| Entry |
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| Gene name |
leuA
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| Definition |
(RefSeq) 2-isopropylmalate synthase
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| KO |
| 2-isopropylmalate synthase [EC: 2.3.3.13] |
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| Organism |
nme Neisseria meningitidis MC58 (serogroup B)
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| Pathway |
| Valine, leucine and isoleucine biosynthesis | | Pyruvate metabolism | | Metabolic pathways | | Biosynthesis of secondary metabolites | | 2-Oxocarboxylic acid metabolism | | Biosynthesis of amino acids |
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| Module |
| Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate |
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| Brite |
KEGG Orthology (KO) [BR:nme00001]
Metabolism
Carbohydrate metabolism
00620 Pyruvate metabolism
NMB1070 (leuA)
Amino acid metabolism
00290 Valine, leucine and isoleucine biosynthesis
NMB1070 (leuA)
Enzymes [BR:nme01000]
2. Transferases
2.3 Acyltransferases
2.3.3 Acyl groups converted into alkyl groups on transfer
2.3.3.13 2-isopropylmalate synthase
NMB1070 (leuA)
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| SSDB |
    |
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| Motif |
 |
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| Other DBs |
NCBI-GeneID: NCBI-ProteinID: UniProt: |
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| Structure |
PDB: |
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| Position |
1090515..1092068
 |
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| AA seq |
517 aa  
MTQTNRVIIFDTTLRDGEQSPGAAMTKEEKIRVARQLEKLGVDIIEAGFAAASPGDFEAV
NAIAKTITKSTVCSLSRAIERDIRQAGEAVAPAPKKRIHTFIATSPIHMEYKLKMKPKQV
IEAAVKAVKIAREYTDDVEFSCEDALRSEIDFLAEICGAVIEAGATTINIPDTVGYSIPY
KTEEFFRELIAKTPNGGKVVWSAHCHNDLGLAVANSLAALKGGARQVECTVNGLGERAGN
ASVEEIVMALKVRHDLFGLETGIDTTQIVPSSKLVSTITGYPVQPNKAIVGANAFSHESG
IHQDGVLKHRETYEIMSAESVGWATNRLSLGKLSGRNAFKTKLADLGIELESEEALNAAF
ARFKELADKKREIFDEDLHALVSDEMGSMNAESYKFISQKISTETGEEPRADIVFSIKGE
EKRASATGSGPVDAIFKAIESVAQSGAALQIYSVNAVTQGTESQGETSVRLARGNRVVNG
QGADTDVLVATAKAYLSALSKLEFSAAKPKAQGSGTI |
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| NT seq |
1554 nt  +upstreamnt +downstreamnt
atgacacagaccaaccgcgttatcattttcgacaccaccctgcgcgacggcgaacaatcg
cccggcgccgctatgaccaaagaggaaaaaatccgcgtcgcccgccagctggaaaaattg
ggtgtggacatcatcgaagcgggttttgccgctgccagcccgggcgatttcgaggcggtc
aatgcgattgcgaaaaccattaccaaatcaacggtctgttcattgtcccgcgccatcgag
cgggacatccgtcaggcgggtgaggccgttgcgcccgcgccgaaaaaacgcatccacacc
ttcatcgccaccagccccatccatatggagtacaaattgaagatgaagccgaagcaggtg
attgaggcggcggtcaaagcggtgaaaatcgctcgtgaatacaccgacgatgtggaattt
tcctgcgaagacgcgttgcgttcggaaatcgatttccttgccgaaatctgcggcgcggtg
attgaagcgggcgcgaccaccatcaatattcccgataccgtcggctattccatcccgtat
aaaaccgaagaatttttccgcgaactgattgccaaaacgcccaacggcggcaaagtcgtt
tggtcggcacactgccacaacgatttgggcttggcggttgccaattcgcttgccgcatta
aaaggcggcgcgcgtcaggtggaatgtactgtcaacggcttgggcgaacgtgcaggcaat
gcttcggttgaagaaatcgtgatggcgttgaaagtgcgccacgacttgttcggcttggaa
accggcatcgataccacgcaaatcgtgccttcgtccaaactggtgtccaccattacgggc
tatcccgtgcagcccaacaaagccattgtcggtgccaatgccttttcgcatgaatcgggc
atccatcaggacggggtgctgaaacaccgcgaaacttacgagattatgtccgccgaatcg
gtcggctgggcaacaaaccgtttgagcttgggcaaattgtccggccgcaacgccttcaaa
accaagctggcggatttgggcatcgagttggaaagcgaagaggcactgaacgcggcattt
gcacgcttcaaagaactcgccgacaaaaaacgcgaaatcttcgatgaagacctgcacgca
ctggtatccgacgaaatgggcagcatgaatgccgagagctacaaattcatctcccaaaaa
atcagcaccgaaaccggagaagaaccgcgcgccgacatcgtgttcagcatcaaaggtgaa
gaaaaacgcgcttccgcaaccggttccggccccgtggatgcgattttcaaagcgattgaa
agcgtggcgcaaagcggcgcggctttgcagatttattccgtcaacgccgtcacgcaaggt
acggaaagccagggcgaaaccagcgtccgtctggcgcgcggcaaccgcgtcgtcaacggt
cagggcgcggataccgacgttttggtcgccaccgccaaagcctacctttccgctttgagc
aagctggaatttagtgccgccaaaccgaaagcgcagggcagcggtacgatttga |
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