KEGG   Nannospalax galili (Upper Galilee mountains blind mole rat): 103743312Help
Entry
103743312         CDS       T03372                                 

Gene name
Insr
Definition
(RefSeq) insulin receptor
  KO
K04527  
insulin receptor [EC:2.7.10.1]
Organism
ngi  Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phospholipase D signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Longevity regulating pathway
Longevity regulating pathway - multiple species
Adherens junction
Insulin signaling pathway
Ovarian steroidogenesis
Regulation of lipolysis in adipocytes
Type II diabetes mellitus
Insulin resistance
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Module
PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:ngi00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    103743312 (Insr)
   04015 Rap1 signaling pathway
    103743312 (Insr)
   04010 MAPK signaling pathway
    103743312 (Insr)
   04066 HIF-1 signaling pathway
    103743312 (Insr)
   04068 FoxO signaling pathway
    103743312 (Insr)
   04072 Phospholipase D signaling pathway
    103743312 (Insr)
   04022 cGMP - PKG signaling pathway
    103743312 (Insr)
   04151 PI3K-Akt signaling pathway
    103743312 (Insr)
   04152 AMPK signaling pathway
    103743312 (Insr)
   04150 mTOR signaling pathway
    103743312 (Insr)
 Cellular Processes
  Cellular community - eukaryotes
   04520 Adherens junction
    103743312 (Insr)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    103743312 (Insr)
   04923 Regulation of lipolysis in adipocyte
    103743312 (Insr)
   04913 Ovarian Steroidogenesis
    103743312 (Insr)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    103743312 (Insr)
  Aging
   04211 Longevity regulating pathway - mammal
    103743312 (Insr)
   04213 Longevity regulating pathway - multiple species
    103743312 (Insr)
 Human Diseases
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    103743312 (Insr)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    103743312 (Insr)
   04931 Insulin resistance
    103743312 (Insr)
Enzymes [BR:ngi01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     103743312 (Insr)
Protein kinases [BR:ngi01001]
 Tyrosine protein kinases
  InsR family [OT]
   103743312 (Insr)
Enzyme-linked receptors [BR:ngi01020]
 Receptor tyrosine kinases
  RTK class II (Insulin receptor family)
   103743312 (Insr)
Cytokine receptors [BR:ngi04050]
 Receptor tyrosine kinase
  RTK class II (Insulin receptor family)
   103743312 (Insr)
CD molecules [BR:ngi04090]
 Proteins
  103743312 (Insr)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
Position
Un
AA seq 1382 aa AA seqDB search
MGAGARRGATAAPLLVAVAALLVGAAGHLYPGEVCPGMDIRNNLTRLQELENCSVIEGHL
QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL
VIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE
ECGDVCPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHTECL
GNCSEPDDPTKCVACRNFYLEGRCVETCPPPFYHFQDWRCVNFSFCQDLHYKCKNSRKPG
CHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPKVCQILEGEKTIDSVTSAQELRGC
TVVNGSLIINIRGGNNLAAELEANLGLIEEISGFLKIRRSYALVSLSFFRKLRLIRGETL
EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE
RNDIALKTNGDQASCENELLKFSFIRTSFDKILLKWEPYWPPDFRDLLGFMLFYKEAPYQ
NVTEFDGQDACGSNSWTVVDIDPPQRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS
DERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVYWE
RQAEDSELFELDYCLKGLKLPSRTWSPPFESDDSQKHNQSEYDDAAGECCSCPKTDSQIL
KELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGEVGNVTAAMPTLPDF
PNISSTITPTSQEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPEERCSVAAYV
SARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPREPNGLIVLYEVSYRRYGDEELHMCV
SRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIG
PLIFVFLFSVVIGSIYLFLRKRQPDGPMGPLYASSNPEYLSASDVFPCSVYVPDEWEVPR
EKITLLRELGQGSFGMVYEGNAKDIIKGEAETRVAVKTVNEAASLRERIEFLNEASVMKG
FTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRPESENNPGRPPPTLQEMIQMA
AEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPV
RWMAPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDPPDN
CADRLTDLMRMCWQFNPKMRPTFLEIVSLLKDDLHPSFPEVSFFHSEENKAPENEELEME
FEDMENVPLDRSSRCQREEAGGREGGSSLSIKRNYEDHIPYTHMNGGKRNGRILTLPRSN
PS
NT seq 4149 nt NT seq  +upstreamnt  +downstreamnt
atgggcgctggggcaaggcggggggccacggccgcaccgctgctggtggcggtggccgcg
ttgctggtgggtgcagccggccacctgtatcctggagaggtgtgtcccggcatggatatt
cggaacaacctcaccaggctgcaggaactggagaactgctcggtcattgagggccatctg
cagattctcctcatgttcaaaacgagacccgaagatttccgcgacctcagtttccccaag
ctcatcatgatcactgactatctgctgctcttccgggtctacgggctggaaagcctgaaa
gacctcttccctaacctcacggtcatccgtggctcccgcctctttttcaactacgcccta
gttatctttgagatggtgcacttgaaggagctggggctctacaacctcatgaatatcacc
cggggctctgtccgcatcgagaagaataacgagctctgctacttggccaccatcgactgg
tcccggatcctggattctgtggaagacaactacatcgttctgaacaaagatgataatgag
gagtgcggggacgtctgtcctggcaccgcgaagggcaagaccaactgccctgccaccgtc
atcaacgggcagttcgtggaacgttgctggacacatagccattgtcagaaagtgtgccca
accatctgtaaatcacatggctgcacagcggaaggcctgtgctgccacacggaatgcctg
ggcaactgttctgagcctgatgaccccaccaagtgcgtggcctgtcgcaatttctacttg
gaaggtcggtgtgtggagacctgtccgccccccttctaccacttccaggactggcgctgt
gtgaacttcagcttttgccaagacctgcactacaaatgcaagaactcaaggaagccaggc
tgccaccaatacgtcattcacaataacaagtgcatccctgagtgtccttctggctacacc
atgaactccagcaacttgatgtgcaccccgtgtctgggaccatgtcctaaggtctgtcaa
atccttgaaggcgagaagaccatcgattcagtaacatctgctcaggagcttcgaggctgc
actgtggtcaatggcagcctgatcatcaacattcgagggggcaacaacttggcagctgaa
ctggaggctaaccttggcctcatcgaagaaatttcagggttcctaaagatccgccgatcg
tatgctctggtatcactttctttcttccgaaagctacgtctgattcgaggagagaccttg
gaaattgggaactactctttctatgccttggacaaccagaacctgcggcagctgtgggac
tggagcaaacacaatctcaccatcactcagggcaagctcttcttccactacaatcccaag
ctctgcttgtctgaaattcacaagatggaggaagtttccggaaccaagggtcgccaggag
agaaacgacattgccctgaagaccaatggggatcaggcatcctgtgaaaatgaattgctt
aaattttctttcattcgaacatcttttgacaagatcttgctgaaatgggagccctactgg
ccccccgacttccgggacctcttgggattcatgcttttctacaaagaggccccttatcag
aatgtgacagagtttgatgggcaggatgcatgtggttccaacagctggaccgtggtagat
attgacccaccccagaggtccaatgatcccaagtcccagaaccaccctgggtggctgatg
cggggcctcaagccctggacccagtatgctatctttgtcaagaccttggtgaccttctct
gatgaacgccggacctatggggccaagagtgacatcatctatgttcagacagatgccacc
aatccttccgttcccctggatcccatatcagtttctaattcctcatcccagattatcttg
aaatggaagcccccatcagaccccaatggcaacatcactcactatttggtatactgggag
aggcaggcggaagacagtgagcttttcgagttggattattgtctcaaagggctgaagctc
ccctcaaggacctggtccccaccttttgagtctgatgactcacagaagcacaatcagagt
gagtacgatgacgcagctggtgaatgctgctcgtgcccaaagaccgattcccagatcctg
aaggagctggaggagtcctcgtttaggaagacctttgaggattacctgcacaatgtggtt
tttgtccccagaaaaacctcttcaggcactggtgctgaggaccctaggccatcccggaaa
cgcagatcccttggagaagtggggaatgtgacggctgccatgcccactctcccagatttt
cctaacatctcttccaccatcacacctacgagccaggaggagcacaggccctttgaaaaa
gtggttaacaaggagtccctggttatctctggccttcggcacttcactggctaccgtatc
gagctgcaggcgtgtaaccaagactccccggaagagaggtgcagtgtggctgcctatgtc
agtgcccggaccatgcctgaagctaaggcagatgacattgttggccctgtgacccatgaa
atctttgagaacaatgttgtacacttgatgtggcaagagccaagggaacccaatggtttg
attgtgctgtatgaagtaagctatcggcggtatggtgatgaggagctacacatgtgtgtt
tctcggaagcattttgccctggaacggggctgcaggctgagagggctctcccctggaaac
tacagtgttcgaatccgggccacctctctggcgggcaatggctcctggacagaacccacc
tatttctacgtgacagattacttagatgtcccatcaaatattgccaaaattatcatcggc
ccactcatctttgtgttcctcttcagtgttgtgattggaagtatttatctattcctgaga
aagaggcagccggatgggccaatgggaccactgtatgcgtcttcaaacccagagtacctc
agtgccagtgatgtgtttccatgttctgtgtacgtaccggatgagtgggaagtgcctcga
gagaagatcaccctcctccgagagctggggcaaggctccttcggcatggtgtatgagggc
aatgccaaggacatcatcaagggcgaggcagagacccgtgtggctgtgaagacagtcaat
gaggcagccagcctccgagaaaggatcgagttcctcaacgaggcatccgtcatgaagggc
ttcacctgtcaccatgtggtccgcctccttggagtggtgtccaagggccagccgacactg
gtggtgatggagttgatggctcatggagacctgaagagccacctccgttctctgcgtcca
gagtctgagaataaccctggccgccctccccctaccctacaagagatgattcagatggca
gcagagattgctgatggcatggcgtacttgaatgccaagaagtttgtgcaccgagacctg
gcagctcgaaactgcatggttgcccatgatttcactgtcaaaattggagacttcggaatg
accagagacatctacgagacagattactaccggaaagggggcaaaggcctgctgcctgtg
cggtggatggcacccgagtccctgaaggatggagtctttactgcttcttctgacatgtgg
tcctttggggtggtcctttgggaaatcaccagcctggcggaacagccttatcaaggcctg
tctaatgagcaggtgttgaaatttgtcatggatggaggctatctggatccgccggataac
tgtgctgacagactcaccgacctgatgcgcatgtgctggcagttcaaccccaagatgcgg
ccgacattcctggagatcgtcagcctcctcaaggatgacctacaccccagctttccagaa
gtttccttcttccacagcgaggagaacaaggctcctgagaacgaagagctggagatggag
tttgaggacatggagaacgttccgttggatcggtcctctcgctgtcagagggaggaggct
gggggccgggagggagggtcctctctcagcatcaaacggaactatgaagaccacatcccc
tacacccacatgaacggaggcaagaggaatggacgcatcctcactttgcctagatcaaat
ccttcctaa

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