KEGG   Nomascus leucogenys (northern white-cheeked gibbon): 100597533Help
Entry
100597533         CDS       T03265                                 

Gene name
INSR
Definition
(RefSeq) insulin receptor
  KO
K04527  
insulin receptor [EC:2.7.10.1]
Organism
nle  Nomascus leucogenys (northern white-cheeked gibbon)
Pathway
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phospholipase D signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Longevity regulating pathway
Longevity regulating pathway - multiple species
Adherens junction
Insulin signaling pathway
Ovarian steroidogenesis
Regulation of lipolysis in adipocytes
Type II diabetes mellitus
Insulin resistance
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Module
PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:nle00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100597533 (INSR)
   04015 Rap1 signaling pathway
    100597533 (INSR)
   04010 MAPK signaling pathway
    100597533 (INSR)
   04066 HIF-1 signaling pathway
    100597533 (INSR)
   04068 FoxO signaling pathway
    100597533 (INSR)
   04072 Phospholipase D signaling pathway
    100597533 (INSR)
   04022 cGMP - PKG signaling pathway
    100597533 (INSR)
   04151 PI3K-Akt signaling pathway
    100597533 (INSR)
   04152 AMPK signaling pathway
    100597533 (INSR)
   04150 mTOR signaling pathway
    100597533 (INSR)
 Cellular Processes
  Cellular community - eukaryotes
   04520 Adherens junction
    100597533 (INSR)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    100597533 (INSR)
   04923 Regulation of lipolysis in adipocyte
    100597533 (INSR)
   04913 Ovarian Steroidogenesis
    100597533 (INSR)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100597533 (INSR)
  Aging
   04211 Longevity regulating pathway - mammal
    100597533 (INSR)
   04213 Longevity regulating pathway - multiple species
    100597533 (INSR)
 Human Diseases
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    100597533 (INSR)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    100597533 (INSR)
   04931 Insulin resistance
    100597533 (INSR)
Enzymes [BR:nle01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     100597533 (INSR)
Protein kinases [BR:nle01001]
 Tyrosine protein kinases
  InsR family [OT]
   100597533 (INSR)
Enzyme-linked receptors [BR:nle01020]
 Receptor tyrosine kinases
  RTK class II (Insulin receptor family)
   100597533 (INSR)
Cytokine receptors [BR:nle04050]
 Receptor tyrosine kinase
  RTK class II (Insulin receptor family)
   100597533 (INSR)
CD molecules [BR:nle04090]
 Proteins
  100597533 (INSR)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
Position
10
AA seq 1318 aa AA seqDB search
MGTLQRKLLIPAGCGVYRARDENTGPRFHVHEAGSAPDPANASTMRLLTCLASCSFSLLV
CPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVY
GLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCY
LATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSH
CQKVCPTICKSHGCTAEGLCCHSECLGNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYH
FQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGP
CPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGY
LKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLF
FHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCKSLGNRLLLFCLESPYQNV
TEFDGQDACGSNSWTVVDIDPPLRSTDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDE
RRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQ
AEDSELFELDYCLKGECGQLCWDWSWFYFHRKTSSGTGAEDPRPSRKRRSLGDVGNVTAA
VPTVAAFPNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEER
CSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGD
EELHLCVSRKHFALERGCRLRGLSPGNYSVRVRATSLAGNGSWTEPTYFYVTDYLDVPSN
IAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVP
DEWEVPREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLN
EASVMKGFTCHHVVSPAGMGHGLAFLPLPSLCLLLLHRATEDTGCNLLPTPHSTKLPILE
PIFPLHFPMSTLRIHSYWIWPPPRACEPFVLSDFGMTRDIYETDYYRKGGKGLLPVRWMA
PESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPER
VTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDM
ENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPRSNPS
NT seq 3957 nt NT seq  +upstreamnt  +downstreamnt
atgggtactttacagagaaagctactcatcccggctggctgcggagtttacagggcccgg
gatgaaaacacagggcccaggtttcatgtccatgaagccggctctgcccctgatcctgct
aatgcatccaccatgcgtctgcttacctgtcttgcttcctgttcattttctcttctagtg
tgtcccggcatggatatccggaacaacctcactaggttgcatgagctggagaattgctct
gtcatcgaaggacacttgcagatactcttgatgttcaaaacgaggcccgaagatttccga
gacctcagtttccccaaactcataatgatcactgattacttgctgctcttccgtgtctat
gggctcgagagcctgaaggacctgttccccaacctcacggtcatccggggatcacgactg
ttctttaactacgcgctggtcatcttcgagatggttcacctcaaggaactcggcctctac
aacctgatgaacatcacccggggttctgtccgcatcgagaagaacaatgagctctgttac
ttggccactatcgactggtcccgtatcctggattctgtggaggataattacatcgtattg
aacaaagatgacaacgaggagtgtggagacatctgtccgggtaccgcgaaaggcaaaacc
aactgcccagccaccgtcatcaacgggcagtttgtcgaacggtgttggactcatagtcac
tgccagaaagtttgcccgaccatctgtaagtcacatggctgcactgccgaaggcctctgt
tgccacagcgagtgcctgggcaactgttctgagcccgacgaccccaccaagtgcgtggcc
tgccgcaacttctacctggacggcagatgtgtggagacctgcccgcccccgtactaccac
ttccaggactggcgctgtgtgaacttcagcttctgccaggacctgcaccacaaatgcaag
aactcgcggaggcagggctgccaccagtacgtcattcacaacaacaagtgcatccctgag
tgtccctccgggtacacgatgaattccagcaacttgctgtgcaccccatgcctgggtccc
tgtcccaaggtgtgccacctcctagaaggcgagaagaccatcgactcggtgacgtctgcc
caggagctccgaggatgcaccgtcatcaacgggagtctgatcatcaacattcgaggaggc
aacaatctggcagctgagctagaagccaacctcggcctcattgaagaaatttcaggttat
ctaaaaatccgccgatcctacgctctggtgtcactttccttcttccggaagttacgtctg
attcgaggagagaccttggaaatcgggaactactccttctatgccttggacaaccagaac
ctaaggcagctctgggattggagcaaacacaacctcaccatcactcaggggaaactcttc
ttccactataaccccaaactctgcctgtcagaaatccacaagatggaagaagtttcagga
accaaggggcgccaggagagaaatgacattgccctgaagaccaatggggaccaggcatcc
tgtaagtcactgggtaaccgccttctgctgttttgtcttgaaagcccttatcagaatgtg
acggagttcgacgggcaggatgcgtgtggttccaacagctggacggtggtagacattgat
ccgcccctgaggtccaccgaccccaaatcacagaaccacccaggatggctgatgcggggt
ctcaagccctggacccagtatgccatctttgtgaagaccctggtcaccttttcggatgaa
cgccggacctatggggccaagagtgacatcatttatgtccagacagatgccaccaacccc
tctgtgcccctggatccaatctcagtgtctaactcatcatcccagattattctgaagtgg
aagcccccctcagaccccaatggcaacatcacccactacctggttttctgggagaggcag
gcggaagacagtgagctgttcgagctggattattgcctcaaaggtgagtgcgggcagctg
tgctgggattggagttggttttatttccacagaaaaacctcttcaggcactggtgccgag
gaccctaggccatctcggaaacgcaggtcccttggcgatgttgggaatgtgacggcagcc
gtgcccacggtggcagctttccccaacacttcctcaaccagcgtgcccacgagtccggag
gagcacaggccctttgagaaggtggtgaacaaggagtcactggtcatctccggcttgcga
cacttcacgggctatcgcatcgagctgcaggcttgcaaccaagacacccctgaggaacgg
tgcagtgtggcagcctacgtcagtgccaggaccatgcctgaagccaaggctgatgacatt
gtcggccctgtgacgcacgaaatctttgagaacaacgtcgtccacttgatgtggcaggag
ccgaaggaacccaatggtctgattgtgctgtatgaagtgagttatcggcgatatggcgat
gaggagctgcatctctgcgtctcccgcaagcacttcgctctggaacggggctgcaggctg
cgcgggctgtcgccggggaactacagcgtgcgagtccgggccacctccctcgcgggcaac
ggctcctggacagaacccacctatttctacgtgacagactatttagatgtcccgtcaaat
attgcaaaaattatcatcggccccctcatctttgtctttctcttcagtgttgtgattgga
agtatttatctattcctgagaaagaggcagccagatgggccgctgggaccactttacgct
tcttcaaatcccgagtatctcagtgccagtgatgtgtttccatgctctgtgtacgtgccg
gacgagtgggaggtgcctcgagagaagatcaccctccttcgagagctggggcagggctcc
tttggcatggtgtatgagggcaacgccagggacatcatcaagggtgaggcagagacccgc
gtggcagtgaagacggtcaacgagtcagccagtctccgagagcggattgagttcctcaat
gaggcctcggtcatgaagggcttcacctgccatcatgtggtgagtccagcggggatggga
catgggctggctttcttgccccttccctctctctgcctcctcctcctgcacagagcaaca
gaggacacagggtgtaacctcctacccaccccccactccactaagcttcccatcctagag
cccatcttcccccttcacttccccatgagtaccctcagaatccattcttactggatttgg
ccaccacccagagcgtgtgaaccttttgtgttgtcagactttggaatgaccagagacatc
tatgaaacggattactaccggaaagggggcaagggtctactccctgtacggtggatggcg
ccggagtccctgaaggatggggtctttaccacttcttctgacatgtggtcctttggcgtg
gtcctttgggaaatcaccagcttggcagaacagccttaccaaggcctgtcgaatgaacag
gtgttgaaatttgtcatggatggagggtatctggatcaacctgacaactgtccagagaga
gtcactgacctcatgcgcatgtgctggcaattcaaccccaagatgaggccaaccttcctg
gagattgtcaacctgctcaaggatgacctgcaccccagctttccggaggtgtcgttcttc
cacagcgaggagaacaaggctcccgagagtgaggagctggagatggagtttgaggacatg
gagaatgtgcccctggaccgttcctcacactgtcagagggaggaggcggggggccgggat
ggagggtcctcgctaggtttcaagcggagctacgaggaacacatcccttacacacacatg
aacggaggcaagaaaaacgggcggattctgaccttgcctcggtccaatccttcctaa

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