KEGG   Ornithorhynchus anatinus (platypus): 100073788Help
Entry
100073788         CDS       T01045                                 

Gene name
PIK3CA
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
oaa  Ornithorhynchus anatinus (platypus)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:oaa00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100073788 (PIK3CA)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100073788 (PIK3CA)
   04015 Rap1 signaling pathway
    100073788 (PIK3CA)
   04012 ErbB signaling pathway
    100073788 (PIK3CA)
   04370 VEGF signaling pathway
    100073788 (PIK3CA)
   04630 Jak-STAT signaling pathway
    100073788 (PIK3CA)
   04668 TNF signaling pathway
    100073788 (PIK3CA)
   04066 HIF-1 signaling pathway
    100073788 (PIK3CA)
   04068 FoxO signaling pathway
    100073788 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    100073788 (PIK3CA)
   04022 cGMP - PKG signaling pathway
    100073788 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    100073788 (PIK3CA)
   04152 AMPK signaling pathway
    100073788 (PIK3CA)
   04150 mTOR signaling pathway
    100073788 (PIK3CA)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    100073788 (PIK3CA)
  Cell growth and death
   04210 Apoptosis
    100073788 (PIK3CA)
  Cell communication
   04510 Focal adhesion
    100073788 (PIK3CA)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100073788 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    100073788 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    100073788 (PIK3CA)
   04660 T cell receptor signaling pathway
    100073788 (PIK3CA)
   04662 B cell receptor signaling pathway
    100073788 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    100073788 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    100073788 (PIK3CA)
   04670 Leukocyte transendothelial migration
    100073788 (PIK3CA)
   04062 Chemokine signaling pathway
    100073788 (PIK3CA)
  Endocrine system
   04910 Insulin signaling pathway
    100073788 (PIK3CA)
   04915 Estrogen signaling pathway
    100073788 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    100073788 (PIK3CA)
   04917 Prolactin signaling pathway
    100073788 (PIK3CA)
   04921 Oxytocin signaling pathway
    100073788 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    100073788 (PIK3CA)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100073788 (PIK3CA)
  Digestive system
   04973 Carbohydrate digestion and absorption
    100073788 (PIK3CA)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100073788 (PIK3CA)
  Nervous system
   04725 Cholinergic synapse
    100073788 (PIK3CA)
   04722 Neurotrophin signaling pathway
    100073788 (PIK3CA)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100073788 (PIK3CA)
  Development
   04380 Osteoclast differentiation
    100073788 (PIK3CA)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100073788 (PIK3CA)
   05205 Proteoglycans in cancer
    100073788 (PIK3CA)
   05203 Viral carcinogenesis
    100073788 (PIK3CA)
   05210 Colorectal cancer
    100073788 (PIK3CA)
   05212 Pancreatic cancer
    100073788 (PIK3CA)
   05214 Glioma
    100073788 (PIK3CA)
   05221 Acute myeloid leukemia
    100073788 (PIK3CA)
   05220 Chronic myeloid leukemia
    100073788 (PIK3CA)
   05218 Melanoma
    100073788 (PIK3CA)
   05211 Renal cell carcinoma
    100073788 (PIK3CA)
   05215 Prostate cancer
    100073788 (PIK3CA)
   05213 Endometrial cancer
    100073788 (PIK3CA)
   05222 Small cell lung cancer
    100073788 (PIK3CA)
   05223 Non-small cell lung cancer
    100073788 (PIK3CA)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    100073788 (PIK3CA)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    100073788 (PIK3CA)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    100073788 (PIK3CA)
   05166 HTLV-I infection
    100073788 (PIK3CA)
   05162 Measles
    100073788 (PIK3CA)
   05164 Influenza A
    100073788 (PIK3CA)
   05161 Hepatitis B
    100073788 (PIK3CA)
   05160 Hepatitis C
    100073788 (PIK3CA)
   05169 Epstein-Barr virus infection
    100073788 (PIK3CA)
   05146 Amoebiasis
    100073788 (PIK3CA)
   05145 Toxoplasmosis
    100073788 (PIK3CA)
   05142 Chagas disease (American trypanosomiasis)
    100073788 (PIK3CA)
Enzymes [BR:oaa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100073788 (PIK3CA)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
Un
AA seq 1068 aa AA seqDB search
MPPRPSSGELWGIHLMPPRIIVECLLPNGMIVTLECLREATLVTIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDVNAPHSRALYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYLLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYTQLPLD
TFTMPSYSRRISTATPYMNGEASAKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLMYDMYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSPVKFPDMTVIEEHANWTVSRELGFNYSHAGLSNRIARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTTPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPRVRAFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFISPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEMYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt NT seq  +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactatggggcatccacttgatgcccccaagaatc
atagtagaatgtctactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
acattagtaactattaaacatgaactctttaaagaagcaagaaagtacccccttcatcaa
ctccttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagagaa
gaattttttgatgaaacgcgacgcctttgtgacctacggctttttcaacctttcctcaaa
gtcattgaaccagtgggcaaccgagaagaaaagatcctcaatcgagaaattggtttcgca
attggaatgcccgtctgtgaatttgacatggtcaaggatccagaagtacaggactttcga
agaaatattcttaatgtttgtaaagaagctgtggatcttcgagatgttaacgcaccccat
agtagagcattgtatgtctatcctccaaatgtagagtcgtcacctgaactgccaaagcac
atatataataaactagataaaggacaaataatagtggtgatttgggtgatagtgtctcca
aataatgacaagcagaaatacaccttaaaaatcaaccacgattgtgtgcccgaacaagtg
atagctgaagcgattaggaaaaaaacacgaagtatgctgctgtcatctgaacaactgaaa
ctctgtgtcttggaatatcagggcaaatatattttaaaagtatgtggatgtgacgaatac
ttactcgaaaagtatcccctgagtcaatataagtatataagaagctgtataatgcttggt
cggatgcccaatttgatgttaatggctaaagaaagcctttatacccagctgccattggat
acttttacaatgccatcttattccagacgcatctccacagcaacaccatatatgaatgga
gaagcttcagcaaaatctctttgggtcattaacagtgcattacgaataaagattctgtgt
gcaacctatgtaaatgtaaatattcgagacattgacaagatttacgttcgaacgggtatc
taccatggaggagaaccattatgtgacaatgtaaatactcagagggtcccttgttccaat
cccagatggaatgaatggctgatgtatgacatgtacattcctgatcttccacgtgctgct
cggctttgcctttccatttgttccgttaaaggcagaaagggtgcaaaagaggaacactgc
cctttggcttggggaaatatcaatttatttgattataccgacactctcgtatctgggaaa
atggctctgaatctgtggccagtgcctcatggattggaagacttgctcaaccctattggt
gtgactggctcaaatccaaataaggaaactccatgcttagagctggaatttgactggttc
agcagccctgtgaagtttccagatatgacagtaattgaagagcatgctaattggactgta
tcccgagaactgggatttaattactcccatgctggactgagtaacaggatagctagagac
aatgagttacgggaaaatgacaaagagcagctccgggcaatttgtacaagagacccactt
tctgaaatcactgagcaagaaaaggacttcctttggagtcacagacattattgtgtgact
accccagaaatcctaccaaaactgcttttgtctgttaaatggaactctagagacgaagta
gcccagatgtactgcttggtaaaagattggccaccaatcaaacccgaacaggcaatggag
cttttggactgtaactatcctgacccgagggtccgagcctttgcagttcgttgcctagaa
aagtatctgactgatgacaaactctctcagtacctcattcaattagtccaggttttgaaa
tatgagcaatatttggataacttgcttgtgagatttttacttaagaaggcactgaccaat
caaaggataggacattttttcttttggcacttaaagtctgaaatgcataataaaacggtc
agccagagatttggtttgcttttggagtcctattgccgtgcatgtggaatgtatctaaaa
cacctgaacaggcaggtggaggctatggagaaattgattaaccttacggatattctcaaa
caggagaagaaggatgaaactcaaaaggtgcagatgaagttcctagtcgaacagatgaga
cggcccgatttcatggatgctttacagggctttatctctcctcttaaccctgcccatcag
ttgggaaatctcaggctcgaggaatgtcggattatgtcgtctgcaaaacggccactgtgg
ttaaattgggagaacccagacatcatgtcagagttgttgtttcagaataacgagatcatc
tttaaaaatggggatgatttacgtcaggatatgttaacacttcagattattcgaattatg
gaaaacatctggcaaaaccagggtcttgacctccggatgttaccttatggatgtctttcg
attggagactgtgtggggcttatcgaggtggtgagaaattcccatacaattatgcaaatt
cagtgtaaaggaggccttaaaggtgcattgcagttcaatagccatacgttgcatcagtgg
ctcaaagacaagaacaaaggagaaatgtatgatgctgccattgatttatttacacgctcc
tgtgctggttattgtgttgctaccttcatcctgggaattggggatcgccacaatagtaac
atcatggtaaaagatgatggacaactgtttcatatagattttggacacttcttggatcac
aaaaagaaaaagtttggttacaaacgggagcgagtgccatttgtcttgacacaagacttc
ttaatagtgattagtaaaggtgcccaagaatgcactaaaacaagagaatttgagaggttt
caggagatgtgttacaaggcttacctagctattcgtcaacatgccaatctcttcataaat
ctgttctctatgatgctcggctctggaatgccagaactacagtccttcgatgacattgcc
tatattcggaaaaccttggccttggataaaacagagcaggaggctctggagtatttcatg
aagcaaatgaatgatgcacaccatggaggctggacaacaaaaatggactggatcttccac
acaattaagcaacatgctttgaactga

  All links  
No link information was found.   
DBGET integrated database retrieval system