaling pathway
ngi05230  Central carbon metabolism in cancer
ngi05415  Diabetic cardiomyopathy
Module
ngi_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:ngi00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    103740537 (Pdhb)
   00020 Citrate cycle (TCA cycle)
    103740537 (Pdhb)
   00620 Pyruvate metabolism
    103740537 (Pdhb)
  09108 Metabolism of cofactors and vitamins
   00785 Lipoic acid metabolism
    103740537 (Pdhb)
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    103740537 (Pdhb)
 09150 Organismal Systems
  09152 Endocrine system
   04922 Glucagon signaling pathway
    103740537 (Pdhb)
 09160 Human Diseases
  09161 Cancer: overview
   05230 Central carbon metabolism in cancer
    103740537 (Pdhb)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    103740537 (Pdhb)
Enzymes [BR:ngi01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.1  pyruvate dehydrogenase (acetyl-transferring)
     103740537 (Pdhb)
SSDB
Motif
Pfam: Transket_pyr Transketolase_C
Other DBs
NCBI-GeneID: 103740537
NCBI-ProteinID: XP_008839413
UniProt: A0A8C6W623
Position
Un
AA seq 359 aa
MAVVAGLLRRPLRQVSGLLKRRFHRSAPAAVQLTVREAINQGMDEELERDETVFLLGEEV
AQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAI
DQVINSAAKTYYMSAGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNS
EDAKGLIKSAIRDNNPVVMLENELMYGVAFELPPEAQSKDFLIPIGKAKIEKQGNHITIV
AHSRPVGHCMEAAAVLSKEGIECEVINLRTIRPMDIEAIEASVMKTNHLITVEGGWPQFG
VGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSVPQVKDIIFAVKKTLNI
NT seq 1080 nt   +upstreamnt  +downstreamnt
atggcggtggtggcgggtctgttacggagacctctgcggcaggtttccgggctgctgaag
aggcgttttcatcgctcggcgcccgcggcggtacagctgacagttcgtgaagctattaat
caaggtatggatgaagaactagaaagagatgaaacggtgtttctgcttggggaagaagtc
gcccagtatgatggtgcttacaaggttagccgaggtctgtggaagaagtatggtgacaag
aggatcatcgacactcccatatcagagatgggctttgctgggatcgctgtaggtgcagct
atggctgggttgcgacccatctgtgaatttatgaccttcaatttctctatgcaagccatc
gatcaggttataaactcagctgccaagacttactacatgtccgctggcctccagcctgtg
cccatagtattcagggggcccaatggtgcctctgcaggtgtagctgctcaacactcacag
tgctttgctgcctggtatgggcactgcccgggcttaaaagtggtcagcccctggaattca
gaggatgcgaaaggactcattaaatcagccattcgtgataataatccagtggtgatgcta
gagaatgaattgatgtatggagtagcatttgaacttcctccagaagctcagtcaaaagat
tttctcattcctattgggaaggccaaaatcgaaaagcaagggaaccacataactatagtt
gcccattcgagacctgtgggccactgtatggaagctgcagccgtgctgtctaaagaggga
atcgaatgtgaggtgataaacttgcgtaccatcagaccaatggacattgaagccatagaa
gccagtgtcatgaagacaaatcatctcataactgtggaaggaggctggcctcaatttggc
gtaggcgctgagatttgtgccagaatcatggaaggccctgccttcaatttcctggatgct
cctgctgttcgtgtcactggtgctgacgtccctatgccttatgcaaagattctagaagac
aactctgtacctcaggttaaagacatcatatttgcagtaaagaaaacattaaatatataa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (12)   
   KEGG PATHWAY (11)   
   KEGG MODULE (1)   
Chemical substance (11)   
   KEGG COMPOUND (11)   
Chemical reaction (5)   
   KEGG ENZYME (1)   
   KEGG REACTION (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   RefSeq(pep) (2)   
DNA sequence (4)   
   RefSeq(nuc) (2)   
   GenBank (1)   
   EMBL (1)   
Protein domain (2)   
   Pfam (2)   
All databases (46)   

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