| Entry |
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| Gene name |
leuA
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| Definition |
(RefSeq) 2-isopropylmalate synthase
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| KO |
| 2-isopropylmalate synthase [EC: 2.3.3.13] |
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| Organism |
nme Neisseria meningitidis MC58 (serogroup B)
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| Pathway |
| Valine, leucine and isoleucine biosynthesis | | Pyruvate metabolism | | Metabolic pathways | | Biosynthesis of secondary metabolites | | 2-Oxocarboxylic acid metabolism | | Biosynthesis of amino acids |
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| Module |
| Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate |
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| Brite |
KEGG Orthology (KO) [BR:nme00001]
Metabolism
Overview
01210 2-Oxocarboxylic acid metabolism
NMB1070 (leuA)
01230 Biosynthesis of amino acids
NMB1070 (leuA)
Carbohydrate metabolism
00620 Pyruvate metabolism
NMB1070 (leuA)
Amino acid metabolism
00290 Valine, leucine and isoleucine biosynthesis
NMB1070 (leuA)
Enzymes [BR:nme01000]
2. Transferases
2.3 Acyltransferases
2.3.3 Acyl groups converted into alkyl groups on transfer
2.3.3.13 2-isopropylmalate synthase
NMB1070 (leuA)
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| SSDB |
    |
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| Motif |
 |
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| Other DBs |
NCBI-GeneID: NCBI-ProteinID: UniProt: |
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| Structure |
PDB: |
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| Position |
1090515..1092068
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| AA seq |
517 aa  
MTQTNRVIIFDTTLRDGEQSPGAAMTKEEKIRVARQLEKLGVDIIEAGFAAASPGDFEAV
NAIAKTITKSTVCSLSRAIERDIRQAGEAVAPAPKKRIHTFIATSPIHMEYKLKMKPKQV
IEAAVKAVKIAREYTDDVEFSCEDALRSEIDFLAEICGAVIEAGATTINIPDTVGYSIPY
KTEEFFRELIAKTPNGGKVVWSAHCHNDLGLAVANSLAALKGGARQVECTVNGLGERAGN
ASVEEIVMALKVRHDLFGLETGIDTTQIVPSSKLVSTITGYPVQPNKAIVGANAFSHESG
IHQDGVLKHRETYEIMSAESVGWATNRLSLGKLSGRNAFKTKLADLGIELESEEALNAAF
ARFKELADKKREIFDEDLHALVSDEMGSMNAESYKFISQKISTETGEEPRADIVFSIKGE
EKRASATGSGPVDAIFKAIESVAQSGAALQIYSVNAVTQGTESQGETSVRLARGNRVVNG
QGADTDVLVATAKAYLSALSKLEFSAAKPKAQGSGTI |
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| NT seq |
1554 nt  +upstreamnt +downstreamnt
atgacacagaccaaccgcgttatcattttcgacaccaccctgcgcgacggcgaacaatcg
cccggcgccgctatgaccaaagaggaaaaaatccgcgtcgcccgccagctggaaaaattg
ggtgtggacatcatcgaagcgggttttgccgctgccagcccgggcgatttcgaggcggtc
aatgcgattgcgaaaaccattaccaaatcaacggtctgttcattgtcccgcgccatcgag
cgggacatccgtcaggcgggtgaggccgttgcgcccgcgccgaaaaaacgcatccacacc
ttcatcgccaccagccccatccatatggagtacaaattgaagatgaagccgaagcaggtg
attgaggcggcggtcaaagcggtgaaaatcgctcgtgaatacaccgacgatgtggaattt
tcctgcgaagacgcgttgcgttcggaaatcgatttccttgccgaaatctgcggcgcggtg
attgaagcgggcgcgaccaccatcaatattcccgataccgtcggctattccatcccgtat
aaaaccgaagaatttttccgcgaactgattgccaaaacgcccaacggcggcaaagtcgtt
tggtcggcacactgccacaacgatttgggcttggcggttgccaattcgcttgccgcatta
aaaggcggcgcgcgtcaggtggaatgtactgtcaacggcttgggcgaacgtgcaggcaat
gcttcggttgaagaaatcgtgatggcgttgaaagtgcgccacgacttgttcggcttggaa
accggcatcgataccacgcaaatcgtgccttcgtccaaactggtgtccaccattacgggc
tatcccgtgcagcccaacaaagccattgtcggtgccaatgccttttcgcatgaatcgggc
atccatcaggacggggtgctgaaacaccgcgaaacttacgagattatgtccgccgaatcg
gtcggctgggcaacaaaccgtttgagcttgggcaaattgtccggccgcaacgccttcaaa
accaagctggcggatttgggcatcgagttggaaagcgaagaggcactgaacgcggcattt
gcacgcttcaaagaactcgccgacaaaaaacgcgaaatcttcgatgaagacctgcacgca
ctggtatccgacgaaatgggcagcatgaatgccgagagctacaaattcatctcccaaaaa
atcagcaccgaaaccggagaagaaccgcgcgccgacatcgtgttcagcatcaaaggtgaa
gaaaaacgcgcttccgcaaccggttccggccccgtggatgcgattttcaaagcgattgaa
agcgtggcgcaaagcggcgcggctttgcagatttattccgtcaacgccgtcacgcaaggt
acggaaagccagggcgaaaccagcgtccgtctggcgcgcggcaaccgcgtcgtcaacggt
cagggcgcggataccgacgttttggtcgccaccgccaaagcctacctttccgctttgagc
aagctggaatttagtgccgccaaaccgaaagcgcagggcagcggtacgatttga |
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