KEGG   Nannospalax galili (Upper Galilee mountains blind mole rat): 103744072
Entry
103744072         CDS       T03372                                 
Name
(RefSeq) steroid 17-alpha-hydroxylase/17,20 lyase
  KO
K00512  steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:1.14.14.19 1.14.14.32]
Organism
ngi  Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
ngi00140  Steroid hormone biosynthesis
ngi01100  Metabolic pathways
ngi04913  Ovarian steroidogenesis
ngi04917  Prolactin signaling pathway
ngi04927  Cortisol synthesis and secretion
ngi04934  Cushing syndrome
Module
ngi_M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
ngi_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
ngi_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
ngi_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:ngi00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    103744072
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    103744072
   04917 Prolactin signaling pathway
    103744072
   04927 Cortisol synthesis and secretion
    103744072
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    103744072
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:ngi00199]
    103744072
Enzymes [BR:ngi01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.19  steroid 17alpha-monooxygenase
     103744072
    1.14.14.32  17alpha-hydroxyprogesterone deacetylase
     103744072
Cytochrome P450 [BR:ngi00199]
 Cytochrome P450, animal type
  CYP17 family
   103744072
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 103744072
NCBI-ProteinID: XP_008843945
UniProt: A0A8C6S079
Position
Un
AA seq 508 aa
MWELVGLLLLILAYIFWSNSKFSGAKFPKSLPFLPVVGSLPFLPRHGHLHVNLFKLQKKY
GPIYSLRLGTTTTVIIGHYQLAKEVLIKKGKEFSGRPQMVTLSLLSDQGKGIAFADSGAH
WQQHRKLVLGTFSLFRDGDLKLEKIICREVSALCDLLLTYNEKSLDLALPVFMSIINVIC
SICFNISYKNGDPKLTTIKTFTEGILDNLGSENLVDIFPWLTIFPNKALEMIKRYVKMRD
EVLTELLEKRKEKFSSDSITNLMDVLIQAKMNADNNNASPDQNSNMFSDKHILATIADIF
GAGVETTTSVVSWIVAFLLHNPQVKMKIQKEIDHNIGFNRTPTFNDRTHLLMLEATIREV
LRIRPVAPMLIPHKANIDSSIGEFTIPKDTHVVINLWALHHNEKEWKQPDQFMPERFLDP
TGSHIINPSLSYLPFGAGPRSCVGEVLARQELFLIMAWLLQRFDLDVPDDGQLPCLTGDP
KVVFLINPFKVKLKVRQAWKDAQAEVNA
NT seq 1527 nt   +upstreamnt  +downstreamnt
atgtgggaacttgtgggtctcttgctgctcatcctagcctatatattttggtctaattca
aagttctctggtgctaagttccccaagagcctcccattcttgcccgtggtgggcagcctg
ccatttctccccagacatggccatttgcatgtcaacttattcaagctgcagaaaaaatat
ggccccatctattctcttcgtctgggtaccacaactacagtgatcatcggtcactatcag
ctggccaaggaagtccttatcaagaagggcaaggagttctccgggcggccccagatggtg
actctcagcctgctgtcggaccagggaaaaggcattgcctttgccgactccggtgcccat
tggcagcagcatcggaaactggtgctgggtaccttctccctgttcagggatggtgacctg
aagctggagaagatcatatgtcgggaggtcagcgcactgtgcgatttgctgcttacctac
aacgagaagtccttagatctggccctgcctgtctttatgtcaattatcaacgtcatctgc
tccatctgcttcaacatctcttacaagaatggggacccaaaattgaccaccataaagacc
tttacggagggcatcctggataatttgggcagcgaaaatctagtggacatattcccatgg
ttgacgattttccccaataaagccctggaaatgataaagaggtatgttaaaatgcgagat
gaagtgctgactgaactactggaaaaacgcaaggagaaattcagcagtgactctatcacc
aacctgatggacgtgctgatacaagccaagatgaatgcagacaacaacaatgccagtcca
gaccagaattcaaatatgttttcagataagcacatccttgccacaatagcagatatcttt
ggggccggtgtggagaccaccacctctgtggtgagttggattgtggccttcctgctgcac
aatcctcaggtgaagatgaagattcaaaaggagattgaccataatataggtttcaaccgt
accccaactttcaatgatcggactcacctcctcatgctggaggccaccatccgagaggtg
cttcgcatcaggccagtggcccccatgctcatcccccacaaggctaacattgactccagc
attggcgagtttaccatccccaaggacacacatgtggtcatcaacctgtgggcactgcat
cacaatgagaaagagtggaagcaaccagatcagttcatgcccgaacgcttcttggatcca
acagggagccacatcatcaatccttccttgagctacttgcctttcggggccggtccccgc
tcctgtgtaggggaagtcctggcccgccaggagctcttcctcatcatggcctggttgctg
cagagatttgacttagatgtgccagatgatgggcagctgccctgcctgacgggtgacccc
aaggtggtctttctgatcaacccattcaaagtgaagcttaaggtgcgccaggcctggaag
gatgcccaggctgaggttaatgcctag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (10)   
   KEGG PATHWAY (6)   
   KEGG MODULE (4)   
Chemical substance (20)   
   KEGG COMPOUND (20)   
Chemical reaction (11)   
   KEGG ENZYME (2)   
   KEGG REACTION (9)   
Genome (1)   
   KEGG GENOME (1)   
Gene (7)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (1)   
   Pfam (1)   
All databases (56)   

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