KEGG   Ornithorhynchus anatinus (platypus): 100076776Help
Entry
100076776         CDS       T01045                                 

Gene name
PLCG2
Definition
(RefSeq) phospholipase C gamma 2
  KO
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
oaa  Ornithorhynchus anatinus (platypus)
Pathway
oaa00562  Inositol phosphate metabolism
oaa01100  Metabolic pathways
oaa01521  EGFR tyrosine kinase inhibitor resistance
oaa04012  ErbB signaling pathway
oaa04014  Ras signaling pathway
oaa04020  Calcium signaling pathway
oaa04064  NF-kappa B signaling pathway
oaa04066  HIF-1 signaling pathway
oaa04070  Phosphatidylinositol signaling system
oaa04072  Phospholipase D signaling pathway
oaa04360  Axon guidance
oaa04370  VEGF signaling pathway
oaa04380  Osteoclast differentiation
oaa04611  Platelet activation
oaa04625  C-type lectin receptor signaling pathway
oaa04650  Natural killer cell mediated cytotoxicity
oaa04662  B cell receptor signaling pathway
oaa04664  Fc epsilon RI signaling pathway
oaa04666  Fc gamma R-mediated phagocytosis
oaa04670  Leukocyte transendothelial migration
oaa04722  Neurotrophin signaling pathway
oaa04750  Inflammatory mediator regulation of TRP channels
oaa04919  Thyroid hormone signaling pathway
oaa04933  AGE-RAGE signaling pathway in diabetic complications
oaa05167  Kaposi's sarcoma-associated herpesvirus infection
oaa05169  Epstein-Barr virus infection
oaa05200  Pathways in cancer
oaa05205  Proteoglycans in cancer
oaa05206  MicroRNAs in cancer
oaa05214  Glioma
oaa05223  Non-small cell lung cancer
oaa05225  Hepatocellular carcinoma
Module
oaa_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:oaa00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100076776 (PLCG2)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100076776 (PLCG2)
   04012 ErbB signaling pathway
    100076776 (PLCG2)
   04370 VEGF signaling pathway
    100076776 (PLCG2)
   04064 NF-kappa B signaling pathway
    100076776 (PLCG2)
   04066 HIF-1 signaling pathway
    100076776 (PLCG2)
   04020 Calcium signaling pathway
    100076776 (PLCG2)
   04070 Phosphatidylinositol signaling system
    100076776 (PLCG2)
   04072 Phospholipase D signaling pathway
    100076776 (PLCG2)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100076776 (PLCG2)
   04625 C-type lectin receptor signaling pathway
    100076776 (PLCG2)
   04650 Natural killer cell mediated cytotoxicity
    100076776 (PLCG2)
   04662 B cell receptor signaling pathway
    100076776 (PLCG2)
   04664 Fc epsilon RI signaling pathway
    100076776 (PLCG2)
   04666 Fc gamma R-mediated phagocytosis
    100076776 (PLCG2)
   04670 Leukocyte transendothelial migration
    100076776 (PLCG2)
  Endocrine system
   04919 Thyroid hormone signaling pathway
    100076776 (PLCG2)
  Nervous system
   04722 Neurotrophin signaling pathway
    100076776 (PLCG2)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100076776 (PLCG2)
  Development
   04360 Axon guidance
    100076776 (PLCG2)
   04380 Osteoclast differentiation
    100076776 (PLCG2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100076776 (PLCG2)
   05206 MicroRNAs in cancer
    100076776 (PLCG2)
   05205 Proteoglycans in cancer
    100076776 (PLCG2)
   05225 Hepatocellular carcinoma
    100076776 (PLCG2)
   05214 Glioma
    100076776 (PLCG2)
   05223 Non-small cell lung cancer
    100076776 (PLCG2)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    100076776 (PLCG2)
  Infectious diseases
   05167 Kaposi's sarcoma-associated herpesvirus infection
    100076776 (PLCG2)
   05169 Epstein-Barr virus infection
    100076776 (PLCG2)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    100076776 (PLCG2)
Enzymes [BR:oaa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100076776 (PLCG2)
Membrane trafficking [BR:oaa04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    100076776 (PLCG2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    100076776 (PLCG2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: PI-PLC-Y SH2 C2 SH3_1 SH3_9 SH3_2 PI-PLC-X EF-hand_like
Motif
Other DBs
NCBI-GeneID: 100076776
NCBI-ProteinID: XP_007669858
Position
Un
AA seq 916 aa AA seqDB search
MAEGPGTVGRWPVVAGGPQQWGTLAVQPGSPLGASTHSLPADGCSPCNEVLDRRGVAVEV
SISLREMKTILPLVNFKVGSAKFLKDKFMEIGAHKDELSFEQFHLFYKKLMFEQQKSILD
EFKKDSSVFILGNTDRPDASAVHLHDFQRFLHTEQQEQWAQDLSKVRERMTKFIDDTMRE
TAEPFLFVDEFLTYLFSKENSIWDEKYDVVDVQDMNNPLSHYWISSSHNTRSGRVQHCRI
RSIVEGGIMKYYLTDNLMFSSIYDLIQHYREAHLRCAEFELRLTDPVPKPNPHESKPWYY
DGLSRGEAEDMLMRIPRDGAFLIRKREGADSYAITFRAKGKVKHCRINQDGRHFVLGTSA
YFESLVELVNYYEKHALYRKMKLRYPVTQELLERYNTERDINSLYDLRMYVDPSEINPST
PQRTVKALYDYKAKQEDELSFCRGALIHNVLKEAGGWWKGDYGGRLQQYFPANYVEDIST
VDFEELEKQIIEDNPLGSLCRGILDLHAYKVVKEPQGRNEKPFVFILDPKKPDDPPVVFA
TDRVEELFEWYQSIREITWKNTTVENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLEN
PDFREIRSFVETKADTIVRQRANELLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGAQM
VALNFQTADKYMQMNHALFSLNGRTGYVLQPESMRNENYDPTPPESQRKMLMTLTVKVLG
ARHLPKLGRSIACPFVEVEICGAEYDNNKFKTTVVNDNGLNPVWAPTQEKVTFEIYDPTL
AFLRFVVYEEDMFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPV
LESEEELYSSCRQLRRRQEELNNQLFLYDTHQNLRNANRDALVNEFNVNENQLQLYQERC
DRRLREKRVSNSKFYS
NT seq 2751 nt NT seq  +upstreamnt  +downstreamnt
atggctgagggtcccgggacggtcggccggtggccggtggtcgcggggggacctcagcag
tggggcacgctggccgtgcagcctggctcacctctgggagcctccacccactccctgcca
gcagatggatgctccccttgcaacgaggtgttggatcgtcgaggagtagcagtggaagtc
agcatcagcctccgagaaatgaagactatacttcccttagtaaacttcaaagtaggcagt
gccaagttcctgaaggataagtttatggaaataggagctcacaaggacgaacttagcttt
gaacagttccatttgttctataaaaaactcatgtttgaacaacaaaaatcaatccttgat
gaattcaaaaaggattcttcggtcttcatcctgggaaatacggaccggccggatgcctca
gctgtccaccttcatgacttccagaggtttctgcacactgaacagcaggaacaatgggca
caggatctcagtaaagtccgggaacggatgacaaagtttattgacgacactatgagagaa
acggctgagcctttcttatttgttgacgagttcctcacctaccttttttcaaaagaaaat
agcatctgggatgaaaagtacgatgtggtagatgttcaggatatgaacaatcctttatct
cattattggatttcttcatcgcataacacgagatcgggccgagtccagcactgccgcatt
cggtccatcgtagagggcggcatcatgaagtactacctgactgacaacctcatgttcagc
agcatctacgacttgatccaacactatcgggaggcccacctgcggtgtgccgagttcgag
ctgcgcctgaccgatccggtgcccaaacctaacccgcatgaatctaaaccctggtactat
gacggcctgagccgaggagaagctgaagacatgctgatgcgaattccccgagatggagcc
tttctgattaggaagagagaaggggcagattcgtacgccattacgttcagggcaaaggga
aaggtgaagcactgccggattaatcaagacgggcgccattttgtgctgggaacttcagcc
tactttgaaagtttggtggagctggtaaactactatgaaaagcacgcactctacagaaaa
atgaagctgcgctatccagtgactcaggagctgctggagcgttataacacggaaagggat
ataaactcactttatgacctcaggatgtatgtggaccctagtgagattaatccttcaacg
cctcagagaactgtgaaggctttatatgactacaaagctaaacaagaagatgaactgagc
ttttgcaggggagccttgattcacaatgtcctgaaggaagcaggaggctggtggaaaggg
gactatggtggacggcttcagcagtattttcccgcaaattatgttgaagacatatcaaca
gttgactttgaagagctcgaaaagcagattatcgaagacaatcctttagggtctctgtgc
aggggcattctggacctccatgcctataaagttgtgaaagaaccacaagggagaaatgaa
aagccttttgtctttatcttggaccccaagaagcccgatgaccctccagtcgtgtttgcg
actgacagagtggaagaactgttcgagtggtatcaaagcatccgagagatcacctggaag
aatacaactgtggagaacaacatgaagtactgggagaagaaccagtcaattgccatagaa
ctgtccgacctggtcgtctactgcaaaccgactagcaaaaccaaggataatttagaaaat
cctgacttccgggaaatacgttcttttgtggaaactaaggccgacaccatcgtcaggcag
agggcaaatgagctcttgaaatacaatcaaaagggactgacccgagtttaccctaaagga
caaagagttgactcctccaattacgacccctttcgtctgtggctctgcggtgctcagatg
gtggctttgaatttccaaactgcagacaaatacatgcagatgaaccacgccctattctcc
ctcaacgggcggaccggatacgtcctgcagcccgaaagcatgagaaatgagaactatgac
ccgacgccaccggaatcgcagcgaaaaatgctcatgacgctgacggtgaaggtccttggg
gctcgccacttacccaagctcggcagaagcatcgcctgcccatttgtagaggtggaaatc
tgcggggccgagtacgataacaataaattcaagacaacggttgtgaatgataatggcctt
aatcccgtctgggctcccacacaggagaaagtgacatttgagatctacgatcccactttg
gcctttctgcgttttgtggtttatgaggaagatatgttcagtgatcccaacttccttgct
catgccacataccccatcaaaggaatcaaatcagggttcaggtcagtccctctcaaaaat
ggttacagtgaggacatcgagctagcttccctgttggttttctgtgaaatgcgtccagtt
ctggaaagtgaagaggagctctactcctcatgccgccagctccgaaggcggcaagaagaa
ctgaacaaccagctcttcctctacgacacccaccaaaacttgcgaaacgccaaccgagat
gctctggtaaatgagttcaatgtaaatgagaatcagctgcagctgtatcaggagaggtgc
gacaggagattaagggagaagagagtcagtaacagcaagttctactcatag

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