KEGG   Ornithorhynchus anatinus (platypus): 100076319
Entry
100076319         CDS       T01045                                 
Symbol
RET
Name
(RefSeq) proto-oncogene tyrosine-protein kinase receptor Ret
  KO
K05126  proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1]
Organism
oaa  Ornithorhynchus anatinus (platypus)
Pathway
oaa04010  MAPK signaling pathway
oaa04020  Calcium signaling pathway
oaa04151  PI3K-Akt signaling pathway
oaa05200  Pathways in cancer
oaa05216  Thyroid cancer
oaa05223  Non-small cell lung cancer
oaa05230  Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:oaa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100076319 (RET)
   04020 Calcium signaling pathway
    100076319 (RET)
   04151 PI3K-Akt signaling pathway
    100076319 (RET)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100076319 (RET)
   05230 Central carbon metabolism in cancer
    100076319 (RET)
  09162 Cancer: specific types
   05216 Thyroid cancer
    100076319 (RET)
   05223 Non-small cell lung cancer
    100076319 (RET)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:oaa01001]
    100076319 (RET)
Enzymes [BR:oaa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     100076319 (RET)
Protein kinases [BR:oaa01001]
 Receptor tyrosine kinases (RTK)
  RET family
   100076319 (RET)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr RET_CLD1 Pkinase RET_CLD3 RET_CLD4 Cadherin RIO1 Cadherin_pro Pkinase_fungal Haspin_kinase ABC1
Other DBs
NCBI-GeneID: 100076319
NCBI-ProteinID: XP_028917087
Ensembl: ENSOANG00000046180
Position
3:complement(113021789..113176093)
AA seq 1105 aa
MSVRGSALGFLLLWEAALGLYFPRDTYSEKLYVDQPAGTPLLYVQALRDSQQEVPRFQLG
QHLYGSYRSQLHENLWFQIHEDTGLLYLNRSLGWKDLKSLSALNGGYPLLNIHLHVFLSP
KPFWENECLWPSCAKVSLSIINTTAPTCSSLKAREFCFLDTGLSFRIKENKPPGTFHQFR
LLPVQQLCPNISISYQLIADAGVPFRCDKESMEVSTRRPLDREQREKYELMAKCTVRMEA
REVDVVVPFPVTVYDEDDTAPYLPRGINTADAVVEYKRKEGTILAKLTVQDADVTPSSGE
LIRKYTNTIVTSDPWVSESFRVDHMPNETTVNSNGSLVRATQHEYRLVLNRSFPITESRS
VQVDVLVNDTDFQGPEGSLLLHFNVTILPVSIRFQNSSYSFSVNRNAHQYAQIGKICIEN
CKEFYGVNIVYRLQSLSSNCSALGILTALEETTGHLYVNDSTVVQRPECTEIQYTVVALD
KQSKKQAKTSIIVVVEGTIMPQEQGCPSSCAVSKRRSECEECGGLGTLTGKCQWRQGDGK
GITKNYSTCTPSLKTCPDGVCDTVESRYPAICPQDCTRGEIIGGHERGDRRGIKAGYGIC
NCFPEEKKCFCEQEDDKEALCDDVCRTVIAGAVLLSFIISVLLSSYFIHRYHKNSPKPPI
ASAEMTFRRPAQAYPISYSSSNVRRPSLDSLENQVSVDTFKIPEDPKWEFPRKNLVLGKT
LGEGEFGKVVKATAFRLKGKAGYTTVAVKMLKENASQSELRDLLSEFNLLKQVNHPHVIK
LYGACSQDGPLYLIVEYAKYGSLRSFLRESRKVGPSYVGSDGNRNSSYLDNPDERALTMG
DLISFAWQISRGMQYLAEMKLVHRDLAARNVLVAEGRKMKISDFGLSRDVYEEDSYVKRS
KGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIAPERLFNLLKTGYR
MERPENCSEEMYNLMLRCWKQEPDKRPTFAEISKELEKMMVKSRDYLDLAASTPSDSLLY
DDGLSEEETPLVDCNNAPLPRTLPSTWIENKLYGMSYPNWPEESPVPLTRFDGTNSVFSR
YANDSVYANWMVSPSAAKFMDKFDS
NT seq 3318 nt   +upstreamnt  +downstreamnt
atgtccgtccggggaagcgcgttgggcttcctcctcctttgggaagctgccctgggcctc
tatttcccccgggatacgtactcagagaagctgtacgttgaccagccggccggcacgccc
ctgctctacgtccaggccttgcgggattctcagcaggaggttccacgcttccagctgggg
cagcacctgtacggcagttaccgttcccagctccacgagaatctctggttccagatccat
gaagacacaggacttctctacctcaacaggagtctgggctggaaggacttgaagagccta
agcgcccttaacggaggatatcctttactaaacatccacctccatgttttcctttccccc
aaacctttctgggagaacgagtgcctctggcctagctgcgccaaagtgtctctctccatc
atcaacaccaccgccccaacctgcagctctctgaaggcgagggagttctgcttcctggat
acgggcctctctttccgcatcaaggagaacaagcctcctggcacattccaccagttccgt
ctcctccctgtgcagcagctctgtcccaacatcagcatctcctaccagctgatagcagat
gcaggtgtccccttccgctgtgacaaggaaagcatggaggtgagcacgcgccggcccctg
gaccgggagcagagggagaagtatgagctgatggccaagtgcacagtgaggatggaggcc
agggaggtggatgtggtggtgcccttccccgtgaccgtgtacgacgaggacgacacagcc
ccctacctcccccgtggcatcaacaccgcggacgcggttgtggagtacaagcggaaggag
gggaccatattggccaagctgacagtgcaagatgcagacgtgacaccgtcctcgggggag
ctcatccggaaatacacgaataccatcgtgaccagtgacccttgggtcagcgagtccttc
cgagtggaccacatgccgaatgagaccacagtcaactccaatggcagcttggtgcgggca
actcagcacgaatacaggctcgtgctgaaccgcagcttccccatcacagagagccggtcc
gtccaagtggacgtgttggtgaatgatacggatttccaaggcccggagggatcgttgctg
ctccacttcaacgtgaccatcctgcccgtcagcatccgatttcagaacagctcctactcg
ttctctgtcaacaggaacgctcaccaatatgcacagattggaaaaatctgcattgaaaat
tgcaaggagttttatggagtgaacatcgtctaccggttgcaatctctcagctccaactgc
agtgctctagggattcttaccgccctggaagaaacaacaggacatctttacgtgaatgac
tccactgtagtccaaaggccggagtgtacagaaatacagtatacagtagtagccttggac
aaacagagcaagaagcaagccaaaacctccattattgttgtggtagaaggaactattatg
cctcaggaacaaggttgcccttcttcctgtgcagtcagcaagcggcgctctgagtgtgaa
gagtgtggaggcctcggaacgctcacgggcaagtgccagtggaggcagggagacggaaaa
ggcatcaccaagaactattcaacgtgcaccccaagcctcaagacttgtccagatggcgtc
tgtgatactgttgagagtagataccctgccatatgtcctcaggattgcacaaggggcgaa
atcatcggtggtcacgagcgtggggaccgccggggaataaaagctggatatggcatctgt
aactgtttcccagaagaaaagaagtgtttttgtgagcaagaagatgacaaagaggcactg
tgtgacgatgtctgccggacggtaatcgcaggcgccgtcctcctctccttcatcatctcg
gtgctgctctcgtcctacttcatccaccgctaccataagaactcgcccaagccacccatc
gcctcagcggagatgactttccgacgccccgcgcaagcctatcccatcagctactcttct
tctaacgtgcgacggccctctctggactctctggagaaccaggtgtcggtggacactttc
aagatccctgaagatccaaaatgggagtttcctcggaagaacctggttcttggaaaaact
cttggggaaggcgagtttgggaaagttgtcaaagctacagccttccgactcaagggaaaa
gctggctacaccaccgtggctgtgaaaatgctgaaagaaaatgcatcccagagtgaactc
cgtgatctgctgtcagagttcaacctcctgaaacaggtcaaccatccacacgtcattaaa
ctctacggagcttgcagtcaggatgggcctctctacctgattgtggagtatgccaaatac
ggctcccttcggagctttctcagggaaagccggaaggtggggcccagctacgtgggcagt
gatggcaatcggaattcgagctacttggacaaccctgatgagagggcactgacaatggga
gacttgatctcattcgcctggcagatctctcgaggaatgcaatatcttgcagaaatgaag
ctggttcatcgtgatctcgctgctagaaacgtgctggtggcagaaggacgtaaaatgaag
atttcagattttggcttgtctagggatgtgtacgaagaggactcctatgtcaagaggagc
aagggtcgaattcctgtcaagtggatggcgattgagtctctttttgatcatatctacact
acccaaagtgatgtgtggtcatttggtgttctactctgggagatcgtgaccctcggcgga
aacccttatcctgggattgctccagaacgactctttaacctcctgaaaactggttacaga
atggaaaggcctgaaaactgcagtgaggaaatgtacaatttgatgttgcggtgctggaag
caagaaccagataagagaccaacctttgcagagattagcaaagaactagagaaaatgatg
gtgaaaagtagggactacttggatcttgctgcttccaccccatccgactccttactctat
gatgacggcctctccgaagaggagacacccctcgtggactgtaataatgctcccctccct
cgaacccttccttccacatggattgaaaacaaactctatggcatgtcatacccgaactgg
cctgaggagagtcctgtaccactcacaagattcgatggcactaactctgtgttttcaaga
tatgcaaatgatagtgtatatgctaactggatggtttcaccctcagcggcaaaatttatg
gacaagtttgatagttaa

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (7)   
   KEGG PATHWAY (7)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (11)   
   Pfam (11)   
All databases (42)   

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