KEGG   Ornithorhynchus anatinus (platypus): 100076776Help
Entry
100076776         CDS       T01045                                 

Gene name
PLCG2
Definition
phospholipase C, gamma 2 (phosphatidylinositol-specific)
Orthology
K05859  
phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
oaa  Ornithorhynchus anatinus (platypus)
Pathway
Inositol phosphate metabolism
Metabolic pathways
ErbB signaling pathway
Ras signaling pathway
Calcium signaling pathway
NF-kappa B signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
VEGF signaling pathway
Osteoclast differentiation
Platelet activation
Natural killer cell mediated cytotoxicity
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Inflammatory mediator regulation of TRP channels
Thyroid hormone signaling pathway
Epstein-Barr virus infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Non-small cell lung cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:oaa00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100076776 (PLCG2)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100076776 (PLCG2)
   04012 ErbB signaling pathway
    100076776 (PLCG2)
   04370 VEGF signaling pathway
    100076776 (PLCG2)
   04064 NF-kappa B signaling pathway
    100076776 (PLCG2)
   04066 HIF-1 signaling pathway
    100076776 (PLCG2)
   04020 Calcium signaling pathway
    100076776 (PLCG2)
   04070 Phosphatidylinositol signaling system
    100076776 (PLCG2)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100076776 (PLCG2)
   04650 Natural killer cell mediated cytotoxicity
    100076776 (PLCG2)
   04662 B cell receptor signaling pathway
    100076776 (PLCG2)
   04664 Fc epsilon RI signaling pathway
    100076776 (PLCG2)
   04666 Fc gamma R-mediated phagocytosis
    100076776 (PLCG2)
   04670 Leukocyte transendothelial migration
    100076776 (PLCG2)
  Endocrine system
   04919 Thyroid hormone signaling pathway
    100076776 (PLCG2)
  Nervous system
   04722 Neurotrophin signaling pathway
    100076776 (PLCG2)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100076776 (PLCG2)
  Development
   04380 Osteoclast differentiation
    100076776 (PLCG2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100076776 (PLCG2)
   05206 MicroRNAs in cancer
    100076776 (PLCG2)
   05205 Proteoglycans in cancer
    100076776 (PLCG2)
   05214 Glioma
    100076776 (PLCG2)
   05223 Non-small cell lung cancer
    100076776 (PLCG2)
  Infectious diseases
   05169 Epstein-Barr virus infection
    100076776 (PLCG2)
Enzymes [BR:oaa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100076776 (PLCG2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
Un
AA seq 916 aa AA seqDB search
MAEGPGTVGRWPVVAGGPQQWGTLAVQPGSPLGASTHSLPADGCSPCNEVLDRRGVAVEV
SISLREMKTILPLVNFKVGSAKFLKDKFMEIGAHKDELSFEQFHLFYKKLMFEQQKSILD
EFKKDSSVFILGNTDRPDASAVHLHDFQRFLHTEQQEQWAQDLSKVRERMTKFIDDTMRE
TAEPFLFVDEFLTYLFSKENSIWDEKYDVVDVQDMNNPLSHYWISSSHNTRSGRVQHCRI
RSIVEGGIMKYYLTDNLMFSSIYDLIQHYREAHLRCAEFELRLTDPVPKPNPHESKPWYY
DGLSRGEAEDMLMRIPRDGAFLIRKREGADSYAITFRAKGKVKHCRINQDGRHFVLGTSA
YFESLVELVNYYEKHALYRKMKLRYPVTQELLERYNTERDINSLYDLRMYVDPSEINPST
PQRTVKALYDYKAKQEDELSFCRGALIHNVLKEAGGWWKGDYGGRLQQYFPANYVEDIST
VDFEELEKQIIEDNPLGSLCRGILDLHAYKVVKEPQGRNEKPFVFILDPKKPDDPPVVFA
TDRVEELFEWYQSIREITWKNTTVENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLEN
PDFREIRSFVETKADTIVRQRANELLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGAQM
VALNFQTADKYMQMNHALFSLNGRTGYVLQPESMRNENYDPTPPESQRKMLMTLTVKVLG
ARHLPKLGRSIACPFVEVEICGAEYDNNKFKTTVVNDNGLNPVWAPTQEKVTFEIYDPTL
AFLRFVVYEEDMFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPV
LESEEELYSSCRQLRRRQEELNNQLFLYDTHQNLRNANRDALVNEFNVNENQLQLYQERC
DRRLREKRVSNSKFYS
NT seq 2751 nt NT seq  +upstreamnt  +downstreamnt
atggctgagggtcccgggacggtcggccggtggccggtggtcgcggggggacctcagcag
tggggcacgctggccgtgcagcctggctcacctctgggagcctccacccactccctgcca
gcagatggatgctccccttgcaacgaggtgttggatcgtcgaggagtagcagtggaagtc
agcatcagcctccgagaaatgaagactatacttcccttagtaaacttcaaagtaggcagt
gccaagttcctgaaggataagtttatggaaataggagctcacaaggacgaacttagcttt
gaacagttccatttgttctataaaaaactcatgtttgaacaacaaaaatcaatccttgat
gaattcaaaaaggattcttcggtcttcatcctgggaaatacggaccggccggatgcctca
gctgtccaccttcatgacttccagaggtttctgcacactgaacagcaggaacaatgggca
caggatctcagtaaagtccgggaacggatgacaaagtttattgacgacactatgagagaa
acggctgagcctttcttatttgttgacgagttcctcacctaccttttttcaaaagaaaat
agcatctgggatgaaaagtacgatgtggtagatgttcaggatatgaacaatcctttatct
cattattggatttcttcatcgcataacacgagatcgggccgagtccagcactgccgcatt
cggtccatcgtagagggcggcatcatgaagtactacctgactgacaacctcatgttcagc
agcatctacgacttgatccaacactatcgggaggcccacctgcggtgtgccgagttcgag
ctgcgcctgaccgatccggtgcccaaacctaacccgcatgaatctaaaccctggtactat
gacggcctgagccgaggagaagctgaagacatgctgatgcgaattccccgagatggagcc
tttctgattaggaagagagaaggggcagattcgtacgccattacgttcagggcaaaggga
aaggtgaagcactgccggattaatcaagacgggcgccattttgtgctgggaacttcagcc
tactttgaaagtttggtggagctggtaaactactatgaaaagcacgcactctacagaaaa
atgaagctgcgctatccagtgactcaggagctgctggagcgttataacacggaaagggat
ataaactcactttatgacctcaggatgtatgtggaccctagtgagattaatccttcaacg
cctcagagaactgtgaaggctttatatgactacaaagctaaacaagaagatgaactgagc
ttttgcaggggagccttgattcacaatgtcctgaaggaagcaggaggctggtggaaaggg
gactatggtggacggcttcagcagtattttcccgcaaattatgttgaagacatatcaaca
gttgactttgaagagctcgaaaagcagattatcgaagacaatcctttagggtctctgtgc
aggggcattctggacctccatgcctataaagttgtgaaagaaccacaagggagaaatgaa
aagccttttgtctttatcttggaccccaagaagcccgatgaccctccagtcgtgtttgcg
actgacagagtggaagaactgttcgagtggtatcaaagcatccgagagatcacctggaag
aatacaactgtggagaacaacatgaagtactgggagaagaaccagtcaattgccatagaa
ctgtccgacctggtcgtctactgcaaaccgactagcaaaaccaaggataatttagaaaat
cctgacttccgggaaatacgttcttttgtggaaactaaggccgacaccatcgtcaggcag
agggcaaatgagctcttgaaatacaatcaaaagggactgacccgagtttaccctaaagga
caaagagttgactcctccaattacgacccctttcgtctgtggctctgcggtgctcagatg
gtggctttgaatttccaaactgcagacaaatacatgcagatgaaccacgccctattctcc
ctcaacgggcggaccggatacgtcctgcagcccgaaagcatgagaaatgagaactatgac
ccgacgccaccggaatcgcagcgaaaaatgctcatgacgctgacggtgaaggtccttggg
gctcgccacttacccaagctcggcagaagcatcgcctgcccatttgtagaggtggaaatc
tgcggggccgagtacgataacaataaattcaagacaacggttgtgaatgataatggcctt
aatcccgtctgggctcccacacaggagaaagtgacatttgagatctacgatcccactttg
gcctttctgcgttttgtggtttatgaggaagatatgttcagtgatcccaacttccttgct
catgccacataccccatcaaaggaatcaaatcagggttcaggtcagtccctctcaaaaat
ggttacagtgaggacatcgagctagcttccctgttggttttctgtgaaatgcgtccagtt
ctggaaagtgaagaggagctctactcctcatgccgccagctccgaaggcggcaagaagaa
ctgaacaaccagctcttcctctacgacacccaccaaaacttgcgaaacgccaaccgagat
gctctggtaaatgagttcaatgtaaatgagaatcagctgcagctgtatcaggagaggtgc
gacaggagattaagggagaagagagtcagtaacagcaagttctactcatag

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